ID   D19L4_HUMAN             Reviewed;         723 AA.
AC   Q7Z388; Q6ZW32; Q6ZW42; Q7Z329;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 136.
DE   RecName: Full=Probable C-mannosyltransferase DPY19L4;
DE            EC=2.4.1.-;
DE   AltName: Full=Dpy-19-like protein 4;
DE   AltName: Full=Protein dpy-19 homolog 4;
GN   Name=DPY19L4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon endothelium, and Uterus;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=16526957; DOI=10.1186/1471-2164-7-45;
RA   Carson A.R., Cheung J., Scherer S.W.;
RT   "Duplication and relocation of the functional DPY19L2 gene within low copy
RT   repeats.";
RL   BMC Genomics 7:45-45(2006).
RN   [6]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation
CC       of tryptophan residues on target proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16526957}.
CC   -!- SIMILARITY: Belongs to the dpy-19 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC85664.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK123618; BAC85664.1; ALT_INIT; mRNA.
DR   EMBL; AK123682; BAC85675.1; -; mRNA.
DR   EMBL; BX538048; CAD97987.1; -; mRNA.
DR   EMBL; BX538174; CAD98049.1; -; mRNA.
DR   EMBL; CH471060; EAW91723.1; -; Genomic_DNA.
DR   EMBL; BC110870; AAI10871.1; -; mRNA.
DR   EMBL; BC126193; AAI26194.1; -; mRNA.
DR   EMBL; BC130576; AAI30577.1; -; mRNA.
DR   CCDS; CCDS34924.1; -.
DR   RefSeq; NP_861452.2; NM_181787.2.
DR   AlphaFoldDB; Q7Z388; -.
DR   SMR; Q7Z388; -.
DR   BioGRID; 130313; 51.
DR   IntAct; Q7Z388; 15.
DR   STRING; 9606.ENSP00000389630; -.
DR   GlyConnect; 1627; 4 N-Linked glycans (2 sites).
DR   GlyCosmos; Q7Z388; 2 sites, 4 glycans.
DR   GlyGen; Q7Z388; 3 sites, 4 N-linked glycans (2 sites).
DR   iPTMnet; Q7Z388; -.
DR   PhosphoSitePlus; Q7Z388; -.
DR   BioMuta; DPY19L4; -.
DR   DMDM; 74713335; -.
DR   CPTAC; CPTAC-1488; -.
DR   EPD; Q7Z388; -.
DR   jPOST; Q7Z388; -.
DR   MassIVE; Q7Z388; -.
DR   MaxQB; Q7Z388; -.
DR   PaxDb; 9606-ENSP00000389630; -.
DR   PeptideAtlas; Q7Z388; -.
DR   ProteomicsDB; 69011; -.
DR   Antibodypedia; 25883; 105 antibodies from 16 providers.
DR   DNASU; 286148; -.
DR   Ensembl; ENST00000414645.6; ENSP00000389630.2; ENSG00000156162.16.
DR   GeneID; 286148; -.
DR   KEGG; hsa:286148; -.
DR   MANE-Select; ENST00000414645.6; ENSP00000389630.2; NM_181787.3; NP_861452.2.
DR   UCSC; uc003ygx.3; human.
DR   AGR; HGNC:27829; -.
DR   CTD; 286148; -.
DR   GeneCards; DPY19L4; -.
DR   HGNC; HGNC:27829; DPY19L4.
DR   HPA; ENSG00000156162; Low tissue specificity.
DR   MIM; 613895; gene.
DR   neXtProt; NX_Q7Z388; -.
DR   OpenTargets; ENSG00000156162; -.
DR   PharmGKB; PA142671955; -.
DR   VEuPathDB; HostDB:ENSG00000156162; -.
DR   eggNOG; KOG4587; Eukaryota.
DR   GeneTree; ENSGT00530000063023; -.
DR   HOGENOM; CLU_014404_1_0_1; -.
DR   InParanoid; Q7Z388; -.
DR   OMA; PKYILFQ; -.
DR   OrthoDB; 242062at2759; -.
DR   PhylomeDB; Q7Z388; -.
DR   TreeFam; TF313376; -.
DR   PathwayCommons; Q7Z388; -.
DR   SignaLink; Q7Z388; -.
DR   BioGRID-ORCS; 286148; 26 hits in 1157 CRISPR screens.
DR   ChiTaRS; DPY19L4; human.
DR   GenomeRNAi; 286148; -.
DR   Pharos; Q7Z388; Tdark.
DR   PRO; PR:Q7Z388; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q7Z388; Protein.
DR   Bgee; ENSG00000156162; Expressed in adrenal tissue and 197 other cell types or tissues.
DR   ExpressionAtlas; Q7Z388; baseline and differential.
DR   GO; GO:0005637; C:nuclear inner membrane; IBA:GO_Central.
DR   GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR   CDD; cd20180; Dpy19L4; 1.
DR   InterPro; IPR018732; Dpy-19/Dpy-19-like.
DR   InterPro; IPR047464; Dpy19L4.
DR   PANTHER; PTHR31488:SF2; C-MANNOSYLTRANSFERASE DPY19L4-RELATED; 1.
DR   PANTHER; PTHR31488; DPY-19-LIKE 1, LIKE (H. SAPIENS); 1.
DR   Pfam; PF10034; Dpy19; 1.
DR   Genevisible; Q7Z388; HS.
PE   1: Evidence at protein level;
KW   Acetylation; Glycosyltransferase; Membrane; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0007744|PubMed:22814378"
FT   CHAIN           2..723
FT                   /note="Probable C-mannosyltransferase DPY19L4"
FT                   /id="PRO_0000311881"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        466..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        489..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        522..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0007744|PubMed:22814378"
FT   CONFLICT        3
FT                   /note="E -> D (in Ref. 2; CAD98049)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        440
FT                   /note="I -> T (in Ref. 1; BAC85664)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        654
FT                   /note="M -> T (in Ref. 1; BAC85675)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   723 AA;  83756 MW;  F1B385FF181F7193 CRC64;
     MAEEEGPPVE LRQRKKPKSS ENKESAKEEK ISDIPIPERA PKHVLFQRFA KIFIGCLAAV
     TSGMMYALYL SAYHERKFWF SNRQELEREI TFQGDSAIYY SYYKDMLKAP SFERGVYELT
     HNNKTVSLKT INAVQQMSLY PELIASILYQ ATGSNEIIEP VYFYIGIVFG LQGIYVTALF
     VTSWLMSGTW LAGMLTVAWF VINRVDTTRI EYSIPLRENW ALPYFACQIA ALTGYLKSNL
     NTYGERFCYL LMSASTYTFM MMWEYSHYLL FLQAISLFLL DTFSVEQSDK VYEVYKIYIF
     SLFLGYLLQF ENPALLVSPL LSLVAALMLA KCLQLNVKKG SFVAKIIKVI NFYLVCTLTI
     TLNIIMKMFV PHKENGHMLK FLEVKFGLNM TKNFTMNWLL CQESLQAPSQ DFFLRLTQSS
     LLPFYILVLI ICFLSMLQVI FRRINGKSLK ETVTLEDGRI GERPEIIYHV IHTILLGSLA
     MVIEGLKYIW IPYVCMLAAF GVCSPELWMT LFKWLRLRTV HPILLALILS MAVPTIIGLS
     LWKEFFPRLM TELMELQEFY DPDTVELMTW IKRQAPVAAV FAGSPQLMGA IKLCTGWMVT
     SLPLYNDDDL LKRNENIYQI YSKRSAEDIY KILTSYKANY LIVEDAICNE VGPMRGCRVK
     DLLDIANGHM VCEEGDKLTY SKYGRFCHEV KINYSPYVNY FTRVYWNRSY FVYKINTVIS
     FQS
//