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Protein

G protein-regulated inducer of neurite outgrowth 1

Gene

GPRIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in neurite outgrowth.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-regulated inducer of neurite outgrowth 1
Short name:
GRIN1
Gene namesi
Name:GPRIN1
Synonyms:KIAA1893
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24835. GPRIN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390183.

Chemistry

ChEMBLiCHEMBL5266.

Polymorphism and mutation databases

BioMutaiGPRIN1.
DMDMi296434528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10081008G protein-regulated inducer of neurite outgrowth 1PRO_0000235977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei237 – 2371PhosphoserineBy similarity
Modified residuei799 – 7991PhosphoserineBy similarity
Modified residuei877 – 8771PhosphothreonineBy similarity
Modified residuei895 – 8951PhosphoserineBy similarity
Modified residuei914 – 9141PhosphoserineBy similarity
Lipidationi999 – 9991S-palmitoyl cysteineBy similarity
Lipidationi1000 – 10001S-palmitoyl cysteineBy similarity

Post-translational modificationi

Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ7Z2K8.
MaxQBiQ7Z2K8.
PaxDbiQ7Z2K8.
PRIDEiQ7Z2K8.

PTM databases

iPTMnetiQ7Z2K8.
PhosphoSiteiQ7Z2K8.

Expressioni

Tissue specificityi

Widely expressed in the central nervous system, with highest levels in spinal cord.1 Publication

Gene expression databases

BgeeiQ7Z2K8.
CleanExiHS_GPRIN1.
GenevisibleiQ7Z2K8. HS.

Organism-specific databases

HPAiHPA036479.

Interactioni

Subunit structurei

Interacts with activated forms of GNAI1, GNAO1 and GNAZ.By similarity

Protein-protein interaction databases

BioGridi125349. 12 interactions.
IntActiQ7Z2K8. 3 interactions.
STRINGi9606.ENSP00000305839.

Structurei

3D structure databases

ProteinModelPortaliQ7Z2K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni899 – 1008110Interaction with GNAO1By similarityAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IJTD. Eukaryota.
ENOG410YQX7. LUCA.
GeneTreeiENSGT00570000079168.
HOGENOMiHOG000112813.
HOVERGENiHBG081574.
InParanoidiQ7Z2K8.
OMAiTKAPSWE.
OrthoDBiEOG7034G5.
PhylomeDBiQ7Z2K8.
TreeFamiTF337047.

Family and domain databases

InterProiIPR032745. GRIN_C.
[Graphical view]
PfamiPF15235. GRIN_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z2K8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTAEDPAWL QLLQKDSSPP GPRPTAFFCP QDGSLGAGSS AMRDYCPSQQ
60 70 80 90 100
KASPAPPRHT PDQSPGMESR HRSPSGAGEG ASCSDGPRGS LACPSPTCFS
110 120 130 140 150
PQESPSKETL EAHGASISGT PEATTSGKPE PVSSVKTEPK SSDDRNPMFL
160 170 180 190 200
EKMDFKSSKQ ADSTSIGKED PGSSRKADPM FTGKAEPEIL GKGDPVAPGR
210 220 230 240 250
MDPMTVRKED LGSLGKVDPL CSSKTYTVSP RKEDPGSLRK VDPVSSDKVD
260 270 280 290 300
PVFPRKEEPR YSGKEHPVSS EKVAPTSAEK VDLVLSGKRD PGPSGKADPM
310 320 330 340 350
PLESMDSAST GKTEPGLLGK LIPGSSGKNG PVSSGTGAPG SLGRLDPTCL
360 370 380 390 400
GMADPASVGN VETVPATKED SRFLGKMDPA SSGEGRPVSG HTDTTASAKT
410 420 430 440 450
DLTSLKNVDP MSSGKVDPVS LGKMDPMCSG KPELLSPGQA ERVSVGKAGT
460 470 480 490 500
VSPGKEDPVS SRREDPISAG SRKTSSEKVN PESSGKTNPV SSGPGDPRSL
510 520 530 540 550
GTAGPPSAVK AEPATGGKGD PLSSEKAGLV ASGKAAPTAS GKAEPLAVGK
560 570 580 590 600
EDPVSKGKAD AGPSGQGDSV SIGKVVSTPG KTVPVPSGKV DPVSLGKAEA
610 620 630 640 650
IPEGKVGSLP LEKGSPVTTT KADPRASGKA QPQSGGKAET KLPGQEGAAA
660 670 680 690 700
PGEAGAVCLK KETPQASEKV DPGSCRKAEP LASGKGEPVS LGKADSAPSR
710 720 730 740 750
KTESPSLGKV VPLSLEKTKP SSSSRQLDRK ALGSARSPEG ARGSEGRVEP
760 770 780 790 800
KAEPVSSTEA SSLGQKDLEA AGAERSPCPE AAAPPPGPRT RDNFTKAPSW
810 820 830 840 850
EASAPPPPRE DAGTQAGAQA CVSVAVSPMS PQDGAGGSAF SFQAAPRAPS
860 870 880 890 900
PPSRRDAGLQ VSLGAAETRS VATGPMTPQA AAPPAFPEVR VRPGSALAAA
910 920 930 940 950
VAPPEPAEPV RDVSWDEKGM TWEVYGAAME VEVLGMAIQK HLERQIEEHG
960 970 980 990 1000
RQGAPAPPPA ARAGPGRSGS VRTAPPDGAA KRPPGLFRAL LQSVRRPRCC

SRAGPTAE
Length:1,008
Mass (Da):102,399
Last modified:May 18, 2010 - v2
Checksum:iDA4AAED9917E570E
GO
Isoform 2 (identifier: Q7Z2K8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     748-798: VEPKAEPVSS...RTRDNFTKAP → QASARPVPRA...SQAPFLITGP
     799-1008: Missing.

