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Protein

Proton-coupled amino acid transporter 1

Gene

SLC36A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.
R-HSA-428559. Proton-coupled neutral amino acid transporters.

Protein family/group databases

TCDBi2.A.18.8.7. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-coupled amino acid transporter 1
Short name:
Proton/amino acid transporter 1
Short name:
hPAT1
Alternative name(s):
Solute carrier family 36 member 1
Gene namesi
Name:SLC36A1
Synonyms:PAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:18761. SLC36A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini73 – 78ExtracellularSequence analysis6
Transmembranei79 – 99Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini100 – 141CytoplasmicSequence analysisAdd BLAST42
Transmembranei142 – 162Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini163 – 190ExtracellularSequence analysisAdd BLAST28
Transmembranei191 – 211Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini212 – 215CytoplasmicSequence analysis4
Transmembranei216 – 236Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini237 – 257ExtracellularSequence analysisAdd BLAST21
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 289CytoplasmicSequence analysisAdd BLAST11
Transmembranei290 – 310Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini311 – 342ExtracellularSequence analysisAdd BLAST32
Transmembranei343 – 363Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini364 – 372CytoplasmicSequence analysis9
Transmembranei373 – 393Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini394 – 397ExtracellularSequence analysis4
Transmembranei398 – 418Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini419 – 439CytoplasmicSequence analysisAdd BLAST21
Transmembranei440 – 460Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini461 – 476ExtracellularSequence analysisAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi180C → A or S: Abolishes the transport function. 1 Publication1
Mutagenesisi329C → A or S: Abolishes the transport function. 1 Publication1
Mutagenesisi473C → A or S: No effect. 1 Publication1

Organism-specific databases

DisGeNETi206358.
OpenTargetsiENSG00000123643.
PharmGKBiPA134870308.

Chemistry databases

ChEMBLiCHEMBL1914279.
DrugBankiDB00659. Acamprosate.
DB00145. Glycine.
DB08847. Hydroxyproline.
DB00160. L-Alanine.
DB08835. Spaglumic Acid.
DB01080. Vigabatrin.
GuidetoPHARMACOLOGYi1161.

Polymorphism and mutation databases

BioMutaiSLC36A1.
DMDMi51316800.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938251 – 476Proton-coupled amino acid transporter 1Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi180 ↔ 3291 Publication
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi470N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ7Z2H8.
PaxDbiQ7Z2H8.
PeptideAtlasiQ7Z2H8.
PRIDEiQ7Z2H8.
TopDownProteomicsiQ7Z2H8-1. [Q7Z2H8-1]

PTM databases

iPTMnetiQ7Z2H8.
PhosphoSitePlusiQ7Z2H8.

Expressioni

Gene expression databases

BgeeiENSG00000123643.
CleanExiHS_SLC36A1.
ExpressionAtlasiQ7Z2H8. baseline and differential.
GenevisibleiQ7Z2H8. HS.

Organism-specific databases

HPAiHPA035937.

Interactioni

Protein-protein interaction databases

BioGridi128503. 3 interactors.
IntActiQ7Z2H8. 7 interactors.
MINTiMINT-4722054.
STRINGi9606.ENSP00000243389.

Chemistry databases

BindingDBiQ7Z2H8.

Structurei

3D structure databases

ProteinModelPortaliQ7Z2H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1304. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000171648.
HOVERGENiHBG057183.
InParanoidiQ7Z2H8.
KOiK14209.
OMAiSHWGRRI.
OrthoDBiEOG091G079T.
PhylomeDBiQ7Z2H8.
TreeFamiTF314873.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z2H8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTQRLRNED YHDYSSTDVS PEESPSEGLN NLSSPGSYQR FGQSNSTTWF
60 70 80 90 100
QTLIHLLKGN IGTGLLGLPL AVKNAGIVMG PISLLIIGIV AVHCMGILVK
110 120 130 140 150
CAHHFCRRLN KSFVDYGDTV MYGLESSPCS WLRNHAHWGR RVVDFFLIVT
160 170 180 190 200
QLGFCCVYFV FLADNFKQVI EAANGTTNNC HNNETVILTP TMDSRLYMLS
210 220 230 240 250
FLPFLVLLVF IRNLRALSIF SLLANITMLV SLVMIYQFIV QRIPDPSHLP
260 270 280 290 300
LVAPWKTYPL FFGTAIFSFE GIGMVLPLEN KMKDPRKFPL ILYLGMVIVT
310 320 330 340 350
ILYISLGCLG YLQFGANIQG SITLNLPNCW LYQSVKLLYS IGIFFTYALQ
360 370 380 390 400
FYVPAEIIIP FFVSRAPEHC ELVVDLFVRT VLVCLTCILA ILIPRLDLVI
410 420 430 440 450
SLVGSVSSSA LALIIPPLLE VTTFYSEGMS PLTIFKDALI SILGFVGFVV
460 470
GTYEALYELI QPSNAPIFIN STCAFI
Length:476
Mass (Da):53,076
Last modified:October 1, 2003 - v1
Checksum:i628AE7FC7A6559F0
GO
Isoform 2 (identifier: Q7Z2H8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-476: Missing.

