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Protein

Iota-conotoxin-like R11.13

Gene
N/A
Organism
Conus radiatus (Rayed cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Iota-conotoxin-like R11.13
OrganismiConus radiatus (Rayed cone)
Taxonomic identifieri61198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri831. R11.13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000035110‹1 – 44Iota-conotoxin-like R11.13Add BLAST›44
PropeptideiPRO_000003511145Removed by a carboxypeptidaseBy similarity1

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 19By similarity
Disulfide bondi12 ↔ 22By similarity
Disulfide bondi18 ↔ 27By similarity
Disulfide bondi21 ↔ 36By similarity
Modified residuei43D-leucineBy similarity1

Keywords - PTMi

D-amino acid, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiQ7Z0A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013141. Conotoxin-I_CS.
IPR012624. Toxin_19.
PfamiView protein in Pfam
PF08088. Toxin_19. 1 hit.
PROSITEiView protein in PROSITE
PS60019. I_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z0A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
GHVPCGKDGR KCGYHADCCN CCLSGICKPS TSWTGCSTST FLLTR
Length:45
Mass (Da):4,755
Last modified:October 1, 2003 - v1
Checksum:iD10D94ED8C16AF14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208950 mRNA. Translation: AAP41532.1.

Similar proteinsi

Entry informationi

Entry nameiCI1BX_CONRA
AccessioniPrimary (citable) accession number: Q7Z0A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: November 22, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families