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Q7Z2Y5

- NRK_HUMAN

UniProt

Q7Z2Y5 - NRK_HUMAN

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Protein

Nik-related protein kinase

Gene

NRK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541ATPPROSITE-ProRule annotation
Active sitei177 – 1771Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
  3. small GTPase regulator activity Source: InterPro

GO - Biological processi

  1. activation of JNKK activity Source: Ensembl
  2. negative regulation of cell proliferation Source: Ensembl
  3. parturition Source: Ensembl
  4. regulation of spongiotrophoblast cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ7Z2Y5.

Names & Taxonomyi

Protein namesi
Recommended name:
Nik-related protein kinase (EC:2.7.11.1)
Gene namesi
Name:NRK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:25391. NRK.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15821582Nik-related protein kinasePRO_0000250511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei852 – 8521Phosphoserine1 Publication
Modified residuei855 – 8551Phosphoserine1 Publication
Modified residuei1027 – 10271Phosphoserine1 Publication
Modified residuei1031 – 10311Phosphoserine1 Publication
Modified residuei1034 – 10341Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7Z2Y5.
PRIDEiQ7Z2Y5.

PTM databases

PhosphoSiteiQ7Z2Y5.

Expressioni

Gene expression databases

BgeeiQ7Z2Y5.
CleanExiHS_NRK.
ExpressionAtlasiQ7Z2Y5. baseline and differential.
GenevestigatoriQ7Z2Y5.

Organism-specific databases

HPAiHPA017238.

Interactioni

Protein-protein interaction databases

MINTiMINT-2807912.
STRINGi9606.ENSP00000414221.

Structurei

3D structure databases

ProteinModelPortaliQ7Z2Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 313289Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini1209 – 1552344CNHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili725 – 75935Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi402 – 570169Gln-richAdd
BLAST
Compositional biasi917 – 97963Asp-richAdd
BLAST

Sequence similaritiesi

Contains 1 CNH domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118848.
HOVERGENiHBG080612.
InParanoidiQ7Z2Y5.
KOiK16313.
OMAiRRRLPWC.
OrthoDBiEOG7Z3F3P.
PhylomeDBiQ7Z2Y5.

Family and domain databases

InterProiIPR001180. Citron.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z2Y5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF
60 70 80 90 100
TAVKVMNARK TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY
110 120 130 140 150
SFHKNIVSFY GAFFKLSPPG QRHQLWMVME LCAAGSVTDV VRMTSNQSLK
160 170 180 190 200
EDWIAYICRE ILQGLAHLHA HRVIHRDIKG QNVLLTHNAE VKLVDFGVSA
210 220 230 240 250
QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV WSVGITAIEM
260 270 280 290 300
AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF
310 320 330 340 350
RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK GIPLIFEREE
360 370 380 390 400
AIKEQYTVRR FRGPSCTHEL LRLPTSSRCR PLRVLHGEPS QPRWLPDREE
410 420 430 440 450
PQVQALQQLQ GAARVFMPLQ ALDSAPKPLK GQAQAPQRLQ GAARVFMPLQ
460 470 480 490 500
AQVKAKASKP LQMQIKAPPR LRRAARVLMP LQAQVRAPRL LQVQSQVSKK
510 520 530 540 550
QQAQTQTSEP QDLDQVPEEF QGQDQVPEQQ RQGQAPEQQQ RHNQVPEQEL
560 570 580 590 600
EQNQAPEQPE VQEQAAEPAQ AETEAEEPES LRVNAQVFLP LLSQDHHVLL
610 620 630 640 650
PLHLDTQVLI PVEGQTEGSP QAQAWTLEPP QAIGSVQALI EGLSRDLLRA
660 670 680 690 700
PNSNNSKPLG PLQTLMENLS SNRFYSQPEQ AREKKSKVST LRQALAKRLS
710 720 730 740 750
PKRFRAKSSW RPEKLELSDL EARRQRRQRR WEDIFNQHEE ELRQVDKDKE
760 770 780 790 800
DESSDNDEVF HSIQAEVQIE PLKPYISNPK KIEVQERSPS VPNNQDHAHH
810 820 830 840 850
VKFSSSVPQR SLLEQAQKPI DIRQRSSQNR QNWLAASESS SEEESPVTGR
860 870 880 890 900
RSQSSPPYST IDQKLLVDIH VPDGFKVGKI SPPVYLTNEW VGYNALSEIF
910 920 930 940 950
RNDWLTPAPV IQPPEEDGDY VELYDASADT DGDDDDESND TFEDTYDHAN
960 970 980 990 1000
GNDDLDNQVD QANDVCKDHD DDNNKFVDDV NNNYYEAPSC PRASYGRDGS
1010 1020 1030 1040 1050
CKQDGYDGSR GKEEAYRGYG SHTANRSHGG SAASEDNAAI GDQEEHAANI
1060 1070 1080 1090 1100
GSERRGSEGD GGKGVVRTSE ESGALGLNGE ENCSETDGPG LKRPASQDFE
1110 1120 1130 1140 1150
YLQEEPGGGN EASNAIDSGA APSAPDHESD NKDISESSTQ SDFSANHSSP
1160 1170 1180 1190 1200
SKGSGMSADA NFASAILYAG FVEVPEESPK QPSEVNVNPL YVSPACKKPL
1210 1220 1230 1240 1250
IHMYEKEFTS EICCGSLWGV NLLLGTRSNL YLMDRSGKAD ITKLIRRRPF
1260 1270 1280 1290 1300
RQIQVLEPLN LLITISGHKN RLRVYHLTWL RNKILNNDPE SKRRQEEMLK
1310 1320 1330 1340 1350
TEEACKAIDK LTGCEHFSVL QHEETTYIAI ALKSSIHLYA WAPKSFDEST
1360 1370 1380 1390 1400
AIKVCIDQSA DSEGDYMSYQ AYIRILAKIQ AADPVNRFKR PDELLHLLKL
1410 1420 1430 1440 1450
KVFPTLDHKP VTVDLAIGSE KRLKIFFSSA DGYHLIDAES EVMSDVTLPK
1460 1470 1480 1490 1500
NPLEIIIPQN IIILPDCLGI GMMLTFNAEA LSVEANEQLF KKILEMWKDI
1510 1520 1530 1540 1550
PSSIAFECTQ RTTGWGQKAI EVRSLQSRVL ESELKRRSIK KLRFLCTRGD
1560 1570 1580
KLFFTSTLRN HHSRVYFMTL GKLEELQSNY DV
Length:1,582
Mass (Da):178,479
Last modified:October 3, 2006 - v2
Checksum:iC9C56860C8AEBFF3
GO
Isoform 2 (identifier: Q7Z2Y5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     333-338: IIKKRQ → MFFSFV

Note: No experimental confirmation available.

Show »
Length:1,250
Mass (Da):140,606
Checksum:i5ACDF85130EFEC4D
GO
Isoform 3 (identifier: Q7Z2Y5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-188: GLAHLHAHRVIHRDIKGQNVLLTHN → PKVIFLGTGCSDSSLKKELCLKHQN
     189-1582: Missing.

Note: No experimental confirmation available.

Show »
Length:188
Mass (Da):21,368
Checksum:i702BC65F8A2DE6ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521D → G in CAD98108. (PubMed:17974005)Curated
Sequence conflicti522 – 5221G → S in CAD98108. (PubMed:17974005)Curated
Sequence conflicti572 – 5721E → G in CAD98108. (PubMed:17974005)Curated
Sequence conflicti705 – 7051R → G in CAD98108. (PubMed:17974005)Curated
Sequence conflicti1138 – 11381S → P in CAD98108. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti355 – 3551Q → H.1 Publication
Corresponds to variant rs55862725 [ dbSNP | Ensembl ].
VAR_040951
Natural varianti358 – 3581V → M.1 Publication
Corresponds to variant rs209373 [ dbSNP | Ensembl ].
VAR_033908
Natural varianti424 – 4241S → C in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication
VAR_040952
Natural varianti426 – 4261P → A.1 Publication
Corresponds to variant rs55635933 [ dbSNP | Ensembl ].
VAR_040953
Natural varianti579 – 5791E → G.1 Publication
Corresponds to variant rs56350428 [ dbSNP | Ensembl ].
VAR_040954
Natural varianti679 – 6791E → G.1 Publication
Corresponds to variant rs35115195 [ dbSNP | Ensembl ].
VAR_040955
Natural varianti727 – 7271R → H.
Corresponds to variant rs33936206 [ dbSNP | Ensembl ].
VAR_051653
Natural varianti880 – 8801I → L in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040956
Natural varianti971 – 9711D → G.1 Publication
Corresponds to variant rs35334892 [ dbSNP | Ensembl ].
VAR_040957
Natural varianti993 – 9931A → E.
Corresponds to variant rs16984889 [ dbSNP | Ensembl ].
VAR_033909
Natural varianti1106 – 11061P → S.1 Publication
Corresponds to variant rs35393519 [ dbSNP | Ensembl ].
VAR_040958
Natural varianti1121 – 11211A → P.1 Publication
Corresponds to variant rs35720774 [ dbSNP | Ensembl ].
VAR_040959
Natural varianti1276 – 12761H → L.1 Publication
Corresponds to variant rs35942881 [ dbSNP | Ensembl ].
VAR_040960
Natural varianti1471 – 14711G → A.1 Publication
Corresponds to variant rs34232354 [ dbSNP | Ensembl ].
VAR_040961
Natural varianti1472 – 14721M → L.1 Publication
Corresponds to variant rs35609510 [ dbSNP | Ensembl ].
VAR_040962

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 332332Missing in isoform 2. 1 PublicationVSP_020654Add
BLAST
Alternative sequencei164 – 18825GLAHL…LLTHN → PKVIFLGTGCSDSSLKKELC LKHQN in isoform 3. 1 PublicationVSP_020655Add
BLAST
Alternative sequencei189 – 15821394Missing in isoform 3. 1 PublicationVSP_020656Add
BLAST
Alternative sequencei333 – 3386IIKKRQ → MFFSFV in isoform 2. 1 PublicationVSP_020657

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538345 mRNA. Translation: CAD98108.1.
Z68339 Genomic DNA. No translation available.
Z69734 Genomic DNA. No translation available.
Z70274 Genomic DNA. No translation available.
Z83850 Genomic DNA. No translation available.
BC108702 mRNA. Translation: AAI08703.1.
AK131549 mRNA. Translation: BAD18683.1.
CCDSiCCDS65305.1. [Q7Z2Y5-1]
RefSeqiNP_940867.2. NM_198465.3. [Q7Z2Y5-1]
XP_006724694.1. XM_006724631.1. [Q7Z2Y5-1]
UniGeneiHs.209527.

Genome annotation databases

EnsembliENST00000243300; ENSP00000434830; ENSG00000123572. [Q7Z2Y5-1]
ENST00000536164; ENSP00000438785; ENSG00000123572. [Q7Z2Y5-3]
GeneIDi203447.
KEGGihsa:203447.
UCSCiuc004emd.3. human. [Q7Z2Y5-1]
uc010npc.1. human. [Q7Z2Y5-2]

Polymorphism databases

DMDMi115502506.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538345 mRNA. Translation: CAD98108.1 .
Z68339 Genomic DNA. No translation available.
Z69734 Genomic DNA. No translation available.
Z70274 Genomic DNA. No translation available.
Z83850 Genomic DNA. No translation available.
BC108702 mRNA. Translation: AAI08703.1 .
AK131549 mRNA. Translation: BAD18683.1 .
CCDSi CCDS65305.1. [Q7Z2Y5-1 ]
RefSeqi NP_940867.2. NM_198465.3. [Q7Z2Y5-1 ]
XP_006724694.1. XM_006724631.1. [Q7Z2Y5-1 ]
UniGenei Hs.209527.

3D structure databases

ProteinModelPortali Q7Z2Y5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-2807912.
STRINGi 9606.ENSP00000414221.

PTM databases

PhosphoSitei Q7Z2Y5.

Polymorphism databases

DMDMi 115502506.

Proteomic databases

PaxDbi Q7Z2Y5.
PRIDEi Q7Z2Y5.

Protocols and materials databases

DNASUi 203447.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243300 ; ENSP00000434830 ; ENSG00000123572 . [Q7Z2Y5-1 ]
ENST00000536164 ; ENSP00000438785 ; ENSG00000123572 . [Q7Z2Y5-3 ]
GeneIDi 203447.
KEGGi hsa:203447.
UCSCi uc004emd.3. human. [Q7Z2Y5-1 ]
uc010npc.1. human. [Q7Z2Y5-2 ]

Organism-specific databases

CTDi 203447.
GeneCardsi GC0XP105067.
H-InvDB HIX0028465.
HGNCi HGNC:25391. NRK.
HPAi HPA017238.
MIMi 300791. gene.
neXtProti NX_Q7Z2Y5.
PharmGKBi PA134869113.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118848.
HOVERGENi HBG080612.
InParanoidi Q7Z2Y5.
KOi K16313.
OMAi RRRLPWC.
OrthoDBi EOG7Z3F3P.
PhylomeDBi Q7Z2Y5.

Enzyme and pathway databases

SignaLinki Q7Z2Y5.

Miscellaneous databases

ChiTaRSi NRK. human.
GeneWikii NRK_(gene).
GenomeRNAii 203447.
NextBioi 90432.
PROi Q7Z2Y5.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z2Y5.
CleanExi HS_NRK.
ExpressionAtlasi Q7Z2Y5. baseline and differential.
Genevestigatori Q7Z2Y5.

Family and domain databases

InterProi IPR001180. Citron.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Fetal kidney.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Ovary.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1291 (ISOFORM 2).
    Tissue: Placenta.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-852; SER-855; SER-1027; SER-1031 AND SER-1034, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-355; MET-358; CYS-424; ALA-426; GLY-579; GLY-679; LEU-880; GLY-971; SER-1106; PRO-1121; LEU-1276; ALA-1471 AND LEU-1472.

Entry informationi

Entry nameiNRK_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2Y5
Secondary accession number(s): Q32ND6, Q5H9K2, Q6ZMP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 26, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3