Show »
Length:386
Mass (Da):43,487
Checksum:i3591BF6A356FD808
GO
Isoform 3 (identifier: Q7Z2H8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-243: RI → IL
     244-476: Missing.

Show »
Length:243
Mass (Da):27,278
Checksum:i602053121F38BE5D
GO

Sequence cautioni

The sequence BAB71435 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72V → A in BAB71435 (PubMed:14702039).Curated1
Sequence conflicti394P → L in AAP47194 (PubMed:12527723).Curated1
Sequence conflicti446V → G in AAP47194 (PubMed:12527723).Curated1
Sequence conflicti449 – 450VV → GG in AAP47194 (PubMed:12527723).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048122362F → L.Corresponds to variant rs9687945dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044390242 – 243RI → IL in isoform 3. 1 Publication2
Alternative sequenceiVSP_044391244 – 476Missing in isoform 3. 1 PublicationAdd BLAST233
Alternative sequenceiVSP_044392387 – 476Missing in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY162213 mRNA. Translation: AAO11787.1.
AF516142 mRNA. Translation: AAP47194.1.
AY227111 mRNA. Translation: AAO37091.1.
AY227112 mRNA. Translation: AAO37092.1.
AY227113 mRNA. Translation: AAO37093.1.
BX537963 mRNA. Translation: CAD97927.1.
AC034205 Genomic DNA. No translation available.
BC136437 mRNA. Translation: AAI36438.1.
BC136438 mRNA. Translation: AAI36439.1.
AK057340 mRNA. Translation: BAB71435.1. Sequence problems.
BK001052 mRNA. Translation: DAA01126.1.
CCDSiCCDS4316.1. [Q7Z2H8-1]
CCDS78073.1. [Q7Z2H8-4]
CCDS83035.1. [Q7Z2H8-3]
RefSeqiNP_001295079.1. NM_001308150.1. [Q7Z2H8-3]
NP_001295080.1. NM_001308151.1. [Q7Z2H8-4]
NP_510968.2. NM_078483.3. [Q7Z2H8-1]
XP_005268443.1. XM_005268386.1. [Q7Z2H8-1]
XP_011535883.1. XM_011537581.1. [Q7Z2H8-1]
XP_011535885.1. XM_011537583.2. [Q7Z2H8-1]
XP_011535886.1. XM_011537584.2. [Q7Z2H8-1]
XP_011535887.1. XM_011537585.1. [Q7Z2H8-1]
XP_011535888.1. XM_011537586.2. [Q7Z2H8-1]
XP_011535889.1. XM_011537587.2. [Q7Z2H8-1]
XP_011535890.1. XM_011537588.2. [Q7Z2H8-1]
XP_011535891.1. XM_011537589.2. [Q7Z2H8-1]
XP_011535892.1. XM_011537590.1. [Q7Z2H8-1]
XP_011535893.1. XM_011537591.1. [Q7Z2H8-1]
XP_011535894.1. XM_011537592.2. [Q7Z2H8-1]
XP_016864705.1. XM_017009216.1. [Q7Z2H8-1]
XP_016864709.1. XM_017009220.1. [Q7Z2H8-4]
UniGeneiHs.269004.

