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Protein

Zinc finger protein 551

Gene

ZNF551

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 551
Alternative name(s):
Zinc finger protein KOX23
Gene namesi
Name:ZNF551
Synonyms:KOX23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25108. ZNF551.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204519.
PharmGKBiPA134993781.

Polymorphism and mutation databases

DMDMi116242860.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476461 – 670Zinc finger protein 551Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineCombined sources1
Cross-linki319Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ7Z340.
PeptideAtlasiQ7Z340.
PRIDEiQ7Z340.

PTM databases

iPTMnetiQ7Z340.
PhosphoSitePlusiQ7Z340.

Expressioni

Gene expression databases

BgeeiENSG00000204519.
CleanExiHS_ZNF551.
ExpressionAtlasiQ7Z340. baseline and differential.
GenevisibleiQ7Z340. HS.

Organism-specific databases

HPAiHPA038187.
HPA038188.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000282296.

Structurei

3D structure databases

ProteinModelPortaliQ7Z340.
SMRiQ7Z340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 100KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7Z340.
KOiK09228.
OMAiHQSVCSE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ7Z340.
TreeFamiTF339848.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR030754. ZNF551.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR24387:SF268. PTHR24387:SF268. 1 hit.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z340-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAPVGRRSP PSPRSSMAAV ALRDSAQGMT FEDVAIYFSQ EEWELLDESQ
60 70 80 90 100
RFLYCDVMLE NFAHVTSLGY CHGMENEAIA SEQSVSIQVR TSKGNTPTQK
110 120 130 140 150
THLSEIKMCV PVLKDILPAA EHQTTSPVQK SYLGSTSMRG FCFSADLHQH
160 170 180 190 200
QKHYNEEEPW KRKVDEATFV TGCRFHVLNY FTCGEAFPAP TDLLQHEATP
210 220 230 240 250
SGEEPHSSSS KHIQAFFNAK SYYKWGEYRK ASSHKHTLVQ HQSVCSEGGL
260 270 280 290 300
YECSKCEKAF TCKNTLVQHQ QIHTGQKMFE CSECEESFSK KCHLILHKII
310 320 330 340 350
HTGERPYECS DREKAFIHKS EFIHHQRRHT GGVRHECGEC RKTFSYKSNL
360 370 380 390 400
IEHQRVHTGE RPYECGECGK SFRQSSSLFR HQRVHSGERP YQCCECGKSF
410 420 430 440 450
RQIFNLIRHR RVHTGEMPYQ CSDCGKSFSC KSELIQHQRI HSGERPYECR
460 470 480 490 500
ECGKSFRQFS NLIRHRSIHT GDRPYECSEC EKSFSRKFIL IQHQRVHTGE
510 520 530 540 550
RPYECSECGK SFTRKSDLIQ HRRIHTGTRP YECSECGKSF RQRSGLIQHR
560 570 580 590 600
RLHTGERPYE CSECGKSFSQ SASLIQHQRV HTGERPYECS ECGKSFSQSS
610 620 630 640 650
SLIQHQRGHT GERPYECSQC GKPFTHKSDL IQHQRVHTGE RPYECSECGK
660 670
SFSRKSNLIR HRRVHTEERP
Length:670
Mass (Da):77,515
Last modified:October 17, 2006 - v3
Checksum:iC6F4E60F4A00F3F1
GO
Isoform 2 (identifier: Q7Z340-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Note: No experimental confirmation available.
Show »
Length:597
Mass (Da):69,333
Checksum:iE7FE42878DDBE745
GO
Isoform 3 (identifier: Q7Z340-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     363-670: Missing.

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):41,375
Checksum:i8EF30907EFB82C56
GO

Sequence cautioni

The sequence AAH05868 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti352E → R in BAC03625 (PubMed:14702039).Curated1
Sequence conflicti354Q → R in BAC03625 (PubMed:14702039).Curated1
Sequence conflicti359G → E in BAC03625 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028077218N → S. Corresponds to variant dbSNP:rs10413864Ensembl.1
Natural variantiVAR_028078550R → W. Corresponds to variant dbSNP:rs12611105Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0147991 – 73Missing in isoform 2. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_014800363 – 670Missing in isoform 3. 1 PublicationAdd BLAST308

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091273 mRNA. Translation: BAC03625.1.
AK300465 mRNA. Translation: BAG62184.1.
BX538151 mRNA. Translation: CAD98037.1.
AC004017 Genomic DNA. No translation available.
BC005868 mRNA. Translation: AAH05868.1. Different initiation.
X52354 mRNA. Translation: CAA36580.1.
CCDSiCCDS12959.2. [Q7Z340-1]
PIRiI37963.
RefSeqiNP_001257867.1. NM_001270938.1.
NP_612356.2. NM_138347.4. [Q7Z340-1]
UniGeneiHs.109540.

Genome annotation databases

EnsembliENST00000282296; ENSP00000282296; ENSG00000204519. [Q7Z340-1]
GeneIDi90233.
KEGGihsa:90233.
UCSCiuc002qpw.6. human. [Q7Z340-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN551_HUMAN
AccessioniPrimary (citable) accession number: Q7Z340
Secondary accession number(s): B4DU22
, P17034, Q8N246, Q9BRY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 17, 2006
Last modified: August 30, 2017
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families