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Protein

Venom serine protease

Gene
N/A
Organism
Polistes dominula (European paper wasp) (Vespa dominula)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Charge relay systemBy similarity
Active sitei126 – 1261Charge relay systemBy similarity
Active sitei220 – 2201Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.492.

Names & Taxonomyi

Protein namesi
Recommended name:
Venom serine protease (EC:3.4.21.-)
Alternative name(s):
Allergen: Pol d 4
OrganismiPolistes dominula (European paper wasp) (Vespa dominula)
Taxonomic identifieri743375 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.By similarity

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3437. Pol d 4.0101.
587. Pol d 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 277258Venom serine proteasePRO_5000090673Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi192 ↔ 207PROSITE-ProRule annotation
Disulfide bondi216 ↔ 246PROSITE-ProRule annotation
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliQ7Z269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 269236Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCGKIILLF ITIIGVAKSR EENCKCGWDN PSRIVNGVET EINEFPMVAR
60 70 80 90 100
LIYPSPGMYC GGTIITPQHI VTAAHCLQKY KRTNYTGIHV VVGEHDYTTD
110 120 130 140 150
TETNVTKRYT IAEVTIHPNY NSHNNDIAIV KTNERFEYSM KVGPVCLPFN
160 170 180 190 200
YMTRNLTNET VTALGWGKLR YNGQNSKVLR KVDLHVITRE QCETHYGAAI
210 220 230 240 250
ANANLLCTFD VGRDACQNDS GGPILWRSPT TDNLILVGVV NFGRTCADDA
260 270
PGGNARVTSF MEFIHNATIG ETYCKAD
Length:277
Mass (Da):30,804
Last modified:September 30, 2003 - v1
Checksum:i9B316A8824C5CDA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY285998 mRNA. Translation: AAP37412.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY285998 mRNA. Translation: AAP37412.1.

3D structure databases

ProteinModelPortaliQ7Z269.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3437. Pol d 4.0101.
587. Pol d 4.
MEROPSiS01.492.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a paper wasp venom serine protease allergen."
    Fitch C.D., Hoffman D.R., Schmidt M.
    J. Allergy Clin. Immunol. 107:S221-S221(2000)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.

Entry informationi

Entry nameiSP4_POLDO
AccessioniPrimary (citable) accession number: Q7Z269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 29, 2010
Last sequence update: September 30, 2003
Last modified: January 6, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.