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Q7Z1K3

- ANIS1_ANISI

UniProt

Q7Z1K3 - ANIS1_ANISI

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Protein
Major allergen Ani s 1
Gene
N/A
Organism
Anisakis simplex (Herring worm)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major allergen Ani s 1
    Alternative name(s):
    21 kDa allergen
    Excretory gland allergen Ans1
    Allergen: Ani s 1
    OrganismiAnisakis simplex (Herring worm)
    Taxonomic identifieri6269 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAnisakidaeAnisakisAnisakis simplex complex

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE. A.simplex is a fish parasite that, when accidentally ingested by humans, may cause allergic reactions in sensitized individuals.1 Publication

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3079. Ani s 1.0101.
    35. Ani s 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 Publication
    Add
    BLAST
    Chaini24 – 194171Major allergen Ani s 1
    PRO_0000016888Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 84 By similarity
    Disulfide bondi38 ↔ 67 By similarity
    Disulfide bondi59 ↔ 80 By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z1K3.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 8457BPTI/Kunitz inhibitor
    Add
    BLAST
    Domaini90 – 13445WR1
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 WR1 domain.

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di4.10.410.10. 1 hit.
    InterProiIPR006150. Cys_repeat_1.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    [Graphical view]
    PfamiPF00014. Kunitz_BPTI. 1 hit.
    [Graphical view]
    PRINTSiPR00759. BASICPTASE.
    SMARTiSM00131. KU. 1 hit.
    SM00289. WR1. 2 hits.
    [Graphical view]
    SUPFAMiSSF57362. SSF57362. 1 hit.
    PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7Z1K3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASMQHFSLA ALLLAASICL GDADRTECQL PLDKGTPCTQ EGGVKPSVAW    50
    WHDDKSGICL SFKYTGCGGN ANRFTTIKNC EQHCKMPDRG ACALGKKPAE 100
    DSNGEQLVCA GMREDKCPNG YQCKMMAFMG LCCPTKEEEL FAREYEGVCK 150
    SGKPVKMDRG SGWMMTILGK SCDDQFCPED AKCERGKLFA NCCK 194
    Length:194
    Mass (Da):21,185
    Last modified:October 1, 2003 - v1
    Checksum:iF1ADA1A463633B37
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371P → Q AA sequence 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB100095 mRNA. Translation: BAC77154.1.
    PIRiA59069.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB100095 mRNA. Translation: BAC77154.1 .
    PIRi A59069.

    3D structure databases

    ProteinModelPortali Q7Z1K3.
    ModBasei Search...

    Protein family/group databases

    Allergomei 3079. Ani s 1.0101.
    35. Ani s 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 4.10.410.10. 1 hit.
    InterProi IPR006150. Cys_repeat_1.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    [Graphical view ]
    Pfami PF00014. Kunitz_BPTI. 1 hit.
    [Graphical view ]
    PRINTSi PR00759. BASICPTASE.
    SMARTi SM00131. KU. 1 hit.
    SM00289. WR1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57362. SSF57362. 1 hit.
    PROSITEi PS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification and molecular cloning of a majpr allergen from Anisakis simplex."
      Shimakura K., Miura H., Ikeda K., Ishizaki S., Nagashima Y., Shiomi K., Shirai T., Kasuya S.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation and characterization of a major allergen from the fish parasite Anisakis simplex."
      Moneo I., Caballero M.L., Gomez F., Ortega E., Alonso M.J.
      J. Allergy Clin. Immunol. 106:177-182(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-40, SUBCELLULAR LOCATION, ALLERGEN.

    Entry informationi

    Entry nameiANIS1_ANISI
    AccessioniPrimary (citable) accession number: Q7Z1K3
    Secondary accession number(s): Q7M4A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: October 1, 2003
    Last modified: April 16, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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