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Q7Z269 (SP4_POLDO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Venom serine protease

EC=3.4.21.-
Alternative name(s):
Allergen=Pol d 4
OrganismPolistes dominula (European paper wasp) (Vespa dominula)
Taxonomic identifier743375 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed by the venom duct.

Allergenic properties

Causes an allergic reaction in human By similarity.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 277258Venom serine protease
PRO_5000090673

Regions

Domain34 – 269236Peptidase S1

Sites

Active site751Charge relay system By similarity
Active site1261Charge relay system By similarity
Active site2201Charge relay system By similarity

Amino acid modifications

Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1551N-linked (GlcNAc...) Potential
Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation2181N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Disulfide bond60 ↔ 76 By similarity
Disulfide bond192 ↔ 207 By similarity
Disulfide bond216 ↔ 246 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7Z269 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 9B316A8824C5CDA6

FASTA27730,804
        10         20         30         40         50         60 
MNCGKIILLF ITIIGVAKSR EENCKCGWDN PSRIVNGVET EINEFPMVAR LIYPSPGMYC 

        70         80         90        100        110        120 
GGTIITPQHI VTAAHCLQKY KRTNYTGIHV VVGEHDYTTD TETNVTKRYT IAEVTIHPNY 

       130        140        150        160        170        180 
NSHNNDIAIV KTNERFEYSM KVGPVCLPFN YMTRNLTNET VTALGWGKLR YNGQNSKVLR 

       190        200        210        220        230        240 
KVDLHVITRE QCETHYGAAI ANANLLCTFD VGRDACQNDS GGPILWRSPT TDNLILVGVV 

       250        260        270 
NFGRTCADDA PGGNARVTSF MEFIHNATIG ETYCKAD 

« Hide

References

[1]"Cloning of a paper wasp venom serine protease allergen."
Fitch C.D., Hoffman D.R., Schmidt M.
J. Allergy Clin. Immunol. 107:S221-S221(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Hymenoptera venom protease allergens."
Winningham K.M., Fitch C.D., Schmidt M., Hoffman D.R.
J. Allergy Clin. Immunol. 114:928-933(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY285998 mRNA. Translation: AAP37412.1.

3D structure databases

ProteinModelPortalQ7Z269.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3437. Pol d 4.0101.
587. Pol d 4.
MEROPSS01.492.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSP4_POLDO
AccessionPrimary (citable) accession number: Q7Z269
Entry history
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Allergens

Nomenclature of allergens and list of entries