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Protein

Leucine-rich repeat-containing protein 70

Gene

LRRC70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS).1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-30808-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 70
Alternative name(s):
Synleurin
Gene namesi
Name:LRRC70
ORF Names:UNQ1891/PRO4337
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:35155. LRRC70.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186105.
PharmGKBiPA164722127.

Polymorphism and mutation databases

BioMutaiLRRC70.
DMDMi74759111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000031775032 – 622Leucine-rich repeat-containing protein 70Add BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi331N-linked (GlcNAc...)Sequence analysis1
Glycosylationi400N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z2Q7.
PRIDEiQ7Z2Q7.

PTM databases

iPTMnetiQ7Z2Q7.
PhosphoSitePlusiQ7Z2Q7.

Expressioni

Tissue specificityi

Expressed at low levels in many tissues, including smooth muscle, brain, uterus, pancreas, cartilage, adipose, spleen and testis.1 Publication

Gene expression databases

BgeeiENSG00000186105.
ExpressionAtlasiQ7Z2Q7. baseline and differential.
GenevisibleiQ7Z2Q7. HS.

Organism-specific databases

HPAiHPA013409.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000399441.

Structurei

3D structure databases

ProteinModelPortaliQ7Z2Q7.
SMRiQ7Z2Q7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 60LRRNTAdd BLAST29
Repeati61 – 82LRR 1Add BLAST22
Repeati85 – 106LRR 2Add BLAST22
Repeati109 – 130LRR 3Add BLAST22
Repeati133 – 154LRR 4Add BLAST22
Repeati157 – 178LRR 5Add BLAST22
Repeati181 – 202LRR 6Add BLAST22
Repeati205 – 226LRR 7Add BLAST22
Repeati229 – 250LRR 8Add BLAST22
Repeati253 – 274LRR 9Add BLAST22
Repeati277 – 298LRR 10Add BLAST22
Repeati301 – 322LRR 11Add BLAST22
Repeati326 – 347LRR 12Add BLAST22
Domaini359 – 406LRRCTAdd BLAST48

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113389.
InParanoidiQ7Z2Q7.
OMAiHHKTTAL.
OrthoDBiEOG091G035W.
PhylomeDBiQ7Z2Q7.
TreeFamiTF331598.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z2Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGLQFSLPC LRLFLVVTCY LLLLLHKEIL GCSSVCQLCT GRQINCRNLG
60 70 80 90 100
LSSIPKNFPE STVFLYLTGN NISYINESEL TGLHSLVALY LDNSNILYVY
110 120 130 140 150
PKAFVQLRHL YFLFLNNNFI KRLDPGIFKG LLNLRNLYLQ YNQVSFVPRG
160 170 180 190 200
VFNDLVSVQY LNLQRNRLTV LGSGTFVGMV ALRILDLSNN NILRISESGF
210 220 230 240 250
QHLENLACLY LGSNNLTKVP SNAFEVLKSL RRLSLSHNPI EAIQPFAFKG
260 270 280 290 300
LANLEYLLLK NSRIRNVTRD GFSGINNLKH LILSHNDLEN LNSDTFSLLK
310 320 330 340 350
NLIYLKLDRN RIISIDNDTF ENMGASLKIL NLSFNNLTAL HPRVLKPLSS
360 370 380 390 400
LIHLQANSNP WECNCKLLGL RDWLASSAIT LNIYCQNPPS MRGRALRYIN
410 420 430 440 450
ITNCVTSSIN VSRAWAVVKS PHIHHKTTAL MMAWHKVTTN GSPLENTETE
460 470 480 490 500
NITFWERIPT SPAGRFFQEN AFGNPLETTA VLPVQIQLTT SVTLNLEKNS
510 520 530 540 550
ALPNDAASMS GKTSLICTQE VEKLNEAFDI LLAFFILACV LIIFLIYKVV
560 570 580 590 600
QFKQKLKASE NSRENRLEYY SFYQSARYNV TASICNTSPN SLESPGLEQI
610 620
RLHKQIVPEN EAQVILFEHS AL
Length:622
Mass (Da):70,301
Last modified:October 1, 2003 - v1
Checksum:i49D2EE78153F2C60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti614V → A in BAC85517 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280614 mRNA. Translation: AAP36706.1.
AY358733 mRNA. Translation: AAQ89095.1.
AK123022 mRNA. Translation: BAC85517.1.
CH471137 Genomic DNA. Translation: EAW51382.1.
CCDSiCCDS47218.1.
RefSeqiNP_852607.3. NM_181506.4.
UniGeneiHs.721348.

Genome annotation databases

EnsembliENST00000334994; ENSP00000399441; ENSG00000186105.
GeneIDi100130733.
KEGGihsa:100130733.
UCSCiuc011cqs.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280614 mRNA. Translation: AAP36706.1.
AY358733 mRNA. Translation: AAQ89095.1.
AK123022 mRNA. Translation: BAC85517.1.
CH471137 Genomic DNA. Translation: EAW51382.1.
CCDSiCCDS47218.1.
RefSeqiNP_852607.3. NM_181506.4.
UniGeneiHs.721348.

3D structure databases

ProteinModelPortaliQ7Z2Q7.
SMRiQ7Z2Q7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000399441.

PTM databases

iPTMnetiQ7Z2Q7.
PhosphoSitePlusiQ7Z2Q7.

Polymorphism and mutation databases

BioMutaiLRRC70.
DMDMi74759111.

Proteomic databases

PaxDbiQ7Z2Q7.
PRIDEiQ7Z2Q7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334994; ENSP00000399441; ENSG00000186105.
GeneIDi100130733.
KEGGihsa:100130733.
UCSCiuc011cqs.1. human.

Organism-specific databases

CTDi100130733.
GeneCardsiLRRC70.
HGNCiHGNC:35155. LRRC70.
HPAiHPA013409.
neXtProtiNX_Q7Z2Q7.
OpenTargetsiENSG00000186105.
PharmGKBiPA164722127.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113389.
InParanoidiQ7Z2Q7.
OMAiHHKTTAL.
OrthoDBiEOG091G035W.
PhylomeDBiQ7Z2Q7.
TreeFamiTF331598.

Enzyme and pathway databases

BioCyciZFISH:G66-30808-MONOMER.

Miscellaneous databases

GenomeRNAii100130733.
PROiQ7Z2Q7.

Gene expression databases

BgeeiENSG00000186105.
ExpressionAtlasiQ7Z2Q7. baseline and differential.
GenevisibleiQ7Z2Q7. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRR70_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2Q7
Secondary accession number(s): Q6ZWI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.