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Q7Z2W9

- RM21_HUMAN

UniProt

Q7Z2W9 - RM21_HUMAN

Protein

39S ribosomal protein L21, mitochondrial

Gene

MRPL21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L21, mitochondrial
    Short name:
    L21mt
    Short name:
    MRP-L21
    Gene namesi
    Name:MRPL21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14479. MRPL21.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30951.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
    BLAST
    Chaini40 – 20516639S ribosomal protein L21, mitochondrialPRO_0000252442Add
    BLAST

    Proteomic databases

    MaxQBiQ7Z2W9.
    PaxDbiQ7Z2W9.
    PRIDEiQ7Z2W9.

    PTM databases

    PhosphoSiteiQ7Z2W9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z2W9.
    BgeeiQ7Z2W9.
    CleanExiHS_MRPL21.
    GenevestigatoriQ7Z2W9.

    Organism-specific databases

    HPAiHPA051657.

    Interactioni

    Protein-protein interaction databases

    BioGridi128594. 12 interactions.
    IntActiQ7Z2W9. 2 interactions.
    MINTiMINT-8051978.
    STRINGi9606.ENSP00000354580.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z2W9.
    SMRiQ7Z2W9. Positions 95-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L21P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG314874.
    HOGENOMiHOG000022586.
    HOVERGENiHBG083573.
    InParanoidiQ7Z2W9.
    KOiK02888.
    OMAiVHFASKQ.
    OrthoDBiEOG7P5T2B.
    PhylomeDBiQ7Z2W9.
    TreeFamiTF324867.

    Family and domain databases

    InterProiIPR028909. L21p-like.
    IPR001787. Ribosomal_L21.
    [Graphical view]
    PfamiPF00829. Ribosomal_L21p. 1 hit.
    [Graphical view]
    SUPFAMiSSF141091. SSF141091. 1 hit.
    TIGRFAMsiTIGR00061. L21. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z2W9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY    50
    VPKTSLSSPP WPEVVLPDPV EETRHHAEVV KKVNEMIVTG QYGRLFAVVH 100
    FASRQWKVTS EDLILIGNEL DLACGERIRL EKVLLVGADN FTLLGKPLLG 150
    KDLVRVEATV IEKTESWPRI IMRFRKRKNF KKKRIVTTPQ TVLRINSIEI 200
    APCLL 205
    Length:205
    Mass (Da):22,815
    Last modified:May 5, 2009 - v2
    Checksum:iB4AF172AB0C1E5FB
    GO
    Isoform 2 (identifier: Q7Z2W9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-85: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:120
    Mass (Da):13,746
    Checksum:iF25AEBA02DCFD41C
    GO

    Sequence cautioni

    The sequence AAH55088.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8585Missing in isoform 2. 1 PublicationVSP_045633Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000808 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74724.1.
    BC055088 mRNA. Translation: AAH55088.1. Different initiation.
    BM915440 mRNA. No translation available.
    CCDSiCCDS44662.1. [Q7Z2W9-2]
    CCDS8186.1. [Q7Z2W9-1]
    RefSeqiNP_852615.1. NM_181514.1. [Q7Z2W9-1]
    NP_852616.1. NM_181515.1. [Q7Z2W9-2]
    UniGeneiHs.503047.

    Genome annotation databases

    EnsembliENST00000362034; ENSP00000354580; ENSG00000197345. [Q7Z2W9-1]
    ENST00000450904; ENSP00000389400; ENSG00000197345. [Q7Z2W9-2]
    GeneIDi219927.
    KEGGihsa:219927.
    UCSCiuc001ooh.3. human. [Q7Z2W9-1]

    Polymorphism databases

    DMDMi229462820.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000808 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74724.1 .
    BC055088 mRNA. Translation: AAH55088.1 . Different initiation.
    BM915440 mRNA. No translation available.
    CCDSi CCDS44662.1. [Q7Z2W9-2 ]
    CCDS8186.1. [Q7Z2W9-1 ]
    RefSeqi NP_852615.1. NM_181514.1. [Q7Z2W9-1 ]
    NP_852616.1. NM_181515.1. [Q7Z2W9-2 ]
    UniGenei Hs.503047.

    3D structure databases

    ProteinModelPortali Q7Z2W9.
    SMRi Q7Z2W9. Positions 95-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128594. 12 interactions.
    IntActi Q7Z2W9. 2 interactions.
    MINTi MINT-8051978.
    STRINGi 9606.ENSP00000354580.

    PTM databases

    PhosphoSitei Q7Z2W9.

    Polymorphism databases

    DMDMi 229462820.

    Proteomic databases

    MaxQBi Q7Z2W9.
    PaxDbi Q7Z2W9.
    PRIDEi Q7Z2W9.

    Protocols and materials databases

    DNASUi 219927.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000362034 ; ENSP00000354580 ; ENSG00000197345 . [Q7Z2W9-1 ]
    ENST00000450904 ; ENSP00000389400 ; ENSG00000197345 . [Q7Z2W9-2 ]
    GeneIDi 219927.
    KEGGi hsa:219927.
    UCSCi uc001ooh.3. human. [Q7Z2W9-1 ]

    Organism-specific databases

    CTDi 219927.
    GeneCardsi GC11M068658.
    HGNCi HGNC:14479. MRPL21.
    HPAi HPA051657.
    MIMi 611834. gene.
    neXtProti NX_Q7Z2W9.
    PharmGKBi PA30951.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314874.
    HOGENOMi HOG000022586.
    HOVERGENi HBG083573.
    InParanoidi Q7Z2W9.
    KOi K02888.
    OMAi VHFASKQ.
    OrthoDBi EOG7P5T2B.
    PhylomeDBi Q7Z2W9.
    TreeFami TF324867.

    Miscellaneous databases

    ChiTaRSi MRPL21. human.
    GenomeRNAii 219927.
    NextBioi 90846.
    PROi Q7Z2W9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z2W9.
    Bgeei Q7Z2W9.
    CleanExi HS_MRPL21.
    Genevestigatori Q7Z2W9.

    Family and domain databases

    InterProi IPR028909. L21p-like.
    IPR001787. Ribosomal_L21.
    [Graphical view ]
    Pfami PF00829. Ribosomal_L21p. 1 hit.
    [Graphical view ]
    SUPFAMi SSF141091. SSF141091. 1 hit.
    TIGRFAMsi TIGR00061. L21. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Melanoma.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM21_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z2W9
    Secondary accession number(s): A6NKU0, C9JPR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3