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Protein

Phospholipid phosphatase-related protein type 4

Gene

PLPPR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.1 Publication

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:HS12901-MONOMER.
BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 4Curated (EC:3.1.3.4)
Alternative name(s):
Brain-specific phosphatidic acid phosphatase-like protein 11 Publication
Lipid phosphate phosphatase-related protein type 41 Publication
Plasticity-related gene 1 protein1 Publication
Short name:
PRG-11 Publication
Gene namesi
Name:PLPPR4Imported
Synonyms:KIAA04551 Publication, LPPR41 Publication, PHP11 Publication, PRG11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23496. PLPPR4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi252H → K: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNETi9890.
OpenTargetsiENSG00000117600.

Polymorphism and mutation databases

BioMutaiLPPR4.
DMDMi74750018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174361 – 763Phospholipid phosphatase-related protein type 4Add BLAST763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1
Glycosylationi214N-linked (GlcNAc...)Sequence analysis1
Glycosylationi219N-linked (GlcNAc...)Sequence analysis1
Glycosylationi268N-linked (GlcNAc...)Sequence analysis1
Modified residuei346PhosphoserineBy similarity1
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1
Modified residuei385PhosphoserineBy similarity1
Glycosylationi432N-linked (GlcNAc...)Sequence analysis1
Modified residuei438PhosphoserineBy similarity1
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1
Modified residuei461PhosphoserineBy similarity1
Modified residuei472PhosphoserineBy similarity1
Glycosylationi513N-linked (GlcNAc...)Sequence analysis1
Glycosylationi543N-linked (GlcNAc...)Sequence analysis1
Glycosylationi568N-linked (GlcNAc...)Sequence analysis1
Modified residuei606PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7Z2D5.
PeptideAtlasiQ7Z2D5.
PRIDEiQ7Z2D5.

PTM databases

DEPODiQ7Z2D5.
iPTMnetiQ7Z2D5.
PhosphoSitePlusiQ7Z2D5.

Expressioni

Tissue specificityi

Specifically expressed in neurons.1 Publication

Gene expression databases

BgeeiENSG00000117600.
ExpressionAtlasiQ7Z2D5. baseline and differential.
GenevisibleiQ7Z2D5. HS.

Organism-specific databases

HPAiCAB009581.

Interactioni

Protein-protein interaction databases

BioGridi115220. 1 interactor.
STRINGi9606.ENSP00000359204.

Structurei

3D structure databases

ProteinModelPortaliQ7Z2D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi695 – 698Poly-His4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB1. Eukaryota.
ENOG410ZGFZ. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ7Z2D5.
KOiK19582.
OMAiNQDPSRV.
OrthoDBiEOG091G02D7.
PhylomeDBiQ7Z2D5.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028684. LPPR4.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF13. PTHR10165:SF13. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z2D5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRAGSSGGR GECDISGAGR LGLEEAARLS CAVHTSPGGG RRPGQAAGMS
60 70 80 90 100
AKERPKGKVI KDSVTLLPCF YFVELPILAS SVVSLYFLEL TDVFKPVHSG
110 120 130 140 150
FSCYDRSLSM PYIEPTQEAI PFLMLLSLAF AGPAITIMVG EGILYCCLSK
160 170 180 190 200
RRNGVGLEPN INAGGCNFNS FLRRAVRFVG VHVFGLCSTA LITDIIQLST
210 220 230 240 250
GYQAPYFLTV CKPNYTSLNV SCKENSYIVE DICSGSDLTV INSGRKSFPS
260 270 280 290 300
QHATLAAFAA VYVSMYFNST LTDSSKLLKP LLVFTFIICG IICGLTRITQ
310 320 330 340 350
YKNHPVDVYC GFLIGGGIAL YLGLYAVGNF LPSDESMFQH RDALRSLTDL
360 370 380 390 400
NQDPNRLLSA KNGSSSDGIA HTEGILNRNH RDASSLTNLK RANADVEIIT
410 420 430 440 450
PRSPMGKENM VTFSNTLPRA NTPSVEDPVR RNASIHASMD SARSKQLLTQ
460 470 480 490 500
WKNKNESRKL SLQVIEPEPG QSPPRSIEMR SSSEPSRVGV NGDHHGPGNQ
510 520 530 540 550
YLKIQPGAVP GCNNSMPGGP RVSIQSRPGS SQLVHIPEET QENISTSPKS
560 570 580 590 600
SSARAKWLKA AEKTVACNRS NSQPRIMQVI AMSKQQGVLQ SSPKNTEGST
610 620 630 640 650
VSCTGSIRYK TLTDHEPSGI VRVEAHPENN RPIIQIPSTE GEGSGSWKWK
660 670 680 690 700
APEKGSLRQT YELNDLNRDS ESCESLKDSF GSGDRKRSNI DSNEHHHHGI
710 720 730 740 750
TTIRVTPVEG SEIGSETLSI SSSRDSTLRR KGNIILIPER SNSPENTRNI
760
FYKGTSPTRA YKD
Length:763
Mass (Da):82,983
Last modified:October 1, 2003 - v1
Checksum:iF0401DD5073EBE71
GO
Isoform 2 (identifier: Q7Z2D5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     552-577: SARAKWLKAAEKTVACNRSNSQPRIM → RVSSKAAPRTLKAARSPALAPSAIKP
     578-763: Missing.

Show »
Length:577
Mass (Da):62,148
Checksum:iBB77A61AD5A407E2
GO
Isoform 3 (identifier: Q7Z2D5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-322: Missing.

Note: No experimental confirmation available.
Show »
Length:705
Mass (Da):76,554
Checksum:i9ED8A85F8A8A419E
GO

Sequence cautioni

The sequence BAA32300 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI22799 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW72991 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18A → S in BAB71245 (PubMed:14702039).Curated1
Sequence conflicti718L → R in CAD39052 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0506182Q → K.Corresponds to variant rs712896dbSNPEnsembl.1
Natural variantiVAR_05061932A → V.Corresponds to variant rs35285687dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046784265 – 322Missing in isoform 3. CuratedAdd BLAST58
Alternative sequenceiVSP_030950552 – 577SARAK…QPRIM → RVSSKAAPRTLKAARSPALA PSAIKP in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_030951578 – 763Missing in isoform 2. 1 PublicationAdd BLAST186

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541281 mRNA. Translation: AAP57770.1.
AY304518 mRNA. Translation: AAP72155.1.
AB007924 mRNA. Translation: BAA32300.3. Different initiation.
AK056665 mRNA. Translation: BAB71245.1.
AK291369 mRNA. Translation: BAF84058.1.
AL139425 Genomic DNA. Translation: CAI22799.1. Sequence problems.
AL139425, AL136147 Genomic DNA. Translation: CAI22800.1.
AL136147, AL139425 Genomic DNA. Translation: CAI23225.1.
CH471097 Genomic DNA. Translation: EAW72991.1. Sequence problems.
CH471097 Genomic DNA. Translation: EAW72992.1.
AF357013 mRNA. Translation: AAO85400.1.
AL834390 mRNA. Translation: CAD39052.1.
CCDSiCCDS53347.1. [Q7Z2D5-3]
CCDS757.1. [Q7Z2D5-1]
RefSeqiNP_001159724.1. NM_001166252.1. [Q7Z2D5-3]
NP_055654.2. NM_014839.4. [Q7Z2D5-1]
UniGeneiHs.13245.

Genome annotation databases

EnsembliENST00000370185; ENSP00000359204; ENSG00000117600. [Q7Z2D5-1]
ENST00000457765; ENSP00000394913; ENSG00000117600. [Q7Z2D5-3]
GeneIDi9890.
KEGGihsa:9890.
UCSCiuc001dse.4. human. [Q7Z2D5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541281 mRNA. Translation: AAP57770.1.
AY304518 mRNA. Translation: AAP72155.1.
AB007924 mRNA. Translation: BAA32300.3. Different initiation.
AK056665 mRNA. Translation: BAB71245.1.
AK291369 mRNA. Translation: BAF84058.1.
AL139425 Genomic DNA. Translation: CAI22799.1. Sequence problems.
AL139425, AL136147 Genomic DNA. Translation: CAI22800.1.
AL136147, AL139425 Genomic DNA. Translation: CAI23225.1.
CH471097 Genomic DNA. Translation: EAW72991.1. Sequence problems.
CH471097 Genomic DNA. Translation: EAW72992.1.
AF357013 mRNA. Translation: AAO85400.1.
AL834390 mRNA. Translation: CAD39052.1.
CCDSiCCDS53347.1. [Q7Z2D5-3]
CCDS757.1. [Q7Z2D5-1]
RefSeqiNP_001159724.1. NM_001166252.1. [Q7Z2D5-3]
NP_055654.2. NM_014839.4. [Q7Z2D5-1]
UniGeneiHs.13245.

3D structure databases

ProteinModelPortaliQ7Z2D5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115220. 1 interactor.
STRINGi9606.ENSP00000359204.

PTM databases

DEPODiQ7Z2D5.
iPTMnetiQ7Z2D5.
PhosphoSitePlusiQ7Z2D5.

Polymorphism and mutation databases

BioMutaiLPPR4.
DMDMi74750018.

Proteomic databases

PaxDbiQ7Z2D5.
PeptideAtlasiQ7Z2D5.
PRIDEiQ7Z2D5.

Protocols and materials databases

DNASUi9890.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370185; ENSP00000359204; ENSG00000117600. [Q7Z2D5-1]
ENST00000457765; ENSP00000394913; ENSG00000117600. [Q7Z2D5-3]
GeneIDi9890.
KEGGihsa:9890.
UCSCiuc001dse.4. human. [Q7Z2D5-1]

Organism-specific databases

CTDi9890.
DisGeNETi9890.
GeneCardsiLPPR4.
HGNCiHGNC:23496. PLPPR4.
HPAiCAB009581.
MIMi607813. gene.
neXtProtiNX_Q7Z2D5.
OpenTargetsiENSG00000117600.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITB1. Eukaryota.
ENOG410ZGFZ. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ7Z2D5.
KOiK19582.
OMAiNQDPSRV.
OrthoDBiEOG091G02D7.
PhylomeDBiQ7Z2D5.

Enzyme and pathway databases

BioCyciZFISH:HS12901-MONOMER.
BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

ChiTaRSiLPPR4. human.
GenomeRNAii9890.
PROiQ7Z2D5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117600.
ExpressionAtlasiQ7Z2D5. baseline and differential.
GenevisibleiQ7Z2D5. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028684. LPPR4.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF13. PTHR10165:SF13. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLPR4_HUMAN
AccessioniPrimary (citable) accession number: Q7Z2D5
Secondary accession number(s): E7EPS1
, O75043, Q5T9R9, Q86XQ5, Q8N3F1, Q96MP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.