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Q7Z2Y5 (NRK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nik-related protein kinase

EC=2.7.11.1
Gene names
Name:NRK
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1582 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Contains 1 CNH domain.

Contains 1 protein kinase domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z2Y5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z2Y5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     333-338: IIKKRQ → MFFSFV
Note: No experimental confirmation available.
Isoform 3 (identifier: Q7Z2Y5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     164-188: GLAHLHAHRVIHRDIKGQNVLLTHN → PKVIFLGTGCSDSSLKKELCLKHQN
     189-1582: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15821582Nik-related protein kinase
PRO_0000250511

Regions

Domain25 – 313289Protein kinase
Domain1209 – 1552344CNH
Nucleotide binding31 – 399ATP By similarity
Coiled coil725 – 75935 Potential
Compositional bias402 – 570169Gln-rich
Compositional bias917 – 97963Asp-rich

Sites

Active site1771Proton acceptor By similarity
Binding site541ATP By similarity

Amino acid modifications

Modified residue8521Phosphoserine Ref.5
Modified residue8551Phosphoserine Ref.5
Modified residue10271Phosphoserine Ref.5
Modified residue10311Phosphoserine Ref.5
Modified residue10341Phosphoserine Ref.5

Natural variations

Alternative sequence1 – 332332Missing in isoform 2.
VSP_020654
Alternative sequence164 – 18825GLAHL…LLTHN → PKVIFLGTGCSDSSLKKELC LKHQN in isoform 3.
VSP_020655
Alternative sequence189 – 15821394Missing in isoform 3.
VSP_020656
Alternative sequence333 – 3386IIKKRQ → MFFSFV in isoform 2.
VSP_020657
Natural variant3551Q → H. Ref.6
Corresponds to variant rs55862725 [ dbSNP | Ensembl ].
VAR_040951
Natural variant3581V → M. Ref.6
Corresponds to variant rs209373 [ dbSNP | Ensembl ].
VAR_033908
Natural variant4241S → C in a breast infiltrating ductal carcinoma sample; somatic mutation. Ref.6
VAR_040952
Natural variant4261P → A. Ref.6
Corresponds to variant rs55635933 [ dbSNP | Ensembl ].
VAR_040953
Natural variant5791E → G. Ref.6
Corresponds to variant rs56350428 [ dbSNP | Ensembl ].
VAR_040954
Natural variant6791E → G. Ref.6
Corresponds to variant rs35115195 [ dbSNP | Ensembl ].
VAR_040955
Natural variant7271R → H.
Corresponds to variant rs33936206 [ dbSNP | Ensembl ].
VAR_051653
Natural variant8801I → L in a colorectal adenocarcinoma sample; somatic mutation. Ref.6
VAR_040956
Natural variant9711D → G. Ref.6
Corresponds to variant rs35334892 [ dbSNP | Ensembl ].
VAR_040957
Natural variant9931A → E.
Corresponds to variant rs16984889 [ dbSNP | Ensembl ].
VAR_033909
Natural variant11061P → S. Ref.6
Corresponds to variant rs35393519 [ dbSNP | Ensembl ].
VAR_040958
Natural variant11211A → P. Ref.6
Corresponds to variant rs35720774 [ dbSNP | Ensembl ].
VAR_040959
Natural variant12761H → L. Ref.6
Corresponds to variant rs35942881 [ dbSNP | Ensembl ].
VAR_040960
Natural variant14711G → A. Ref.6
Corresponds to variant rs34232354 [ dbSNP | Ensembl ].
VAR_040961
Natural variant14721M → L. Ref.6
Corresponds to variant rs35609510 [ dbSNP | Ensembl ].
VAR_040962

Experimental info

Sequence conflict1521D → G in CAD98108. Ref.1
Sequence conflict5221G → S in CAD98108. Ref.1
Sequence conflict5721E → G in CAD98108. Ref.1
Sequence conflict7051R → G in CAD98108. Ref.1
Sequence conflict11381S → P in CAD98108. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: C9C56860C8AEBFF3

