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Protein

Nik-related protein kinase

Gene

NRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPPROSITE-ProRule annotation1
Active sitei177Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 39ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS04674-MONOMER.
SignaLinkiQ7Z2Y5.

Names & Taxonomyi

Protein namesi
Recommended name:
Nik-related protein kinase (EC:2.7.11.1)
Gene namesi
Name:NRK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:25391. NRK.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi203447.
OpenTargetsiENSG00000123572.
PharmGKBiPA134869113.

Polymorphism and mutation databases

BioMutaiNRK.
DMDMi115502506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002505111 – 1582Nik-related protein kinaseAdd BLAST1582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei1027PhosphoserineCombined sources1
Modified residuei1031PhosphoserineCombined sources1
Modified residuei1034PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z2Y5.
PaxDbiQ7Z2Y5.
PeptideAtlasiQ7Z2Y5.
PRIDEiQ7Z2Y5.

PTM databases

iPTMnetiQ7Z2Y5.
PhosphoSitePlusiQ7Z2Y5.

Expressioni

Gene expression databases

BgeeiENSG00000123572.
CleanExiHS_NRK.
ExpressionAtlasiQ7Z2Y5. baseline and differential.
GenevisibleiQ7Z2Y5. HS.

Organism-specific databases

HPAiHPA017238.

Interactioni

Protein-protein interaction databases

MINTiMINT-2807912.
STRINGi9606.ENSP00000438378.

Structurei

3D structure databases

ProteinModelPortaliQ7Z2Y5.
SMRiQ7Z2Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 313Protein kinasePROSITE-ProRule annotationAdd BLAST289
Domaini1209 – 1552CNHPROSITE-ProRule annotationAdd BLAST344

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili725 – 759Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi402 – 570Gln-richAdd BLAST169
Compositional biasi917 – 979Asp-richAdd BLAST63

Sequence similaritiesi

Contains 1 CNH domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
ENOG410YEAG. LUCA.
GeneTreeiENSGT00810000125351.
HOVERGENiHBG080612.
InParanoidiQ7Z2Y5.
KOiK16313.
OMAiEDIFNQH.
OrthoDBiEOG091G00RS.
PhylomeDBiQ7Z2Y5.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z2Y5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF
60 70 80 90 100
TAVKVMNARK TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY
110 120 130 140 150
SFHKNIVSFY GAFFKLSPPG QRHQLWMVME LCAAGSVTDV VRMTSNQSLK
160 170 180 190 200
EDWIAYICRE ILQGLAHLHA HRVIHRDIKG QNVLLTHNAE VKLVDFGVSA
210 220 230 240 250
QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV WSVGITAIEM
260 270 280 290 300
AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF
310 320 330 340 350
RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK GIPLIFEREE
360 370 380 390 400
AIKEQYTVRR FRGPSCTHEL LRLPTSSRCR PLRVLHGEPS QPRWLPDREE
410 420 430 440 450
PQVQALQQLQ GAARVFMPLQ ALDSAPKPLK GQAQAPQRLQ GAARVFMPLQ
460 470 480 490 500
AQVKAKASKP LQMQIKAPPR LRRAARVLMP LQAQVRAPRL LQVQSQVSKK
510 520 530 540 550
QQAQTQTSEP QDLDQVPEEF QGQDQVPEQQ RQGQAPEQQQ RHNQVPEQEL
560 570 580 590 600
EQNQAPEQPE VQEQAAEPAQ AETEAEEPES LRVNAQVFLP LLSQDHHVLL
610 620 630 640 650
PLHLDTQVLI PVEGQTEGSP QAQAWTLEPP QAIGSVQALI EGLSRDLLRA
660 670 680 690 700
PNSNNSKPLG PLQTLMENLS SNRFYSQPEQ AREKKSKVST LRQALAKRLS
710 720 730 740 750
PKRFRAKSSW RPEKLELSDL EARRQRRQRR WEDIFNQHEE ELRQVDKDKE
760 770 780 790 800
DESSDNDEVF HSIQAEVQIE PLKPYISNPK KIEVQERSPS VPNNQDHAHH
810 820 830 840 850
VKFSSSVPQR SLLEQAQKPI DIRQRSSQNR QNWLAASESS SEEESPVTGR
860 870 880 890 900
RSQSSPPYST IDQKLLVDIH VPDGFKVGKI SPPVYLTNEW VGYNALSEIF
910 920 930 940 950
RNDWLTPAPV IQPPEEDGDY VELYDASADT DGDDDDESND TFEDTYDHAN
960 970 980 990 1000
GNDDLDNQVD QANDVCKDHD DDNNKFVDDV NNNYYEAPSC PRASYGRDGS
1010 1020 1030 1040 1050
CKQDGYDGSR GKEEAYRGYG SHTANRSHGG SAASEDNAAI GDQEEHAANI
1060 1070 1080 1090 1100
GSERRGSEGD GGKGVVRTSE ESGALGLNGE ENCSETDGPG LKRPASQDFE
1110 1120 1130 1140 1150
YLQEEPGGGN EASNAIDSGA APSAPDHESD NKDISESSTQ SDFSANHSSP
1160 1170 1180 1190 1200
SKGSGMSADA NFASAILYAG FVEVPEESPK QPSEVNVNPL YVSPACKKPL
1210 1220 1230 1240 1250
IHMYEKEFTS EICCGSLWGV NLLLGTRSNL YLMDRSGKAD ITKLIRRRPF
1260 1270 1280 1290 1300
RQIQVLEPLN LLITISGHKN RLRVYHLTWL RNKILNNDPE SKRRQEEMLK
1310 1320 1330 1340 1350
TEEACKAIDK LTGCEHFSVL QHEETTYIAI ALKSSIHLYA WAPKSFDEST
1360 1370 1380 1390 1400
AIKVCIDQSA DSEGDYMSYQ AYIRILAKIQ AADPVNRFKR PDELLHLLKL
1410 1420 1430 1440 1450
KVFPTLDHKP VTVDLAIGSE KRLKIFFSSA DGYHLIDAES EVMSDVTLPK
1460 1470 1480 1490 1500
NPLEIIIPQN IIILPDCLGI GMMLTFNAEA LSVEANEQLF KKILEMWKDI
1510 1520 1530 1540 1550
PSSIAFECTQ RTTGWGQKAI EVRSLQSRVL ESELKRRSIK KLRFLCTRGD
1560 1570 1580
KLFFTSTLRN HHSRVYFMTL GKLEELQSNY DV
Length:1,582
Mass (Da):178,479
Last modified:October 3, 2006 - v2
Checksum:iC9C56860C8AEBFF3
GO
Isoform 2 (identifier: Q7Z2Y5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     333-338: IIKKRQ → MFFSFV

Note: No experimental confirmation available.
Show »
Length:1,250
Mass (Da):140,606
Checksum:i5ACDF85130EFEC4D
GO
Isoform 3 (identifier: Q7Z2Y5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-188: GLAHLHAHRVIHRDIKGQNVLLTHN → PKVIFLGTGCSDSSLKKELCLKHQN
     189-1582: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):21,368
Checksum:i702BC65F8A2DE6ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152D → G in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti522G → S in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti572E → G in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti705R → G in CAD98108 (PubMed:17974005).Curated1
Sequence conflicti1138S → P in CAD98108 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040951355Q → H.1 PublicationCorresponds to variant rs55862725dbSNPEnsembl.1
Natural variantiVAR_033908358V → M.1 PublicationCorresponds to variant rs209373dbSNPEnsembl.1
Natural variantiVAR_040952424S → C in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040953426P → A.1 PublicationCorresponds to variant rs55635933dbSNPEnsembl.1
Natural variantiVAR_040954579E → G.1 PublicationCorresponds to variant rs56350428dbSNPEnsembl.1
Natural variantiVAR_040955679E → G.1 PublicationCorresponds to variant rs35115195dbSNPEnsembl.1
Natural variantiVAR_051653727R → H.Corresponds to variant rs33936206dbSNPEnsembl.1
Natural variantiVAR_040956880I → L in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs764355898dbSNPEnsembl.1
Natural variantiVAR_040957971D → G.1 PublicationCorresponds to variant rs35334892dbSNPEnsembl.1
Natural variantiVAR_033909993A → E.Corresponds to variant rs16984889dbSNPEnsembl.1
Natural variantiVAR_0409581106P → S.1 PublicationCorresponds to variant rs35393519dbSNPEnsembl.1
Natural variantiVAR_0409591121A → P.1 PublicationCorresponds to variant rs35720774dbSNPEnsembl.1
Natural variantiVAR_0409601276H → L.1 PublicationCorresponds to variant rs35942881dbSNPEnsembl.1
Natural variantiVAR_0409611471G → A.1 PublicationCorresponds to variant rs34232354dbSNPEnsembl.1
Natural variantiVAR_0409621472M → L.1 PublicationCorresponds to variant rs35609510dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0206541 – 332Missing in isoform 2. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_020655164 – 188GLAHL…LLTHN → PKVIFLGTGCSDSSLKKELC LKHQN in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_020656189 – 1582Missing in isoform 3. 1 PublicationAdd BLAST1394
Alternative sequenceiVSP_020657333 – 338IIKKRQ → MFFSFV in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538345 mRNA. Translation: CAD98108.1.
Z68339 Genomic DNA. No translation available.
Z69734 Genomic DNA. No translation available.
Z70274 Genomic DNA. No translation available.
Z83850 Genomic DNA. No translation available.
BC108702 mRNA. Translation: AAI08703.1.
AK131549 mRNA. Translation: BAD18683.1.
CCDSiCCDS65305.1. [Q7Z2Y5-1]
RefSeqiNP_940867.2. NM_198465.3. [Q7Z2Y5-1]
UniGeneiHs.209527.

Genome annotation databases

EnsembliENST00000243300; ENSP00000434830; ENSG00000123572. [Q7Z2Y5-1]
ENST00000536164; ENSP00000438785; ENSG00000123572. [Q7Z2Y5-3]
GeneIDi203447.
KEGGihsa:203447.
UCSCiuc065ans.1. human. [Q7Z2Y5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538345 mRNA. Translation: CAD98108.1.
Z68339 Genomic DNA. No translation available.
Z69734 Genomic DNA. No translation available.
Z70274 Genomic DNA. No translation available.
Z83850 Genomic DNA. No translation available.
BC108702 mRNA. Translation: AAI08703.1.
AK131549 mRNA. Translation: BAD18683.1.
CCDSiCCDS65305.1. [Q7Z2Y5-1]
RefSeqiNP_940867.2. NM_198465.3. [Q7Z2Y5-1]
UniGeneiHs.209527.

3D structure databases

ProteinModelPortaliQ7Z2Y5.
SMRiQ7Z2Y5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-2807912.
STRINGi9606.ENSP00000438378.

PTM databases

iPTMnetiQ7Z2Y5.
PhosphoSitePlusiQ7Z2Y5.

Polymorphism and mutation databases

BioMutaiNRK.
DMDMi115502506.

Proteomic databases

EPDiQ7Z2Y5.
PaxDbiQ7Z2Y5.
PeptideAtlasiQ7Z2Y5.
PRIDEiQ7Z2Y5.

Protocols and materials databases

DNASUi203447.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243300; ENSP00000434830; ENSG00000123572. [Q7Z2Y5-1]
ENST00000536164; ENSP00000438785; ENSG00000123572. [Q7Z2Y5-3]
GeneIDi203447.
KEGGihsa:203447.
UCSCiuc065ans.1. human. [Q7Z2Y5-1]

Organism-specific databases

CTDi203447.
DisGeNETi203447.
GeneCardsiNRK.
H-InvDBHIX0028465.
HGNCiHGNC:25391. NRK.
HPAiHPA017238.
MIMi300791. gene.
neXtProtiNX_Q7Z2Y5.
OpenTargetsiENSG00000123572.
PharmGKBiPA134869113.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
ENOG410YEAG. LUCA.
GeneTreeiENSGT00810000125351.
HOVERGENiHBG080612.
InParanoidiQ7Z2Y5.
KOiK16313.
OMAiEDIFNQH.
OrthoDBiEOG091G00RS.
PhylomeDBiQ7Z2Y5.

Enzyme and pathway databases

BioCyciZFISH:HS04674-MONOMER.
SignaLinkiQ7Z2Y5.

Miscellaneous databases

ChiTaRSiNRK. human.
GeneWikiiNRK_(gene).
GenomeRNAii203447.
PROiQ7Z2Y5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123572.
CleanExiHS_NRK.
ExpressionAtlasiQ7Z2Y5. baseline and differential.
GenevisibleiQ7Z2Y5. HS.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRK_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2Y5
Secondary accession number(s): Q32ND6, Q5H9K2, Q6ZMP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.