Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Iota-conotoxin RXIA

Gene
N/A
Organism
Conus radiatus (Rayed cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels. Produces general excitatory symptoms upon intracorporeal injection and repetitive action potentials in the frog cutaneous pectoris muscle. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.2 Publications

Miscellaneous

Does not have effect on sodium channels Nav1.1/SCN1A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A and on potassium channels Kv7.2/KCNQ2, Kv7.3/KCNQ3, Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.4/KCNA4, Kv1.5/KCNA5 and Kv1.6/KCNA6 (PubMed:18486102, PubMed:17696362).2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Iota-conotoxin RXIA
Alternative name(s):
R11.6
r11a
OrganismiConus radiatus (Rayed cone)
Taxonomic identifieri61198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConusPhasmoconus

Organism-specific databases

ConoServeri840 RXIA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868681 – 46Iota-conotoxin RXIAAdd BLAST46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24-hydroxyproline; partial1 Publication1
Disulfide bondi5 ↔ 191 Publication
Modified residuei114-hydroxyproline; partial1 Publication1
Disulfide bondi12 ↔ 221 Publication
Disulfide bondi18 ↔ 271 Publication
Disulfide bondi21 ↔ 381 Publication
Modified residuei294-hydroxyproline1 Publication1
Modified residuei44D-phenylalanine1 Publication1

Post-translational modificationi

The natural D-Phe-44 form of the peptide is more potent than the L-Phe-44 form.

Keywords - PTMi

D-amino acid, Disulfide bond, Hydroxylation

Proteomic databases

PRIDEiQ7Z094

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

Secondary structure

146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 10Combined sources3
Beta strandi18 – 23Combined sources6
Beta strandi26 – 29Combined sources4
Beta strandi32 – 35Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JRYNMR-A1-46[»]
2JTUNMR-A1-38[»]
2P4LNMR-A1-46[»]
ProteinModelPortaliQ7Z094
SMRiQ7Z094
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z094

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR012624 Toxin_19
PfamiView protein in Pfam
PF08088 Toxin_19, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
GPSFCKADEK PCEYHADCCN CCLSGICAPS TNWILPGCST SSFFKI
Length:46
Mass (Da):4,936
Last modified:October 1, 2003 - v1
Checksum:i32C2812A24D82675
GO

Mass spectrometryi

Molecular mass is 3816.7 Da from positions 1 - 46. Determined by LSI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208959 mRNA Translation: AAP41541.1

Similar proteinsi

Entry informationi

Entry nameiCI1BA_CONRA
AccessioniPrimary (citable) accession number: Q7Z094
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health