FASTA1,582178,479
        10         20         30         40         50         60 
MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGAF TAVKVMNARK 

        70         80         90        100        110        120 
TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY SFHKNIVSFY GAFFKLSPPG 

       130        140        150        160        170        180 
QRHQLWMVME LCAAGSVTDV VRMTSNQSLK EDWIAYICRE ILQGLAHLHA HRVIHRDIKG 

       190        200        210        220        230        240 
QNVLLTHNAE VKLVDFGVSA QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV 

       250        260        270        280        290        300 
WSVGITAIEM AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF 

       310        320        330        340        350        360 
RPTSANMLQH PFVRDIKNER HVVESLTRHL TGIIKKRQKK GIPLIFEREE AIKEQYTVRR 

       370        380        390        400        410        420 
FRGPSCTHEL LRLPTSSRCR PLRVLHGEPS QPRWLPDREE PQVQALQQLQ GAARVFMPLQ 

       430        440        450        460        470        480 
ALDSAPKPLK GQAQAPQRLQ GAARVFMPLQ AQVKAKASKP LQMQIKAPPR LRRAARVLMP 

       490        500        510        520        530        540 
LQAQVRAPRL LQVQSQVSKK QQAQTQTSEP QDLDQVPEEF QGQDQVPEQQ RQGQAPEQQQ 

       550        560        570        580        590        600 
RHNQVPEQEL EQNQAPEQPE VQEQAAEPAQ AETEAEEPES LRVNAQVFLP LLSQDHHVLL 

       610        620        630        640        650        660 
PLHLDTQVLI PVEGQTEGSP QAQAWTLEPP QAIGSVQALI EGLSRDLLRA PNSNNSKPLG 

       670        680        690        700        710        720 
PLQTLMENLS SNRFYSQPEQ AREKKSKVST LRQALAKRLS PKRFRAKSSW RPEKLELSDL 

       730        740        750        760        770        780 
EARRQRRQRR WEDIFNQHEE ELRQVDKDKE DESSDNDEVF HSIQAEVQIE PLKPYISNPK 

       790        800        810        820        830        840 
KIEVQERSPS VPNNQDHAHH VKFSSSVPQR SLLEQAQKPI DIRQRSSQNR QNWLAASESS 

       850        860        870        880        890        900 
SEEESPVTGR RSQSSPPYST IDQKLLVDIH VPDGFKVGKI SPPVYLTNEW VGYNALSEIF 

       910        920        930        940        950        960 
RNDWLTPAPV IQPPEEDGDY VELYDASADT DGDDDDESND TFEDTYDHAN GNDDLDNQVD 

       970        980        990       1000       1010       1020 
QANDVCKDHD DDNNKFVDDV NNNYYEAPSC PRASYGRDGS CKQDGYDGSR GKEEAYRGYG 

      1030       1040       1050       1060       1070       1080 
SHTANRSHGG SAASEDNAAI GDQEEHAANI GSERRGSEGD GGKGVVRTSE ESGALGLNGE 

      1090       1100       1110       1120       1130       1140 
ENCSETDGPG LKRPASQDFE YLQEEPGGGN EASNAIDSGA APSAPDHESD NKDISESSTQ 

      1150       1160       1170       1180       1190       1200 
SDFSANHSSP SKGSGMSADA NFASAILYAG FVEVPEESPK QPSEVNVNPL YVSPACKKPL 

      1210       1220       1230       1240       1250       1260 
IHMYEKEFTS EICCGSLWGV NLLLGTRSNL YLMDRSGKAD ITKLIRRRPF RQIQVLEPLN 

      1270       1280       1290       1300       1310       1320 
LLITISGHKN RLRVYHLTWL RNKILNNDPE SKRRQEEMLK TEEACKAIDK LTGCEHFSVL 

