Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phospholipid phosphatase-related protein type 4

Gene

PLPPR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.1 Publication

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 4Curated (EC:3.1.3.4)
Alternative name(s):
Brain-specific phosphatidic acid phosphatase-like protein 11 Publication
Lipid phosphate phosphatase-related protein type 41 Publication
Plasticity-related gene 1 protein1 Publication
Short name:
PRG-11 Publication
Gene namesi
Name:PLPPR4Imported
Synonyms:KIAA04551 Publication, LPPR41 Publication, PHP11 Publication, PRG11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23496. PLPPR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei67 – 8721HelicalSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence analysisAdd
BLAST
Transmembranei276 – 29621HelicalSequence analysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi252 – 2521H → K: Loss of activity. 1 Publication

Polymorphism and mutation databases

BioMutaiLPPR4.
DMDMi74750018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Phospholipid phosphatase-related protein type 4PRO_0000317436Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361PhosphoserineBy similarity
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence analysis
Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence analysis
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence analysis
Modified residuei346 – 3461PhosphoserineBy similarity
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence analysis
Modified residuei385 – 3851PhosphoserineBy similarity
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence analysis
Modified residuei438 – 4381PhosphoserineBy similarity
Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence analysis
Modified residuei461 – 4611PhosphoserineBy similarity
Modified residuei472 – 4721PhosphoserineBy similarity
Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence analysis
Glycosylationi543 – 5431N-linked (GlcNAc...)Sequence analysis
Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence analysis
Modified residuei606 – 6061PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7Z2D5.
PRIDEiQ7Z2D5.

PTM databases

DEPODiQ7Z2D5.
iPTMnetiQ7Z2D5.
PhosphoSiteiQ7Z2D5.

Expressioni

Tissue specificityi

Specifically expressed in neurons.1 Publication

Gene expression databases

BgeeiQ7Z2D5.
ExpressionAtlasiQ7Z2D5. baseline and differential.
GenevisibleiQ7Z2D5. HS.

Organism-specific databases

HPAiHPA008798.

Interactioni

Protein-protein interaction databases

BioGridi115220. 1 interaction.
STRINGi9606.ENSP00000359204.

Structurei

3D structure databases

ProteinModelPortaliQ7Z2D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi695 – 6984Poly-His

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB1. Eukaryota.
ENOG410ZGFZ. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ7Z2D5.
KOiK19582.
OMAiNQDPSRV.
OrthoDBiEOG771272.
PhylomeDBiQ7Z2D5.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028684. LPPR4.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF13. PTHR10165:SF13. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z2D5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRAGSSGGR GECDISGAGR LGLEEAARLS CAVHTSPGGG RRPGQAAGMS
60 70 80 90 100
AKERPKGKVI KDSVTLLPCF YFVELPILAS SVVSLYFLEL TDVFKPVHSG
110 120 130 140 150
FSCYDRSLSM PYIEPTQEAI PFLMLLSLAF AGPAITIMVG EGILYCCLSK
160 170 180 190 200
RRNGVGLEPN INAGGCNFNS FLRRAVRFVG VHVFGLCSTA LITDIIQLST
210 220 230 240 250
GYQAPYFLTV CKPNYTSLNV SCKENSYIVE DICSGSDLTV INSGRKSFPS
260 270 280 290 300
QHATLAAFAA VYVSMYFNST LTDSSKLLKP LLVFTFIICG IICGLTRITQ
310 320 330 340 350
YKNHPVDVYC GFLIGGGIAL YLGLYAVGNF LPSDESMFQH RDALRSLTDL
360 370 380 390 400
NQDPNRLLSA KNGSSSDGIA HTEGILNRNH RDASSLTNLK RANADVEIIT
410 420 430 440 450
PRSPMGKENM VTFSNTLPRA NTPSVEDPVR RNASIHASMD SARSKQLLTQ
460 470 480 490 500
WKNKNESRKL SLQVIEPEPG QSPPRSIEMR SSSEPSRVGV NGDHHGPGNQ
510 520 530 540 550
YLKIQPGAVP GCNNSMPGGP RVSIQSRPGS SQLVHIPEET QENISTSPKS
560 570 580 590 600
SSARAKWLKA AEKTVACNRS NSQPRIMQVI AMSKQQGVLQ SSPKNTEGST
610 620 630 640 650
VSCTGSIRYK TLTDHEPSGI VRVEAHPENN RPIIQIPSTE GEGSGSWKWK
660 670 680 690 700
APEKGSLRQT YELNDLNRDS ESCESLKDSF GSGDRKRSNI DSNEHHHHGI
710 720 730 740 750
TTIRVTPVEG SEIGSETLSI SSSRDSTLRR KGNIILIPER SNSPENTRNI
760
FYKGTSPTRA YKD
Length:763
Mass (Da):82,983
Last modified:October 1, 2003 - v1
Checksum:iF0401DD5073EBE71
GO
Isoform 2 (identifier: Q7Z2D5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     552-577: SARAKWLKAAEKTVACNRSNSQPRIM → RVSSKAAPRTLKAARSPALAPSAIKP
     578-763: Missing.

Show »
Length:577
Mass (Da):62,148
Checksum:iBB77A61AD5A407E2
GO
Isoform 3 (identifier: Q7Z2D5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-322: Missing.

