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Protein

Venom serine protease

Gene
N/A
Organism
Polistes dominula (European paper wasp) (Vespa dominula)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemBy similarity1
Active sitei126Charge relay systemBy similarity1
Active sitei220Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.492.

Names & Taxonomyi

Protein namesi
Recommended name:
Venom serine protease (EC:3.4.21.-)
Alternative name(s):
Allergen: Pol d 4
OrganismiPolistes dominula (European paper wasp) (Vespa dominula)
Taxonomic identifieri743375 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.By similarity

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3437. Pol d 4.0101.
587. Pol d 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500009067320 – 277Venom serine proteaseAdd BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Glycosylationi158N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi192 ↔ 207PROSITE-ProRule annotation
Disulfide bondi216 ↔ 246PROSITE-ProRule annotation
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliQ7Z269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 269Peptidase S1PROSITE-ProRule annotationAdd BLAST236

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCGKIILLF ITIIGVAKSR EENCKCGWDN PSRIVNGVET EINEFPMVAR
60 70 80 90 100
LIYPSPGMYC GGTIITPQHI VTAAHCLQKY KRTNYTGIHV VVGEHDYTTD
110 120 130 140 150
TETNVTKRYT IAEVTIHPNY NSHNNDIAIV KTNERFEYSM KVGPVCLPFN
160 170 180 190 200
YMTRNLTNET VTALGWGKLR YNGQNSKVLR KVDLHVITRE QCETHYGAAI
210 220 230 240 250
ANANLLCTFD VGRDACQNDS GGPILWRSPT TDNLILVGVV NFGRTCADDA
260 270
PGGNARVTSF MEFIHNATIG ETYCKAD
Length:277
Mass (Da):30,804
Last modified:October 1, 2003 - v1
Checksum:i9B316A8824C5CDA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY285998 mRNA. Translation: AAP37412.1.
RefSeqiNP_001310266.1. NM_001323337.1.

Genome annotation databases

GeneIDi107070494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY285998 mRNA. Translation: AAP37412.1.
RefSeqiNP_001310266.1. NM_001323337.1.

3D structure databases

ProteinModelPortaliQ7Z269.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3437. Pol d 4.0101.
587. Pol d 4.
MEROPSiS01.492.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107070494.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSP4_POLDO
AccessioniPrimary (citable) accession number: Q7Z269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.