Q7Z2W9 (RM21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L21, mitochondrial
Short name=L21mt
Short name=MRP-L21

Gene names

Name:

MRPL21

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the ribosomal protein L21P family.
Sequence caution	The sequence AAH55088.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z2W9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z2W9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 39	39	Mitochondrion Potential
	Chain	40 – 205	166	39S ribosomal protein L21, mitochondrial		PRO_0000252442
Natural variations
	Alternative sequence	1 – 85	85	Missing in isoform 2.		VSP_045633

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: B4AF172AB0C1E5FB	FASTA	205	22,815
	10 20 30 40 50 60 MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY VPKTSLSSPP 70 80 90 100 110 120 WPEVVLPDPV EETRHHAEVV KKVNEMIVTG QYGRLFAVVH FASRQWKVTS EDLILIGNEL 130 140 150 160 170 180 DLACGERIRL EKVLLVGADN FTLLGKPLLG KDLVRVEATV IEKTESWPRI IMRFRKRKNF 190 200 KKKRIVTTPQ TVLRINSIEI APCLL
	Isoform 2 [UniParc]. Checksum: F25AEBA02DCFD41C	FASTA	120	13,746
	10 20 30 40 50 60 MIVTGQYGRL FAVVHFASRQ WKVTSEDLIL IGNELDLACG ERIRLEKVLL VGADNFTLLG 70 80 90 100 110 120 KPLLGKDLVR VEATVIEKTE SWPRIIMRFR KRKNFKKKRI VTTPQTVLRI NSIEIAPCLL

References

[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Melanoma.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000808 Genomic DNA. No translation available. CH471076 Genomic DNA. Translation: EAW74724.1. BC055088 mRNA. Translation: AAH55088.1. Different initiation. BM915440 mRNA. No translation available.
IPI	IPI00375677. IPI00903193.
RefSeq	NP_852615.1. NM_181514.1. NP_852616.1. NM_181515.1.
UniGene	Hs.503047.
3D structure databases
ProteinModelPortal	Q7Z2W9.
SMR	Q7Z2W9. Positions 95-199.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z2W9. 1 interaction.
STRING	9606.ENSP00000354580.
PTM databases
PhosphoSite	Q7Z2W9.
Polymorphism databases
DMDM	229462820.
Proteomic databases
PaxDb	Q7Z2W9.
PRIDE	Q7Z2W9.
Protocols and materials databases
DNASU	219927.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000362034; ENSP00000354580; ENSG00000197345. ENST00000450904; ENSP00000389400; ENSG00000197345.
GeneID	219927.
KEGG	hsa:219927.
UCSC	uc001ooh.3. human.
Organism-specific databases
CTD	219927.
GeneCards	GC11M068658.
HGNC	HGNC:14479. MRPL21.
HPA	HPA051657.
MIM	611834. gene.
neXtProt	NX_Q7Z2W9.
PharmGKB	PA30951.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG314874.
HOGENOM	HOG000022586.
HOVERGEN	HBG083573.
InParanoid	Q7Z2W9.
KO	K02888.
OMA	TILRINT.
OrthoDB	EOG4FN4K1.
Gene expression databases
ArrayExpress	Q7Z2W9.
Bgee	Q7Z2W9.
CleanEx	HS_MRPL21.
Genevestigator	Q7Z2W9.
GermOnline	ENSG00000197345. Homo sapiens.
Family and domain databases
InterPro	IPR001787. Ribosomal_L21. [Graphical view]
PANTHER	PTHR21349. PTHR21349. 1 hit.
Pfam	PF00829. Ribosomal_L21p. 1 hit. [Graphical view]
TIGRFAMs	TIGR00061. L21. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	MRPL21. human.
GenomeRNAi	219927.
NextBio	90846.
SOURCE	Search...

Entry information

Entry name

RM21_HUMAN

Accession

Primary (citable) accession number: Q7Z2W9
Secondary accession number(s): A6NKU0, C9JPR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.