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Q7Z020 (TRPA1_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transient receptor potential cation channel subfamily A member 1

Short name=dTRPA1
Alternative name(s):
Ankyrin-like with transmembrane domains protein 1
Short name=dANKTM1
Gene names
Name:TrpA1
Synonyms:Anktm1
ORF Names:CG5751
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1296 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential for thermotaxis by sensing environmental temperature. Receptor-activated non-selective cation channel involved in detection of sensations such as temperature. Involved in heat nociception by being activated by warm temperature of about 24-29 degrees Celsius. Ref.3 Ref.4

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Disruption phenotype

Eliminates avoidance of elevated temperatures along a thermal gradient. Ref.4

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. [View classification]

Contains 14 ANK repeats.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform E (identifier: Q7Z020-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform F (identifier: Q7Z020-2)

The sequence of this isoform differs from the canonical sequence as follows:
     789-819: AFLQCPFMFAKIDEKTGESITTASPIPLPAL → WPYQKTPEQIEAKRKEFNDPKWRPAPLAVV
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12961296Transient receptor potential cation channel subfamily A member 1
PRO_0000215373

Regions

Topological domain1 – 852852Cytoplasmic Potential
Transmembrane853 – 87321Helical; Name=1; Potential
Topological domain874 – 92653Extracellular Potential
Transmembrane927 – 94721Helical; Name=2; Potential
Topological domain948 – 9558Cytoplasmic Potential
Transmembrane956 – 97621Helical; Name=3; Potential
Topological domain977 – 98812Extracellular Potential
Transmembrane989 – 100921Helical; Name=4; Potential
Topological domain1010 – 103122Cytoplasmic Potential
Transmembrane1032 – 105221Helical; Name=5; Potential
Topological domain1053 – 107018Extracellular Potential
Transmembrane1071 – 109323Helical; Name=6; Potential
Topological domain1094 – 110310Cytoplasmic Potential
Transmembrane1104 – 112421Helical; Name=7; Potential
Topological domain1125 – 1296172Extracellular Potential
Repeat188 – 21730ANK 1
Repeat221 – 25030ANK 2
Repeat254 – 28330ANK 3
Repeat289 – 31830ANK 4
Repeat323 – 35230ANK 5
Repeat364 – 39330ANK 6
Repeat397 – 42630ANK 7
Repeat435 – 46430ANK 8
Repeat468 – 49730ANK 9
Repeat542 – 57130ANK 10
Repeat575 – 60430ANK 11
Repeat611 – 64030ANK 12
Repeat643 – 67331ANK 13
Repeat677 – 70630ANK 14

Amino acid modifications

Glycosylation8841N-linked (GlcNAc...) Potential
Glycosylation9011N-linked (GlcNAc...) Potential
Glycosylation9221N-linked (GlcNAc...) Potential
Glycosylation11741N-linked (GlcNAc...) Potential
Glycosylation12931N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence789 – 81931AFLQC…PLPAL → WPYQKTPEQIEAKRKEFNDP KWRPAPLAVV in isoform F.
VSP_030263

Sequences

Sequence LengthMass (Da)Tools
Isoform E [UniParc].

Last modified May 26, 2009. Version 3.
Checksum: F7A213B00F2E274E

FASTA1,296145,971
        10         20         30         40         50         60 
MPKLYNGVYS GQCGALSPPD LMEAQPKLLP KPRSNSSGST GRNSKYWIFS MIIERSAGPK 

        70         80         90        100        110        120 
RIEIDGDDAD TPLEAILPAE PPAEVCLLRD SPFRILRSTM TSGDKETPKR EDFASALRFL 

       130        140        150        160        170        180 
MGGCAREPEM TAMAPLNLPK KWARILRMSS TPKIPIVDYL EAAESGNLDD FKRLFMADNS 

       190        200        210        220        230        240 
RIALKDAKGR TAAHQAAARN RVNILRYIRD QNGDFNAKDN AGNTPLHIAV ESDAYDALDY 

       250        260        270        280        290        300 
LLSIPVDTGV LNEKKQAPVH LATELNKVKS LRVMGQYRNV IDIQQGGEHG RTALHLAAIY 

       310        320        330        340        350        360 
DHEECARILI TEFDACPRKP CNNGYYPIHE AAKNASSKTM EVFFQWGEQR GCTREEMISF 

       370        380        390        400        410        420 
YDSEGNVPLH SAVHGGDIKA VELCLKSGAK ISTQQHDLST PVHLACAQGA IDIVKLMFEM 

       430        440        450        460        470        480 
QPMEKRLCLS CTDVQKMTPL HCASMFDHPD IVSYLVAEGA DINALDKEHR SPLLLAASRS 

