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Protein

TRMT1-like protein

Gene

TRMT1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in motor coordination and exploratory behavior.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri184 – 20623C2H2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • methyltransferase activity Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
  • tRNA binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Behavior, tRNA processing

Keywords - Ligandi

Metal-binding, RNA-binding, S-adenosyl-L-methionine, tRNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
TRMT1-like protein (EC:2.1.1.-)
Gene namesi
Name:TRMT1L
Synonyms:C1orf25, TRM1L
ORF Names:MSTP070
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16782. TRMT1L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25612.

Polymorphism and mutation databases

BioMutaiTRMT1L.
DMDMi166988174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733TRMT1-like proteinPRO_0000317568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z2T5.
PaxDbiQ7Z2T5.
PeptideAtlasiQ7Z2T5.
PRIDEiQ7Z2T5.

PTM databases

PhosphoSiteiQ7Z2T5.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ7Z2T5.
CleanExiHS_C1orf25.
ExpressionAtlasiQ7Z2T5. baseline and differential.
GenevisibleiQ7Z2T5. HS.

Organism-specific databases

HPAiHPA026728.
HPA054464.

Interactioni

Protein-protein interaction databases

BioGridi123562. 19 interactions.
IntActiQ7Z2T5. 4 interactions.
MINTiMINT-5009710.
STRINGi9606.ENSP00000356476.

Structurei

3D structure databases

ProteinModelPortaliQ7Z2T5.
SMRiQ7Z2T5. Positions 227-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini227 – 688462Trm1 methyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.PROSITE-ProRule annotation
Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation
Contains 1 Trm1 methyltransferase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri184 – 20623C2H2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1867.
GeneTreeiENSGT00530000063646.
HOGENOMiHOG000154681.
HOVERGENiHBG057055.
InParanoidiQ7Z2T5.
OMAiRHISIQR.
OrthoDBiEOG7CCBQR.
PhylomeDBiQ7Z2T5.
TreeFamiTF300851.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR002905. Trm1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10631. PTHR10631. 1 hit.
PfamiPF02005. TRM. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51626. SAM_MT_TRM1. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z2T5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENMAEEELL PLEKEEVEVA QVQVPTPARD SAGVPAPAPD SALDSAPTPA
60 70 80 90 100
SAPAPAPALA QAPALSPSLA SAPEEAKSKR HISIQRQLAD LENLAFVTDG
110 120 130 140 150
NFDSASSLNS DNLDAGNRQA CPLCPKEKFR ACNSHKLRRH LQNLHWKVSV
160 170 180 190 200
EFEGYRMCIC HLPCRPVKPN IIGEQITSKM GAHYHCIICS ATITRRTDML
210 220 230 240 250
GHVRRHMNKG ETKSSYIAAS TAKPPKEILK EADTDVQVCP NYSIPQKTDS
260 270 280 290 300
YFNPKMKLNR QLIFCTLAAL AEERKPLECL DAFGATGIMG LQWAKHLGNA
310 320 330 340 350
VKVTINDLNE NSVTLIQENC HLNKLKVVVD SKEKEKSDDI LEEGEKNLGN
360 370 380 390 400
IKVTKMDANV LMHLRSFDFI HLDPFGTSVN YLDSAFRNIR NLGIVSVTST
410 420 430 440 450
DISSLYAKAQ HVARRHYGCN IVRTEYYKEL AARIVVAAVA RAAARCNKGI
460 470 480 490 500
EVLFAVALEH FVLVVVRVLR GPTSADETAK KIQYLIHCQW CEERIFQKDG
510 520 530 540 550
NMVEENPYRQ LPCNCHGSMP GKTAIELGPL WSSSLFNTGF LKRMLFESLH
560 570 580 590 600
HGLDDIQTLI KTLIFESECT PQSQFSIHAS SNVNKQEENG VFIKTTDDTT
610 620 630 640 650
TDNYIAQGKR KSNEMITNLG KKQKTDVSTE HPPFYYNIHR HSIKGMNMPK
660 670 680 690 700
LKKFLCYLSQ AGFRVSRTHF DPMGVRTDAP LMQFKSILLK YSTPTYTGGQ
710 720 730
SESHVQSASE DTVTERVEMS VNDKAEASGC RRW
Length:733
Mass (Da):81,747
Last modified:February 5, 2008 - v2
Checksum:i364B6BD4F22D1B08
GO
Isoform 2 (identifier: Q7Z2T5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     505-733: ENPYRQLPCN...KAEASGCRRW → DYSANFVISY...VMEACLERQQ

Note: No experimental confirmation available.
Show »
Length:390
Mass (Da):43,952
Checksum:i9FD3050EE2D66CB8
GO