Show »
Length:798
Mass (Da):80,948
Checksum:iB8E73BED0226E863
GO

Sequence cautioni

The sequence BAB67786.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 2388Missing in CAD38868 (PubMed:17974005).Curated
Sequence conflicti680 – 6801P → A in CAD38868 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211P → T.1 Publication
Corresponds to variant rs17854765 [ dbSNP | Ensembl ].
VAR_063136
Natural varianti300 – 3001M → V.3 Publications
Corresponds to variant rs6556276 [ dbSNP | Ensembl ].
VAR_063137
Natural varianti337 – 3371G → A.
Corresponds to variant rs10037225 [ dbSNP | Ensembl ].
VAR_056902
Natural varianti357 – 3571S → P.
Corresponds to variant rs34285890 [ dbSNP | Ensembl ].
VAR_056903

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei748 – 79851VEPKA…FTKAP → QASARPVPRAAAECAPAAVL LAGGTHGRVICPHFVRPSFR PSQAPFLITGP in isoform 2. 1 PublicationVSP_018546Add
BLAST
Alternative sequencei799 – 1008210Missing in isoform 2. 1 PublicationVSP_018547Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067480 mRNA. Translation: BAB67786.1. Different initiation.
AC091934 Genomic DNA. No translation available.
BC052950 mRNA. Translation: AAH52950.1.
AL834165 mRNA. Translation: CAD38868.1.
CCDSiCCDS4405.1. [Q7Z2K8-1]
RefSeqiNP_443131.2. NM_052899.2. [Q7Z2K8-1]
XP_005265863.1. XM_005265806.3. [Q7Z2K8-1]
UniGeneiHs.150549.

Genome annotation databases

EnsembliENST00000303991; ENSP00000305839; ENSG00000169258. [Q7Z2K8-1]
GeneIDi114787.
KEGGihsa:114787.
UCSCiuc003meo.2. human. [Q7Z2K8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067480 mRNA. Translation: BAB67786.1. Different initiation.
AC091934 Genomic DNA. No translation available.
BC052950 mRNA. Translation: AAH52950.1.
AL834165 mRNA. Translation: CAD38868.1.
CCDSiCCDS4405.1. [Q7Z2K8-1]
RefSeqiNP_443131.2. NM_052899.2. [Q7Z2K8-1]
XP_005265863.1. XM_005265806.3. [Q7Z2K8-1]
UniGeneiHs.150549.

3D structure databases

ProteinModelPortaliQ7Z2K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125349. 12 interactions.
IntActiQ7Z2K8. 3 interactions.
STRINGi9606.ENSP00000305839.

Chemistry

ChEMBLiCHEMBL5266.

PTM databases

iPTMnetiQ7Z2K8.
PhosphoSiteiQ7Z2K8.

Polymorphism and mutation databases

BioMutaiGPRIN1.
DMDMi296434528.

Proteomic databases

EPDiQ7Z2K8.
MaxQBiQ7Z2K8.
PaxDbiQ7Z2K8.
PRIDEiQ7Z2K8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303991; ENSP00000305839; ENSG00000169258. [Q7Z2K8-1]
GeneIDi114787.
KEGGihsa:114787.
UCSCiuc003meo.2. human. [Q7Z2K8-1]

Organism-specific databases

CTDi114787.
GeneCardsiGPRIN1.
H-InvDBHIX0200714.
HGNCiHGNC:24835. GPRIN1.
HPAiHPA036479.
MIMi611239. gene.
neXtProtiNX_Q7Z2K8.
PharmGKBiPA162390183.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJTD. Eukaryota.
ENOG410YQX7. LUCA.
GeneTreeiENSGT00570000079168.
HOGENOMiHOG000112813.
HOVERGENiHBG081574.
InParanoidiQ7Z2K8.
OMAiTKAPSWE.
OrthoDBiEOG7034G5.
PhylomeDBiQ7Z2K8.
TreeFamiTF337047.

Miscellaneous databases

GenomeRNAii114787.
PROiQ7Z2K8.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z2K8.
CleanExiHS_GPRIN1.
GenevisibleiQ7Z2K8. HS.

Family and domain databases

InterProiIPR032745. GRIN_C.
[Graphical view]
PfamiPF15235. GRIN_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-300.
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-121 AND VAL-300.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 183-897 (ISOFORM 1), VARIANT VAL-300.
    Tissue: Brain.
  5. "A candidate target for G protein action in brain."
    Chen L.T., Gilman A.G., Kozasa T.
    J. Biol. Chem. 274:26931-26938(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGRIN1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2K8
Secondary accession number(s): C9JM70, Q8ND74, Q96PZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.