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Protein

Putative protein ZNF720

Gene

ZNF720

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein ZNF720
Gene namesi
Name:ZNF720
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26987. ZNF720.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485683.

Polymorphism and mutation databases

BioMutaiZNF720.
DMDMi74738650.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126126Putative protein ZNF720PRO_0000330293Add
BLAST

Proteomic databases

EPDiQ7Z2F6.
PaxDbiQ7Z2F6.
PRIDEiQ7Z2F6.

PTM databases

iPTMnetiQ7Z2F6.
PhosphoSiteiQ7Z2F6.

Expressioni

Gene expression databases

BgeeiQ7Z2F6.
CleanExiHS_ZNF720.
ExpressionAtlasiQ7Z2F6. baseline and differential.
GenevisibleiQ7Z2F6. HS.

Organism-specific databases

HPAiHPA041570.

Interactioni

Protein-protein interaction databases

BioGridi125864. 2 interactions.
IntActiQ7Z2F6. 4 interactions.
STRINGi9606.ENSP00000319222.

Structurei

3D structure databases

ProteinModelPortaliQ7Z2F6.
SMRiQ7Z2F6. Positions 4-44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 KRAB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129909.
HOGENOMiHOG000231475.
HOVERGENiHBG067759.
InParanoidiQ7Z2F6.
OrthoDBiEOG7GN2R9.
PhylomeDBiQ7Z2F6.
TreeFamiTF340491.

Family and domain databases

InterProiIPR001909. KRAB.
IPR026613. KRAB_dom_C2H2_Znf_fam.
[Graphical view]
PANTHERiPTHR23232. PTHR23232. 1 hit.
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z2F6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLTFRDVA IEFSREEWEH LDSDQKLLYG DVMLENYGNL VSLGLAVSKP
60 70 80 90 100
DLITFLEQRK EPWNVKSAET VAIQPDIFSH DTQGLLRKKL IEASFQKVIL
110 120
DGYGSCGPQN LNLRKEWESE GKIILW
Length:126
Mass (Da):14,454
Last modified:October 1, 2003 - v1
Checksum:iBF678E7D8AEF7DA3
GO
Isoform 2 (identifier: Q7Z2F6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-74: VAIQ → MVNV
     123-126: IILW → CEGHNGYYDG...SLLKVCFTNK

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):20,246
Checksum:i2A28FE8BC1ACB898
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7070Missing in isoform 2. 1 PublicationVSP_033024Add
BLAST
Alternative sequencei71 – 744VAIQ → MVNV in isoform 2. 1 PublicationVSP_033025
Alternative sequencei123 – 1264IILW → CEGHNGYYDGHTKCKTTTYN KNLTVTGGQKHEKTQFMSVA FSKPCVSVSKCQHQFLKLTF SFKGNLDNPNSDLVHVSNNH LNQLKYRTGVNVQSNISEKE RFKNEEVISKYDQFDGSLLK VCFTNK in isoform 2. 1 PublicationVSP_033026

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128671 mRNA. No translation available.
CH471192 Genomic DNA. Translation: EAW52108.1.
BC018134 mRNA. Translation: AAH18134.1.
BC055408 mRNA. Translation: AAH55408.1.
CCDSiCCDS45473.1. [Q7Z2F6-1]
RefSeqiNP_001124385.1. NM_001130913.1.
UniGeneiHs.528826.

Genome annotation databases

EnsembliENST00000316491; ENSP00000319222; ENSG00000197302. [Q7Z2F6-1]
ENST00000398696; ENSP00000443758; ENSG00000197302. [Q7Z2F6-2]
GeneIDi124411.
KEGGihsa:124411.
UCSCiuc002ecn.5. human. [Q7Z2F6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128671 mRNA. No translation available.
CH471192 Genomic DNA. Translation: EAW52108.1.
BC018134 mRNA. Translation: AAH18134.1.
BC055408 mRNA. Translation: AAH55408.1.
CCDSiCCDS45473.1. [Q7Z2F6-1]
RefSeqiNP_001124385.1. NM_001130913.1.
UniGeneiHs.528826.

3D structure databases

ProteinModelPortaliQ7Z2F6.
SMRiQ7Z2F6. Positions 4-44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125864. 2 interactions.
IntActiQ7Z2F6. 4 interactions.
STRINGi9606.ENSP00000319222.

PTM databases

iPTMnetiQ7Z2F6.
PhosphoSiteiQ7Z2F6.

Polymorphism and mutation databases

BioMutaiZNF720.
DMDMi74738650.

Proteomic databases

EPDiQ7Z2F6.
PaxDbiQ7Z2F6.
PRIDEiQ7Z2F6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316491; ENSP00000319222; ENSG00000197302. [Q7Z2F6-1]
ENST00000398696; ENSP00000443758; ENSG00000197302. [Q7Z2F6-2]
GeneIDi124411.
KEGGihsa:124411.
UCSCiuc002ecn.5. human. [Q7Z2F6-1]

Organism-specific databases

CTDi124411.
GeneCardsiZNF720.
HGNCiHGNC:26987. ZNF720.
HPAiHPA041570.
neXtProtiNX_Q7Z2F6.
PharmGKBiPA143485683.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129909.
HOGENOMiHOG000231475.
HOVERGENiHBG067759.
InParanoidiQ7Z2F6.
OrthoDBiEOG7GN2R9.
PhylomeDBiQ7Z2F6.
TreeFamiTF340491.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF720. human.
GenomeRNAii124411.
PROiQ7Z2F6.

Gene expression databases

BgeeiQ7Z2F6.
CleanExiHS_ZNF720.
ExpressionAtlasiQ7Z2F6. baseline and differential.
GenevisibleiQ7Z2F6. HS.

Family and domain databases

InterProiIPR001909. KRAB.
IPR026613. KRAB_dom_C2H2_Znf_fam.
[Graphical view]
PANTHERiPTHR23232. PTHR23232. 1 hit.
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Urinary bladder and Uterus.

Entry informationi

Entry nameiZN720_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2F6
Secondary accession number(s): Q6ZQX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it does not contain a canonical C2H2-type zinc-finger.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.