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Q7Z388

- D19L4_HUMAN

UniProt

Q7Z388 - D19L4_HUMAN

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Protein

Probable C-mannosyltransferase DPY19L4

Gene
DPY19L4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins By similarity.

GO - Molecular functioni

  1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-mannosyltransferase DPY19L4 (EC:2.4.1.-)
Alternative name(s):
Dpy-19-like protein 4
Protein dpy-19 homolog 4
Gene namesi
Name:DPY19L4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:27829. DPY19L4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7221Helical; Reviewed predictionAdd
BLAST
Transmembranei161 – 17818Helical; Reviewed predictionAdd
BLAST
Transmembranei184 – 20219Helical; Reviewed predictionAdd
BLAST
Transmembranei222 – 24019Helical; Reviewed predictionAdd
BLAST
Transmembranei260 – 28021Helical; Reviewed predictionAdd
BLAST
Transmembranei292 – 31019Helical; Reviewed predictionAdd
BLAST
Transmembranei316 – 33722Helical; Reviewed predictionAdd
BLAST
Transmembranei349 – 37022Helical; Reviewed predictionAdd
BLAST
Transmembranei421 – 44121Helical; Reviewed predictionAdd
BLAST
Transmembranei466 – 48621Helical; Reviewed predictionAdd
BLAST
Transmembranei489 – 50921Helical; Reviewed predictionAdd
BLAST
Transmembranei522 – 54221Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671955.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 723722Probable C-mannosyltransferase DPY19L4PRO_0000311881Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7Z388.
PaxDbiQ7Z388.
PRIDEiQ7Z388.

PTM databases

PhosphoSiteiQ7Z388.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiQ7Z388.
BgeeiQ7Z388.
CleanExiHS_DPY19L4.
GenevestigatoriQ7Z388.

Organism-specific databases

HPAiHPA024780.

Interactioni

Protein-protein interaction databases

BioGridi130313. 4 interactions.
IntActiQ7Z388. 1 interaction.
STRINGi9606.ENSP00000389630.

Structurei

3D structure databases

ProteinModelPortaliQ7Z388.

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-19 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG236656.
HOGENOMiHOG000007319.
HOVERGENiHBG107792.
InParanoidiQ7Z388.
OMAiASTYTFM.
OrthoDBiEOG7N37BZ.
PhylomeDBiQ7Z388.
TreeFamiTF313376.

Family and domain databases

InterProiIPR018732. Dpy-19.
[Graphical view]
PfamiPF10034. Dpy19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z388-1 [UniParc]FASTAAdd to Basket

« Hide

MAEEEGPPVE LRQRKKPKSS ENKESAKEEK ISDIPIPERA PKHVLFQRFA    50
KIFIGCLAAV TSGMMYALYL SAYHERKFWF SNRQELEREI TFQGDSAIYY 100
SYYKDMLKAP SFERGVYELT HNNKTVSLKT INAVQQMSLY PELIASILYQ 150
ATGSNEIIEP VYFYIGIVFG LQGIYVTALF VTSWLMSGTW LAGMLTVAWF 200
VINRVDTTRI EYSIPLRENW ALPYFACQIA ALTGYLKSNL NTYGERFCYL 250
LMSASTYTFM MMWEYSHYLL FLQAISLFLL DTFSVEQSDK VYEVYKIYIF 300
SLFLGYLLQF ENPALLVSPL LSLVAALMLA KCLQLNVKKG SFVAKIIKVI 350
NFYLVCTLTI TLNIIMKMFV PHKENGHMLK FLEVKFGLNM TKNFTMNWLL 400
CQESLQAPSQ DFFLRLTQSS LLPFYILVLI ICFLSMLQVI FRRINGKSLK 450
ETVTLEDGRI GERPEIIYHV IHTILLGSLA MVIEGLKYIW IPYVCMLAAF 500
GVCSPELWMT LFKWLRLRTV HPILLALILS MAVPTIIGLS LWKEFFPRLM 550
TELMELQEFY DPDTVELMTW IKRQAPVAAV FAGSPQLMGA IKLCTGWMVT 600
SLPLYNDDDL LKRNENIYQI YSKRSAEDIY KILTSYKANY LIVEDAICNE 650
VGPMRGCRVK DLLDIANGHM VCEEGDKLTY SKYGRFCHEV KINYSPYVNY 700
FTRVYWNRSY FVYKINTVIS FQS 723
Length:723
Mass (Da):83,756
Last modified:October 1, 2003 - v1
Checksum:iF1B385FF181F7193
GO

Sequence cautioni

The sequence BAC85664.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31E → D in CAD98049. 1 Publication
Sequence conflicti440 – 4401I → T in BAC85664. 1 Publication
Sequence conflicti654 – 6541M → T in BAC85675. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK123618 mRNA. Translation: BAC85664.1. Different initiation.
AK123682 mRNA. Translation: BAC85675.1.
BX538048 mRNA. Translation: CAD97987.1.
BX538174 mRNA. Translation: CAD98049.1.
CH471060 Genomic DNA. Translation: EAW91723.1.
BC110870 mRNA. Translation: AAI10871.1.
BC126193 mRNA. Translation: AAI26194.1.
BC130576 mRNA. Translation: AAI30577.1.
CCDSiCCDS34924.1.
RefSeqiNP_861452.2. NM_181787.2.
UniGeneiHs.567828.

Genome annotation databases

EnsembliENST00000414645; ENSP00000389630; ENSG00000156162.
GeneIDi286148.
KEGGihsa:286148.
UCSCiuc003ygx.2. human.

Polymorphism databases

DMDMi74713335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK123618 mRNA. Translation: BAC85664.1 . Different initiation.
AK123682 mRNA. Translation: BAC85675.1 .
BX538048 mRNA. Translation: CAD97987.1 .
BX538174 mRNA. Translation: CAD98049.1 .
CH471060 Genomic DNA. Translation: EAW91723.1 .
BC110870 mRNA. Translation: AAI10871.1 .
BC126193 mRNA. Translation: AAI26194.1 .
BC130576 mRNA. Translation: AAI30577.1 .
CCDSi CCDS34924.1.
RefSeqi NP_861452.2. NM_181787.2.
UniGenei Hs.567828.

3D structure databases

ProteinModelPortali Q7Z388.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130313. 4 interactions.
IntActi Q7Z388. 1 interaction.
STRINGi 9606.ENSP00000389630.

PTM databases

PhosphoSitei Q7Z388.

Polymorphism databases

DMDMi 74713335.

Proteomic databases

MaxQBi Q7Z388.
PaxDbi Q7Z388.
PRIDEi Q7Z388.

Protocols and materials databases

DNASUi 286148.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000414645 ; ENSP00000389630 ; ENSG00000156162 .
GeneIDi 286148.
KEGGi hsa:286148.
UCSCi uc003ygx.2. human.

Organism-specific databases

CTDi 286148.
GeneCardsi GC08P095802.
HGNCi HGNC:27829. DPY19L4.
HPAi HPA024780.
MIMi 613895. gene.
neXtProti NX_Q7Z388.
PharmGKBi PA142671955.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236656.
HOGENOMi HOG000007319.
HOVERGENi HBG107792.
InParanoidi Q7Z388.
OMAi ASTYTFM.
OrthoDBi EOG7N37BZ.
PhylomeDBi Q7Z388.
TreeFami TF313376.

Miscellaneous databases

ChiTaRSi DPY19L4. human.
GenomeRNAii 286148.
NextBioi 96034.
PROi Q7Z388.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7Z388.
Bgeei Q7Z388.
CleanExi HS_DPY19L4.
Genevestigatori Q7Z388.

Family and domain databases

InterProi IPR018732. Dpy-19.
[Graphical view ]
Pfami PF10034. Dpy19. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon endothelium and Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Duplication and relocation of the functional DPY19L2 gene within low copy repeats."
    Carson A.R., Cheung J., Scherer S.W.
    BMC Genomics 7:45-45(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiD19L4_HUMAN
AccessioniPrimary (citable) accession number: Q7Z388
Secondary accession number(s): Q6ZW32, Q6ZW42, Q7Z329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi