Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7Z2Y5

- NRK_HUMAN

UniProt

Q7Z2Y5 - NRK_HUMAN

Protein

Nik-related protein kinase

Gene

NRK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541ATPPROSITE-ProRule annotation
    Active sitei177 – 1771Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW
    3. small GTPase regulator activity Source: InterPro

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ7Z2Y5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nik-related protein kinase (EC:2.7.11.1)
    Gene namesi
    Name:NRK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:25391. NRK.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134869113.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15821582Nik-related protein kinasePRO_0000250511Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei852 – 8521Phosphoserine1 Publication
    Modified residuei855 – 8551Phosphoserine1 Publication
    Modified residuei1027 – 10271Phosphoserine1 Publication
    Modified residuei1031 – 10311Phosphoserine1 Publication
    Modified residuei1034 – 10341Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ7Z2Y5.
    PRIDEiQ7Z2Y5.

    PTM databases

    PhosphoSiteiQ7Z2Y5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z2Y5.
    BgeeiQ7Z2Y5.
    CleanExiHS_NRK.
    GenevestigatoriQ7Z2Y5.

    Organism-specific databases

    HPAiHPA017238.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-2807912.
    STRINGi9606.ENSP00000414221.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z2Y5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 313289Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini1209 – 1552344CNHPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili725 – 75935Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi402 – 570169Gln-richAdd
    BLAST
    Compositional biasi917 – 97963Asp-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CNH domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG080612.
    InParanoidiQ7Z2Y5.
    KOiK16313.
    OMAiRRRLPWC.
    OrthoDBiEOG7Z3F3P.
    PhylomeDBiQ7Z2Y5.

    Family and domain databases

    InterProiIPR001180. Citron.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00780. CNH. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50219. CNH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z2Y5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF     50
    TAVKVMNARK TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY 100
    SFHKNIVSFY GAFFKLSPPG QRHQLWMVME LCAAGSVTDV VRMTSNQSLK 150
    EDWIAYICRE ILQGLAHLHA HRVIHRDIKG QNVLLTHNAE VKLVDFGVSA 200
    QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV WSVGITAIEM 250
    AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF 300
    RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK GIPLIFEREE 350
    AIKEQYTVRR FRGPSCTHEL LRLPTSSRCR PLRVLHGEPS QPRWLPDREE 400
    PQVQALQQLQ GAARVFMPLQ ALDSAPKPLK GQAQAPQRLQ GAARVFMPLQ 450
    AQVKAKASKP LQMQIKAPPR LRRAARVLMP LQAQVRAPRL LQVQSQVSKK 500
    QQAQTQTSEP QDLDQVPEEF QGQDQVPEQQ RQGQAPEQQQ RHNQVPEQEL 550
    EQNQAPEQPE VQEQAAEPAQ AETEAEEPES LRVNAQVFLP LLSQDHHVLL 600
    PLHLDTQVLI PVEGQTEGSP QAQAWTLEPP QAIGSVQALI EGLSRDLLRA 650
    PNSNNSKPLG PLQTLMENLS SNRFYSQPEQ AREKKSKVST LRQALAKRLS 700
    PKRFRAKSSW RPEKLELSDL EARRQRRQRR WEDIFNQHEE ELRQVDKDKE 750
    DESSDNDEVF HSIQAEVQIE PLKPYISNPK KIEVQERSPS VPNNQDHAHH 800
    VKFSSSVPQR SLLEQAQKPI DIRQRSSQNR QNWLAASESS SEEESPVTGR 850
    RSQSSPPYST IDQKLLVDIH VPDGFKVGKI SPPVYLTNEW VGYNALSEIF 900
    RNDWLTPAPV IQPPEEDGDY VELYDASADT DGDDDDESND TFEDTYDHAN 950
    GNDDLDNQVD QANDVCKDHD DDNNKFVDDV NNNYYEAPSC PRASYGRDGS 1000
    CKQDGYDGSR GKEEAYRGYG SHTANRSHGG SAASEDNAAI GDQEEHAANI 1050
    GSERRGSEGD GGKGVVRTSE ESGALGLNGE ENCSETDGPG LKRPASQDFE 1100
    YLQEEPGGGN EASNAIDSGA APSAPDHESD NKDISESSTQ SDFSANHSSP 1150
    SKGSGMSADA NFASAILYAG FVEVPEESPK QPSEVNVNPL YVSPACKKPL 1200
    IHMYEKEFTS EICCGSLWGV NLLLGTRSNL YLMDRSGKAD ITKLIRRRPF 1250
    RQIQVLEPLN LLITISGHKN RLRVYHLTWL RNKILNNDPE SKRRQEEMLK 1300
    TEEACKAIDK LTGCEHFSVL QHEETTYIAI ALKSSIHLYA WAPKSFDEST 1350
    AIKVCIDQSA DSEGDYMSYQ AYIRILAKIQ AADPVNRFKR PDELLHLLKL 1400
    KVFPTLDHKP VTVDLAIGSE KRLKIFFSSA DGYHLIDAES EVMSDVTLPK 1450
    NPLEIIIPQN IIILPDCLGI GMMLTFNAEA LSVEANEQLF KKILEMWKDI 1500
    PSSIAFECTQ RTTGWGQKAI EVRSLQSRVL ESELKRRSIK KLRFLCTRGD 1550
    KLFFTSTLRN HHSRVYFMTL GKLEELQSNY DV 1582
    Length:1,582
    Mass (Da):178,479
    Last modified:October 3, 2006 - v2
    Checksum:iC9C56860C8AEBFF3
    GO
    Isoform 2 (identifier: Q7Z2Y5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-332: Missing.
         333-338: IIKKRQ → MFFSFV

