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Protein

Iota-conotoxin-like r11b

Gene
N/A
Organism
Conus radiatus (Rayed cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels (By similarity). Produces excitatory symptoms when injected intracranially into mice and is lethal at higher doses. Exposure to frog cutaneous pectoris induces spontaneous and repetitive action potentials. This effect is slowly reversible. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Iota-conotoxin-like r11b
Alternative name(s):
I-superfamily conotoxin R11.14
OrganismiConus radiatus (Rayed cone)
Taxonomic identifieri61198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri842. RXIB.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868711 – 46Iota-conotoxin-like r11bAdd BLAST46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24-hydroxyproline1 Publication1
Disulfide bondi5 ↔ 19By similarity
Modified residuei114-hydroxyproline1 Publication1
Disulfide bondi12 ↔ 22By similarity
Disulfide bondi18 ↔ 27By similarity
Disulfide bondi21 ↔ 38By similarity
Modified residuei294-hydroxyproline1 Publication1
Modified residuei44D-phenylalanine1 Publication1

Post-translational modificationi

The natural D-Phe form of the peptide is more potent than the synthetic L-Phe form.

Keywords - PTMi

D-amino acid, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliQ7Z092.
SMRiQ7Z092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013141. Conotoxin-I_CS.
IPR012624. Toxin_19.
PfamiView protein in Pfam
PF08088. Toxin_19. 1 hit.
PROSITEiView protein in PROSITE
PS60019. I_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7Z092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
GPSFCKANGK PCSYHADCCN CCLSGICKPS TNVILPGCST SSFFRI
Length:46
Mass (Da):4,819
Last modified:October 1, 2003 - v1
Checksum:iEA48F7B3E4DA3B4E
GO

Mass spectrometryi

Molecular mass is 4857.6 Da from positions 1 - 46. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208961 mRNA. Translation: AAP41543.1.

Similar proteinsi

Entry informationi

Entry nameiCI1BB_CONRA
AccessioniPrimary (citable) accession number: Q7Z092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families