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Protein

Probable C-mannosyltransferase DPY19L4

Gene

DPY19L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.By similarity

GO - Molecular functioni

  1. mannosyltransferase activity Source: GO_Central

GO - Biological processi

  1. protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-mannosyltransferase DPY19L4 (EC:2.4.1.-)
Alternative name(s):
Dpy-19-like protein 4
Protein dpy-19 homolog 4
Gene namesi
Name:DPY19L4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:27829. DPY19L4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei161 – 17818HelicalSequence AnalysisAdd
BLAST
Transmembranei184 – 20219HelicalSequence AnalysisAdd
BLAST
Transmembranei222 – 24019HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST
Transmembranei292 – 31019HelicalSequence AnalysisAdd
BLAST
Transmembranei316 – 33722HelicalSequence AnalysisAdd
BLAST
Transmembranei349 – 37022HelicalSequence AnalysisAdd
BLAST
Transmembranei421 – 44121HelicalSequence AnalysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence AnalysisAdd
BLAST
Transmembranei489 – 50921HelicalSequence AnalysisAdd
BLAST
Transmembranei522 – 54221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nuclear inner membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671955.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 723722Probable C-mannosyltransferase DPY19L4PRO_0000311881Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7Z388.
PaxDbiQ7Z388.
PRIDEiQ7Z388.

PTM databases

PhosphoSiteiQ7Z388.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ7Z388.
CleanExiHS_DPY19L4.
ExpressionAtlasiQ7Z388. baseline and differential.
GenevestigatoriQ7Z388.

Organism-specific databases

HPAiHPA024780.

Interactioni

Protein-protein interaction databases

BioGridi130313. 7 interactions.
IntActiQ7Z388. 1 interaction.
STRINGi9606.ENSP00000389630.

Structurei

3D structure databases

ProteinModelPortaliQ7Z388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG236656.
GeneTreeiENSGT00530000063023.
HOGENOMiHOG000007319.
HOVERGENiHBG107792.
InParanoidiQ7Z388.
OMAiASTYTFM.
OrthoDBiEOG7N37BZ.
PhylomeDBiQ7Z388.
TreeFamiTF313376.

Family and domain databases

InterProiIPR018732. Dpy-19/Dpy-19-like.
IPR030040. DPY19L4.
[Graphical view]
PANTHERiPTHR31488. PTHR31488. 1 hit.
PTHR31488:SF2. PTHR31488:SF2. 1 hit.
PfamiPF10034. Dpy19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEEGPPVE LRQRKKPKSS ENKESAKEEK ISDIPIPERA PKHVLFQRFA
60 70 80 90 100
KIFIGCLAAV TSGMMYALYL SAYHERKFWF SNRQELEREI TFQGDSAIYY
110 120 130 140 150
SYYKDMLKAP SFERGVYELT HNNKTVSLKT INAVQQMSLY PELIASILYQ
160 170 180 190 200
ATGSNEIIEP VYFYIGIVFG LQGIYVTALF VTSWLMSGTW LAGMLTVAWF
210 220 230 240 250
VINRVDTTRI EYSIPLRENW ALPYFACQIA ALTGYLKSNL NTYGERFCYL
260 270 280 290 300
LMSASTYTFM MMWEYSHYLL FLQAISLFLL DTFSVEQSDK VYEVYKIYIF
310 320 330 340 350
SLFLGYLLQF ENPALLVSPL LSLVAALMLA KCLQLNVKKG SFVAKIIKVI
360 370 380 390 400
NFYLVCTLTI TLNIIMKMFV PHKENGHMLK FLEVKFGLNM TKNFTMNWLL
410 420 430 440 450
CQESLQAPSQ DFFLRLTQSS LLPFYILVLI ICFLSMLQVI FRRINGKSLK
460 470 480 490 500
ETVTLEDGRI GERPEIIYHV IHTILLGSLA MVIEGLKYIW IPYVCMLAAF
510 520 530 540 550
GVCSPELWMT LFKWLRLRTV HPILLALILS MAVPTIIGLS LWKEFFPRLM
560 570 580 590 600
TELMELQEFY DPDTVELMTW IKRQAPVAAV FAGSPQLMGA IKLCTGWMVT
610 620 630 640 650
SLPLYNDDDL LKRNENIYQI YSKRSAEDIY KILTSYKANY LIVEDAICNE
660 670 680 690 700
VGPMRGCRVK DLLDIANGHM VCEEGDKLTY SKYGRFCHEV KINYSPYVNY
710 720
FTRVYWNRSY FVYKINTVIS FQS
Length:723
Mass (Da):83,756
Last modified:October 1, 2003 - v1
Checksum:iF1B385FF181F7193
GO

