Q7Z2Y5 (NRK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nik-related protein kinase
EC=2.7.11.1

Gene names

Name:

NRK

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1582 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CNH domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW small GTPase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z2Y5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z2Y5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     333-338: IIKKRQ → MFFSFV

Note: No experimental confirmation available.

Isoform 3 (identifier: Q7Z2Y5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     164-188: GLAHLHAHRVIHRDIKGQNVLLTHN → PKVIFLGTGCSDSSLKKELCLKHQN
     189-1582: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1582	1582	Nik-related protein kinase		PRO_0000250511
Regions
	Domain	25 – 313	289	Protein kinase
	Domain	1209 – 1552	344	CNH
	Nucleotide binding	31 – 39	9	ATP By similarity
	Coiled coil	725 – 759	35	Potential
	Compositional bias	402 – 570	169	Gln-rich
	Compositional bias	917 – 979	63	Asp-rich
Sites
	Active site	177	1	Proton acceptor By similarity
	Binding site	54	1	ATP By similarity
Amino acid modifications
	Modified residue	852	1	Phosphoserine Ref.5
	Modified residue	855	1	Phosphoserine Ref.5
	Modified residue	1027	1	Phosphoserine Ref.5
	Modified residue	1031	1	Phosphoserine Ref.5
	Modified residue	1034	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	1 – 332	332	Missing in isoform 2.		VSP_020654
	Alternative sequence	164 – 188	25	GLAHL…LLTHN → PKVIFLGTGCSDSSLKKELC LKHQN in isoform 3.		VSP_020655
	Alternative sequence	189 – 1582	1394	Missing in isoform 3.		VSP_020656
	Alternative sequence	333 – 338	6	IIKKRQ → MFFSFV in isoform 2.		VSP_020657
	Natural variant	355	1	Q → H. Ref.6 Corresponds to variant rs55862725 [ dbSNP | Ensembl ].		VAR_040951
	Natural variant	358	1	V → M. Ref.6 Corresponds to variant rs209373 [ dbSNP | Ensembl ].		VAR_033908
	Natural variant	424	1	S → C in a breast infiltrating ductal carcinoma sample; somatic mutation. Ref.6		VAR_040952
	Natural variant	426	1	P → A. Ref.6 Corresponds to variant rs55635933 [ dbSNP | Ensembl ].		VAR_040953
	Natural variant	579	1	E → G. Ref.6 Corresponds to variant rs56350428 [ dbSNP | Ensembl ].		VAR_040954
	Natural variant	679	1	E → G. Ref.6 Corresponds to variant rs35115195 [ dbSNP | Ensembl ].		VAR_040955
	Natural variant	727	1	R → H. Corresponds to variant rs33936206 [ dbSNP | Ensembl ].		VAR_051653
	Natural variant	880	1	I → L in a colorectal adenocarcinoma sample; somatic mutation. Ref.6		VAR_040956
	Natural variant	971	1	D → G. Ref.6 Corresponds to variant rs35334892 [ dbSNP | Ensembl ].		VAR_040957
	Natural variant	993	1	A → E. Corresponds to variant rs16984889 [ dbSNP | Ensembl ].		VAR_033909
	Natural variant	1106	1	P → S. Ref.6 Corresponds to variant rs35393519 [ dbSNP | Ensembl ].		VAR_040958
	Natural variant	1121	1	A → P. Ref.6 Corresponds to variant rs35720774 [ dbSNP | Ensembl ].		VAR_040959
	Natural variant	1276	1	H → L. Ref.6 Corresponds to variant rs35942881 [ dbSNP | Ensembl ].		VAR_040960
	Natural variant	1471	1	G → A. Ref.6 Corresponds to variant rs34232354 [ dbSNP | Ensembl ].		VAR_040961
	Natural variant	1472	1	M → L. Ref.6 Corresponds to variant rs35609510 [ dbSNP | Ensembl ].		VAR_040962
Experimental info
	Sequence conflict	152	1	D → G in CAD98108. Ref.1
	Sequence conflict	522	1	G → S in CAD98108. Ref.1
	Sequence conflict	572	1	E → G in CAD98108. Ref.1
	Sequence conflict	705	1	R → G in CAD98108. Ref.1
	Sequence conflict	1138	1	S → P in CAD98108. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: C9C56860C8AEBFF3	FASTA	1,582	178,479
	10 20 30 40 50 60 MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF TAVKVMNARK 70 80 90 100 110 120 TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY SFHKNIVSFY GAFFKLSPPG 130 140 150 160 170 180 QRHQLWMVME LCAAGSVTDV VRMTSNQSLK EDWIAYICRE ILQGLAHLHA HRVIHRDIKG 190 200 210 220 230 240 QNVLLTHNAE VKLVDFGVSA QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV 250 260 270 280 290 300 WSVGITAIEM AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF 310 320 330 340 350 360 RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK GIPLIFEREE AIKEQYTVRR 370 380 390 400 410 420 FRGPSCTHEL LRLPTSSRCR PLRVLHGEPS QPRWLPDREE PQVQALQQLQ GAARVFMPLQ 430 440 450 460 470 480 ALDSAPKPLK GQAQAPQRLQ GAARVFMPLQ AQVKAKASKP LQMQIKAPPR LRRAARVLMP 490 500 510 520 530 540 LQAQVRAPRL LQVQSQVSKK QQAQTQTSEP QDLDQVPEEF QGQDQVPEQQ RQGQAPEQQQ 550 560 570 580 590 600 RHNQVPEQEL EQNQAPEQPE VQEQAAEPAQ AETEAEEPES LRVNAQVFLP LLSQDHHVLL 610 620 630 640 650 660 PLHLDTQVLI PVEGQTEGSP QAQAWTLEPP QAIGSVQALI EGLSRDLLRA PNSNNSKPLG 670 680 690 700 710 720 PLQTLMENLS SNRFYSQPEQ AREKKSKVST LRQALAKRLS PKRFRAKSSW RPEKLELSDL 730 740 750 760 770 780 EARRQRRQRR WEDIFNQHEE ELRQVDKDKE DESSDNDEVF HSIQAEVQIE PLKPYISNPK 790 800 810 820 830 840 KIEVQERSPS VPNNQDHAHH VKFSSSVPQR SLLEQAQKPI DIRQRSSQNR QNWLAASESS 850 860 870 880 890 900 SEEESPVTGR RSQSSPPYST IDQKLLVDIH VPDGFKVGKI SPPVYLTNEW VGYNALSEIF 910 920 930 940 950 960 RNDWLTPAPV IQPPEEDGDY VELYDASADT DGDDDDESND TFEDTYDHAN GNDDLDNQVD 970 980 990 1000 1010 1020 QANDVCKDHD DDNNKFVDDV NNNYYEAPSC PRASYGRDGS CKQDGYDGSR GKEEAYRGYG 1030 1040 1050 1060 1070 1080 SHTANRSHGG SAASEDNAAI GDQEEHAANI GSERRGSEGD GGKGVVRTSE ESGALGLNGE 1090 1100 1110 1120 1130 1140 ENCSETDGPG LKRPASQDFE YLQEEPGGGN EASNAIDSGA APSAPDHESD NKDISESSTQ 1150 1160 1170 1180 1190 1200 SDFSANHSSP SKGSGMSADA NFASAILYAG FVEVPEESPK QPSEVNVNPL YVSPACKKPL 1210 1220 1230 1240 1250 1260 IHMYEKEFTS EICCGSLWGV NLLLGTRSNL YLMDRSGKAD ITKLIRRRPF RQIQVLEPLN 1270 1280 1290 1300 1310 