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Q7Z2K6 (ERMP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endoplasmic reticulum metallopeptidase 1

EC=3.4.-.-
Alternative name(s):
Felix-ina
Gene names
Name:ERMP1
Synonyms:FXNA, KIAA1815
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length904 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures By similarity.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the peptidase M28 family.

Sequence caution

The sequence BAB15604.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 904904Endoplasmic reticulum metallopeptidase 1
PRO_0000259492

Regions

Topological domain1 – 6363Cytoplasmic Potential
Transmembrane64 – 8421Helical; Potential
Topological domain85 – 399315Extracellular Potential
Transmembrane400 – 42021Helical; Potential
Topological domain421 – 45737Cytoplasmic Potential
Transmembrane458 – 47821Helical; Potential
Topological domain479 – 48911Extracellular Potential
Transmembrane490 – 51021Helical; Potential
Topological domain511 – 5199Cytoplasmic Potential
Transmembrane520 – 54021Helical; Potential
Topological domain5411Extracellular Potential
Transmembrane542 – 56221Helical; Potential
Topological domain563 – 57917Cytoplasmic Potential
Transmembrane580 – 60021Helical; Potential
Topological domain601 – 62121Extracellular Potential
Transmembrane622 – 64221Helical; Potential
Topological domain643 – 6519Cytoplasmic Potential
Transmembrane652 – 67221Helical; Potential
Topological domain673 – 904232Extracellular Potential

Sites

Active site2071 By similarity
Active site2511 By similarity
Metal binding2051Zinc 1 By similarity
Metal binding2171Zinc 1 By similarity
Metal binding2171Zinc 2; catalytic By similarity
Metal binding2521Zinc 2; catalytic By similarity
Metal binding2781Zinc 1 By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.7
Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation7301N-linked (GlcNAc...) Ref.5
Disulfide bond204 ↔ 222 By similarity

Natural variations

Natural variant441S → N.
Corresponds to variant rs13284203 [ dbSNP | Ensembl ].
VAR_028945

Experimental info

Sequence conflict7281E → A in BAB15604. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7Z2K6 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: 3A723027C53092EF

FASTA904100,231
        10         20         30         40         50         60 
MEWGSESAAV RRHRVGVERR EGAAAAPPPE REARAQEPLV DGCSGGGRTR KRSPGGSGGA 

        70         80         90        100        110        120 
SRGAGTGLSE VRAALGLALY LIALRTLVQL SLQQLVLRGA AGHRGEFDAL QARDYLEHIT 

       130        140        150        160        170        180 
SIGPRTTGSP ENEILTVHYL LEQIKLIEVQ SNSLHKISVD VQRPTGSFSI DFLGGFTSYY 

       190        200        210        220        230        240 
DNITNVVVKL EPRDGAQHAV LANCHFDSVA NSPGASDDAV SCSVMLEVLR VLSTSSEALH 

       250        260        270        280        290        300 
HAVIFLFNGA EENVLQASHG FITQHPWASL IRAFINLEAA GVGGKELVFQ TGPENPWLVQ 

       310        320        330        340        350        360 
AYVSAAKHPF ASVVAQEVFQ SGIIPSDTDF RIYRDFGNIP GIDLAFIENG YIYHTKYDTA 

       370        380        390        400        410        420 
DRILTDSIQR AGDNILAVLK HLATSDMLAA ASKYRHGNMV FFDVLGLFVI AYPSRIGSII 

       430        440        450        460        470        480 
NYMVVMGVVL YLGKKFLQPK HKTGNYKKDF LCGLGITLIS WFTSLVTVLI IAVFISLIGQ 

       490        500        510        520        530        540 
SLSWYNHFYV SVCLYGTATV AKIILIHTLA KRFYYMNASA QYLGEVFFDI SLFVHCCFLV 

       550        560        570        580        590        600 
TLTYQGLCSA FISAVWVAFP LLTKLCVHKD FKQHGAQGKF IAFYLLGMFI PYLYALYLIW 

       610        620        630        640        650        660 
AVFEMFTPIL GRSGSEIPPD VVLASILAGC TMILSSYFIN FIYLAKSTKK TMLTLTLVCA 

       670        680        690        700        710        720 
ITFLLVCSGT FFPYSSNPAN PKPKRVFLQH MTRTFHDLEG NAVKRDSGIW INGFDYTGIS 

       730        740        750        760        770        780 
HITPHIPEIN DSIRAHCEEN APLCGFPWYL PVHFLIRKNW YLPAPEVSPR NPPHFRLISK 

       790        800        810        820        830        840 
EQTPWDSIKL TFEATGPSHM SFYVRAHKGS TLSQWSLGNG TPVTSKGGDY FVFYSHGLQA 

       850        860        870        880        890        900 
SAWQFWIEVQ VSEEHPEGMV TVAIAAHYLS GEDKRSPQLD ALKEKFPDWT FPSAWVCTYD 


LFVF 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hepatoma and Hippocampus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-904.
Tissue: Brain.
[4]Ohara O., Nagase T., Kikuno R.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[5]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-730.
Tissue: Liver.
[6]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK026962 mRNA. Translation: BAB15604.1. Different initiation.
AK127218 mRNA. Translation: BAG54455.1.
BC031630 mRNA. Translation: AAH31630.2.
BC136771 mRNA. Translation: AAI36772.1.
BC136773 mRNA. Translation: AAI36774.1.
AB058718 mRNA. Translation: BAB47444.2.
CCDSCCDS34983.1.
RefSeqNP_079172.2. NM_024896.2.
UniGeneHs.591078.

3D structure databases

ProteinModelPortalQ7Z2K6.
SMRQ7Z2K6. Positions 185-373.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123025. 3 interactions.
STRING9606.ENSP00000340427.

Protein family/group databases

MEROPSM28.018.

PTM databases

PhosphoSiteQ7Z2K6.

Polymorphism databases

DMDM117949602.

Proteomic databases

MaxQBQ7Z2K6.
PaxDbQ7Z2K6.
PeptideAtlasQ7Z2K6.
PRIDEQ7Z2K6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339450; ENSP00000340427; ENSG00000099219.
ENST00000462592; ENSP00000417160; ENSG00000099219.
GeneID79956.
KEGGhsa:79956.
UCSCuc003zjm.1. human.

Organism-specific databases

CTD79956.
GeneCardsGC09M005756.
H-InvDBHIX0007903.
HGNCHGNC:23703. ERMP1.
HPAHPA020584.
MIM611156. gene.
neXtProtNX_Q7Z2K6.
PharmGKBPA162385366.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2234.
HOGENOMHOG000230679.
HOVERGENHBG096075.
InParanoidQ7Z2K6.
OMAGKFIAFY.
OrthoDBEOG78H3TS.
PhylomeDBQ7Z2K6.
TreeFamTF314836.

Gene expression databases

ArrayExpressQ7Z2K6.
BgeeQ7Z2K6.
CleanExHS_ERMP1.
GenevestigatorQ7Z2K6.

Family and domain databases

InterProIPR007484. Peptidase_M28.
[Graphical view]
PfamPF04389. Peptidase_M28. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79956.
NextBio69937.
PROQ7Z2K6.
SOURCESearch...

Entry information

Entry nameERMP1_HUMAN
AccessionPrimary (citable) accession number: Q7Z2K6
Secondary accession number(s): B2RNA4, Q8N5T5, Q9H5M1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM