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Protein

Major allergen Ani s 1

Gene
N/A
Organism
Anisakis simplex (Herring worm)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.968.

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Ani s 1
Alternative name(s):
21 kDa allergen
Excretory gland allergen Ans1
Allergen: Ani s 1
OrganismiAnisakis simplex (Herring worm)
Taxonomic identifieri6269 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAnisakidaeAnisakisAnisakis simplex complex

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE. A.simplex is a fish parasite that, when accidentally ingested by humans, may cause allergic reactions in sensitized individuals.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3079. Ani s 1.0101.
35. Ani s 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 194171Major allergen Ani s 1PRO_0000016888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 84PROSITE-ProRule annotation
Disulfide bondi38 ↔ 67PROSITE-ProRule annotation
Disulfide bondi59 ↔ 80PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ7Z1K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 8457BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd
BLAST
Domaini90 – 13445WR1Add
BLAST

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation
Contains 1 WR1 domain.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
InterProiIPR006150. Cys_repeat_1.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
SM00289. WR1. 2 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z1K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASMQHFSLA ALLLAASICL GDADRTECQL PLDKGTPCTQ EGGVKPSVAW
60 70 80 90 100
WHDDKSGICL SFKYTGCGGN ANRFTTIKNC EQHCKMPDRG ACALGKKPAE
110 120 130 140 150
DSNGEQLVCA GMREDKCPNG YQCKMMAFMG LCCPTKEEEL FAREYEGVCK
160 170 180 190
SGKPVKMDRG SGWMMTILGK SCDDQFCPED AKCERGKLFA NCCK
Length:194
Mass (Da):21,185
Last modified:October 1, 2003 - v1
Checksum:iF1ADA1A463633B37
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371P → Q AA sequence (PubMed:10887322).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100095 mRNA. Translation: BAC77154.1.
PIRiA59069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100095 mRNA. Translation: BAC77154.1.
PIRiA59069.

3D structure databases

ProteinModelPortaliQ7Z1K3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3079. Ani s 1.0101.
35. Ani s 1.
MEROPSiI02.968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
InterProiIPR006150. Cys_repeat_1.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
SM00289. WR1. 2 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Purification and molecular cloning of a majpr allergen from Anisakis simplex."
    Shimakura K., Miura H., Ikeda K., Ishizaki S., Nagashima Y., Shiomi K., Shirai T., Kasuya S.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of a major allergen from the fish parasite Anisakis simplex."
    Moneo I., Caballero M.L., Gomez F., Ortega E., Alonso M.J.
    J. Allergy Clin. Immunol. 106:177-182(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-40, SUBCELLULAR LOCATION, ALLERGEN.

Entry informationi

Entry nameiANIS1_ANISI
AccessioniPrimary (citable) accession number: Q7Z1K3
Secondary accession number(s): Q7M4A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.