    Note: No experimental confirmation available.

    Show »
    Length:1,250
    Mass (Da):140,606
    Checksum:i5ACDF85130EFEC4D
    GO
    Isoform 3 (identifier: Q7Z2Y5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         164-188: GLAHLHAHRVIHRDIKGQNVLLTHN → PKVIFLGTGCSDSSLKKELCLKHQN
         189-1582: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:188
    Mass (Da):21,368
    Checksum:i702BC65F8A2DE6ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1521D → G in CAD98108. (PubMed:17974005)Curated
    Sequence conflicti522 – 5221G → S in CAD98108. (PubMed:17974005)Curated
    Sequence conflicti572 – 5721E → G in CAD98108. (PubMed:17974005)Curated
    Sequence conflicti705 – 7051R → G in CAD98108. (PubMed:17974005)Curated
    Sequence conflicti1138 – 11381S → P in CAD98108. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti355 – 3551Q → H.1 Publication
    Corresponds to variant rs55862725 [ dbSNP | Ensembl ].
    VAR_040951
    Natural varianti358 – 3581V → M.1 Publication
    Corresponds to variant rs209373 [ dbSNP | Ensembl ].
    VAR_033908
    Natural varianti424 – 4241S → C in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication
    VAR_040952
    Natural varianti426 – 4261P → A.1 Publication
    Corresponds to variant rs55635933 [ dbSNP | Ensembl ].
    VAR_040953
    Natural varianti579 – 5791E → G.1 Publication
    Corresponds to variant rs56350428 [ dbSNP | Ensembl ].
    VAR_040954
    Natural varianti679 – 6791E → G.1 Publication
    Corresponds to variant rs35115195 [ dbSNP | Ensembl ].
    VAR_040955
    Natural varianti727 – 7271R → H.
    Corresponds to variant rs33936206 [ dbSNP | Ensembl ].
    VAR_051653
    Natural varianti880 – 8801I → L in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040956
    Natural varianti971 – 9711D → G.1 Publication
    Corresponds to variant rs35334892 [ dbSNP | Ensembl ].
    VAR_040957
    Natural varianti993 – 9931A → E.
    Corresponds to variant rs16984889 [ dbSNP | Ensembl ].
    VAR_033909
    Natural varianti1106 – 11061P → S.1 Publication
    Corresponds to variant rs35393519 [ dbSNP | Ensembl ].
    VAR_040958
    Natural varianti1121 – 11211A → P.1 Publication
    Corresponds to variant rs35720774 [ dbSNP | Ensembl ].
    VAR_040959
    Natural varianti1276 – 12761H → L.1 Publication
    Corresponds to variant rs35942881 [ dbSNP | Ensembl ].
    VAR_040960
    Natural varianti1471 – 14711G → A.1 Publication
    Corresponds to variant rs34232354 [ dbSNP | Ensembl ].
    VAR_040961
    Natural varianti1472 – 14721M → L.1 Publication
    Corresponds to variant rs35609510 [ dbSNP | Ensembl ].
    VAR_040962

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 332332Missing in isoform 2. 1 PublicationVSP_020654Add
    BLAST
    Alternative sequencei164 – 18825GLAHL…LLTHN → PKVIFLGTGCSDSSLKKELC LKHQN in isoform 3. 1 PublicationVSP_020655Add
    BLAST
    Alternative sequencei189 – 15821394Missing in isoform 3. 1 PublicationVSP_020656Add
    BLAST
    Alternative sequencei333 – 3386IIKKRQ → MFFSFV in isoform 2. 1 PublicationVSP_020657

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX538345 mRNA. Translation: CAD98108.1.
    Z68339 Genomic DNA. No translation available.
    Z69734 Genomic DNA. No translation available.
    Z70274 Genomic DNA. No translation available.
    Z83850 Genomic DNA. No translation available.
    BC108702 mRNA. Translation: AAI08703.1.
    AK131549 mRNA. Translation: BAD18683.1.
    CCDSiCCDS65305.1. [Q7Z2Y5-1]
    RefSeqiNP_940867.2. NM_198465.3. [Q7Z2Y5-1]
    XP_006724694.1. XM_006724631.1. [Q7Z2Y5-1]
    UniGeneiHs.209527.

    Genome annotation databases

    EnsembliENST00000243300; ENSP00000434830; ENSG00000123572. [Q7Z2Y5-1]
    ENST00000536164; ENSP00000438785; ENSG00000123572. [Q7Z2Y5-3]
    GeneIDi203447.
    KEGGihsa:203447.
    UCSCiuc004emd.3. human. [Q7Z2Y5-1]
    uc010npc.1. human. [Q7Z2Y5-2]

    Polymorphism databases

    DMDMi115502506.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX538345 mRNA. Translation: CAD98108.1 .
    Z68339 Genomic DNA. No translation available.
    Z69734 Genomic DNA. No translation available.
    Z70274 Genomic DNA. No translation available.
    Z83850 Genomic DNA. No translation available.
    BC108702 mRNA. Translation: AAI08703.1 .
    AK131549 mRNA. Translation: BAD18683.1 .
    CCDSi CCDS65305.1. [Q7Z2Y5-1 ]
    RefSeqi NP_940867.2. NM_198465.3. [Q7Z2Y5-1 ]
    XP_006724694.1. XM_006724631.1. [Q7Z2Y5-1 ]
    UniGenei Hs.209527.

    3D structure databases

    ProteinModelPortali Q7Z2Y5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-2807912.
    STRINGi 9606.ENSP00000414221.

    PTM databases

    PhosphoSitei Q7Z2Y5.

    Polymorphism databases

    DMDMi 115502506.

    Proteomic databases

    PaxDbi Q7Z2Y5.
    PRIDEi Q7Z2Y5.

    Protocols and materials databases

    DNASUi 203447.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000243300 ; ENSP00000434830 ; ENSG00000123572 . [Q7Z2Y5-1 ]
    ENST00000536164 ; ENSP00000438785 ; ENSG00000123572 . [Q7Z2Y5-3 ]
    GeneIDi 203447.
    KEGGi hsa:203447.
    UCSCi uc004emd.3. human. [Q7Z2Y5-1 ]
    uc010npc.1. human. [Q7Z2Y5-2 ]

    Organism-specific databases

    CTDi 203447.
    GeneCardsi GC0XP105067.
    H-InvDB HIX0028465.
    HGNCi HGNC:25391. NRK.
    HPAi HPA017238.
    MIMi 300791. gene.
    neXtProti NX_Q7Z2Y5.
    PharmGKBi PA134869113.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG080612.
    InParanoidi Q7Z2Y5.
    KOi K16313.
    OMAi RRRLPWC.
    OrthoDBi EOG7Z3F3P.
    PhylomeDBi Q7Z2Y5.

    Enzyme and pathway databases

    SignaLinki Q7Z2Y5.

    Miscellaneous databases

    GeneWikii NRK_(gene).
    GenomeRNAii 203447.
    NextBioi 90432.
    PROi Q7Z2Y5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z2Y5.
    Bgeei Q7Z2Y5.
    CleanExi HS_NRK.
    Genevestigatori Q7Z2Y5.

    Family and domain databases

    InterProi IPR001180. Citron.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00780. CNH. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50219. CNH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Fetal kidney.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Ovary.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1291 (ISOFORM 2).
      Tissue: Placenta.
    5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-852; SER-855; SER-1027; SER-1031 AND SER-1034, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-355; MET-358; CYS-424; ALA-426; GLY-579; GLY-679; LEU-880; GLY-971; SER-1106; PRO-1121; LEU-1276; ALA-1471 AND LEU-1472.

    Entry informationi

    Entry nameiNRK_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z2Y5
    Secondary accession number(s): Q32ND6, Q5H9K2, Q6ZMP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3