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Protein

Probable C-mannosyltransferase DPY19L4

Gene

DPY19L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-mannosyltransferase DPY19L4 (EC:2.4.1.-)
Alternative name(s):
Dpy-19-like protein 4
Protein dpy-19 homolog 4
Gene namesi
Name:DPY19L4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000156162.16.
HGNCiHGNC:27829. DPY19L4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei161 – 178HelicalSequence analysisAdd BLAST18
Transmembranei184 – 202HelicalSequence analysisAdd BLAST19
Transmembranei222 – 240HelicalSequence analysisAdd BLAST19
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei292 – 310HelicalSequence analysisAdd BLAST19
Transmembranei316 – 337HelicalSequence analysisAdd BLAST22
Transmembranei349 – 370HelicalSequence analysisAdd BLAST22
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Transmembranei489 – 509HelicalSequence analysisAdd BLAST21
Transmembranei522 – 542HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156162.
PharmGKBiPA142671955.

Polymorphism and mutation databases

BioMutaiDPY19L4.
DMDMi74713335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003118812 – 723Probable C-mannosyltransferase DPY19L4Add BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ7Z388.
MaxQBiQ7Z388.
PaxDbiQ7Z388.
PeptideAtlasiQ7Z388.
PRIDEiQ7Z388.

PTM databases

iPTMnetiQ7Z388.
PhosphoSitePlusiQ7Z388.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000156162.
CleanExiHS_DPY19L4.
ExpressionAtlasiQ7Z388. baseline and differential.
GenevisibleiQ7Z388. HS.

Organism-specific databases

HPAiHPA024780.

Interactioni

Protein-protein interaction databases

BioGridi130313. 23 interactors.
IntActiQ7Z388. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ7Z388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4587. Eukaryota.
ENOG410XRWN. LUCA.
GeneTreeiENSGT00530000063023.
HOGENOMiHOG000007319.
HOVERGENiHBG107792.
InParanoidiQ7Z388.
OMAiASTYTFM.
OrthoDBiEOG091G02PL.
PhylomeDBiQ7Z388.
TreeFamiTF313376.

Family and domain databases

InterProiView protein in InterPro
IPR018732. Dpy-19/Dpy-19-like.
IPR030040. DPY19L4.
PANTHERiPTHR31488. PTHR31488. 1 hit.
PTHR31488:SF2. PTHR31488:SF2. 1 hit.
PfamiView protein in Pfam
PF10034. Dpy19. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEEGPPVE LRQRKKPKSS ENKESAKEEK ISDIPIPERA PKHVLFQRFA
60 70 80 90 100
KIFIGCLAAV TSGMMYALYL SAYHERKFWF SNRQELEREI TFQGDSAIYY
110 120 130 140 150
SYYKDMLKAP SFERGVYELT HNNKTVSLKT INAVQQMSLY PELIASILYQ
160 170 180 190 200
ATGSNEIIEP VYFYIGIVFG LQGIYVTALF VTSWLMSGTW LAGMLTVAWF
210 220 230 240 250
VINRVDTTRI EYSIPLRENW ALPYFACQIA ALTGYLKSNL NTYGERFCYL
260 270 280 290 300
LMSASTYTFM MMWEYSHYLL FLQAISLFLL DTFSVEQSDK VYEVYKIYIF
310 320 330 340 350
SLFLGYLLQF ENPALLVSPL LSLVAALMLA KCLQLNVKKG SFVAKIIKVI
360 370 380 390 400
NFYLVCTLTI TLNIIMKMFV PHKENGHMLK FLEVKFGLNM TKNFTMNWLL
410 420 430 440 450
CQESLQAPSQ DFFLRLTQSS LLPFYILVLI ICFLSMLQVI FRRINGKSLK
460 470 480 490 500
ETVTLEDGRI GERPEIIYHV IHTILLGSLA MVIEGLKYIW IPYVCMLAAF
510 520 530 540 550
GVCSPELWMT LFKWLRLRTV HPILLALILS MAVPTIIGLS LWKEFFPRLM
560 570 580 590 600
TELMELQEFY DPDTVELMTW IKRQAPVAAV FAGSPQLMGA IKLCTGWMVT
610 620 630 640 650
SLPLYNDDDL LKRNENIYQI YSKRSAEDIY KILTSYKANY LIVEDAICNE
660 670 680 690 700
VGPMRGCRVK DLLDIANGHM VCEEGDKLTY SKYGRFCHEV KINYSPYVNY
710 720
FTRVYWNRSY FVYKINTVIS FQS
Length:723
Mass (Da):83,756
Last modified:October 1, 2003 - v1
Checksum:iF1B385FF181F7193
GO

Sequence cautioni

The sequence BAC85664 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3E → D in CAD98049 (PubMed:17974005).Curated1
Sequence conflicti440I → T in BAC85664 (PubMed:14702039).Curated1
Sequence conflicti654M → T in BAC85675 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123618 mRNA. Translation: BAC85664.1. Different initiation.
AK123682 mRNA. Translation: BAC85675.1.
BX538048 mRNA. Translation: CAD97987.1.
BX538174 mRNA. Translation: CAD98049.1.
CH471060 Genomic DNA. Translation: EAW91723.1.
BC110870 mRNA. Translation: AAI10871.1.
BC126193 mRNA. Translation: AAI26194.1.
BC130576 mRNA. Translation: AAI30577.1.
CCDSiCCDS34924.1.
RefSeqiNP_861452.2. NM_181787.2.
UniGeneiHs.567828.

Genome annotation databases

EnsembliENST00000414645; ENSP00000389630; ENSG00000156162.
GeneIDi286148.
KEGGihsa:286148.
UCSCiuc003ygx.3. human.

Similar proteinsi

Entry informationi

Entry nameiD19L4_HUMAN
AccessioniPrimary (citable) accession number: Q7Z388
Secondary accession number(s): Q6ZW32, Q6ZW42, Q7Z329
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2003
Last modified: October 25, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families