       490        500        510        520        530        540 
GWKTVHLLIR LGACISVKDA AARNVLHFVI MNGGRLTDFA EQVANCQTQA QLKLLLNEKD 

       550        560        570        580        590        600 
SMGCSPLHYA SRDGHIRSLE NLIRLGACIN LKNNNNESPL HFAARYGRYN TVRQLLDSEK 

       610        620        630        640        650        660 
GSFIINESDG AGMTPLHISS QQGHTRVVQL LLNRGALLHR DHTGRNPLQL AAMSGYTETI 

       670        680        690        700        710        720 
ELLHSVHSHL LDQVDKDGNT ALHLATMENK PHAISVLMSM GCKLVYNVLD MSAIDYAIYY 

       730        740        750        760        770        780 
KYPEAALAMV THEERANEVM ALRSDKHPCV TLALIASMPK VFEAVQDKCI TKANCKKDSK 

       790        800        810        820        830        840 
SFYIKYSFAF LQCPFMFAKI DEKTGESITT ASPIPLPALN TMVTHGRVEL LAHPLSQKYL 

       850        860        870        880        890        900 
QMKWNSYGKY FHLANLLIYS IFLVFVTIYS SLMMNNIELK AGDNKTMSQY CNMGWEQLTM 

       910        920        930        940        950        960 
NLSQNPSVAS QIRLDSCEER INRTTAILFC AVVIVVYILL NSMRELIQIY QQKLHYILET 

       970        980        990       1000       1010       1020 
VNLISWVLYI SALVMVTPAF QPDGGINTIH YSAASIAVFL SWFRLLLFLQ RFDQVGIYVV 

      1030       1040       1050       1060       1070       1080 
MFLEILQTLI KVLMVFSILI IAFGLAFYIL LSKIIDPQPN HLSFSNIPMS LLRTFSMMLG 

      1090       1100       1110       1120       1130       1140 
ELDFVGTYVN TYYRDQLKVP MTSFLILSVF MILMPILLMN LLIGLAVGDI ESVRRNAQLK 

      1150       1160       1170       1180       1190       1200 
RLAMQVVLHT ELERKLPHVW LQRVDKMELI EYPNETKCKL GFCDFILRKW FSNPFTEDSS 

      1210       1220       1230       1240       1250       1260 
MDVISFDNND DYINAELERQ RRKLRDISRM LEQQHHLVRL IVQKMEIKTE ADDVDEGISP 

      1270       1280       1290 
NELRSVVGLR SAGGNRWNSP RVRNKLRAAL SFNKSM 

« Hide

Isoform F [UniParc].

Checksum: 01333DE406A37216
Show »

FASTA1,295146,256

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[3]"Ion channels: opposite thermosensor in fruitfly and mouse."
Viswanath V., Story G.M., Peier A.M., Petrus M.J., Lee V.M., Hwang S.W., Patapoutian A., Jegla T.
Nature 423:822-823(2003) [PubMed: 12815418] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-1296 (ISOFORM E), FUNCTION.
[4]"The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis."
Rosenzweig M., Brennan K.M., Tayler T.D., Phelps P.O., Patapoutian A., Garrity P.A.
Genes Dev. 19:419-424(2005) [PubMed: 15681611] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Web resources

Protein Spotlight

The power behind pain - Issue 82 of May 2007

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014296 Genomic DNA. Translation: AAF50356.4.
AE014296 Genomic DNA. Translation: ABW08500.3.
AY302598 mRNA. Translation: AAP76197.1.
RefSeqNP_001097554.3. NM_001104084.3.
NP_648263.4. NM_140006.4.
UniGeneDm.15461.

3D structure databases

ProteinModelPortalQ7Z020.
SMRQ7Z020. Positions 48-768.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7Z020.

Protein family/group databases

TCDB1.A.4.6.2. transient receptor potential Ca2+ channel (TRP-CC) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0300208; FBpp0289445; FBgn0035934.
GeneID39015.
KEGGdme:Dmel_CG5751.

Organism-specific databases

CTD8989.
FlyBaseFBgn0035934. TrpA1.

Phylogenomic databases

eggNOGinNOG08973.
GeneTreeEMGT00070000025711.
InParanoidQ7Z020.
OrthoDBEOG415DV7.
PhylomeDBQ7Z020.

Gene expression databases

BgeeQ7Z020.

Family and domain databases

InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 4 hits.
KOK04984.
PfamPF12796. Ank_2. 5 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 15 hits.
[Graphical view]
SUPFAMSSF48403. ANK. 3 hits.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio811470.

Entry information

Entry nameTRPA1_DROME
AccessionPrimary (citable) accession number: Q7Z020
Secondary accession number(s): A8JNP0, Q9VSQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 26, 2009
Last modified: January 25, 2012
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries