Q7Z156 (VA5_POLSR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Venom allergen 5 Alternative name(s): Allergen Pol s V Antigen 5 Short name=Ag5 Cysteine-rich venom protein Short name=CRVP Allergen=Pol s 5
Organism	Polybia scutellaris rioplatensis (Camoati)
Taxonomic identifier	260979 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Vespoidea › Vespidae › Polistinae › Epiponini › Polybia › Polybia scutellaris

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Monomer. Ref.1
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland. Ref.1
Allergenic properties	Causes an allergic reaction in human. In most vespids, Antigen 5 is a potent allergen. Pol s 5 is a variant with a much lower allergenicity. It has a reduced IgE response and anaphylactic activity. Ref.1
Sequence similarities	Belongs to the CRISP family. Contains 1 SCP domain.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Venom allergen 5		PRO_0000211538
Regions
	Domain	48 – 192	145	SCP
Amino acid modifications
	Disulfide bond	4 ↔ 16		By similarity UniProtKB P10736
	Disulfide bond	8 ↔ 105		By similarity UniProtKB P10736
	Disulfide bond	29 ↔ 97		By similarity UniProtKB P10736
	Disulfide bond	173 ↔ 190		By similarity UniProtKB P10736
Experimental info
	Sequence conflict	28	1	Missing in AAP57536. Ref.2
	Sequence conflict	95	1	N → S in AAP57536. Ref.2
	Sequence conflict	155	1	A → S in AAP57536. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q7Z156 [UniParc]. Last modified February 2, 2004. Version 2. Checksum: 35E2D236344DF74C	FASTA	207	23,209
	10 20 30 40 50 60 NKYCNIKCSK VAHTVCQYGE STKPSSKNCN KVSITSVGVT EEEKKLIVDE HNRFRQKVAQ 70 80 90 100 110 120 GLETRGNPGP QPAASDMNNL VWNDELAYIA QVWANQCQFF VHDKCRNTAQ YQVGQNIAYS 130 140 150 160 170 180 ASTAAYPGIV SLIVLWENEV KDFNYSQGIT KENFAKVGHY TQVVWAKTKE VGCGSIKYIE 190 200 KGMKSHYLVC NYGPAGNYMG QPIYTKK

References

[1]	"Structural and immunological aspects of Polybia scutellaris antigen 5." Pirpignani M.L., Rivera E., Hellman U., Biscoglio de Jimenez Bonino M. Arch. Biochem. Biophys. 407:224-230(2002) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, SUBUNIT, TISSUE SPECIFICITY, ALLERGEN. Tissue: Venom.
[2]	"cDNA cloning of Polybia scutellaris Ag5." Pirpignani M.L., King T.P., Biscoglio M. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY299635 mRNA. Translation: AAP57536.1.
3D structure databases
ProteinModelPortal	Q7Z156.
SMR	Q7Z156. Positions 1-207.
ModBase	Search...
Protein family/group databases
Allergome	3494. Poly s 5.0101. 771. Poly s 5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.33.10. 1 hit.
InterPro	IPR001283. Allrgn_V5/Tpx1. IPR018244. Allrgn_V5/Tpx1_CS. IPR014044. CAP_domain. IPR002413. V5_allergen. [Graphical view]
PANTHER	PTHR10334. PTHR10334. 1 hit.
Pfam	PF00188. CAP. 1 hit. [Graphical view]
PRINTS	PR00838. V5ALLERGEN. PR00837. V5TPXLIKE.
SMART	SM00198. SCP. 1 hit. [Graphical view]
SUPFAM	SSF55797. SCP-like_extracellular. 1 hit.
PROSITE	PS01009. CRISP_1. 1 hit. PS01010. CRISP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VA5_POLSR

Accession

Primary (citable) accession number: Q7Z156
Secondary accession number(s): P82958

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	February 2, 2004
Last modified:	May 1, 2013
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)