Q7Z2K6 (ERMP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endoplasmic reticulum metallopeptidase 1
EC=3.4.-.-

Alternative name(s):
Felix-ina

Gene names

Name:	ERMP1
Synonyms:	FXNA, KIAA1815

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	904 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures By similarity.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the peptidase M28 family.
Sequence caution	The sequence BAB15604.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 904	904	Endoplasmic reticulum metallopeptidase 1		PRO_0000259492
Regions
	Topological domain	1 – 63	63	Cytoplasmic Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Topological domain	85 – 399	315	Extracellular Potential
	Transmembrane	400 – 420	21	Helical; Potential
	Topological domain	421 – 457	37	Cytoplasmic Potential
	Transmembrane	458 – 478	21	Helical; Potential
	Topological domain	479 – 489	11	Extracellular Potential
	Transmembrane	490 – 510	21	Helical; Potential
	Topological domain	511 – 519	9	Cytoplasmic Potential
	Transmembrane	520 – 540	21	Helical; Potential
	Topological domain	541	1	Extracellular Potential
	Transmembrane	542 – 562	21	Helical; Potential
	Topological domain	563 – 579	17	Cytoplasmic Potential
	Transmembrane	580 – 600	21	Helical; Potential
	Topological domain	601 – 621	21	Extracellular Potential
	Transmembrane	622 – 642	21	Helical; Potential
	Topological domain	643 – 651	9	Cytoplasmic Potential
	Transmembrane	652 – 672	21	Helical; Potential
	Topological domain	673 – 904	232	Extracellular Potential
Sites
	Active site	207	1	By similarity
	Active site	251	1	By similarity
	Metal binding	205	1	Zinc 2 By similarity
	Metal binding	217	1	Zinc 1 By similarity
	Metal binding	217	1	Zinc 2 By similarity
	Metal binding	252	1	Zinc 1 By similarity
	Metal binding	278	1	Zinc 2 By similarity
	Metal binding	354	1	Zinc 1 By similarity
Amino acid modifications
	Modified residue	66	1	Phosphothreonine By similarity
	Modified residue	69	1	Phosphoserine By similarity
	Glycosylation	182	1	N-linked (GlcNAc...) Potential
	Glycosylation	730	1	N-linked (GlcNAc...) Ref.5
	Disulfide bond	204 ↔ 222		By similarity
Natural variations
	Natural variant	44	1	S → N. Corresponds to variant rs13284203 [ dbSNP | Ensembl ].		VAR_028945
Experimental info
	Sequence conflict	728	1	E → A in BAB15604. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q7Z2K6 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 3A723027C53092EF	FASTA	904	100,231
	10 20 30 40 50 60 MEWGSESAAV RRHRVGVERR EGAAAAPPPE REARAQEPLV DGCSGGGRTR KRSPGGSGGA 70 80 90 100 110 120 SRGAGTGLSE VRAALGLALY LIALRTLVQL SLQQLVLRGA AGHRGEFDAL QARDYLEHIT 130 140 150 160 170 180 SIGPRTTGSP ENEILTVHYL LEQIKLIEVQ SNSLHKISVD VQRPTGSFSI DFLGGFTSYY 190 200 210 220 230 240 DNITNVVVKL EPRDGAQHAV LANCHFDSVA NSPGASDDAV SCSVMLEVLR VLSTSSEALH 250 260 270 280 290 300 HAVIFLFNGA EENVLQASHG FITQHPWASL IRAFINLEAA GVGGKELVFQ TGPENPWLVQ 310 320 330 340 350 360 AYVSAAKHPF ASVVAQEVFQ SGIIPSDTDF RIYRDFGNIP GIDLAFIENG YIYHTKYDTA 370 380 390 400 410 420 DRILTDSIQR AGDNILAVLK HLATSDMLAA ASKYRHGNMV FFDVLGLFVI AYPSRIGSII 430 440 450 460 470 480 NYMVVMGVVL YLGKKFLQPK HKTGNYKKDF LCGLGITLIS WFTSLVTVLI IAVFISLIGQ 490 500 510 520 530 540 SLSWYNHFYV SVCLYGTATV AKIILIHTLA KRFYYMNASA QYLGEVFFDI SLFVHCCFLV 550 560 570 580 590 600 TLTYQGLCSA FISAVWVAFP LLTKLCVHKD FKQHGAQGKF IAFYLLGMFI PYLYALYLIW 610 620 630 640 650 660 AVFEMFTPIL GRSGSEIPPD VVLASILAGC TMILSSYFIN FIYLAKSTKK TMLTLTLVCA 670 680 690 700 710 720 ITFLLVCSGT FFPYSSNPAN PKPKRVFLQH MTRTFHDLEG NAVKRDSGIW INGFDYTGIS 730 740 750 760 770 780 HITPHIPEIN DSIRAHCEEN APLCGFPWYL PVHFLIRKNW YLPAPEVSPR NPPHFRLISK 790 800 810 820 830 840 EQTPWDSIKL TFEATGPSHM SFYVRAHKGS TLSQWSLGNG TPVTSKGGDY FVFYSHGLQA 850 860 870 880 890 900 SAWQFWIEVQ VSEEHPEGMV TVAIAAHYLS GEDKRSPQLD ALKEKFPDWT FPSAWVCTYD LFVF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hepatoma and Hippocampus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-904. Tissue: Brain.
[4]	Ohara O., Nagase T., Kikuno R. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-730, MASS SPECTROMETRY. Tissue: Liver.
[6]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK026962 mRNA. Translation: BAB15604.1. Different initiation. AK127218 mRNA. Translation: BAG54455.1. BC031630 mRNA. Translation: AAH31630.2. BC136771 mRNA. Translation: AAI36772.1. BC136773 mRNA. Translation: AAI36774.1. AB058718 mRNA. Translation: BAB47444.2.
IPI	IPI00257903.
RefSeq	NP_079172.2. NM_024896.2.
UniGene	Hs.591078.
3D structure databases
ProteinModelPortal	Q7Z2K6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000340427.
Protein family/group databases
MEROPS	M28.018.
PTM databases
PhosphoSite	Q7Z2K6.
Polymorphism databases
DMDM	117949602.
Proteomic databases
PaxDb	Q7Z2K6.
PeptideAtlas	Q7Z2K6.
PRIDE	Q7Z2K6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339450; ENSP00000340427; ENSG00000099219. ENST00000462592; ENSP00000417160; ENSG00000099219.
GeneID	79956.
KEGG	hsa:79956.
UCSC	uc003zjm.1. human.
Organism-specific databases
CTD	79956.
GeneCards	GC09M005756.
H-InvDB	HIX0007903.
HGNC	HGNC:23703. ERMP1.
HPA	HPA020584.
MIM	611156. gene.
neXtProt	NX_Q7Z2K6.
PharmGKB	PA162385366.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2234.
HOGENOM	HOG000230679.
HOVERGEN	HBG096075.
InParanoid	Q7Z2K6.
OMA	LQHMTRT.
OrthoDB	EOG4BK535.
PhylomeDB	Q7Z2K6.
Gene expression databases
ArrayExpress	Q7Z2K6.
Bgee	Q7Z2K6.
CleanEx	HS_ERMP1.
Genevestigator	Q7Z2K6.
GermOnline	ENSG00000099219. Homo sapiens.
Family and domain databases
InterPro	IPR007484. Peptidase_M28. [Graphical view]
Pfam	PF04389. Peptidase_M28. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79956.
NextBio	69937.
SOURCE	Search...

Entry information

Entry name

ERMP1_HUMAN

Accession

Primary (citable) accession number: Q7Z2K6
Secondary accession number(s): B2RNA4, Q8N5T5, Q9H5M1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	May 1, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.