Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7Z2W7

- TRPM8_HUMAN

UniProt

Q7Z2W7 - TRPM8_HUMAN

Protein

Transient receptor potential cation channel subfamily M member 8

Gene

TRPM8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.3 Publications

    GO - Molecular functioni

    1. calcium channel activity Source: Ensembl

    GO - Biological processi

    1. calcium ion transmembrane transport Source: Reactome
    2. cellular calcium ion homeostasis Source: Ensembl
    3. ion transmembrane transport Source: Reactome
    4. protein homotetramerization Source: Ensembl
    5. protein homotrimerization Source: Ensembl
    6. response to cold Source: Ensembl
    7. thermoception Source: Ensembl
    8. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Sensory transduction, Transport

    Enzyme and pathway databases

    ReactomeiREACT_169333. TRP channels.

    Protein family/group databases

    TCDBi1.A.4.5.7. the transient receptor potential ca(2+) channel (trp-cc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transient receptor potential cation channel subfamily M member 8
    Alternative name(s):
    Long transient receptor potential channel 6
    Short name:
    LTrpC-6
    Short name:
    LTrpC6
    Transient receptor potential p8
    Short name:
    Trp-p8
    Gene namesi
    Name:TRPM8
    Synonyms:LTRPC6, TRPP8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:17961. TRPM8.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane
    Note: Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts By similarity. Located in the endoplasmic reticulum in prostate cancer cells.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. external side of plasma membrane Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane raft Source: UniProtKB-SubCell
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi821 – 8211N → Q: No effect on glycosylation or ability to form functional channels. 1 Publication
    Mutagenesisi934 – 9341N → Q: Abolishes glycosylation. 1 Publication
    Mutagenesisi946 – 9461H → N: No effect on glycosylation or channel activity. 1 Publication
    Mutagenesisi1089 – 10891L → P: Abolishes multimerization and channel activity. Reduces cell surface expression. 1 Publication

    Organism-specific databases

    PharmGKBiPA38270.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11041104Transient receptor potential cation channel subfamily M member 8PRO_0000215333Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi934 – 9341N-linked (GlcNAc...) (complex)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ7Z2W7.
    PRIDEiQ7Z2W7.

    PTM databases

    PhosphoSiteiQ7Z2W7.

    Expressioni

    Tissue specificityi

    Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors.4 Publications

    Gene expression databases

    ArrayExpressiQ7Z2W7.
    BgeeiQ7Z2W7.
    CleanExiHS_TRPM8.
    GenevestigatoriQ7Z2W7.

    Organism-specific databases

    HPAiHPA024117.
    HPA029542.

    Interactioni

    Subunit structurei

    Homotetramer By similarity. Isoform 2 and isoform 3 interact with the C-terminus of isoform 1 in a thermosensitive manner with decreased interaction at 21 degrees Celsius compared to 37 degrees Celsius.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi122512. 6 interactions.
    STRINGi9606.ENSP00000323926.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z2W7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 691691CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini713 – 73422ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini756 – 7594CytoplasmicSequence Analysis
    Topological domaini781 – 79414ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini816 – 82914CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini851 – 958108ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini980 – 1104125CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei692 – 71221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei735 – 75521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei760 – 78021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei795 – 81521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei830 – 85021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei959 – 97921Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni187 – 1959Epitope; activates specific cytotoxic T lymphocytes

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1071 – 110434Sequence AnalysisAdd
    BLAST

    Domaini

    The coiled coil region is required for multimerization.

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253824.
    HOGENOMiHOG000236350.
    HOVERGENiHBG100888.
    InParanoidiQ7Z2W7.
    KOiK04983.
    OMAiDFAHCTF.
    OrthoDBiEOG725DH1.
    PhylomeDBiQ7Z2W7.
    TreeFamiTF314204.

    Family and domain databases

    InterProiIPR005821. Ion_trans_dom.
    IPR029603. TRPM8.
    [Graphical view]
    PANTHERiPTHR13800:SF9. PTHR13800:SF9. 1 hit.
    PfamiPF00520. Ion_trans. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z2W7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFRAARLSM RNRRNDTLDS TRTLYSSASR STDLSYSESD LVNFIQANFK     50
    KRECVFFTKD SKATENVCKC GYAQSQHMEG TQINQSEKWN YKKHTKEFPT 100
    DAFGDIQFET LGKKGKYIRL SCDTDAEILY ELLTQHWHLK TPNLVISVTG 150
    GAKNFALKPR MRKIFSRLIY IAQSKGAWIL TGGTHYGLMK YIGEVVRDNT 200
    ISRSSEENIV AIGIAAWGMV SNRDTLIRNC DAEGYFLAQY LMDDFTRDPL 250
    YILDNNHTHL LLVDNGCHGH PTVEAKLRNQ LEKYISERTI QDSNYGGKIP 300
    IVCFAQGGGK ETLKAINTSI KNKIPCVVVE GSGQIADVIA SLVEVEDALT 350
    SSAVKEKLVR FLPRTVSRLP EEETESWIKW LKEILECSHL LTVIKMEEAG 400
    DEIVSNAISY ALYKAFSTSE QDKDNWNGQL KLLLEWNQLD LANDEIFTND 450
    RRWESADLQE VMFTALIKDR PKFVRLFLEN GLNLRKFLTH DVLTELFSNH 500
    FSTLVYRNLQ IAKNSYNDAL LTFVWKLVAN FRRGFRKEDR NGRDEMDIEL 550
    HDVSPITRHP LQALFIWAIL QNKKELSKVI WEQTRGCTLA ALGASKLLKT 600
    LAKVKNDINA AGESEELANE YETRAVELFT ECYSSDEDLA EQLLVYSCEA 650
    WGGSNCLELA VEATDQHFIA QPGVQNFLSK QWYGEISRDT KNWKIILCLF 700
    IIPLVGCGFV SFRKKPVDKH KKLLWYYVAF FTSPFVVFSW NVVFYIAFLL 750
    LFAYVLLMDF HSVPHPPELV LYSLVFVLFC DEVRQWYVNG VNYFTDLWNV 800
    MDTLGLFYFI AGIVFRLHSS NKSSLYSGRV IFCLDYIIFT LRLIHIFTVS 850
    RNLGPKIIML QRMLIDVFFF LFLFAVWMVA FGVARQGILR QNEQRWRWIF 900
    RSVIYEPYLA MFGQVPSDVD GTTYDFAHCT FTGNESKPLC VELDEHNLPR 950
    FPEWITIPLV CIYMLSTNIL LVNLLVAMFG YTVGTVQENN DQVWKFQRYF 1000
    LVQEYCSRLN IPFPFIVFAY FYMVVKKCFK CCCKEKNMES SVCCFKNEDN 1050
    ETLAWEGVMK ENYLVKINTK ANDTSEEMRH RFRQLDTKLN DLKGLLKEIA 1100
    NKIK 1104
    Length:1,104
    Mass (Da):127,685
    Last modified:April 3, 2007 - v2
    Checksum:i5D88F5081EDFA632
    GO
    Isoform 2 (identifier: Q7Z2W7-2) [UniParc]FASTAAdd to Basket

    Also known as: sTRPM8-18, sM8-18

    The sequence of this isoform differs from the canonical sequence as follows:
         1-188: Missing.
         234-242: GYFLAQYLM → VPVGQEEVC
         243-1104: Missing.

    Show »
    Length:54
    Mass (Da):5,940
    Checksum:i5DB74DAF67EBDCED
    GO
    Isoform 3 (identifier: Q7Z2W7-3) [UniParc]FASTAAdd to Basket

    Also known as: sTRPM8-6, sM8-6

    The sequence of this isoform differs from the canonical sequence as follows:
         1-77: Missing.
         234-242: GYFLAQYLM → VPVGQEEVC
         243-1104: Missing.

    Show »
    Length:165
    Mass (Da):18,655
    Checksum:i1EC4CEA05A33B6B6
    GO
    Isoform 4 (identifier: Q7Z2W7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2: MS → MQ
         3-314: Missing.
         675-784: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:682
    Mass (Da):79,096
    Checksum:iADF16E630E91F0EB
    GO

    Sequence cautioni

    The sequence AAH01135.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAS45276.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581T → I in AAM10446. (PubMed:11325849)Curated
    Sequence conflicti693 – 6931W → R in BAB86335. 1 PublicationCurated
    Sequence conflicti795 – 7951T → A in AAP92167. (PubMed:16174775)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti247 – 2471R → T.
    Corresponds to variant rs13004520 [ dbSNP | Ensembl ].
    VAR_052383
    Natural varianti251 – 2511Y → C.
    Corresponds to variant rs17868387 [ dbSNP | Ensembl ].
    VAR_052384
    Natural varianti419 – 4191S → N.
    Corresponds to variant rs7593557 [ dbSNP | Ensembl ].
    VAR_059837
    Natural varianti462 – 4621M → T.
    Corresponds to variant rs28902173 [ dbSNP | Ensembl ].
    VAR_052385
    Natural varianti732 – 7321T → I.
    Corresponds to variant rs17862932 [ dbSNP | Ensembl ].
    VAR_052386
    Natural varianti821 – 8211N → S.
    Corresponds to variant rs28902201 [ dbSNP | Ensembl ].
    VAR_052387

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 188188Missing in isoform 2. 2 PublicationsVSP_053268Add
    BLAST
    Alternative sequencei1 – 7777Missing in isoform 3. 1 PublicationVSP_012330Add
    BLAST
    Alternative sequencei1 – 22MS → MQ in isoform 4. 1 PublicationVSP_054505
    Alternative sequencei3 – 314312Missing in isoform 4. 1 PublicationVSP_054506Add
    BLAST
    Alternative sequencei234 – 2429GYFLAQYLM → VPVGQEEVC in isoform 2 and isoform 3. 2 PublicationsVSP_012332
    Alternative sequencei243 – 1104862Missing in isoform 2 and isoform 3. 2 PublicationsVSP_012333Add
    BLAST
    Alternative sequencei675 – 784110Missing in isoform 4. 1 PublicationVSP_054507Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY090109 mRNA. Translation: AAM10446.1.
    AY328400 mRNA. Translation: AAP92167.1.
    DQ139309 mRNA. Translation: AAZ73614.1.
    AY532375 mRNA. Translation: AAS45275.1.
    AY532376 mRNA. Translation: AAS45276.1. Different initiation.
    AC005538 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW71068.1.
    BC001135 mRNA. Translation: AAH01135.1. Different initiation.
    BC126342 mRNA. Translation: AAI26343.1.
    AB061779 mRNA. Translation: BAB86335.1.
    CCDSiCCDS33407.1. [Q7Z2W7-1]
    RefSeqiNP_076985.4. NM_024080.4. [Q7Z2W7-1]
    UniGeneiHs.366053.

    Genome annotation databases

    EnsembliENST00000324695; ENSP00000323926; ENSG00000144481. [Q7Z2W7-1]
    ENST00000355722; ENSP00000347956; ENSG00000144481.
    ENST00000409625; ENSP00000386771; ENSG00000144481. [Q7Z2W7-3]
    ENST00000433712; ENSP00000404423; ENSG00000144481. [Q7Z2W7-4]
    GeneIDi79054.
    KEGGihsa:79054.
    UCSCiuc002vvh.3. human. [Q7Z2W7-1]
    uc002vvi.3. human. [Q7Z2W7-2]
    uc002vvj.3. human. [Q7Z2W7-3]

    Polymorphism databases

    DMDMi143811469.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY090109 mRNA. Translation: AAM10446.1 .
    AY328400 mRNA. Translation: AAP92167.1 .
    DQ139309 mRNA. Translation: AAZ73614.1 .
    AY532375 mRNA. Translation: AAS45275.1 .
    AY532376 mRNA. Translation: AAS45276.1 . Different initiation.
    AC005538 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW71068.1 .
    BC001135 mRNA. Translation: AAH01135.1 . Different initiation.
    BC126342 mRNA. Translation: AAI26343.1 .
    AB061779 mRNA. Translation: BAB86335.1 .
    CCDSi CCDS33407.1. [Q7Z2W7-1 ]
    RefSeqi NP_076985.4. NM_024080.4. [Q7Z2W7-1 ]
    UniGenei Hs.366053.

    3D structure databases

    ProteinModelPortali Q7Z2W7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122512. 6 interactions.
    STRINGi 9606.ENSP00000323926.

    Chemistry

    BindingDBi Q7Z2W7.
    ChEMBLi CHEMBL1075319.
    DrugBanki DB00825. Menthol.
    GuidetoPHARMACOLOGYi 500.

    Protein family/group databases

    TCDBi 1.A.4.5.7. the transient receptor potential ca(2+) channel (trp-cc) family.

    PTM databases

    PhosphoSitei Q7Z2W7.

    Polymorphism databases

    DMDMi 143811469.

    Proteomic databases

    PaxDbi Q7Z2W7.
    PRIDEi Q7Z2W7.

    Protocols and materials databases

    DNASUi 79054.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324695 ; ENSP00000323926 ; ENSG00000144481 . [Q7Z2W7-1 ]
    ENST00000355722 ; ENSP00000347956 ; ENSG00000144481 .
    ENST00000409625 ; ENSP00000386771 ; ENSG00000144481 . [Q7Z2W7-3 ]
    ENST00000433712 ; ENSP00000404423 ; ENSG00000144481 . [Q7Z2W7-4 ]
    GeneIDi 79054.
    KEGGi hsa:79054.
    UCSCi uc002vvh.3. human. [Q7Z2W7-1 ]
    uc002vvi.3. human. [Q7Z2W7-2 ]
    uc002vvj.3. human. [Q7Z2W7-3 ]

    Organism-specific databases

    CTDi 79054.
    GeneCardsi GC02P234842.
    HGNCi HGNC:17961. TRPM8.
    HPAi HPA024117.
    HPA029542.
    MIMi 606678. gene.
    neXtProti NX_Q7Z2W7.
    PharmGKBi PA38270.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253824.
    HOGENOMi HOG000236350.
    HOVERGENi HBG100888.
    InParanoidi Q7Z2W7.
    KOi K04983.
    OMAi DFAHCTF.
    OrthoDBi EOG725DH1.
    PhylomeDBi Q7Z2W7.
    TreeFami TF314204.

    Enzyme and pathway databases

    Reactomei REACT_169333. TRP channels.

    Miscellaneous databases

    GeneWikii TRPM8.
    GenomeRNAii 79054.
    NextBioi 67809.
    PROi Q7Z2W7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z2W7.
    Bgeei Q7Z2W7.
    CleanExi HS_TRPM8.
    Genevestigatori Q7Z2W7.

    Family and domain databases

    InterProi IPR005821. Ion_trans_dom.
    IPR029603. TRPM8.
    [Graphical view ]
    PANTHERi PTHR13800:SF9. PTHR13800:SF9. 1 hit.
    Pfami PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins."
      Tsavaler L., Shapero M.H., Morkowski S., Laus R.
      Cancer Res. 61:3760-3769(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Prostate.
    2. "Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells."
      Thebault S., Lemonnier L., Bidaux G., Flourakis M., Bavencoffe A., Gordienko D., Roudbaraki M., Delcourt P., Panchin Y., Shuba Y., Skryma R., Prevarskaya N.
      J. Biol. Chem. 280:39423-39435(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Prostate and Prostate cancer.
    3. "Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms."
      Bidaux G., Beck B., Zholos A., Gordienko D., Lemonnier L., Flourakis M., Roudbaraki M., Borowiec A.S., Fernandez J., Delcourt P., Lepage G., Shuba Y., Skryma R., Prevarskaya N.
      J. Biol. Chem. 287:2948-2962(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Prostate cancer.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
      Tissue: Skin.
    7. "Molecular cloning of a novel member of LTRP channel family, LTRPC6."
      Sano Y., Inamura K., Miyake A., Mochizuki S., Yokoi H., Kitada C., Nozawa K., Matsushime H., Furuichi K.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-1104 (ISOFORM 1).
    8. "Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8."
      Kiessling A., Fuessel S., Schmitz M., Stevanovic S., Meye A., Weigle B., Klenk U., Wirth M.P., Rieber E.P.
      Prostate 56:270-279(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, EPITOPE MAPPING.
    9. "The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels."
      Voets T., Droogmans G., Wissenbach U., Janssens A., Flockerzi V., Nilius B.
      Nature 430:748-754(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. Cited for: GLYCOSYLATION AT ASN-934, MUTAGENESIS OF ASN-821; ASN-934; HIS-946 AND LEU-1089, ROLE OF COILED COIL DOMAIN.

    Entry informationi

    Entry nameiTRPM8_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z2W7
    Secondary accession number(s): A0AVG2
    , Q3YFM7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein.
    Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3