Q7Z388 (D19L4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable C-mannosyltransferase DPY19L4
EC=2.4.1.-

Alternative name(s):
Dpy-19-like protein 4
Protein dpy-19 homolog 4

Gene names

Name:

DPY19L4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	723 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Widely expressed. Ref.5
Sequence similarities	Belongs to the dpy-19 family.
Sequence caution	The sequence BAC85664.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 723	723	Probable C-mannosyltransferase DPY19L4		PRO_0000311881
Regions
	Transmembrane	52 – 72	21	Helical; Potential
	Transmembrane	161 – 178	18	Helical; Potential
	Transmembrane	184 – 202	19	Helical; Potential
	Transmembrane	222 – 240	19	Helical; Potential
	Transmembrane	260 – 280	21	Helical; Potential
	Transmembrane	292 – 310	19	Helical; Potential
	Transmembrane	316 – 337	22	Helical; Potential
	Transmembrane	349 – 370	22	Helical; Potential
	Transmembrane	421 – 441	21	Helical; Potential
	Transmembrane	466 – 486	21	Helical; Potential
	Transmembrane	489 – 509	21	Helical; Potential
	Transmembrane	522 – 542	21	Helical; Potential
Experimental info
	Sequence conflict	3	1	E → D in CAD98049. Ref.2
	Sequence conflict	440	1	I → T in BAC85664. Ref.1
	Sequence conflict	654	1	M → T in BAC85675. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q7Z388 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: F1B385FF181F7193	FASTA	723	83,756
	10 20 30 40 50 60 MAEEEGPPVE LRQRKKPKSS ENKESAKEEK ISDIPIPERA PKHVLFQRFA KIFIGCLAAV 70 80 90 100 110 120 TSGMMYALYL SAYHERKFWF SNRQELEREI TFQGDSAIYY SYYKDMLKAP SFERGVYELT 130 140 150 160 170 180 HNNKTVSLKT INAVQQMSLY PELIASILYQ ATGSNEIIEP VYFYIGIVFG LQGIYVTALF 190 200 210 220 230 240 VTSWLMSGTW LAGMLTVAWF VINRVDTTRI EYSIPLRENW ALPYFACQIA ALTGYLKSNL 250 260 270 280 290 300 NTYGERFCYL LMSASTYTFM MMWEYSHYLL FLQAISLFLL DTFSVEQSDK VYEVYKIYIF 310 320 330 340 350 360 SLFLGYLLQF ENPALLVSPL LSLVAALMLA KCLQLNVKKG SFVAKIIKVI NFYLVCTLTI 370 380 390 400 410 420 TLNIIMKMFV PHKENGHMLK FLEVKFGLNM TKNFTMNWLL CQESLQAPSQ DFFLRLTQSS 430 440 450 460 470 480 LLPFYILVLI ICFLSMLQVI FRRINGKSLK ETVTLEDGRI GERPEIIYHV IHTILLGSLA 490 500 510 520 530 540 MVIEGLKYIW IPYVCMLAAF GVCSPELWMT LFKWLRLRTV HPILLALILS MAVPTIIGLS 550 560 570 580 590 600 LWKEFFPRLM TELMELQEFY DPDTVELMTW IKRQAPVAAV FAGSPQLMGA IKLCTGWMVT 610 620 630 640 650 660 SLPLYNDDDL LKRNENIYQI YSKRSAEDIY KILTSYKANY LIVEDAICNE VGPMRGCRVK 670 680 690 700 710 720 DLLDIANGHM VCEEGDKLTY SKYGRFCHEV KINYSPYVNY FTRVYWNRSY FVYKINTVIS FQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tongue.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon endothelium and Uterus.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[5]	"Duplication and relocation of the functional DPY19L2 gene within low copy repeats." Carson A.R., Cheung J., Scherer S.W. BMC Genomics 7:45-45(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK123618 mRNA. Translation: BAC85664.1. Different initiation. AK123682 mRNA. Translation: BAC85675.1. BX538048 mRNA. Translation: CAD97987.1. BX538174 mRNA. Translation: CAD98049.1. CH471060 Genomic DNA. Translation: EAW91723.1. BC110870 mRNA. Translation: AAI10871.1. BC126193 mRNA. Translation: AAI26194.1. BC130576 mRNA. Translation: AAI30577.1.
IPI	IPI00334281.
RefSeq	NP_861452.2. NM_181787.2.
UniGene	Hs.567828.
3D structure databases
ProteinModelPortal	Q7Z388.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z388. 1 interaction.
STRING	9606.ENSP00000389630.
PTM databases
PhosphoSite	Q7Z388.
Polymorphism databases
DMDM	74713335.
Proteomic databases
PaxDb	Q7Z388.
PRIDE	Q7Z388.
Protocols and materials databases
DNASU	286148.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000414645; ENSP00000389630; ENSG00000156162.
GeneID	286148.
KEGG	hsa:286148.
UCSC	uc003ygx.2. human.
Organism-specific databases
CTD	286148.
GeneCards	GC08P095802.
HGNC	HGNC:27829. DPY19L4.
HPA	HPA024780.
MIM	613895. gene.
neXtProt	NX_Q7Z388.
PharmGKB	PA142671955.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG236656.
HOGENOM	HOG000007319.
HOVERGEN	HBG107792.
InParanoid	Q7Z388.
OMA	STYTFMM.
OrthoDB	EOG4FJ88G.
PhylomeDB	Q7Z388.
Gene expression databases
ArrayExpress	Q7Z388.
Bgee	Q7Z388.
CleanEx	HS_DPY19L4.
Genevestigator	Q7Z388.
Family and domain databases
InterPro	IPR018732. Dpy-19. [Graphical view]
Pfam	PF10034. Dpy19. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DPY19L4. human.
GenomeRNAi	286148.
NextBio	96034.
SOURCE	Search...

Entry information

Entry name

D19L4_HUMAN

Accession

Primary (citable) accession number: Q7Z388
Secondary accession number(s): Q6ZW32, Q6ZW42, Q7Z329

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	October 1, 2003
Last modified:	May 29, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.