      1330       1340       1350       1360       1370       1380 
QHEETTYIAI ALKSSIHLYA WAPKSFDEST AIKVCIDQSA DSEGDYMSYQ AYIRILAKIQ 

      1390       1400       1410       1420       1430       1440 
AADPVNRFKR PDELLHLLKL KVFPTLDHKP VTVDLAIGSE KRLKIFFSSA DGYHLIDAES 

      1450       1460       1470       1480       1490       1500 
EVMSDVTLPK NPLEIIIPQN IIILPDCLGI GMMLTFNAEA LSVEANEQLF KKILEMWKDI 

      1510       1520       1530       1540       1550       1560 
PSSIAFECTQ RTTGWGQKAI EVRSLQSRVL ESELKRRSIK KLRFLCTRGD KLFFTSTLRN 

      1570       1580 
HHSRVYFMTL GKLEELQSNY DV 

« Hide

Isoform 2 [UniParc].

Checksum: 5ACDF85130EFEC4D
Show »

FASTA1,250140,606
Isoform 3 [UniParc].

Checksum: 702BC65F8A2DE6ED
Show »

FASTA18821,368

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Fetal kidney.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Ovary.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1291 (ISOFORM 2).
Tissue: Placenta.
[5]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-852; SER-855; SER-1027; SER-1031 AND SER-1034, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-355; MET-358; CYS-424; ALA-426; GLY-579; GLY-679; LEU-880; GLY-971; SER-1106; PRO-1121; LEU-1276; ALA-1471 AND LEU-1472.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX538345 mRNA. Translation: CAD98108.1.
Z68339 Genomic DNA. No translation available.
Z69734 Genomic DNA. No translation available.
Z70274 Genomic DNA. No translation available.
Z83850 Genomic DNA. No translation available.
BC108702 mRNA. Translation: AAI08703.1.
AK131549 mRNA. Translation: BAD18683.1.
CCDSCCDS65305.1. [Q7Z2Y5-1]
RefSeqNP_940867.2. NM_198465.3. [Q7Z2Y5-1]
XP_006724694.1. XM_006724631.1. [Q7Z2Y5-1]
UniGeneHs.209527.

3D structure databases

ProteinModelPortalQ7Z2Y5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-2807912.
STRING9606.ENSP00000414221.

PTM databases

PhosphoSiteQ7Z2Y5.

Polymorphism databases

DMDM115502506.

Proteomic databases

PaxDbQ7Z2Y5.
PRIDEQ7Z2Y5.

Protocols and materials databases

DNASU203447.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000243300; ENSP00000434830; ENSG00000123572. [Q7Z2Y5-1]
ENST00000536164; ENSP00000438785; ENSG00000123572. [Q7Z2Y5-3]
GeneID203447.
KEGGhsa:203447.
UCSCuc004emd.3. human. [Q7Z2Y5-1]
uc010npc.1. human. [Q7Z2Y5-2]

Organism-specific databases

CTD203447.
GeneCardsGC0XP105067.
H-InvDBHIX0028465.
HGNCHGNC:25391. NRK.
HPAHPA017238.
MIM300791. gene.
neXtProtNX_Q7Z2Y5.
PharmGKBPA134869113.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOVERGENHBG080612.
InParanoidQ7Z2Y5.
KOK16313.
OMARRRLPWC.
OrthoDBEOG7Z3F3P.
PhylomeDBQ7Z2Y5.

Enzyme and pathway databases

SignaLinkQ7Z2Y5.

Gene expression databases

ArrayExpressQ7Z2Y5.
BgeeQ7Z2Y5.
CleanExHS_NRK.
GenevestigatorQ7Z2Y5.

Family and domain databases

InterProIPR001180. Citron.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNRK_(gene).
GenomeRNAi203447.
NextBio90432.
PROQ7Z2Y5.
SOURCESearch...

Entry information

Entry nameNRK_HUMAN
AccessionPrimary (citable) accession number: Q7Z2Y5
Secondary accession number(s): Q32ND6, Q5H9K2, Q6ZMP2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM