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Q7Z2W7

- TRPM8_HUMAN

UniProt

Q7Z2W7 - TRPM8_HUMAN

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Protein

Transient receptor potential cation channel subfamily M member 8

Gene

TRPM8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.3 Publications

GO - Molecular functioni

  1. calcium channel activity Source: Ensembl

GO - Biological processi

  1. calcium ion transmembrane transport Source: Reactome
  2. cellular calcium ion homeostasis Source: Ensembl
  3. detection of temperature stimulus Source: InterPro
  4. ion transmembrane transport Source: Reactome
  5. protein homotetramerization Source: Ensembl
  6. protein homotrimerization Source: Ensembl
  7. response to cold Source: Ensembl
  8. thermoception Source: Ensembl
  9. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport

Enzyme and pathway databases

ReactomeiREACT_169333. TRP channels.

Protein family/group databases

TCDBi1.A.4.5.7. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 8
Alternative name(s):
Long transient receptor potential channel 6
Short name:
LTrpC-6
Short name:
LTrpC6
Transient receptor potential p8
Short name:
Trp-p8
Gene namesi
Name:TRPM8
Synonyms:LTRPC6, TRPP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:17961. TRPM8.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane
Note: Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts By similarity. Located in the endoplasmic reticulum in prostate cancer cells.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. external side of plasma membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi821 – 8211N → Q: No effect on glycosylation or ability to form functional channels. 1 Publication
Mutagenesisi934 – 9341N → Q: Abolishes glycosylation. 1 Publication
Mutagenesisi946 – 9461H → N: No effect on glycosylation or channel activity. 1 Publication
Mutagenesisi1089 – 10891L → P: Abolishes multimerization and channel activity. Reduces cell surface expression. 1 Publication

Organism-specific databases

PharmGKBiPA38270.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11041104Transient receptor potential cation channel subfamily M member 8PRO_0000215333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi934 – 9341N-linked (GlcNAc...) (complex)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z2W7.
PRIDEiQ7Z2W7.

PTM databases

PhosphoSiteiQ7Z2W7.

Expressioni

Tissue specificityi

Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors.4 Publications

Gene expression databases

BgeeiQ7Z2W7.
CleanExiHS_TRPM8.
ExpressionAtlasiQ7Z2W7. baseline and differential.
GenevestigatoriQ7Z2W7.

Organism-specific databases

HPAiHPA024117.
HPA029542.

Interactioni

Subunit structurei

Homotetramer By similarity. Isoform 2 and isoform 3 interact with the C-terminus of isoform 1 in a thermosensitive manner with decreased interaction at 21 degrees Celsius compared to 37 degrees Celsius.By similarity1 Publication

Protein-protein interaction databases

BioGridi122512. 6 interactions.
STRINGi9606.ENSP00000323926.

Structurei

3D structure databases

ProteinModelPortaliQ7Z2W7.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 691691CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini713 – 73422ExtracellularSequence AnalysisAdd
BLAST
Topological domaini756 – 7594CytoplasmicSequence Analysis
Topological domaini781 – 79414ExtracellularSequence AnalysisAdd
BLAST
Topological domaini816 – 82914CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini851 – 958108ExtracellularSequence AnalysisAdd
BLAST
Topological domaini980 – 1104125CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei692 – 71221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei735 – 75521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei760 – 78021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei795 – 81521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei830 – 85021Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei959 – 97921Helical; Name=6Sequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni187 – 1959Epitope; activates specific cytotoxic T lymphocytes

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1071 – 110434Sequence AnalysisAdd
BLAST

Domaini

The coiled coil region is required for multimerization.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253824.
GeneTreeiENSGT00760000119127.
HOGENOMiHOG000236350.
HOVERGENiHBG100888.
InParanoidiQ7Z2W7.
KOiK04983.
OMAiDFAHCTF.
OrthoDBiEOG725DH1.
PhylomeDBiQ7Z2W7.
TreeFamiTF314204.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029603. TRPM8.
[Graphical view]
PANTHERiPTHR13800:SF9. PTHR13800:SF9. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z2W7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFRAARLSM RNRRNDTLDS TRTLYSSASR STDLSYSESD LVNFIQANFK
60 70 80 90 100
KRECVFFTKD SKATENVCKC GYAQSQHMEG TQINQSEKWN YKKHTKEFPT
110 120 130 140 150
DAFGDIQFET LGKKGKYIRL SCDTDAEILY ELLTQHWHLK TPNLVISVTG
160 170 180 190 200
GAKNFALKPR MRKIFSRLIY IAQSKGAWIL TGGTHYGLMK YIGEVVRDNT
210 220 230 240 250
ISRSSEENIV AIGIAAWGMV SNRDTLIRNC DAEGYFLAQY LMDDFTRDPL
260 270 280 290 300
YILDNNHTHL LLVDNGCHGH PTVEAKLRNQ LEKYISERTI QDSNYGGKIP
310 320 330 340 350
IVCFAQGGGK ETLKAINTSI KNKIPCVVVE GSGQIADVIA SLVEVEDALT
360 370 380 390 400
SSAVKEKLVR FLPRTVSRLP EEETESWIKW LKEILECSHL LTVIKMEEAG
410 420 430 440 450
DEIVSNAISY ALYKAFSTSE QDKDNWNGQL KLLLEWNQLD LANDEIFTND
460 470 480 490 500
RRWESADLQE VMFTALIKDR PKFVRLFLEN GLNLRKFLTH DVLTELFSNH
510 520 530 540 550
FSTLVYRNLQ IAKNSYNDAL LTFVWKLVAN FRRGFRKEDR NGRDEMDIEL
560 570 580 590 600
HDVSPITRHP LQALFIWAIL QNKKELSKVI WEQTRGCTLA ALGASKLLKT
610 620 630 640 650
LAKVKNDINA AGESEELANE YETRAVELFT ECYSSDEDLA EQLLVYSCEA
660 670 680 690 700
WGGSNCLELA VEATDQHFIA QPGVQNFLSK QWYGEISRDT KNWKIILCLF
710 720 730 740 750
IIPLVGCGFV SFRKKPVDKH KKLLWYYVAF FTSPFVVFSW NVVFYIAFLL
760 770 780 790 800
LFAYVLLMDF HSVPHPPELV LYSLVFVLFC DEVRQWYVNG VNYFTDLWNV
810 820 830 840 850
MDTLGLFYFI AGIVFRLHSS NKSSLYSGRV IFCLDYIIFT LRLIHIFTVS
860 870 880 890 900
RNLGPKIIML QRMLIDVFFF LFLFAVWMVA FGVARQGILR QNEQRWRWIF
910 920 930 940 950
RSVIYEPYLA MFGQVPSDVD GTTYDFAHCT FTGNESKPLC VELDEHNLPR
960 970 980 990 1000
FPEWITIPLV CIYMLSTNIL LVNLLVAMFG YTVGTVQENN DQVWKFQRYF
1010 1020 1030 1040 1050
LVQEYCSRLN IPFPFIVFAY FYMVVKKCFK CCCKEKNMES SVCCFKNEDN
1060 1070 1080 1090 1100
ETLAWEGVMK ENYLVKINTK ANDTSEEMRH RFRQLDTKLN DLKGLLKEIA

NKIK
Length:1,104
Mass (Da):127,685
Last modified:April 3, 2007 - v2
Checksum:i5D88F5081EDFA632
GO
Isoform 2 (identifier: Q7Z2W7-2) [UniParc]FASTAAdd to Basket

Also known as: sTRPM8-18, sM8-18

The sequence of this isoform differs from the canonical sequence as follows:
     1-188: Missing.
     234-242: GYFLAQYLM → VPVGQEEVC
     243-1104: Missing.

Show »
Length:54
Mass (Da):5,940
Checksum:i5DB74DAF67EBDCED
GO
Isoform 3 (identifier: Q7Z2W7-3) [UniParc]FASTAAdd to Basket

Also known as: sTRPM8-6, sM8-6

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     234-242: GYFLAQYLM → VPVGQEEVC
     243-1104: Missing.

Show »
Length:165
Mass (Da):18,655
Checksum:i1EC4CEA05A33B6B6
GO
Isoform 4 (identifier: Q7Z2W7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MS → MQ
     3-314: Missing.
     675-784: Missing.

Note: No experimental confirmation available.

Show »
Length:682
Mass (Da):79,096
Checksum:iADF16E630E91F0EB
GO

Sequence cautioni

The sequence AAH01135.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAS45276.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581T → I in AAM10446. (PubMed:11325849)Curated
Sequence conflicti693 – 6931W → R in BAB86335. 1 PublicationCurated
Sequence conflicti795 – 7951T → A in AAP92167. (PubMed:16174775)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471R → T.
Corresponds to variant rs13004520 [ dbSNP | Ensembl ].
VAR_052383
Natural varianti251 – 2511Y → C.
Corresponds to variant rs17868387 [ dbSNP | Ensembl ].
VAR_052384
Natural varianti419 – 4191S → N.
Corresponds to variant rs7593557 [ dbSNP | Ensembl ].
VAR_059837
Natural varianti462 – 4621M → T.
Corresponds to variant rs28902173 [ dbSNP | Ensembl ].
VAR_052385
Natural varianti732 – 7321T → I.
Corresponds to variant rs17862932 [ dbSNP | Ensembl ].
VAR_052386
Natural varianti821 – 8211N → S.
Corresponds to variant rs28902201 [ dbSNP | Ensembl ].
VAR_052387

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 188188Missing in isoform 2. 2 PublicationsVSP_053268Add
BLAST
Alternative sequencei1 – 7777Missing in isoform 3. 1 PublicationVSP_012330Add
BLAST
Alternative sequencei1 – 22MS → MQ in isoform 4. 1 PublicationVSP_054505
Alternative sequencei3 – 314312Missing in isoform 4. 1 PublicationVSP_054506Add
BLAST
Alternative sequencei234 – 2429GYFLAQYLM → VPVGQEEVC in isoform 2 and isoform 3. 2 PublicationsVSP_012332
Alternative sequencei243 – 1104862Missing in isoform 2 and isoform 3. 2 PublicationsVSP_012333Add
BLAST
Alternative sequencei675 – 784110Missing in isoform 4. 1 PublicationVSP_054507Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY090109 mRNA. Translation: AAM10446.1.
AY328400 mRNA. Translation: AAP92167.1.
DQ139309 mRNA. Translation: AAZ73614.1.
AY532375 mRNA. Translation: AAS45275.1.
AY532376 mRNA. Translation: AAS45276.1. Different initiation.
AC005538 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW71068.1.
BC001135 mRNA. Translation: AAH01135.1. Different initiation.
BC126342 mRNA. Translation: AAI26343.1.
AB061779 mRNA. Translation: BAB86335.1.
CCDSiCCDS33407.1. [Q7Z2W7-1]
RefSeqiNP_076985.4. NM_024080.4. [Q7Z2W7-1]
UniGeneiHs.366053.

Genome annotation databases

EnsembliENST00000324695; ENSP00000323926; ENSG00000144481. [Q7Z2W7-1]
ENST00000355722; ENSP00000347956; ENSG00000144481.
ENST00000409625; ENSP00000386771; ENSG00000144481. [Q7Z2W7-3]
GeneIDi79054.
KEGGihsa:79054.
UCSCiuc002vvh.3. human. [Q7Z2W7-1]
uc002vvi.3. human. [Q7Z2W7-2]
uc002vvj.3. human. [Q7Z2W7-3]
uc010fyj.3. human.

Polymorphism databases

DMDMi143811469.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY090109 mRNA. Translation: AAM10446.1 .
AY328400 mRNA. Translation: AAP92167.1 .
DQ139309 mRNA. Translation: AAZ73614.1 .
AY532375 mRNA. Translation: AAS45275.1 .
AY532376 mRNA. Translation: AAS45276.1 . Different initiation.
AC005538 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW71068.1 .
BC001135 mRNA. Translation: AAH01135.1 . Different initiation.
BC126342 mRNA. Translation: AAI26343.1 .
AB061779 mRNA. Translation: BAB86335.1 .
CCDSi CCDS33407.1. [Q7Z2W7-1 ]
RefSeqi NP_076985.4. NM_024080.4. [Q7Z2W7-1 ]
UniGenei Hs.366053.

3D structure databases

ProteinModelPortali Q7Z2W7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122512. 6 interactions.
STRINGi 9606.ENSP00000323926.

Chemistry

BindingDBi Q7Z2W7.
ChEMBLi CHEMBL1075319.
DrugBanki DB00825. Menthol.
GuidetoPHARMACOLOGYi 500.

Protein family/group databases

TCDBi 1.A.4.5.7. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

PhosphoSitei Q7Z2W7.

Polymorphism databases

DMDMi 143811469.

Proteomic databases

PaxDbi Q7Z2W7.
PRIDEi Q7Z2W7.

Protocols and materials databases

DNASUi 79054.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324695 ; ENSP00000323926 ; ENSG00000144481 . [Q7Z2W7-1 ]
ENST00000355722 ; ENSP00000347956 ; ENSG00000144481 .
ENST00000409625 ; ENSP00000386771 ; ENSG00000144481 . [Q7Z2W7-3 ]
GeneIDi 79054.
KEGGi hsa:79054.
UCSCi uc002vvh.3. human. [Q7Z2W7-1 ]
uc002vvi.3. human. [Q7Z2W7-2 ]
uc002vvj.3. human. [Q7Z2W7-3 ]
uc010fyj.3. human.

Organism-specific databases

CTDi 79054.
GeneCardsi GC02P234842.
HGNCi HGNC:17961. TRPM8.
HPAi HPA024117.
HPA029542.
MIMi 606678. gene.
neXtProti NX_Q7Z2W7.
PharmGKBi PA38270.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253824.
GeneTreei ENSGT00760000119127.
HOGENOMi HOG000236350.
HOVERGENi HBG100888.
InParanoidi Q7Z2W7.
KOi K04983.
OMAi DFAHCTF.
OrthoDBi EOG725DH1.
PhylomeDBi Q7Z2W7.
TreeFami TF314204.

Enzyme and pathway databases

Reactomei REACT_169333. TRP channels.

Miscellaneous databases

GeneWikii TRPM8.
GenomeRNAii 79054.
NextBioi 67809.
PROi Q7Z2W7.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z2W7.
CleanExi HS_TRPM8.
ExpressionAtlasi Q7Z2W7. baseline and differential.
Genevestigatori Q7Z2W7.

Family and domain databases

InterProi IPR005821. Ion_trans_dom.
IPR029603. TRPM8.
[Graphical view ]
PANTHERi PTHR13800:SF9. PTHR13800:SF9. 1 hit.
Pfami PF00520. Ion_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins."
    Tsavaler L., Shapero M.H., Morkowski S., Laus R.
    Cancer Res. 61:3760-3769(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Prostate.
  2. "Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells."
    Thebault S., Lemonnier L., Bidaux G., Flourakis M., Bavencoffe A., Gordienko D., Roudbaraki M., Delcourt P., Panchin Y., Shuba Y., Skryma R., Prevarskaya N.
    J. Biol. Chem. 280:39423-39435(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Prostate and Prostate cancer.
  3. "Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms."
    Bidaux G., Beck B., Zholos A., Gordienko D., Lemonnier L., Flourakis M., Roudbaraki M., Borowiec A.S., Fernandez J., Delcourt P., Lepage G., Shuba Y., Skryma R., Prevarskaya N.
    J. Biol. Chem. 287:2948-2962(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Prostate cancer.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Skin.
  7. "Molecular cloning of a novel member of LTRP channel family, LTRPC6."
    Sano Y., Inamura K., Miyake A., Mochizuki S., Yokoi H., Kitada C., Nozawa K., Matsushime H., Furuichi K.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1104 (ISOFORM 1).
  8. "Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8."
    Kiessling A., Fuessel S., Schmitz M., Stevanovic S., Meye A., Weigle B., Klenk U., Wirth M.P., Rieber E.P.
    Prostate 56:270-279(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, EPITOPE MAPPING.
  9. "The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels."
    Voets T., Droogmans G., Wissenbach U., Janssens A., Flockerzi V., Nilius B.
    Nature 430:748-754(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. Cited for: GLYCOSYLATION AT ASN-934, MUTAGENESIS OF ASN-821; ASN-934; HIS-946 AND LEU-1089, ROLE OF COILED COIL DOMAIN.

Entry informationi

Entry nameiTRPM8_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2W7
Secondary accession number(s): A0AVG2
, Q3YFM7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein.
Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3