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Protein

39S ribosomal protein L21, mitochondrial

Gene

MRPL21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L21, mitochondrial
Short name:
L21mt
Short name:
MRP-L21
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL21m1 Publication
Gene namesi
Name:MRPL21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000197345.12.
HGNCiHGNC:14479. MRPL21.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197345.
PharmGKBiPA30951.

Polymorphism and mutation databases

BioMutaiMRPL21.
DMDMi229462820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionSequence analysisAdd BLAST39
ChainiPRO_000025244240 – 20539S ribosomal protein L21, mitochondrialAdd BLAST166

Proteomic databases

EPDiQ7Z2W9.
MaxQBiQ7Z2W9.
PaxDbiQ7Z2W9.
PeptideAtlasiQ7Z2W9.
PRIDEiQ7Z2W9.

PTM databases

iPTMnetiQ7Z2W9.
PhosphoSitePlusiQ7Z2W9.

Expressioni

Gene expression databases

BgeeiENSG00000197345.
CleanExiHS_MRPL21.
ExpressionAtlasiQ7Z2W9. baseline and differential.
GenevisibleiQ7Z2W9. HS.

Organism-specific databases

HPAiHPA051657.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi128594. 53 interactors.
CORUMiQ7Z2W9.
IntActiQ7Z2W9. 10 interactors.
MINTiMINT-8051978.
STRINGi9606.ENSP00000354580.

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni55 – 57Combined sources3
Helixi69 – 89Combined sources21
Beta strandi96 – 101Combined sources6
Beta strandi104 – 109Combined sources6
Beta strandi113 – 118Combined sources6
Beta strandi127 – 130Combined sources4
Beta strandi133 – 137Combined sources5
Beta strandi139 – 144Combined sources6
Beta strandi146 – 148Combined sources3
Turni151 – 153Combined sources3
Beta strandi154 – 165Combined sources12
Beta strandi169 – 175Combined sources7
Turni176 – 179Combined sources4
Beta strandi180 – 186Combined sources7
Beta strandi189 – 200Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40S1-205[»]
3J9Melectron microscopy3.50S1-205[»]
ProteinModelPortaliQ7Z2W9.
SMRiQ7Z2W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1686. Eukaryota.
ENOG4111TX4. LUCA.
GeneTreeiENSGT00390000005535.
HOGENOMiHOG000022586.
HOVERGENiHBG083573.
InParanoidiQ7Z2W9.
KOiK02888.
OMAiCERINQQ.
OrthoDBiEOG091G0VBY.
PhylomeDBiQ7Z2W9.
TreeFamiTF324867.

Family and domain databases

InterProiView protein in InterPro
IPR028909. L21p-like.
IPR001787. Ribosomal_L21.
PfamiView protein in Pfam
PF00829. Ribosomal_L21p. 1 hit.
SUPFAMiSSF141091. SSF141091. 1 hit.
TIGRFAMsiTIGR00061. L21. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z2W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY
60 70 80 90 100
VPKTSLSSPP WPEVVLPDPV EETRHHAEVV KKVNEMIVTG QYGRLFAVVH
110 120 130 140 150
FASRQWKVTS EDLILIGNEL DLACGERIRL EKVLLVGADN FTLLGKPLLG
160 170 180 190 200
KDLVRVEATV IEKTESWPRI IMRFRKRKNF KKKRIVTTPQ TVLRINSIEI

APCLL
Length:205
Mass (Da):22,815
Last modified:May 5, 2009 - v2
Checksum:iB4AF172AB0C1E5FB
GO
Isoform 2 (identifier: Q7Z2W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Note: No experimental confirmation available.
Show »
Length:120
Mass (Da):13,746
Checksum:iF25AEBA02DCFD41C
GO

Sequence cautioni

The sequence AAH55088 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0456331 – 85Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000808 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74724.1.
BC055088 mRNA. Translation: AAH55088.1. Different initiation.
BM915440 mRNA. No translation available.
CCDSiCCDS44662.1. [Q7Z2W9-2]
CCDS8186.1. [Q7Z2W9-1]
RefSeqiNP_852615.1. NM_181514.1. [Q7Z2W9-1]
NP_852616.1. NM_181515.1. [Q7Z2W9-2]
UniGeneiHs.503047.

Genome annotation databases

EnsembliENST00000362034; ENSP00000354580; ENSG00000197345. [Q7Z2W9-1]
ENST00000450904; ENSP00000389400; ENSG00000197345. [Q7Z2W9-2]
GeneIDi219927.
KEGGihsa:219927.
UCSCiuc001ooh.4. human. [Q7Z2W9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRM21_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2W9
Secondary accession number(s): A6NKU0, C9JPR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 5, 2009
Last modified: September 27, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families