1320 LLITISGHKN RLRVYHLTWL RNKILNNDPE SKRRQEEMLK TEEACKAIDK LTGCEHFSVL 1330 1340 1350 1360 1370 1380 QHEETTYIAI ALKSSIHLYA WAPKSFDEST AIKVCIDQSA DSEGDYMSYQ AYIRILAKIQ 1390 1400 1410 1420 1430 1440 AADPVNRFKR PDELLHLLKL KVFPTLDHKP VTVDLAIGSE KRLKIFFSSA DGYHLIDAES 1450 1460 1470 1480 1490 1500 EVMSDVTLPK NPLEIIIPQN IIILPDCLGI GMMLTFNAEA LSVEANEQLF KKILEMWKDI 1510 1520 1530 1540 1550 1560 PSSIAFECTQ RTTGWGQKAI EVRSLQSRVL ESELKRRSIK KLRFLCTRGD KLFFTSTLRN 1570 1580 HHSRVYFMTL GKLEELQSNY DV
	Isoform 2 [UniParc]. Checksum: 5ACDF85130EFEC4D	FASTA	1,250	140,606
	10 20 30 40 50 60 MFFSFVKKGI PLIFEREEAI KEQYTVRRFR GPSCTHELLR LPTSSRCRPL RVLHGEPSQP 70 80 90 100 110 120 RWLPDREEPQ VQALQQLQGA ARVFMPLQAL DSAPKPLKGQ AQAPQRLQGA ARVFMPLQAQ 130 140 150 160 170 180 VKAKASKPLQ MQIKAPPRLR RAARVLMPLQ AQVRAPRLLQ VQSQVSKKQQ AQTQTSEPQD 190 200 210 220 230 240 LDQVPEEFQG QDQVPEQQRQ GQAPEQQQRH NQVPEQELEQ NQAPEQPEVQ EQAAEPAQAE 250 260 270 280 290 300 TEAEEPESLR VNAQVFLPLL SQDHHVLLPL HLDTQVLIPV EGQTEGSPQA QAWTLEPPQA 310 320 330 340 350 360 IGSVQALIEG LSRDLLRAPN SNNSKPLGPL QTLMENLSSN RFYSQPEQAR EKKSKVSTLR 370 380 390 400 410 420 QALAKRLSPK RFRAKSSWRP EKLELSDLEA RRQRRQRRWE DIFNQHEEEL RQVDKDKEDE 430 440 450 460 470 480 SSDNDEVFHS IQAEVQIEPL KPYISNPKKI EVQERSPSVP NNQDHAHHVK FSSSVPQRSL 490 500 510 520 530 540 LEQAQKPIDI RQRSSQNRQN WLAASESSSE EESPVTGRRS QSSPPYSTID QKLLVDIHVP 550 560 570 580 590 600 DGFKVGKISP PVYLTNEWVG YNALSEIFRN DWLTPAPVIQ PPEEDGDYVE LYDASADTDG 610 620 630 640 650 660 DDDDESNDTF EDTYDHANGN DDLDNQVDQA NDVCKDHDDD NNKFVDDVNN NYYEAPSCPR 670 680 690 700 710 720 ASYGRDGSCK QDGYDGSRGK EEAYRGYGSH TANRSHGGSA ASEDNAAIGD QEEHAANIGS 730 740 750 760 770 780 ERRGSEGDGG KGVVRTSEES GALGLNGEEN CSETDGPGLK RPASQDFEYL QEEPGGGNEA 790 800 810 820 830 840 SNAIDSGAAP SAPDHESDNK DISESSTQSD FSANHSSPSK GSGMSADANF ASAILYAGFV 850 860 870 880 890 900 EVPEESPKQP SEVNVNPLYV SPACKKPLIH MYEKEFTSEI CCGSLWGVNL LLGTRSNLYL 910 920 930 940 950 960 MDRSGKADIT KLIRRRPFRQ IQVLEPLNLL ITISGHKNRL RVYHLTWLRN KILNNDPESK 970 980 990 1000 1010 1020 RRQEEMLKTE EACKAIDKLT GCEHFSVLQH EETTYIAIAL KSSIHLYAWA PKSFDESTAI 1030 1040 1050 1060 1070 1080 KVCIDQSADS EGDYMSYQAY IRILAKIQAA DPVNRFKRPD ELLHLLKLKV FPTLDHKPVT 1090 1100 1110 1120 1130 1140 VDLAIGSEKR LKIFFSSADG YHLIDAESEV MSDVTLPKNP LEIIIPQNII ILPDCLGIGM 1150 1160 1170 1180 1190 1200 MLTFNAEALS VEANEQLFKK ILEMWKDIPS SIAFECTQRT TGWGQKAIEV RSLQSRVLES 1210 1220 1230 1240 1250 ELKRRSIKKL RFLCTRGDKL FFTSTLRNHH SRVYFMTLGK LEELQSNYDV
	Isoform 3 [UniParc]. Checksum: 702BC65F8A2DE6ED	FASTA	188	21,368
	10 20 30 40 50 60 MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF TAVKVMNARK 70 80 90 100 110 120 TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY SFHKNIVSFY GAFFKLSPPG 130 140 150 160 170 180 QRHQLWMVME LCAAGSVTDV VRMTSNQSLK EDWIAYICRE ILQPKVIFLG TGCSDSSLKK ELCLKHQN

References

[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Fetal kidney.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Ovary.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1291 (ISOFORM 2). Tissue: Placenta.
[5]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-852; SER-855; SER-1027; SER-1031 AND SER-1034, MASS SPECTROMETRY.
[6]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-355; MET-358; CYS-424; ALA-426; GLY-579; GLY-679; LEU-880; GLY-971; SER-1106; PRO-1121; LEU-1276; ALA-1471 AND LEU-1472.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX538345 mRNA. Translation: CAD98108.1. Z68339 Genomic DNA. No translation available. Z69734 Genomic DNA. No translation available. Z70274 Genomic DNA. No translation available. Z83850 Genomic DNA. No translation available. BC108702 mRNA. Translation: AAI08703.1. AK131549 mRNA. Translation: BAD18683.1.
IPI	IPI00375682. IPI00787350. IPI00871409.
RefSeq	NP_940867.2. NM_198465.2.
UniGene	Hs.209527.
3D structure databases
HSSP	HSSP built from PDB template 1F3M based on UniProtKB Q13153.
ProteinModelPortal	Q7Z2Y5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000414221.
PTM databases
PhosphoSite	Q7Z2Y5.
Polymorphism databases
DMDM	115502506.
Proteomic databases
PaxDb	Q7Z2Y5.
PRIDE	Q7Z2Y5.
Protocols and materials databases
DNASU	203447.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000243300; ENSP00000434830; ENSG00000123572. ENST00000536164; ENSP00000438785; ENSG00000123572.
GeneID	203447.
KEGG	hsa:203447.
UCSC	uc004emd.3. human. uc010npc.1. human.
Organism-specific databases
CTD	203447.
GeneCards	GC0XP105067.
H-InvDB	HIX0028465.
HGNC	HGNC:25391. NRK.
HPA	HPA017238.
MIM	300791. gene.
neXtProt	NX_Q7Z2Y5.
PharmGKB	PA134869113.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG080612.
InParanoid	Q7Z2Y5.
KO	K16313.
Enzyme and pathway databases
Pathway_Interaction_DB	tnfpathway. TNF receptor signaling pathway.
Gene expression databases
ArrayExpress	Q7Z2Y5.
Bgee	Q7Z2Y5.
CleanEx	HS_NRK.
Genevestigator	Q7Z2Y5.
GermOnline	ENSG00000123572. Homo sapiens.
Family and domain databases
InterPro	IPR001180. Citron. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00780. CNH. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50219. CNH. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	203447.
NextBio	90432.
SOURCE	Search...

Entry information

Entry name

NRK_HUMAN

Accession

Primary (citable) accession number: Q7Z2Y5
Secondary accession number(s): Q32ND6, Q5H9K2, Q6ZMP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.