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Protein

Highly divergent homeobox

Gene

HDX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi3 – 6361Homeobox 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi435 – 49864Homeobox 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Highly divergent homeobox
Gene namesi
Name:HDX
Synonyms:CXorf43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:26411. HDX.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390630.

Polymorphism and mutation databases

BioMutaiHDX.
DMDMi74762426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 690690Highly divergent homeoboxPRO_0000299487Add
BLAST

Proteomic databases

PaxDbiQ7Z353.
PRIDEiQ7Z353.

PTM databases

iPTMnetiQ7Z353.
PhosphoSiteiQ7Z353.

Expressioni

Gene expression databases

BgeeiQ7Z353.
CleanExiHS_HDX.
ExpressionAtlasiQ7Z353. baseline and differential.
GenevisibleiQ7Z353. HS.

Organism-specific databases

HPAiHPA047189.

Interactioni

Protein-protein interaction databases

BioGridi126559. 3 interactions.
STRINGi9606.ENSP00000297977.

Structurei

Secondary structure

1
690
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi444 – 45411Combined sources
Turni455 – 4595Combined sources
Helixi463 – 47614Combined sources
Helixi480 – 49718Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DA4NMR-A435-501[»]
ProteinModelPortaliQ7Z353.
SMRiQ7Z353. Positions 4-72, 435-507.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z353.

Family & Domainsi

Sequence similaritiesi

Contains 2 homeobox DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiENOG410IE54. Eukaryota.
ENOG4110JHR. LUCA.
GeneTreeiENSGT00390000008591.
HOGENOMiHOG000112876.
HOVERGENiHBG095615.
InParanoidiQ7Z353.
OMAiSSQEEPN.
OrthoDBiEOG7PK8Z3.
PhylomeDBiQ7Z353.
TreeFamiTF330998.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z353-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLRSVFTVE QQRILQRYYE NGMTNQSKNC FQLILQCAQE TKLDFSVVRT
60 70 80 90 100
WVGNKRRKMS SKNSESGTAT TGTSLSAPDI TVRNVVNIAR PSSQQSSWTS
110 120 130 140 150
ANNDVIVTGI YSPASSSSRQ GTNKHTDTQI TEAHKIPIQK TATKNDTEFQ
160 170 180 190 200
LHIPVQRQVA HCKNASLLLG EKTIILSRQT SVLNAGNSVF NHAKKNYGNS
210 220 230 240 250
SVQASEMTVP QKPSVCHRPC KIEPVGIQRS YKPEHTGPAL HNLCGQKPTI
260 270 280 290 300
RDPYCRTQNL EIREVFSLAV SDYPQRILGG NAPQKPSSAE GNCLSIAMET
310 320 330 340 350
GDAEDEYARE EELASMRAQI PSYSRFYESG SSLRAENQST TLPGPGRNMP
360 370 380 390 400
NSQMVNIRDM SDNVLYQNRN YHLTPRTSLH TASSTMYSNT NPLRSNFSPH
410 420 430 440 450
FASSNQLRLS QNQNNYQISG NLTVPWITGC SRKRALQDRT QFSDRDLATL
460 470 480 490 500
KKYWDNGMTS LGSVCREKIE AVATELNVDC EIVRTWIGNR RRKYRLMGIE
510 520 530 540 550
VPPPRGGPAD FSEQPESGSL SALTPGEEAG PEVGEDNDRN DEVSICLSEG
560 570 580 590 600
SSQEEPNEVV PNDARAHKEE DHHAVTTDNV KIEIIDDEES DMISNSEVEQ
610 620 630 640 650
VNSFLDYKNE EVKFIENELE IQKQKYFKLQ TFVRSLILAM KADDKEQQQA
660 670 680 690
LLSDLPPELE EMDFNHASLE PDDTSFSVSS LSEKNVSESL
Length:690
Mass (Da):77,206
Last modified:October 1, 2003 - v1
Checksum:i572AA4D182400736
GO
Isoform 2 (identifier: Q7Z353-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:632
Mass (Da):70,225
Checksum:iC1ACD1B97E5F95C2
GO

Sequence cautioni

The sequence CAI42095.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti193 – 1931A → T.
Corresponds to variant rs35653454 [ dbSNP | Ensembl ].
VAR_034827
Natural varianti397 – 3971F → S.2 Publications
Corresponds to variant rs35161124 [ dbSNP | Ensembl ].
VAR_034828

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5858Missing in isoform 2. 1 PublicationVSP_027708Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055240 mRNA. Translation: BAB70886.1.
BX538112 mRNA. Translation: CAD98024.1.
AK290050 mRNA. Translation: BAF82739.1.
AL035552, AL022160 Genomic DNA. Translation: CAI42056.1.
AL022160 Genomic DNA. Translation: CAI42095.1. Sequence problems.
AL022160, AL035552 Genomic DNA. Translation: CAI42096.1.
CH471104 Genomic DNA. Translation: EAW98572.1.
CH471104 Genomic DNA. Translation: EAW98573.1.
BC101720 mRNA. Translation: AAI01721.1.
BC101722 mRNA. Translation: AAI01723.1.
BC143522 mRNA. Translation: AAI43523.1.
CCDSiCCDS35342.1. [Q7Z353-1]
CCDS55456.1. [Q7Z353-2]
RefSeqiNP_001170949.1. NM_001177478.1. [Q7Z353-2]
NP_001170950.1. NM_001177479.1. [Q7Z353-1]
NP_653258.2. NM_144657.4. [Q7Z353-1]
XP_006724682.1. XM_006724619.1. [Q7Z353-2]
XP_011529164.1. XM_011530862.1. [Q7Z353-1]
XP_011529165.1. XM_011530863.1. [Q7Z353-1]
XP_011529166.1. XM_011530864.1. [Q7Z353-1]
UniGeneiHs.559546.

Genome annotation databases

EnsembliENST00000297977; ENSP00000297977; ENSG00000165259. [Q7Z353-1]
ENST00000373177; ENSP00000362272; ENSG00000165259. [Q7Z353-1]
ENST00000506585; ENSP00000423670; ENSG00000165259. [Q7Z353-2]
GeneIDi139324.
KEGGihsa:139324.
UCSCiuc004eek.3. human. [Q7Z353-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055240 mRNA. Translation: BAB70886.1.
BX538112 mRNA. Translation: CAD98024.1.
AK290050 mRNA. Translation: BAF82739.1.
AL035552, AL022160 Genomic DNA. Translation: CAI42056.1.
AL022160 Genomic DNA. Translation: CAI42095.1. Sequence problems.
AL022160, AL035552 Genomic DNA. Translation: CAI42096.1.
CH471104 Genomic DNA. Translation: EAW98572.1.
CH471104 Genomic DNA. Translation: EAW98573.1.
BC101720 mRNA. Translation: AAI01721.1.
BC101722 mRNA. Translation: AAI01723.1.
BC143522 mRNA. Translation: AAI43523.1.
CCDSiCCDS35342.1. [Q7Z353-1]
CCDS55456.1. [Q7Z353-2]
RefSeqiNP_001170949.1. NM_001177478.1. [Q7Z353-2]
NP_001170950.1. NM_001177479.1. [Q7Z353-1]
NP_653258.2. NM_144657.4. [Q7Z353-1]
XP_006724682.1. XM_006724619.1. [Q7Z353-2]
XP_011529164.1. XM_011530862.1. [Q7Z353-1]
XP_011529165.1. XM_011530863.1. [Q7Z353-1]
XP_011529166.1. XM_011530864.1. [Q7Z353-1]
UniGeneiHs.559546.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DA4NMR-A435-501[»]
ProteinModelPortaliQ7Z353.
SMRiQ7Z353. Positions 4-72, 435-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126559. 3 interactions.
STRINGi9606.ENSP00000297977.

PTM databases

iPTMnetiQ7Z353.
PhosphoSiteiQ7Z353.

Polymorphism and mutation databases

BioMutaiHDX.
DMDMi74762426.

Proteomic databases

PaxDbiQ7Z353.
PRIDEiQ7Z353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297977; ENSP00000297977; ENSG00000165259. [Q7Z353-1]
ENST00000373177; ENSP00000362272; ENSG00000165259. [Q7Z353-1]
ENST00000506585; ENSP00000423670; ENSG00000165259. [Q7Z353-2]
GeneIDi139324.
KEGGihsa:139324.
UCSCiuc004eek.3. human. [Q7Z353-1]

Organism-specific databases

CTDi139324.
GeneCardsiHDX.
HGNCiHGNC:26411. HDX.
HPAiHPA047189.
neXtProtiNX_Q7Z353.
PharmGKBiPA162390630.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE54. Eukaryota.
ENOG4110JHR. LUCA.
GeneTreeiENSGT00390000008591.
HOGENOMiHOG000112876.
HOVERGENiHBG095615.
InParanoidiQ7Z353.
OMAiSSQEEPN.
OrthoDBiEOG7PK8Z3.
PhylomeDBiQ7Z353.
TreeFamiTF330998.

Miscellaneous databases

EvolutionaryTraceiQ7Z353.
GenomeRNAii139324.
PROiQ7Z353.

Gene expression databases

BgeeiQ7Z353.
CleanExiHS_HDX.
ExpressionAtlasiQ7Z353. baseline and differential.
GenevisibleiQ7Z353. HS.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-397.
    Tissue: Brain and Hippocampus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon endothelium.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-397.
    Tissue: Heart and Lung.
  6. Bienvenut W.V., Vousden K.H., Lukashchuk N.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 164-194; 257-263; 326-347; 614-623 AND 629-634, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Lung carcinoma.
  7. "Solution structure of the homeobox domain of the hypothetical protein, DKFZp686K21156."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 435-501.

Entry informationi

Entry nameiHDX_HUMAN
AccessioniPrimary (citable) accession number: Q7Z353
Secondary accession number(s): A8K1Y5
, B7ZL18, Q5JZB4, Q96NK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.