Note: No experimental confirmation available.
Show »
Length:705
Mass (Da):76,554
Checksum:i9ED8A85F8A8A419E
GO

Sequence cautioni

The sequence BAA32300.3 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI22799.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAW72991.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181A → S in BAB71245 (PubMed:14702039).Curated
Sequence conflicti718 – 7181L → R in CAD39052 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21Q → K.
Corresponds to variant rs712896 [ dbSNP | Ensembl ].
VAR_050618
Natural varianti32 – 321A → V.
Corresponds to variant rs35285687 [ dbSNP | Ensembl ].
VAR_050619

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei265 – 32258Missing in isoform 3. CuratedVSP_046784Add
BLAST
Alternative sequencei552 – 57726SARAK…QPRIM → RVSSKAAPRTLKAARSPALA PSAIKP in isoform 2. 1 PublicationVSP_030950Add
BLAST
Alternative sequencei578 – 763186Missing in isoform 2. 1 PublicationVSP_030951Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541281 mRNA. Translation: AAP57770.1.
AY304518 mRNA. Translation: AAP72155.1.
AB007924 mRNA. Translation: BAA32300.3. Different initiation.
AK056665 mRNA. Translation: BAB71245.1.
AK291369 mRNA. Translation: BAF84058.1.
AL139425 Genomic DNA. Translation: CAI22799.1. Sequence problems.
AL139425, AL136147 Genomic DNA. Translation: CAI22800.1.
AL136147, AL139425 Genomic DNA. Translation: CAI23225.1.
CH471097 Genomic DNA. Translation: EAW72991.1. Sequence problems.
CH471097 Genomic DNA. Translation: EAW72992.1.
AF357013 mRNA. Translation: AAO85400.1.
AL834390 mRNA. Translation: CAD39052.1.
CCDSiCCDS53347.1. [Q7Z2D5-3]
CCDS757.1. [Q7Z2D5-1]
RefSeqiNP_001159724.1. NM_001166252.1. [Q7Z2D5-3]
NP_055654.2. NM_014839.4. [Q7Z2D5-1]
UniGeneiHs.13245.

Genome annotation databases

EnsembliENST00000370185; ENSP00000359204; ENSG00000117600. [Q7Z2D5-1]
ENST00000457765; ENSP00000394913; ENSG00000117600. [Q7Z2D5-3]
GeneIDi9890.
KEGGihsa:9890.
UCSCiuc001dse.4. human. [Q7Z2D5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541281 mRNA. Translation: AAP57770.1.
AY304518 mRNA. Translation: AAP72155.1.
AB007924 mRNA. Translation: BAA32300.3. Different initiation.
AK056665 mRNA. Translation: BAB71245.1.
AK291369 mRNA. Translation: BAF84058.1.
AL139425 Genomic DNA. Translation: CAI22799.1. Sequence problems.
AL139425, AL136147 Genomic DNA. Translation: CAI22800.1.
AL136147, AL139425 Genomic DNA. Translation: CAI23225.1.
CH471097 Genomic DNA. Translation: EAW72991.1. Sequence problems.
CH471097 Genomic DNA. Translation: EAW72992.1.
AF357013 mRNA. Translation: AAO85400.1.
AL834390 mRNA. Translation: CAD39052.1.
CCDSiCCDS53347.1. [Q7Z2D5-3]
CCDS757.1. [Q7Z2D5-1]
RefSeqiNP_001159724.1. NM_001166252.1. [Q7Z2D5-3]
NP_055654.2. NM_014839.4. [Q7Z2D5-1]
UniGeneiHs.13245.

3D structure databases

ProteinModelPortaliQ7Z2D5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115220. 1 interaction.
STRINGi9606.ENSP00000359204.

PTM databases

DEPODiQ7Z2D5.
iPTMnetiQ7Z2D5.
PhosphoSiteiQ7Z2D5.

Polymorphism and mutation databases

BioMutaiLPPR4.
DMDMi74750018.

Proteomic databases

PaxDbiQ7Z2D5.
PRIDEiQ7Z2D5.

Protocols and materials databases

DNASUi9890.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370185; ENSP00000359204; ENSG00000117600. [Q7Z2D5-1]
ENST00000457765; ENSP00000394913; ENSG00000117600. [Q7Z2D5-3]
GeneIDi9890.
KEGGihsa:9890.
UCSCiuc001dse.4. human. [Q7Z2D5-1]

Organism-specific databases

CTDi9890.
GeneCardsiLPPR4.
HGNCiHGNC:23496. PLPPR4.
HPAiHPA008798.
MIMi607813. gene.
neXtProtiNX_Q7Z2D5.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITB1. Eukaryota.
ENOG410ZGFZ. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ7Z2D5.
KOiK19582.
OMAiNQDPSRV.
OrthoDBiEOG771272.
PhylomeDBiQ7Z2D5.

Enzyme and pathway databases

BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

ChiTaRSiLPPR4. human.
GenomeRNAii9890.
PROiQ7Z2D5.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z2D5.
ExpressionAtlasiQ7Z2D5. baseline and differential.
GenevisibleiQ7Z2D5. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028684. LPPR4.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF13. PTHR10165:SF13. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting."
    Braeuer A.U., Savaskan N.E., Kuehn H., Prehn S., Ninnemann O., Nitsch R.
    Nat. Neurosci. 6:572-578(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF HIS-252.
    Tissue: Brain.
  2. "Lipid phosphate phosphatase related proteins."
    Morris A.J., Sigal Y.J., McDermott M., Sciorra V.A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-763 (ISOFORM 1).
    Tissue: Brain.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "A new brain specific member of the PAP-2 family."
    Ninnemann O., Brauer A.U., Savaskan N., Nitsch R.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-763 (ISOFORM 1).
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 111-763 (ISOFORM 1).
    Tissue: Amygdala.

Entry informationi

Entry nameiPLPR4_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2D5
Secondary accession number(s): E7EPS1
, O75043, Q5T9R9, Q86XQ5, Q8N3F1, Q96MP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.