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Q7Z2W9 (RM21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L21, mitochondrial

Short name=L21mt
Short name=MRP-L21
Gene names
Name:MRPL21
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the ribosomal protein L21P family.

Sequence caution

The sequence AAH55088.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22681889. Source: UniProtKB

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z2W9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z2W9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion Potential
Chain40 – 20516639S ribosomal protein L21, mitochondrial
PRO_0000252442

Natural variations

Alternative sequence1 – 8585Missing in isoform 2.
VSP_045633

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: B4AF172AB0C1E5FB

FASTA20522,815
        10         20         30         40         50         60 
MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY VPKTSLSSPP 

        70         80         90        100        110        120 
WPEVVLPDPV EETRHHAEVV KKVNEMIVTG QYGRLFAVVH FASRQWKVTS EDLILIGNEL 

       130        140        150        160        170        180 
DLACGERIRL EKVLLVGADN FTLLGKPLLG KDLVRVEATV IEKTESWPRI IMRFRKRKNF 

       190        200 
KKKRIVTTPQ TVLRINSIEI APCLL 

« Hide

Isoform 2 [UniParc].

Checksum: F25AEBA02DCFD41C
Show »

FASTA12013,746

References

[1]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Melanoma.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP000808 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74724.1.
BC055088 mRNA. Translation: AAH55088.1. Different initiation.
BM915440 mRNA. No translation available.
RefSeqNP_852615.1. NM_181514.1.
NP_852616.1. NM_181515.1.
UniGeneHs.503047.

3D structure databases

ProteinModelPortalQ7Z2W9.
SMRQ7Z2W9. Positions 95-199.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128594. 12 interactions.
IntActQ7Z2W9. 2 interactions.
MINTMINT-8051978.
STRING9606.ENSP00000354580.

PTM databases

PhosphoSiteQ7Z2W9.

Polymorphism databases

DMDM229462820.

Proteomic databases

PaxDbQ7Z2W9.
PRIDEQ7Z2W9.

Protocols and materials databases

DNASU219927.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000362034; ENSP00000354580; ENSG00000197345. [Q7Z2W9-1]
ENST00000450904; ENSP00000389400; ENSG00000197345. [Q7Z2W9-2]
GeneID219927.
KEGGhsa:219927.
UCSCuc001ooh.3. human. [Q7Z2W9-1]

Organism-specific databases

CTD219927.
GeneCardsGC11M068658.
HGNCHGNC:14479. MRPL21.
HPAHPA051657.
MIM611834. gene.
neXtProtNX_Q7Z2W9.
PharmGKBPA30951.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314874.
HOGENOMHOG000022586.
HOVERGENHBG083573.
InParanoidQ7Z2W9.
KOK02888.
OMANELDVAC.
OrthoDBEOG7P5T2B.
PhylomeDBQ7Z2W9.
TreeFamTF324867.

Gene expression databases

ArrayExpressQ7Z2W9.
BgeeQ7Z2W9.
CleanExHS_MRPL21.
GenevestigatorQ7Z2W9.

Family and domain databases

InterProIPR028909. L21p-like.
IPR001787. Ribosomal_L21.
[Graphical view]
PfamPF00829. Ribosomal_L21p. 1 hit.
[Graphical view]
SUPFAMSSF141091. SSF141091. 1 hit.
TIGRFAMsTIGR00061. L21. 1 hit.
ProtoNetSearch...

Other

ChiTaRSMRPL21. human.
GenomeRNAi219927.
NextBio90846.
PROQ7Z2W9.
SOURCESearch...

Entry information

Entry nameRM21_HUMAN
AccessionPrimary (citable) accession number: Q7Z2W9
Secondary accession number(s): A6NKU0, C9JPR2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM