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Q7Z2T5

- TRM1L_HUMAN

UniProt

Q7Z2T5 - TRM1L_HUMAN

Protein

TRMT1-like protein

Gene

TRMT1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    May play a role in motor coordination and exploratory behavior.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri184 – 20623C2H2-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. poly(A) RNA binding Source: UniProtKB
    3. tRNA (guanine-N2-)-methyltransferase activity Source: InterPro
    4. tRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Behavior, tRNA processing

    Keywords - Ligandi

    Metal-binding, RNA-binding, S-adenosyl-L-methionine, tRNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TRMT1-like protein (EC:2.1.1.-)
    Gene namesi
    Name:TRMT1L
    Synonyms:C1orf25, TRM1L
    ORF Names:MSTP070
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:16782. TRMT1L.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25612.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 733733TRMT1-like proteinPRO_0000317568Add
    BLAST

    Proteomic databases

    MaxQBiQ7Z2T5.
    PaxDbiQ7Z2T5.
    PeptideAtlasiQ7Z2T5.
    PRIDEiQ7Z2T5.

    PTM databases

    PhosphoSiteiQ7Z2T5.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    BgeeiQ7Z2T5.
    CleanExiHS_C1orf25.
    GenevestigatoriQ7Z2T5.

    Organism-specific databases

    HPAiHPA026728.
    HPA054464.

    Interactioni

    Protein-protein interaction databases

    BioGridi123562. 13 interactions.
    IntActiQ7Z2T5. 2 interactions.
    MINTiMINT-5009710.
    STRINGi9606.ENSP00000356476.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z2T5.
    SMRiQ7Z2T5. Positions 227-540.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini227 – 688462Trm1 methyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.PROSITE-ProRule annotation
    Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation
    Contains 1 Trm1 methyltransferase domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri184 – 20623C2H2-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1867.
    HOGENOMiHOG000154681.
    HOVERGENiHBG057055.
    InParanoidiQ7Z2T5.
    OMAiIFESECT.
    OrthoDBiEOG7CCBQR.
    PhylomeDBiQ7Z2T5.
    TreeFamiTF300851.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR002905. Trm1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PANTHERiPTHR10631. PTHR10631. 1 hit.
    PfamiPF02005. TRM. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 2 hits.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51626. SAM_MT_TRM1. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z2T5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENMAEEELL PLEKEEVEVA QVQVPTPARD SAGVPAPAPD SALDSAPTPA    50
    SAPAPAPALA QAPALSPSLA SAPEEAKSKR HISIQRQLAD LENLAFVTDG 100
    NFDSASSLNS DNLDAGNRQA CPLCPKEKFR ACNSHKLRRH LQNLHWKVSV 150
    EFEGYRMCIC HLPCRPVKPN IIGEQITSKM GAHYHCIICS ATITRRTDML 200
    GHVRRHMNKG ETKSSYIAAS TAKPPKEILK EADTDVQVCP NYSIPQKTDS 250
    YFNPKMKLNR QLIFCTLAAL AEERKPLECL DAFGATGIMG LQWAKHLGNA 300
    VKVTINDLNE NSVTLIQENC HLNKLKVVVD SKEKEKSDDI LEEGEKNLGN 350
    IKVTKMDANV LMHLRSFDFI HLDPFGTSVN YLDSAFRNIR NLGIVSVTST 400
    DISSLYAKAQ HVARRHYGCN IVRTEYYKEL AARIVVAAVA RAAARCNKGI 450
    EVLFAVALEH FVLVVVRVLR GPTSADETAK KIQYLIHCQW CEERIFQKDG 500
    NMVEENPYRQ LPCNCHGSMP GKTAIELGPL WSSSLFNTGF LKRMLFESLH 550
    HGLDDIQTLI KTLIFESECT PQSQFSIHAS SNVNKQEENG VFIKTTDDTT 600
    TDNYIAQGKR KSNEMITNLG KKQKTDVSTE HPPFYYNIHR HSIKGMNMPK 650
    LKKFLCYLSQ AGFRVSRTHF DPMGVRTDAP LMQFKSILLK YSTPTYTGGQ 700
    SESHVQSASE DTVTERVEMS VNDKAEASGC RRW 733
    Length:733
    Mass (Da):81,747
    Last modified:February 5, 2008 - v2
    Checksum:i364B6BD4F22D1B08
    GO
    Isoform 2 (identifier: Q7Z2T5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-156: Missing.
         505-733: ENPYRQLPCN...KAEASGCRRW → DYSANFVISY...VMEACLERQQ

    Note: No experimental confirmation available.

