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Protein

Leucine-rich repeat-containing protein 70

Gene

LRRC70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS).1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 70
Alternative name(s):
Synleurin
Gene namesi
Name:LRRC70
ORF Names:UNQ1891/PRO4337
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:35155. LRRC70.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei527 – 54721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164722127.

Polymorphism and mutation databases

BioMutaiLRRC70.
DMDMi74759111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 622591Leucine-rich repeat-containing protein 70PRO_0000317750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence analysis
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence analysis
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z2Q7.
PRIDEiQ7Z2Q7.

PTM databases

PhosphoSiteiQ7Z2Q7.

Expressioni

Tissue specificityi

Expressed at low levels in many tissues, including smooth muscle, brain, uterus, pancreas, cartilage, adipose, spleen and testis.1 Publication

Gene expression databases

BgeeiQ7Z2Q7.
ExpressionAtlasiQ7Z2Q7. baseline and differential.
GenevisibleiQ7Z2Q7. HS.

Organism-specific databases

HPAiHPA013409.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000399441.

Structurei

3D structure databases

ProteinModelPortaliQ7Z2Q7.
SMRiQ7Z2Q7. Positions 8-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 6029LRRNTAdd
BLAST
Repeati61 – 8222LRR 1Add
BLAST
Repeati85 – 10622LRR 2Add
BLAST
Repeati109 – 13022LRR 3Add
BLAST
Repeati133 – 15422LRR 4Add
BLAST
Repeati157 – 17822LRR 5Add
BLAST
Repeati181 – 20222LRR 6Add
BLAST
Repeati205 – 22622LRR 7Add
BLAST
Repeati229 – 25022LRR 8Add
BLAST
Repeati253 – 27422LRR 9Add
BLAST
Repeati277 – 29822LRR 10Add
BLAST
Repeati301 – 32222LRR 11Add
BLAST
Repeati326 – 34722LRR 12Add
BLAST
Domaini359 – 40648LRRCTAdd
BLAST

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113389.
InParanoidiQ7Z2Q7.
OMAiHHKTTAL.
OrthoDBiEOG7WHH9Z.
PhylomeDBiQ7Z2Q7.
TreeFamiTF331598.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z2Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGLQFSLPC LRLFLVVTCY LLLLLHKEIL GCSSVCQLCT GRQINCRNLG
60 70 80 90 100
LSSIPKNFPE STVFLYLTGN NISYINESEL TGLHSLVALY LDNSNILYVY
110 120 130 140 150
PKAFVQLRHL YFLFLNNNFI KRLDPGIFKG LLNLRNLYLQ YNQVSFVPRG
160 170 180 190 200
VFNDLVSVQY LNLQRNRLTV LGSGTFVGMV ALRILDLSNN NILRISESGF
210 220 230 240 250
QHLENLACLY LGSNNLTKVP SNAFEVLKSL RRLSLSHNPI EAIQPFAFKG
260 270 280 290 300
LANLEYLLLK NSRIRNVTRD GFSGINNLKH LILSHNDLEN LNSDTFSLLK
310 320 330 340 350
NLIYLKLDRN RIISIDNDTF ENMGASLKIL NLSFNNLTAL HPRVLKPLSS
360 370 380 390 400
LIHLQANSNP WECNCKLLGL RDWLASSAIT LNIYCQNPPS MRGRALRYIN
410 420 430 440 450
ITNCVTSSIN VSRAWAVVKS PHIHHKTTAL MMAWHKVTTN GSPLENTETE
460 470 480 490 500
NITFWERIPT SPAGRFFQEN AFGNPLETTA VLPVQIQLTT SVTLNLEKNS
510 520 530 540 550
ALPNDAASMS GKTSLICTQE VEKLNEAFDI LLAFFILACV LIIFLIYKVV
560 570 580 590 600
QFKQKLKASE NSRENRLEYY SFYQSARYNV TASICNTSPN SLESPGLEQI
610 620
RLHKQIVPEN EAQVILFEHS AL
Length:622
Mass (Da):70,301
Last modified:October 1, 2003 - v1
Checksum:i49D2EE78153F2C60
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti614 – 6141V → A in BAC85517 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280614 mRNA. Translation: AAP36706.1.
AY358733 mRNA. Translation: AAQ89095.1.
AK123022 mRNA. Translation: BAC85517.1.
CH471137 Genomic DNA. Translation: EAW51382.1.
CCDSiCCDS47218.1.
RefSeqiNP_852607.3. NM_181506.4.
UniGeneiHs.721348.

Genome annotation databases

EnsembliENST00000334994; ENSP00000399441; ENSG00000186105.
GeneIDi100130733.
KEGGihsa:100130733.
UCSCiuc011cqs.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280614 mRNA. Translation: AAP36706.1.
AY358733 mRNA. Translation: AAQ89095.1.
AK123022 mRNA. Translation: BAC85517.1.
CH471137 Genomic DNA. Translation: EAW51382.1.
CCDSiCCDS47218.1.
RefSeqiNP_852607.3. NM_181506.4.
UniGeneiHs.721348.

3D structure databases

ProteinModelPortaliQ7Z2Q7.
SMRiQ7Z2Q7. Positions 8-404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000399441.

PTM databases

PhosphoSiteiQ7Z2Q7.

Polymorphism and mutation databases

BioMutaiLRRC70.
DMDMi74759111.

Proteomic databases

PaxDbiQ7Z2Q7.
PRIDEiQ7Z2Q7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334994; ENSP00000399441; ENSG00000186105.
GeneIDi100130733.
KEGGihsa:100130733.
UCSCiuc011cqs.1. human.

Organism-specific databases

CTDi100130733.
GeneCardsiLRRC70.
HGNCiHGNC:35155. LRRC70.
HPAiHPA013409.
neXtProtiNX_Q7Z2Q7.
PharmGKBiPA164722127.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113389.
InParanoidiQ7Z2Q7.
OMAiHHKTTAL.
OrthoDBiEOG7WHH9Z.
PhylomeDBiQ7Z2Q7.
TreeFamiTF331598.

Miscellaneous databases

GenomeRNAii100130733.
NextBioi20789232.
PROiQ7Z2Q7.

Gene expression databases

BgeeiQ7Z2Q7.
ExpressionAtlasiQ7Z2Q7. baseline and differential.
GenevisibleiQ7Z2Q7. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses."
    Wang W., Yang Y., Li L., Shi Y.
    Biochem. Biophys. Res. Commun. 305:981-988(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLRR70_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2Q7
Secondary accession number(s): Q6ZWI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.