Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Venom allergen 5

Gene
N/A
Organism
Polybia scutellaris rioplatensis (Camoati)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 5
Alternative name(s):
Allergen Pol s V
Antigen 5
Short name:
Ag5
Cysteine-rich venom protein
Short name:
CRVP
Allergen: Pol s 5
OrganismiPolybia scutellaris rioplatensis (Camoati)
Taxonomic identifieri260979 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaeEpiponiniPolybia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. In most vespids, Antigen 5 is a potent allergen. Pol s 5 is a variant with a much lower allergenicity. It has a reduced IgE response and anaphylactic activity.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3494. Poly s 5.0101.
771. Poly s 5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115381 – 207Venom allergen 5Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 16By similarity
Disulfide bondi8 ↔ 105By similarity
Disulfide bondi29 ↔ 97By similarity
Disulfide bondi173 ↔ 190By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ7Z156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 192SCPAdd BLAST145

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NKYCNIKCSK VAHTVCQYGE STKPSSKNCN KVSITSVGVT EEEKKLIVDE
60 70 80 90 100
HNRFRQKVAQ GLETRGNPGP QPAASDMNNL VWNDELAYIA QVWANQCQFF
110 120 130 140 150
VHDKCRNTAQ YQVGQNIAYS ASTAAYPGIV SLIVLWENEV KDFNYSQGIT
160 170 180 190 200
KENFAKVGHY TQVVWAKTKE VGCGSIKYIE KGMKSHYLVC NYGPAGNYMG

QPIYTKK
Length:207
Mass (Da):23,209
Last modified:February 2, 2004 - v2
Checksum:i35E2D236344DF74C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28Missing in AAP57536 (Ref. 2) Curated1
Sequence conflicti95N → S in AAP57536 (Ref. 2) Curated1
Sequence conflicti155A → S in AAP57536 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299635 mRNA. Translation: AAP57536.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299635 mRNA. Translation: AAP57536.1.

3D structure databases

ProteinModelPortaliQ7Z156.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3494. Poly s 5.0101.
771. Poly s 5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVA5_POLSR
AccessioniPrimary (citable) accession number: Q7Z156
Secondary accession number(s): P82958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: February 2, 2004
Last modified: October 5, 2016
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.