Genome annotation databases

EnsembliENST00000243389; ENSP00000243389; ENSG00000123643. [Q7Z2H8-1]
ENST00000429484; ENSP00000395640; ENSG00000123643. [Q7Z2H8-4]
ENST00000520701; ENSP00000428140; ENSG00000123643. [Q7Z2H8-1]
ENST00000616007; ENSP00000480948; ENSG00000123643. [Q7Z2H8-3]
GeneIDi206358.
KEGGihsa:206358.
UCSCiuc003luc.4. human. [Q7Z2H8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY162213 mRNA. Translation: AAO11787.1.
AF516142 mRNA. Translation: AAP47194.1.
AY227111 mRNA. Translation: AAO37091.1.
AY227112 mRNA. Translation: AAO37092.1.
AY227113 mRNA. Translation: AAO37093.1.
BX537963 mRNA. Translation: CAD97927.1.
AC034205 Genomic DNA. No translation available.
BC136437 mRNA. Translation: AAI36438.1.
BC136438 mRNA. Translation: AAI36439.1.
AK057340 mRNA. Translation: BAB71435.1. Sequence problems.
BK001052 mRNA. Translation: DAA01126.1.
CCDSiCCDS4316.1. [Q7Z2H8-1]
CCDS78073.1. [Q7Z2H8-4]
CCDS83035.1. [Q7Z2H8-3]
RefSeqiNP_001295079.1. NM_001308150.1. [Q7Z2H8-3]
NP_001295080.1. NM_001308151.1. [Q7Z2H8-4]
NP_510968.2. NM_078483.3. [Q7Z2H8-1]
XP_005268443.1. XM_005268386.1. [Q7Z2H8-1]
XP_011535883.1. XM_011537581.1. [Q7Z2H8-1]
XP_011535885.1. XM_011537583.2. [Q7Z2H8-1]
XP_011535886.1. XM_011537584.2. [Q7Z2H8-1]
XP_011535887.1. XM_011537585.1. [Q7Z2H8-1]
XP_011535888.1. XM_011537586.2. [Q7Z2H8-1]
XP_011535889.1. XM_011537587.2. [Q7Z2H8-1]
XP_011535890.1. XM_011537588.2. [Q7Z2H8-1]
XP_011535891.1. XM_011537589.2. [Q7Z2H8-1]
XP_011535892.1. XM_011537590.1. [Q7Z2H8-1]
XP_011535893.1. XM_011537591.1. [Q7Z2H8-1]
XP_011535894.1. XM_011537592.2. [Q7Z2H8-1]
XP_016864705.1. XM_017009216.1. [Q7Z2H8-1]
XP_016864709.1. XM_017009220.1. [Q7Z2H8-4]
UniGeneiHs.269004.

3D structure databases

ProteinModelPortaliQ7Z2H8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128503. 3 interactors.
IntActiQ7Z2H8. 7 interactors.
MINTiMINT-4722054.
STRINGi9606.ENSP00000243389.

Chemistry databases

BindingDBiQ7Z2H8.
ChEMBLiCHEMBL1914279.
DrugBankiDB00659. Acamprosate.
DB00145. Glycine.
DB08847. Hydroxyproline.
DB00160. L-Alanine.
DB08835. Spaglumic Acid.
DB01080. Vigabatrin.
GuidetoPHARMACOLOGYi1161.

Protein family/group databases

TCDBi2.A.18.8.7. the amino acid/auxin permease (aaap) family.

PTM databases

iPTMnetiQ7Z2H8.
PhosphoSitePlusiQ7Z2H8.

Polymorphism and mutation databases

BioMutaiSLC36A1.
DMDMi51316800.

Proteomic databases

MaxQBiQ7Z2H8.
PaxDbiQ7Z2H8.
PeptideAtlasiQ7Z2H8.
PRIDEiQ7Z2H8.
TopDownProteomicsiQ7Z2H8-1. [Q7Z2H8-1]

Protocols and materials databases

DNASUi206358.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243389; ENSP00000243389; ENSG00000123643. [Q7Z2H8-1]
ENST00000429484; ENSP00000395640; ENSG00000123643. [Q7Z2H8-4]
ENST00000520701; ENSP00000428140; ENSG00000123643. [Q7Z2H8-1]
ENST00000616007; ENSP00000480948; ENSG00000123643. [Q7Z2H8-3]
GeneIDi206358.
KEGGihsa:206358.
UCSCiuc003luc.4. human. [Q7Z2H8-1]

Organism-specific databases

CTDi206358.
DisGeNETi206358.
GeneCardsiSLC36A1.
HGNCiHGNC:18761. SLC36A1.
HPAiHPA035937.
MIMi606561. gene.
neXtProtiNX_Q7Z2H8.
OpenTargetsiENSG00000123643.
PharmGKBiPA134870308.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1304. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000171648.
HOVERGENiHBG057183.
InParanoidiQ7Z2H8.
KOiK14209.
OMAiSHWGRRI.
OrthoDBiEOG091G079T.
PhylomeDBiQ7Z2H8.
TreeFamiTF314873.

Enzyme and pathway databases

ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.
R-HSA-428559. Proton-coupled neutral amino acid transporters.

Miscellaneous databases

ChiTaRSiSLC36A1. human.
GeneWikiiSLC36A1.
GenomeRNAii206358.
PROiQ7Z2H8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123643.
CleanExiHS_SLC36A1.
ExpressionAtlasiQ7Z2H8. baseline and differential.
GenevisibleiQ7Z2H8. HS.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS36A1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2H8
Secondary accession number(s): C9JI34
, Q1LZ56, Q7Z7C0, Q86YK4, Q96M74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.