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Protein

G protein-regulated inducer of neurite outgrowth 1

Gene

GPRIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in neurite outgrowth.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-regulated inducer of neurite outgrowth 1
Short name:
GRIN1
Gene namesi
Name:GPRIN1
Synonyms:KIAA1893
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000169258.6
HGNCiHGNC:24835 GPRIN1
MIMi611239 gene
neXtProtiNX_Q7Z2K8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169258
PharmGKBiPA162390183

Chemistry databases

ChEMBLiCHEMBL5266

Polymorphism and mutation databases

BioMutaiGPRIN1
DMDMi296434528

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002359771 – 1008G protein-regulated inducer of neurite outgrowth 1Add BLAST1008

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphothreonineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei237PhosphoserineBy similarity1
Modified residuei436PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei615PhosphoserineCombined sources1
Modified residuei737PhosphoserineCombined sources1
Modified residuei799PhosphoserineBy similarity1
Modified residuei877PhosphothreonineBy similarity1
Modified residuei895PhosphoserineBy similarity1
Modified residuei914PhosphoserineBy similarity1
Modified residuei993PhosphoserineCombined sources1
Lipidationi999S-palmitoyl cysteineBy similarity1
Lipidationi1000S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ7Z2K8
MaxQBiQ7Z2K8
PaxDbiQ7Z2K8
PeptideAtlasiQ7Z2K8
PRIDEiQ7Z2K8

PTM databases

iPTMnetiQ7Z2K8
PhosphoSitePlusiQ7Z2K8

Expressioni

Tissue specificityi

Widely expressed in the central nervous system, with highest levels in spinal cord.1 Publication

Gene expression databases

BgeeiENSG00000169258
CleanExiHS_GPRIN1
GenevisibleiQ7Z2K8 HS

Organism-specific databases

HPAiHPA036478
HPA070892

Interactioni

Subunit structurei

Interacts with activated forms of GNAI1, GNAO1 and GNAZ.By similarity

Protein-protein interaction databases

BioGridi125349, 19 interactors
IntActiQ7Z2K8, 5 interactors
STRINGi9606.ENSP00000305839

Structurei

3D structure databases

ProteinModelPortaliQ7Z2K8
SMRiQ7Z2K8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni899 – 1008Interaction with GNAO1By similarityAdd BLAST110

Phylogenomic databases

eggNOGiENOG410IJTD Eukaryota
ENOG410YQX7 LUCA
GeneTreeiENSGT00570000079168
HOGENOMiHOG000112813
HOVERGENiHBG081574
InParanoidiQ7Z2K8
OMAiFTKAPSW
OrthoDBiEOG091G037S
PhylomeDBiQ7Z2K8
TreeFamiTF337047

Family and domain databases

InterProiView protein in InterPro
IPR032745 GRIN_C
PfamiView protein in Pfam
PF15235 GRIN_C, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z2K8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTAEDPAWL QLLQKDSSPP GPRPTAFFCP QDGSLGAGSS AMRDYCPSQQ
60 70 80 90 100
KASPAPPRHT PDQSPGMESR HRSPSGAGEG ASCSDGPRGS LACPSPTCFS
110 120 130 140 150
PQESPSKETL EAHGASISGT PEATTSGKPE PVSSVKTEPK SSDDRNPMFL
160 170 180 190 200
EKMDFKSSKQ ADSTSIGKED PGSSRKADPM FTGKAEPEIL GKGDPVAPGR
210 220 230 240 250
MDPMTVRKED LGSLGKVDPL CSSKTYTVSP RKEDPGSLRK VDPVSSDKVD
260 270 280 290 300
PVFPRKEEPR YSGKEHPVSS EKVAPTSAEK VDLVLSGKRD PGPSGKADPM
310 320 330 340 350
PLESMDSAST GKTEPGLLGK LIPGSSGKNG PVSSGTGAPG SLGRLDPTCL
360 370 380 390 400
GMADPASVGN VETVPATKED SRFLGKMDPA SSGEGRPVSG HTDTTASAKT
410 420 430 440 450
DLTSLKNVDP MSSGKVDPVS LGKMDPMCSG KPELLSPGQA ERVSVGKAGT
460 470 480 490 500
VSPGKEDPVS SRREDPISAG SRKTSSEKVN PESSGKTNPV SSGPGDPRSL
510 520 530 540 550
GTAGPPSAVK AEPATGGKGD PLSSEKAGLV ASGKAAPTAS GKAEPLAVGK
560 570 580 590 600
EDPVSKGKAD AGPSGQGDSV SIGKVVSTPG KTVPVPSGKV DPVSLGKAEA
610 620 630 640 650
IPEGKVGSLP LEKGSPVTTT KADPRASGKA QPQSGGKAET KLPGQEGAAA
660 670 680 690 700
PGEAGAVCLK KETPQASEKV DPGSCRKAEP LASGKGEPVS LGKADSAPSR
710 720 730 740 750
KTESPSLGKV VPLSLEKTKP SSSSRQLDRK ALGSARSPEG ARGSEGRVEP
760 770 780 790 800
KAEPVSSTEA SSLGQKDLEA AGAERSPCPE AAAPPPGPRT RDNFTKAPSW
810 820 830 840 850
EASAPPPPRE DAGTQAGAQA CVSVAVSPMS PQDGAGGSAF SFQAAPRAPS
860 870 880 890 900
PPSRRDAGLQ VSLGAAETRS VATGPMTPQA AAPPAFPEVR VRPGSALAAA
910 920 930 940 950
VAPPEPAEPV RDVSWDEKGM TWEVYGAAME VEVLGMAIQK HLERQIEEHG
960 970 980 990 1000
RQGAPAPPPA ARAGPGRSGS VRTAPPDGAA KRPPGLFRAL LQSVRRPRCC

SRAGPTAE
Length:1,008
Mass (Da):102,399
Last modified:May 18, 2010 - v2
Checksum:iDA4AAED9917E570E
GO
Isoform 2 (identifier: Q7Z2K8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     748-798: VEPKAEPVSS...RTRDNFTKAP → QASARPVPRA...SQAPFLITGP
     799-1008: Missing.

Show »
Length:798
Mass (Da):80,948
Checksum:iB8E73BED0226E863
GO

Sequence cautioni

The sequence BAB67786 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231 – 238Missing in CAD38868 (PubMed:17974005).Curated8
Sequence conflicti680P → A in CAD38868 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063136121P → T1 PublicationCorresponds to variant dbSNP:rs17854765Ensembl.1
Natural variantiVAR_063137300M → V3 PublicationsCorresponds to variant dbSNP:rs6556276Ensembl.1
Natural variantiVAR_056902337G → A. Corresponds to variant dbSNP:rs10037225Ensembl.1
Natural variantiVAR_056903357S → P. Corresponds to variant dbSNP:rs34285890Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018546748 – 798VEPKA…FTKAP → QASARPVPRAAAECAPAAVL LAGGTHGRVICPHFVRPSFR PSQAPFLITGP in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_018547799 – 1008Missing in isoform 2. 1 PublicationAdd BLAST210

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067480 mRNA Translation: BAB67786.1 Different initiation.
AC091934 Genomic DNA No translation available.
BC052950 mRNA Translation: AAH52950.1
AL834165 mRNA Translation: CAD38868.1
CCDSiCCDS4405.1 [Q7Z2K8-1]
RefSeqiNP_443131.2, NM_052899.2 [Q7Z2K8-1]
UniGeneiHs.150549

Genome annotation databases

EnsembliENST00000303991; ENSP00000305839; ENSG00000169258 [Q7Z2K8-1]
GeneIDi114787
KEGGihsa:114787
UCSCiuc003meo.2 human [Q7Z2K8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGRIN1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2K8
Secondary accession number(s): C9JM70, Q8ND74, Q96PZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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