    Show »
    Length:390
    Mass (Da):43,952
    Checksum:i9FD3050EE2D66CB8
    GO

    Sequence cautioni

    The sequence AAH39738.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAQ13590.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAI17851.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561R → G in BAC11302. (PubMed:14702039)Curated
    Sequence conflicti319 – 3191N → S in BAD18605. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 156156Missing in isoform 2. 1 PublicationVSP_031042Add
    BLAST
    Alternative sequencei505 – 733229ENPYR…GCRRW → DYSANFVISYTGFPFVNRQD IRKTHIDSCLVTVMEACLER QQ in isoform 2. 1 PublicationVSP_031043Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288399 mRNA. Translation: AAG60618.1.
    AK074936 mRNA. Translation: BAC11302.1.
    AK074993 mRNA. Translation: BAC11341.1.
    AK131460 mRNA. Translation: BAD18605.1.
    AL109865, AL136133 Genomic DNA. Translation: CAI17847.1.
    AL136133, AL109865 Genomic DNA. Translation: CAI17938.1.
    AL109865 Genomic DNA. Translation: CAI17851.1. Sequence problems.
    CH471067 Genomic DNA. Translation: EAW91190.1.
    BC039738 mRNA. Translation: AAH39738.1. Sequence problems.
    BC045535 mRNA. Translation: AAH45535.1.
    AF163261 mRNA. Translation: AAQ13590.1. Different initiation.
    CCDSiCCDS1366.1. [Q7Z2T5-1]
    RefSeqiNP_001189352.1. NM_001202423.1.
    NP_112196.3. NM_030934.4. [Q7Z2T5-1]
    UniGeneiHs.107149.

    Genome annotation databases

    EnsembliENST00000367506; ENSP00000356476; ENSG00000121486. [Q7Z2T5-1]
    GeneIDi81627.
    KEGGihsa:81627.
    UCSCiuc001grf.4. human. [Q7Z2T5-1]

    Polymorphism databases

    DMDMi166988174.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288399 mRNA. Translation: AAG60618.1 .
    AK074936 mRNA. Translation: BAC11302.1 .
    AK074993 mRNA. Translation: BAC11341.1 .
    AK131460 mRNA. Translation: BAD18605.1 .
    AL109865 , AL136133 Genomic DNA. Translation: CAI17847.1 .
    AL136133 , AL109865 Genomic DNA. Translation: CAI17938.1 .
    AL109865 Genomic DNA. Translation: CAI17851.1 . Sequence problems.
    CH471067 Genomic DNA. Translation: EAW91190.1 .
    BC039738 mRNA. Translation: AAH39738.1 . Sequence problems.
    BC045535 mRNA. Translation: AAH45535.1 .
    AF163261 mRNA. Translation: AAQ13590.1 . Different initiation.
    CCDSi CCDS1366.1. [Q7Z2T5-1 ]
    RefSeqi NP_001189352.1. NM_001202423.1.
    NP_112196.3. NM_030934.4. [Q7Z2T5-1 ]
    UniGenei Hs.107149.

    3D structure databases

    ProteinModelPortali Q7Z2T5.
    SMRi Q7Z2T5. Positions 227-540.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123562. 13 interactions.
    IntActi Q7Z2T5. 2 interactions.
    MINTi MINT-5009710.
    STRINGi 9606.ENSP00000356476.

    PTM databases

    PhosphoSitei Q7Z2T5.

    Polymorphism databases

    DMDMi 166988174.

    Proteomic databases

    MaxQBi Q7Z2T5.
    PaxDbi Q7Z2T5.
    PeptideAtlasi Q7Z2T5.
    PRIDEi Q7Z2T5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367506 ; ENSP00000356476 ; ENSG00000121486 . [Q7Z2T5-1 ]
    GeneIDi 81627.
    KEGGi hsa:81627.
    UCSCi uc001grf.4. human. [Q7Z2T5-1 ]

    Organism-specific databases

    CTDi 81627.
    GeneCardsi GC01M185088.
    H-InvDB HIX0001421.
    HGNCi HGNC:16782. TRMT1L.
    HPAi HPA026728.
    HPA054464.
    MIMi 611673. gene.
    neXtProti NX_Q7Z2T5.
    PharmGKBi PA25612.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1867.
    HOGENOMi HOG000154681.
    HOVERGENi HBG057055.
    InParanoidi Q7Z2T5.
    OMAi IFESECT.
    OrthoDBi EOG7CCBQR.
    PhylomeDBi Q7Z2T5.
    TreeFami TF300851.

    Miscellaneous databases

    GenomeRNAii 81627.
    NextBioi 72006.
    PROi Q7Z2T5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7Z2T5.
    CleanExi HS_C1orf25.
    Genevestigatori Q7Z2T5.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR002905. Trm1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    PANTHERi PTHR10631. PTHR10631. 1 hit.
    Pfami PF02005. TRM. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51626. SAM_MT_TRM1. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus."
      Sood R., Bonner T.I., Malakowska I., Stephan D.A., Robbins C.M., Connors T.D., Morgenbesser S.D., Su K., Faruque M.U., Pinkett H., Graham C., Baxevanis A.D., Klinger K.W., Landes G.M., Trent J.M., Carpten J.D.
      Genomics 73:211-222(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Teratocarcinoma and Testis.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    6. Hui R.T.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 423-733.
      Tissue: Aorta.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTRM1L_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z2T5
    Secondary accession number(s): Q5TEN0
    , Q6ZMX0, Q8IWH5, Q8NC68, Q9BZQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3