Sequence cautioni

The sequence BAC85664.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31E → D in CAD98049 (PubMed:17974005).Curated
Sequence conflicti440 – 4401I → T in BAC85664 (PubMed:14702039).Curated
Sequence conflicti654 – 6541M → T in BAC85675 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123618 mRNA. Translation: BAC85664.1. Different initiation.
AK123682 mRNA. Translation: BAC85675.1.
BX538048 mRNA. Translation: CAD97987.1.
BX538174 mRNA. Translation: CAD98049.1.
CH471060 Genomic DNA. Translation: EAW91723.1.
BC110870 mRNA. Translation: AAI10871.1.
BC126193 mRNA. Translation: AAI26194.1.
BC130576 mRNA. Translation: AAI30577.1.
CCDSiCCDS34924.1.
RefSeqiNP_861452.2. NM_181787.2.
UniGeneiHs.567828.

Genome annotation databases

EnsembliENST00000414645; ENSP00000389630; ENSG00000156162.
GeneIDi286148.
KEGGihsa:286148.
UCSCiuc003ygx.2. human.

Polymorphism databases

DMDMi74713335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123618 mRNA. Translation: BAC85664.1. Different initiation.
AK123682 mRNA. Translation: BAC85675.1.
BX538048 mRNA. Translation: CAD97987.1.
BX538174 mRNA. Translation: CAD98049.1.
CH471060 Genomic DNA. Translation: EAW91723.1.
BC110870 mRNA. Translation: AAI10871.1.
BC126193 mRNA. Translation: AAI26194.1.
BC130576 mRNA. Translation: AAI30577.1.
CCDSiCCDS34924.1.
RefSeqiNP_861452.2. NM_181787.2.
UniGeneiHs.567828.

3D structure databases

ProteinModelPortaliQ7Z388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130313. 7 interactions.
IntActiQ7Z388. 1 interaction.
STRINGi9606.ENSP00000389630.

PTM databases

PhosphoSiteiQ7Z388.

Polymorphism databases

DMDMi74713335.

Proteomic databases

MaxQBiQ7Z388.
PaxDbiQ7Z388.
PRIDEiQ7Z388.

Protocols and materials databases

DNASUi286148.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000414645; ENSP00000389630; ENSG00000156162.
GeneIDi286148.
KEGGihsa:286148.
UCSCiuc003ygx.2. human.

Organism-specific databases

CTDi286148.
GeneCardsiGC08P095802.
HGNCiHGNC:27829. DPY19L4.
HPAiHPA024780.
MIMi613895. gene.
neXtProtiNX_Q7Z388.
PharmGKBiPA142671955.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG236656.
GeneTreeiENSGT00530000063023.
HOGENOMiHOG000007319.
HOVERGENiHBG107792.
InParanoidiQ7Z388.
OMAiASTYTFM.
OrthoDBiEOG7N37BZ.
PhylomeDBiQ7Z388.
TreeFamiTF313376.

Miscellaneous databases

ChiTaRSiDPY19L4. human.
GenomeRNAii286148.
NextBioi96034.
PROiQ7Z388.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z388.
CleanExiHS_DPY19L4.
ExpressionAtlasiQ7Z388. baseline and differential.
GenevestigatoriQ7Z388.

Family and domain databases

InterProiIPR018732. Dpy-19/Dpy-19-like.
IPR030040. DPY19L4.
[Graphical view]
PANTHERiPTHR31488. PTHR31488. 1 hit.
PTHR31488:SF2. PTHR31488:SF2. 1 hit.
PfamiPF10034. Dpy19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon endothelium and Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Duplication and relocation of the functional DPY19L2 gene within low copy repeats."
    Carson A.R., Cheung J., Scherer S.W.
    BMC Genomics 7:45-45(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiD19L4_HUMAN
AccessioniPrimary (citable) accession number: Q7Z388
Secondary accession number(s): Q6ZW32, Q6ZW42, Q7Z329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2003
Last modified: March 4, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.