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Protein

Trafficking protein particle complex subunit 11

Gene

TRAPPC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.2 Publications

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • Golgi organization Source: UniProtKB
  • protein complex oligomerization Source: UniProtKB
  • regulation of protein complex stability Source: UniProtKB

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 11
Gene namesi
Name:TRAPPC11
Synonyms:C4orf41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168538.15
HGNCiHGNC:25751 TRAPPC11
MIMi614138 gene
neXtProtiNX_Q7Z392

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Involvement in diseasei

Limb-girdle muscular dystrophy 2S (LGMD2S)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of limb-girdle muscular dystrophy characterized by proximal muscle weakness with childhood onset, resulting in gait abnormalities and scapular winging. Serum creatine kinase is increased. A subset of patients may show a hyperkinetic movement disorder with chorea, ataxia, or dystonia and global developmental delay.
See also OMIM:615356
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070158980G → R in LGMD2S. 1 PublicationCorresponds to variant dbSNP:rs397509417EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNETi60684
MalaCardsiTRAPPC11
MIMi615356 phenotype
OpenTargetsiENSG00000168538
Orphaneti369840 Autosomal recessive limb-girdle muscular dystrophy type 2S
369847 Intellectual disability-hyperkinetic movement-truncal ataxia syndrome
PharmGKBiPA162379849

Polymorphism and mutation databases

BioMutaiTRAPPC11
DMDMi205696378

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003480721 – 1133Trafficking protein particle complex subunit 11Add BLAST1133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ7Z392
MaxQBiQ7Z392
PaxDbiQ7Z392
PeptideAtlasiQ7Z392
PRIDEiQ7Z392

PTM databases

iPTMnetiQ7Z392
PhosphoSitePlusiQ7Z392

Expressioni

Gene expression databases

BgeeiENSG00000168538
CleanExiHS_C4orf41
ExpressionAtlasiQ7Z392 baseline and differential
GenevisibleiQ7Z392 HS

Organism-specific databases

HPAiHPA045427

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121957, 22 interactors
CORUMiQ7Z392
DIPiDIP-48282N
IntActiQ7Z392, 7 interactors
STRINGi9606.ENSP00000335371

Structurei

3D structure databases

ProteinModelPortaliQ7Z392
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAPPC11 family.Curated

Phylogenomic databases

eggNOGiKOG4386 Eukaryota
ENOG410XSTE LUCA
GeneTreeiENSGT00390000006550
HOVERGENiHBG107625
InParanoidiQ7Z392
KOiK20308
OMAiKLWADRI
OrthoDBiEOG091G00VZ
PhylomeDBiQ7Z392
TreeFamiTF314022

Family and domain databases

InterProiView protein in InterPro
IPR021773 Foie-gras_1
IPR025876 TRAPPC11_C
PfamiView protein in Pfam
PF11817 Foie-gras_1, 1 hit
PF12742 Gryzun-like, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z392-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPTQWDFPV ELCCRPMAFV TLTGLDVVYN AVHRAVWDAF CANRRADRVP
60 70 80 90 100
ISFKVLPGDH EYPKCRPKRT SYEWYIPKGI LKTGWMNKHL NLVPALVVVF
110 120 130 140 150
YELDWDEPQW KEKQSECATR VEIVRQSLQG RNTKVAVVLI QKKTPLPPGE
160 170 180 190 200
DVIASERAAA LCNACELSGK SLFVLPHTDH LVGYIIRLEN AFYEHAQTYY
210 220 230 240 250
YTEIRRVKSH KEFLNKTTHQ LLFVRHQFKI AFFSELKQDT QNALKNYRTA
260 270 280 290 300
YNLVHELRAH ETNILEIKTM AGFINYKICR LCFQHNTPLD AIAQFRKHID
310 320 330 340 350
LCKKKIGSAE LSFEHDAWMS KQFQAFGDLF DEAIKLGLTA IQTQNPGFYY
360 370 380 390 400
QQAAYYAQER KQLAKTLCNH EASVMYPNPD PLETQTGVLD FYGQRSWRQG
410 420 430 440 450
ILSFDLSDPE KEKVGILAIQ LKERNVVHSE IIITLLSNAV AQFKKYKCPR
460 470 480 490 500
MKSHLMVQMG EEYYYAKDYT KALKLLDYVM CDYRSEGWWT LLTSVLTTAL
510 520 530 540 550
KCSYLMAQLK DYITYSLELL GRASTLKDDQ KSRIEKNLIN VLMNESPDPE
560 570 580 590 600
PDCDILAVKT AQKLWADRIS LAGSNIFTIG VQDFVPFVQC KAKFHAPSFH
610 620 630 640 650
VDVPVQFDIY LKADCPHPIR FSKLCVSFNN QEYNQFCVIE EASKANEVLE
660 670 680 690 700
NLTQGKMCLV PGKTRKLLFK FVAKTEDVGK KIEITSVDLA LGNETGRCVV
710 720 730 740 750
LNWQGGGGDA ASSQEALQAA RSFKRRPKLP DNEVHWDSII IQASTMIISR
760 770 780 790 800
VPNISVHLLH EPPALTNEMY CLVVTVQSHE KTQIRDVKLT AGLKPGQDAN
810 820 830 840 850
LTQKTHVTLH GTELCDESYP ALLTDIPVGD LHPGEQLEKM LYVRCGTVGS
860 870 880 890 900
RMFLVYVSYL INTTVEEKEI VCKCHKDETV TIETVFPFDV AVKFVSTKFE
910 920 930 940 950
HLERVYADIP FLLMTDLLSA SPWALTIVSS ELQLAPSMTT VDQLESQVDN
960 970 980 990 1000
VILQTGESAS ECFCLQCPSL GNIEGGVATG HYIISWKRTS AMENIPIITT
1010 1020 1030 1040 1050
VITLPHVIVE NIPLHVNADL PSFGRVRESL PVKYHLQNKT DLVQDVEISV
1060 1070 1080 1090 1100
EPSDAFMFSG LKQIRLRILP GTEQEMLYNF YPLMAGYQQL PSLNINLLRF
1110 1120 1130
PNFTNQLLRR FIPTSIFVKP QGRLMDDTSI AAA
Length:1,133
Mass (Da):128,881
Last modified:September 2, 2008 - v2
Checksum:i6048FB396E946D4A
GO
Isoform 2 (identifier: Q7Z392-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-656: Missing.
     1067-1086: RILPGTEQEMLYNFYPLMAG → PAQAFYTYQYFCQATGSTHG
     1087-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):47,632
Checksum:i727C5FC79B7310A9
GO
Isoform 3 (identifier: Q7Z392-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1067-1086: RILPGTEQEMLYNFYPLMAG → PAQAFYTYQYFCQATGSTHG
     1087-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:1,086
Mass (Da):123,376
Checksum:i12B530B43141DEFE
GO
Isoform 4 (identifier: Q7Z392-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     962-1018: CFCLQCPSLG...VENIPLHVNA → LYYLLEKDLS...VVTCQVSPTE
     1019-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:1,018
Mass (Da):115,985
Checksum:i077A324FCE23D967
GO

Sequence cautioni

The sequence BAB14240 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14556 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15617 differs from that shown. Reason: Erroneous termination at position 1063. Translated as Gln.Curated
The sequence BAG37533 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB66686 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD91169 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD97983 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70T → A in AAH51724 (PubMed:15489334).Curated1
Sequence conflicti197Q → L in AAH51724 (PubMed:15489334).Curated1
Sequence conflicti312S → F in AAH51724 (PubMed:15489334).Curated1
Sequence conflicti397W → R in BAG37533 (PubMed:14702039).Curated1
Sequence conflicti467K → E in AAH51724 (PubMed:15489334).Curated1
Sequence conflicti544N → K in BAB15617 (PubMed:14702039).Curated1
Sequence conflicti660V → L in AAH51724 (PubMed:15489334).Curated1
Sequence conflicti661P → L in BAB15617 (PubMed:14702039).Curated1
Sequence conflicti697R → K in CAG38584 (Ref. 4) Curated1
Sequence conflicti723 – 744Missing in BAB14556 (PubMed:14702039).CuratedAdd BLAST22
Sequence conflicti812T → P in CAD91169 (PubMed:17974005).Curated1
Sequence conflicti812T → P in CAG38584 (Ref. 4) Curated1
Sequence conflicti812T → P in CAB66686 (PubMed:11230166).Curated1
Sequence conflicti842Y → C in BAB15617 (PubMed:14702039).Curated1
Sequence conflicti865V → I in BAB14240 (PubMed:14702039).Curated1
Sequence conflicti869E → G in BAB14556 (PubMed:14702039).Curated1
Sequence conflicti1011N → S in BAB14240 (PubMed:14702039).Curated1
Sequence conflicti1030L → S in BAB14556 (PubMed:14702039).Curated1
Sequence conflicti1112I → L in CAD97983 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078126381P → A Found in a patient with congenital disorder of glycosylation; unknown pathological significance. 1 Publication1
Natural variantiVAR_070158980G → R in LGMD2S. 1 PublicationCorresponds to variant dbSNP:rs397509417EnsemblClinVar.1
Natural variantiVAR_0781271104T → A Found in a patient with congenital disorder of glycosylation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs78663235EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0350951 – 656Missing in isoform 2. 1 PublicationAdd BLAST656
Alternative sequenceiVSP_035096962 – 1018CFCLQ…LHVNA → LYYLLEKDLSNGEYPHHHNC HHSAARDCGEYPSPCECRSA VIWACQRVVTCQVSPTE in isoform 4. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0350971019 – 1133Missing in isoform 4. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_0350981067 – 1086RILPG…PLMAG → PAQAFYTYQYFCQATGSTHG in isoform 2 and isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0350991087 – 1133Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833571 mRNA Translation: CAD91169.1 Different initiation.
BX538044 mRNA Translation: CAD97983.1 Different initiation.
BC051724 mRNA Translation: AAH51724.1
BC139745 mRNA Translation: AAI39746.1
AK022778 mRNA Translation: BAB14240.1 Different initiation.
AK023390 mRNA Translation: BAB14556.1 Different initiation.
AK026992 mRNA Translation: BAB15617.1 Sequence problems.
AK315057 mRNA Translation: BAG37533.1 Different initiation.
CR533553 mRNA Translation: CAG38584.1
AL136752 mRNA Translation: CAB66686.1 Different initiation.
CCDSiCCDS34112.1 [Q7Z392-1]
CCDS47166.1 [Q7Z392-3]
RefSeqiNP_068761.4, NM_021942.5 [Q7Z392-1]
NP_951008.1, NM_199053.2 [Q7Z392-3]
UniGeneiHs.443240

Genome annotation databases

EnsembliENST00000334690; ENSP00000335371; ENSG00000168538 [Q7Z392-1]
ENST00000357207; ENSP00000349738; ENSG00000168538 [Q7Z392-3]
GeneIDi60684
KEGGihsa:60684
UCSCiuc003ivw.3 human [Q7Z392-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTPC11_HUMAN
AccessioniPrimary (citable) accession number: Q7Z392
Secondary accession number(s): A4QPB8
, B2RCD6, Q5U5I7, Q6FI73, Q86T25, Q9H0L1, Q9H5K9, Q9H8Q1, Q9H9I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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