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Protein

Zinc finger protein 551

Gene

ZNF551

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 551
Alternative name(s):
Zinc finger protein KOX23
Gene namesi
Name:ZNF551
Synonyms:KOX23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000204519.10
HGNCiHGNC:25108 ZNF551
neXtProtiNX_Q7Z340

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204519
PharmGKBiPA134993781

Polymorphism and mutation databases

DMDMi116242860

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476461 – 670Zinc finger protein 551Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineCombined sources1
Cross-linki319Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ7Z340
PeptideAtlasiQ7Z340
PRIDEiQ7Z340

PTM databases

iPTMnetiQ7Z340
PhosphoSitePlusiQ7Z340

Expressioni

Gene expression databases

BgeeiENSG00000204519
CleanExiHS_ZNF551
ExpressionAtlasiQ7Z340 baseline and differential
GenevisibleiQ7Z340 HS

Organism-specific databases

HPAiHPA038187
HPA038188

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000282296

Structurei

3D structure databases

ProteinModelPortaliQ7Z340
SMRiQ7Z340
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 100KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ7Z340
KOiK09228
OMAiHQSVCSE
OrthoDBiEOG091G02KC
PhylomeDBiQ7Z340
TreeFamiTF339848

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z340-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAPVGRRSP PSPRSSMAAV ALRDSAQGMT FEDVAIYFSQ EEWELLDESQ
60 70 80 90 100
RFLYCDVMLE NFAHVTSLGY CHGMENEAIA SEQSVSIQVR TSKGNTPTQK
110 120 130 140 150
THLSEIKMCV PVLKDILPAA EHQTTSPVQK SYLGSTSMRG FCFSADLHQH
160 170 180 190 200
QKHYNEEEPW KRKVDEATFV TGCRFHVLNY FTCGEAFPAP TDLLQHEATP
210 220 230 240 250
SGEEPHSSSS KHIQAFFNAK SYYKWGEYRK ASSHKHTLVQ HQSVCSEGGL
260 270 280 290 300
YECSKCEKAF TCKNTLVQHQ QIHTGQKMFE CSECEESFSK KCHLILHKII
310 320 330 340 350
HTGERPYECS DREKAFIHKS EFIHHQRRHT GGVRHECGEC RKTFSYKSNL
360 370 380 390 400
IEHQRVHTGE RPYECGECGK SFRQSSSLFR HQRVHSGERP YQCCECGKSF
410 420 430 440 450
RQIFNLIRHR RVHTGEMPYQ CSDCGKSFSC KSELIQHQRI HSGERPYECR
460 470 480 490 500
ECGKSFRQFS NLIRHRSIHT GDRPYECSEC EKSFSRKFIL IQHQRVHTGE
510 520 530 540 550
RPYECSECGK SFTRKSDLIQ HRRIHTGTRP YECSECGKSF RQRSGLIQHR
560 570 580 590 600
RLHTGERPYE CSECGKSFSQ SASLIQHQRV HTGERPYECS ECGKSFSQSS
610 620 630 640 650
SLIQHQRGHT GERPYECSQC GKPFTHKSDL IQHQRVHTGE RPYECSECGK
660 670
SFSRKSNLIR HRRVHTEERP
Length:670
Mass (Da):77,515
Last modified:October 17, 2006 - v3
Checksum:iC6F4E60F4A00F3F1
GO
Isoform 2 (identifier: Q7Z340-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Note: No experimental confirmation available.
Show »
Length:597
Mass (Da):69,333
Checksum:iE7FE42878DDBE745
GO
Isoform 3 (identifier: Q7Z340-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     363-670: Missing.

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):41,375
Checksum:i8EF30907EFB82C56
GO

Sequence cautioni

The sequence AAH05868 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti352E → R in BAC03625 (PubMed:14702039).Curated1
Sequence conflicti354Q → R in BAC03625 (PubMed:14702039).Curated1
Sequence conflicti359G → E in BAC03625 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028077218N → S. Corresponds to variant dbSNP:rs10413864Ensembl.1
Natural variantiVAR_028078550R → W. Corresponds to variant dbSNP:rs12611105Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0147991 – 73Missing in isoform 2. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_014800363 – 670Missing in isoform 3. 1 PublicationAdd BLAST308

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091273 mRNA Translation: BAC03625.1
AK300465 mRNA Translation: BAG62184.1
BX538151 mRNA Translation: CAD98037.1
AC004017 Genomic DNA No translation available.
BC005868 mRNA Translation: AAH05868.1 Different initiation.
X52354 mRNA Translation: CAA36580.1
CCDSiCCDS12959.2 [Q7Z340-1]
PIRiI37963
RefSeqiNP_001257867.1, NM_001270938.1
NP_612356.2, NM_138347.4 [Q7Z340-1]
UniGeneiHs.109540

Genome annotation databases

EnsembliENST00000282296; ENSP00000282296; ENSG00000204519 [Q7Z340-1]
GeneIDi90233
KEGGihsa:90233
UCSCiuc002qpw.6 human [Q7Z340-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN551_HUMAN
AccessioniPrimary (citable) accession number: Q7Z340
Secondary accession number(s): B4DU22
, P17034, Q8N246, Q9BRY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 17, 2006
Last modified: March 28, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health