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Q7Z388

- D19L4_HUMAN

UniProt

Q7Z388 - D19L4_HUMAN

Protein

Probable C-mannosyltransferase DPY19L4

Gene

DPY19L4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.By similarity

    GO - Molecular functioni

    1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable C-mannosyltransferase DPY19L4 (EC:2.4.1.-)
    Alternative name(s):
    Dpy-19-like protein 4
    Protein dpy-19 homolog 4
    Gene namesi
    Name:DPY19L4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:27829. DPY19L4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671955.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 723722Probable C-mannosyltransferase DPY19L4PRO_0000311881Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ7Z388.
    PaxDbiQ7Z388.
    PRIDEiQ7Z388.

    PTM databases

    PhosphoSiteiQ7Z388.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ7Z388.
    BgeeiQ7Z388.
    CleanExiHS_DPY19L4.
    GenevestigatoriQ7Z388.

    Organism-specific databases

    HPAiHPA024780.

    Interactioni

    Protein-protein interaction databases

    BioGridi130313. 4 interactions.
    IntActiQ7Z388. 1 interaction.
    STRINGi9606.ENSP00000389630.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z388.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 17818HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei316 – 33722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei349 – 37022HelicalSequence AnalysisAdd
    BLAST
    Transmembranei421 – 44121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei466 – 48621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei489 – 50921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei522 – 54221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dpy-19 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG236656.
    HOGENOMiHOG000007319.
    HOVERGENiHBG107792.
    InParanoidiQ7Z388.
    OMAiASTYTFM.
    OrthoDBiEOG7N37BZ.
    PhylomeDBiQ7Z388.
    TreeFamiTF313376.

    Family and domain databases

    InterProiIPR018732. Dpy-19.
    [Graphical view]
    PfamiPF10034. Dpy19. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7Z388-1 [UniParc]FASTAAdd to Basket

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    MAEEEGPPVE LRQRKKPKSS ENKESAKEEK ISDIPIPERA PKHVLFQRFA    50
    KIFIGCLAAV TSGMMYALYL SAYHERKFWF SNRQELEREI TFQGDSAIYY 100
    SYYKDMLKAP SFERGVYELT HNNKTVSLKT INAVQQMSLY PELIASILYQ 150
    ATGSNEIIEP VYFYIGIVFG LQGIYVTALF VTSWLMSGTW LAGMLTVAWF 200
    VINRVDTTRI EYSIPLRENW ALPYFACQIA ALTGYLKSNL NTYGERFCYL 250
    LMSASTYTFM MMWEYSHYLL FLQAISLFLL DTFSVEQSDK VYEVYKIYIF 300
    SLFLGYLLQF ENPALLVSPL LSLVAALMLA KCLQLNVKKG SFVAKIIKVI 350
    NFYLVCTLTI TLNIIMKMFV PHKENGHMLK FLEVKFGLNM TKNFTMNWLL 400
    CQESLQAPSQ DFFLRLTQSS LLPFYILVLI ICFLSMLQVI FRRINGKSLK 450
    ETVTLEDGRI GERPEIIYHV IHTILLGSLA MVIEGLKYIW IPYVCMLAAF 500
    GVCSPELWMT LFKWLRLRTV HPILLALILS MAVPTIIGLS LWKEFFPRLM 550
    TELMELQEFY DPDTVELMTW IKRQAPVAAV FAGSPQLMGA IKLCTGWMVT 600
    SLPLYNDDDL LKRNENIYQI YSKRSAEDIY KILTSYKANY LIVEDAICNE 650
    VGPMRGCRVK DLLDIANGHM VCEEGDKLTY SKYGRFCHEV KINYSPYVNY 700
    FTRVYWNRSY FVYKINTVIS FQS 723
    Length:723
    Mass (Da):83,756
    Last modified:October 1, 2003 - v1
    Checksum:iF1B385FF181F7193
    GO

    Sequence cautioni

    The sequence BAC85664.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31E → D in CAD98049. (PubMed:17974005)Curated
    Sequence conflicti440 – 4401I → T in BAC85664. (PubMed:14702039)Curated
    Sequence conflicti654 – 6541M → T in BAC85675. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK123618 mRNA. Translation: BAC85664.1. Different initiation.
    AK123682 mRNA. Translation: BAC85675.1.
    BX538048 mRNA. Translation: CAD97987.1.
    BX538174 mRNA. Translation: CAD98049.1.
    CH471060 Genomic DNA. Translation: EAW91723.1.
    BC110870 mRNA. Translation: AAI10871.1.
    BC126193 mRNA. Translation: AAI26194.1.
    BC130576 mRNA. Translation: AAI30577.1.
    CCDSiCCDS34924.1.
    RefSeqiNP_861452.2. NM_181787.2.
    UniGeneiHs.567828.

    Genome annotation databases

    EnsembliENST00000414645; ENSP00000389630; ENSG00000156162.
    GeneIDi286148.
    KEGGihsa:286148.
    UCSCiuc003ygx.2. human.

    Polymorphism databases

    DMDMi74713335.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK123618 mRNA. Translation: BAC85664.1 . Different initiation.
    AK123682 mRNA. Translation: BAC85675.1 .
    BX538048 mRNA. Translation: CAD97987.1 .
    BX538174 mRNA. Translation: CAD98049.1 .
    CH471060 Genomic DNA. Translation: EAW91723.1 .
    BC110870 mRNA. Translation: AAI10871.1 .
    BC126193 mRNA. Translation: AAI26194.1 .
    BC130576 mRNA. Translation: AAI30577.1 .
    CCDSi CCDS34924.1.
    RefSeqi NP_861452.2. NM_181787.2.
    UniGenei Hs.567828.

    3D structure databases

    ProteinModelPortali Q7Z388.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130313. 4 interactions.
    IntActi Q7Z388. 1 interaction.
    STRINGi 9606.ENSP00000389630.

    PTM databases

    PhosphoSitei Q7Z388.

    Polymorphism databases

    DMDMi 74713335.

    Proteomic databases

    MaxQBi Q7Z388.
    PaxDbi Q7Z388.
    PRIDEi Q7Z388.

    Protocols and materials databases

    DNASUi 286148.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000414645 ; ENSP00000389630 ; ENSG00000156162 .
    GeneIDi 286148.
    KEGGi hsa:286148.
    UCSCi uc003ygx.2. human.

    Organism-specific databases

    CTDi 286148.
    GeneCardsi GC08P095802.
    HGNCi HGNC:27829. DPY19L4.
    HPAi HPA024780.
    MIMi 613895. gene.
    neXtProti NX_Q7Z388.
    PharmGKBi PA142671955.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG236656.
    HOGENOMi HOG000007319.
    HOVERGENi HBG107792.
    InParanoidi Q7Z388.
    OMAi ASTYTFM.
    OrthoDBi EOG7N37BZ.
    PhylomeDBi Q7Z388.
    TreeFami TF313376.

    Miscellaneous databases

    ChiTaRSi DPY19L4. human.
    GenomeRNAii 286148.
    NextBioi 96034.
    PROi Q7Z388.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z388.
    Bgeei Q7Z388.
    CleanExi HS_DPY19L4.
    Genevestigatori Q7Z388.

    Family and domain databases

    InterProi IPR018732. Dpy-19.
    [Graphical view ]
    Pfami PF10034. Dpy19. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon endothelium and Uterus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    5. "Duplication and relocation of the functional DPY19L2 gene within low copy repeats."
      Carson A.R., Cheung J., Scherer S.W.
      BMC Genomics 7:45-45(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiD19L4_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z388
    Secondary accession number(s): Q6ZW32, Q6ZW42, Q7Z329
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3