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Protein

39S ribosomal protein L21, mitochondrial

Gene

MRPL21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L21, mitochondrial
Short name:
L21mt
Short name:
MRP-L21
Gene namesi
Name:MRPL21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14479. MRPL21.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30951.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
BLAST
Chaini40 – 20516639S ribosomal protein L21, mitochondrialPRO_0000252442Add
BLAST

Proteomic databases

MaxQBiQ7Z2W9.
PaxDbiQ7Z2W9.
PRIDEiQ7Z2W9.

PTM databases

PhosphoSiteiQ7Z2W9.

Expressioni

Gene expression databases

BgeeiQ7Z2W9.
CleanExiHS_MRPL21.
ExpressionAtlasiQ7Z2W9. baseline and differential.
GenevestigatoriQ7Z2W9.

Organism-specific databases

HPAiHPA051657.

Interactioni

Protein-protein interaction databases

BioGridi128594. 21 interactions.
IntActiQ7Z2W9. 2 interactions.
MINTiMINT-8051978.
STRINGi9606.ENSP00000354580.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40S1-205[»]
ProteinModelPortaliQ7Z2W9.
SMRiQ7Z2W9. Positions 95-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L21P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG314874.
GeneTreeiENSGT00390000005535.
HOGENOMiHOG000022586.
HOVERGENiHBG083573.
InParanoidiQ7Z2W9.
KOiK02888.
OMAiVHFASKQ.
OrthoDBiEOG7P5T2B.
PhylomeDBiQ7Z2W9.
TreeFamiTF324867.

Family and domain databases

InterProiIPR028909. L21p-like.
IPR001787. Ribosomal_L21.
[Graphical view]
PfamiPF00829. Ribosomal_L21p. 1 hit.
[Graphical view]
SUPFAMiSSF141091. SSF141091. 1 hit.
TIGRFAMsiTIGR00061. L21. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z2W9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY
60 70 80 90 100
VPKTSLSSPP WPEVVLPDPV EETRHHAEVV KKVNEMIVTG QYGRLFAVVH
110 120 130 140 150
FASRQWKVTS EDLILIGNEL DLACGERIRL EKVLLVGADN FTLLGKPLLG
160 170 180 190 200
KDLVRVEATV IEKTESWPRI IMRFRKRKNF KKKRIVTTPQ TVLRINSIEI

APCLL
Length:205
Mass (Da):22,815
Last modified:May 5, 2009 - v2
Checksum:iB4AF172AB0C1E5FB
GO
Isoform 2 (identifier: Q7Z2W9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Note: No experimental confirmation available.

Show »
Length:120
Mass (Da):13,746
Checksum:iF25AEBA02DCFD41C
GO

Sequence cautioni

The sequence AAH55088.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585Missing in isoform 2. 1 PublicationVSP_045633Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000808 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74724.1.
BC055088 mRNA. Translation: AAH55088.1. Different initiation.
BM915440 mRNA. No translation available.
CCDSiCCDS44662.1. [Q7Z2W9-2]
CCDS8186.1. [Q7Z2W9-1]
RefSeqiNP_852615.1. NM_181514.1. [Q7Z2W9-1]
NP_852616.1. NM_181515.1. [Q7Z2W9-2]
UniGeneiHs.503047.

Genome annotation databases

EnsembliENST00000362034; ENSP00000354580; ENSG00000197345. [Q7Z2W9-1]
ENST00000450904; ENSP00000389400; ENSG00000197345. [Q7Z2W9-2]
GeneIDi219927.
KEGGihsa:219927.
UCSCiuc001ooh.3. human. [Q7Z2W9-1]

Polymorphism databases

DMDMi229462820.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000808 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74724.1.
BC055088 mRNA. Translation: AAH55088.1. Different initiation.
BM915440 mRNA. No translation available.
CCDSiCCDS44662.1. [Q7Z2W9-2]
CCDS8186.1. [Q7Z2W9-1]
RefSeqiNP_852615.1. NM_181514.1. [Q7Z2W9-1]
NP_852616.1. NM_181515.1. [Q7Z2W9-2]
UniGeneiHs.503047.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40S1-205[»]
ProteinModelPortaliQ7Z2W9.
SMRiQ7Z2W9. Positions 95-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128594. 21 interactions.
IntActiQ7Z2W9. 2 interactions.
MINTiMINT-8051978.
STRINGi9606.ENSP00000354580.

PTM databases

PhosphoSiteiQ7Z2W9.

Polymorphism databases

DMDMi229462820.

Proteomic databases

MaxQBiQ7Z2W9.
PaxDbiQ7Z2W9.
PRIDEiQ7Z2W9.

Protocols and materials databases

DNASUi219927.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362034; ENSP00000354580; ENSG00000197345. [Q7Z2W9-1]
ENST00000450904; ENSP00000389400; ENSG00000197345. [Q7Z2W9-2]
GeneIDi219927.
KEGGihsa:219927.
UCSCiuc001ooh.3. human. [Q7Z2W9-1]

Organism-specific databases

CTDi219927.
GeneCardsiGC11M068658.
HGNCiHGNC:14479. MRPL21.
HPAiHPA051657.
MIMi611834. gene.
neXtProtiNX_Q7Z2W9.
PharmGKBiPA30951.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG314874.
GeneTreeiENSGT00390000005535.
HOGENOMiHOG000022586.
HOVERGENiHBG083573.
InParanoidiQ7Z2W9.
KOiK02888.
OMAiVHFASKQ.
OrthoDBiEOG7P5T2B.
PhylomeDBiQ7Z2W9.
TreeFamiTF324867.

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

ChiTaRSiMRPL21. human.
GenomeRNAii219927.
NextBioi90846.
PROiQ7Z2W9.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z2W9.
CleanExiHS_MRPL21.
ExpressionAtlasiQ7Z2W9. baseline and differential.
GenevestigatoriQ7Z2W9.

Family and domain databases

InterProiIPR028909. L21p-like.
IPR001787. Ribosomal_L21.
[Graphical view]
PfamiPF00829. Ribosomal_L21p. 1 hit.
[Graphical view]
SUPFAMiSSF141091. SSF141091. 1 hit.
TIGRFAMsiTIGR00061. L21. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Melanoma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM21_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2W9
Secondary accession number(s): A6NKU0, C9JPR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 5, 2009
Last modified: January 7, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.