Sequence cautioni

The sequence AAH39738.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAQ13590.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI17851.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561R → G in BAC11302 (PubMed:14702039).Curated
Sequence conflicti319 – 3191N → S in BAD18605 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 156156Missing in isoform 2. 1 PublicationVSP_031042Add
BLAST
Alternative sequencei505 – 733229ENPYR…GCRRW → DYSANFVISYTGFPFVNRQD IRKTHIDSCLVTVMEACLER QQ in isoform 2. 1 PublicationVSP_031043Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288399 mRNA. Translation: AAG60618.1.
AK074936 mRNA. Translation: BAC11302.1.
AK074993 mRNA. Translation: BAC11341.1.
AK131460 mRNA. Translation: BAD18605.1.
AL109865, AL136133 Genomic DNA. Translation: CAI17847.1.
AL136133, AL109865 Genomic DNA. Translation: CAI17938.1.
AL109865 Genomic DNA. Translation: CAI17851.1. Sequence problems.
CH471067 Genomic DNA. Translation: EAW91190.1.
BC039738 mRNA. Translation: AAH39738.1. Sequence problems.
BC045535 mRNA. Translation: AAH45535.1.
AF163261 mRNA. Translation: AAQ13590.1. Different initiation.
CCDSiCCDS1366.1. [Q7Z2T5-1]
RefSeqiNP_001189352.1. NM_001202423.1.
NP_112196.3. NM_030934.4. [Q7Z2T5-1]
UniGeneiHs.107149.

Genome annotation databases

EnsembliENST00000367506; ENSP00000356476; ENSG00000121486. [Q7Z2T5-1]
GeneIDi81627.
KEGGihsa:81627.
UCSCiuc001grf.4. human. [Q7Z2T5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288399 mRNA. Translation: AAG60618.1.
AK074936 mRNA. Translation: BAC11302.1.
AK074993 mRNA. Translation: BAC11341.1.
AK131460 mRNA. Translation: BAD18605.1.
AL109865, AL136133 Genomic DNA. Translation: CAI17847.1.
AL136133, AL109865 Genomic DNA. Translation: CAI17938.1.
AL109865 Genomic DNA. Translation: CAI17851.1. Sequence problems.
CH471067 Genomic DNA. Translation: EAW91190.1.
BC039738 mRNA. Translation: AAH39738.1. Sequence problems.
BC045535 mRNA. Translation: AAH45535.1.
AF163261 mRNA. Translation: AAQ13590.1. Different initiation.
CCDSiCCDS1366.1. [Q7Z2T5-1]
RefSeqiNP_001189352.1. NM_001202423.1.
NP_112196.3. NM_030934.4. [Q7Z2T5-1]
UniGeneiHs.107149.

3D structure databases

ProteinModelPortaliQ7Z2T5.
SMRiQ7Z2T5. Positions 227-540.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123562. 19 interactions.
IntActiQ7Z2T5. 4 interactions.
MINTiMINT-5009710.
STRINGi9606.ENSP00000356476.

PTM databases

PhosphoSiteiQ7Z2T5.

Polymorphism and mutation databases

BioMutaiTRMT1L.
DMDMi166988174.

Proteomic databases

MaxQBiQ7Z2T5.
PaxDbiQ7Z2T5.
PeptideAtlasiQ7Z2T5.
PRIDEiQ7Z2T5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367506; ENSP00000356476; ENSG00000121486. [Q7Z2T5-1]
GeneIDi81627.
KEGGihsa:81627.
UCSCiuc001grf.4. human. [Q7Z2T5-1]

Organism-specific databases

CTDi81627.
GeneCardsiGC01M185088.
H-InvDBHIX0001421.
HGNCiHGNC:16782. TRMT1L.
HPAiHPA026728.
HPA054464.
MIMi611673. gene.
neXtProtiNX_Q7Z2T5.
PharmGKBiPA25612.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1867.
GeneTreeiENSGT00530000063646.
HOGENOMiHOG000154681.
HOVERGENiHBG057055.
InParanoidiQ7Z2T5.
OMAiRHISIQR.
OrthoDBiEOG7CCBQR.
PhylomeDBiQ7Z2T5.
TreeFamiTF300851.

Miscellaneous databases

GenomeRNAii81627.
NextBioi72006.
PROiQ7Z2T5.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z2T5.
CleanExiHS_C1orf25.
ExpressionAtlasiQ7Z2T5. baseline and differential.
GenevisibleiQ7Z2T5. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR002905. Trm1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10631. PTHR10631. 1 hit.
PfamiPF02005. TRM. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51626. SAM_MT_TRM1. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus."
    Sood R., Bonner T.I., Malakowska I., Stephan D.A., Robbins C.M., Connors T.D., Morgenbesser S.D., Su K., Faruque M.U., Pinkett H., Graham C., Baxevanis A.D., Klinger K.W., Landes G.M., Trent J.M., Carpten J.D.
    Genomics 73:211-222(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma and Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  6. Hui R.T.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 423-733.
    Tissue: Aorta.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTRM1L_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2T5
Secondary accession number(s): Q5TEN0
, Q6ZMX0, Q8IWH5, Q8NC68, Q9BZQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 24, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.