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Q7Z1K3 (ANIS1_ANISI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major allergen Ani s 1
Alternative name(s):
21 kDa allergen
Excretory gland allergen Ans1
Allergen=Ani s 1
OrganismAnisakis simplex (Herring worm)
Taxonomic identifier6269 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAnisakidaeAnisakisAnisakis simplex complex

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Ref.2.

Allergenic properties

Causes an allergic reaction in human. Binds to IgE. A.simplex is a fish parasite that, when accidentally ingested by humans, may cause allergic reactions in sensitized individuals. Ref.2

Sequence similarities

Contains 1 BPTI/Kunitz inhibitor domain.

Contains 1 WR1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainSignal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.2
Chain24 – 194171Major allergen Ani s 1
PRO_0000016888

Regions

Domain28 – 8457BPTI/Kunitz inhibitor
Domain90 – 13445WR1

Amino acid modifications

Disulfide bond28 ↔ 84 By similarity
Disulfide bond38 ↔ 67 By similarity
Disulfide bond59 ↔ 80 By similarity

Experimental info

Sequence conflict371P → Q AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q7Z1K3 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: F1ADA1A463633B37

FASTA19421,185
        10         20         30         40         50         60 
MASMQHFSLA ALLLAASICL GDADRTECQL PLDKGTPCTQ EGGVKPSVAW WHDDKSGICL 

        70         80         90        100        110        120 
SFKYTGCGGN ANRFTTIKNC EQHCKMPDRG ACALGKKPAE DSNGEQLVCA GMREDKCPNG 

       130        140        150        160        170        180 
YQCKMMAFMG LCCPTKEEEL FAREYEGVCK SGKPVKMDRG SGWMMTILGK SCDDQFCPED 

       190 
AKCERGKLFA NCCK 

« Hide

References

[1]"Purification and molecular cloning of a majpr allergen from Anisakis simplex."
Shimakura K., Miura H., Ikeda K., Ishizaki S., Nagashima Y., Shiomi K., Shirai T., Kasuya S.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Isolation and characterization of a major allergen from the fish parasite Anisakis simplex."
Moneo I., Caballero M.L., Gomez F., Ortega E., Alonso M.J.
J. Allergy Clin. Immunol. 106:177-182(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-40, SUBCELLULAR LOCATION, ALLERGEN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB100095 mRNA. Translation: BAC77154.1.
PIRA59069.

3D structure databases

ProteinModelPortalQ7Z1K3.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3079. Ani s 1.0101.
35. Ani s 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D4.10.410.10. 1 hit.
InterProIPR006150. Cys_repeat_1.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamPF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSPR00759. BASICPTASE.
SMARTSM00131. KU. 1 hit.
SM00289. WR1. 2 hits.
[Graphical view]
SUPFAMSSF57362. SSF57362. 1 hit.
PROSITEPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameANIS1_ANISI
AccessionPrimary (citable) accession number: Q7Z1K3
Secondary accession number(s): Q7M4A7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries