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Q7YZT6 (TPS1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1

EC=2.4.1.15
Alternative name(s):
Trehalose-6-phosphate synthase 1
UDP-glucose-glucosephosphate glucosyltransferase 1
Gene names
Name:tps-1
Synonyms:tps1
ORF Names:ZK54.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process.

Catalytic activity

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Developmental stage

Expressed in all development stages. Ref.1

Disruption phenotype

No visible phenotype. Ref.1

Sequence similarities

In the N-terminal section; belongs to the glycosyltransferase 20 family.

In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtrehalose biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionalpha,alpha-trehalose-phosphate synthase (UDP-forming) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q7YZT6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform b (identifier: Q7YZT6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13311331Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1
PRO_0000385176

Natural variations

Alternative sequence1 – 3737Missing in isoform b.
VSP_038112

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 80A59C0D37783E75

FASTA1,331150,819
        10         20         30         40         50         60 
MTDTATGVHS NANGVEKVPT PVFSIEGEPT QETAPTRMDP FDRPKNDNDP FEDALKRCHK 

        70         80         90        100        110        120 
ILEKLDCPFV TGKEKDLDES DDMTENEDHD EMANEDDGIP SNEKKVETRK MDCTSGQLLA 

       130        140        150        160        170        180 
PKLPEKAESI SSASESSEDS ESVAILKYTV RTCYAIWKKR QKNSEIALKG LMIVLELCLS 

       190        200        210        220        230        240 
QPSARDDAFS ALLETLGYNT VTFWKAVVPQ IYNSDLSYAT QYREALLFSL VLYDVNHSKN 

       250        260        270        280        290        300 
RLRELYAAVP GVRQSMLGIR AKQFGERYRH LQMKIARSRA SSRMSSKMGS EENLPAMASM 

       310        320        330        340        350        360 
MNDVVFDEEP HTQSPLVDMS HDKQRVINVS NAPPVSISRK TSGSWEIKQG SGGLVACVDP 

       370        380        390        400        410        420 
VMSADKKNIW LSNLGVNMQE ELKEHSTSTN SLGLPLIKQA CAGEVFCVLE RNEKKEELTP 

       430        440        450        460        470        480 
KQQAVESDMS LLSVLNTYNK HSYQLNPVVV NQDDYNTYYG GISNGLLWPA LHNLPQYISP 

       490        500        510        520        530        540 
CFDDPELLRE QWCAYVRVNY LFAINAARNS RAQDFIWIHD YHLMLCGQIM RSLESSLDIG 

       550        560        570        580        590        600 
FFIHIPFQPP ANFMTKYKTV ADPIMRALLR FTKVGFQTSR DRDTFVKLVA KHIKRTKIEY 

       610        620        630        640        650        660 
DSRLDRYTIE HDGWTCSLGV FPVSIKIADF VNIAKNPQTI IEAEEIKKQI MGRSADGGQL 

       670        680        690        700        710        720 
FFSVERFDYT KGISEKLRAW QRYFEKYPDR IGKDVLFQVA VTNRRSVDSY RQYQDDVLAV 

       730        740        750        760        770        780 
ADLINQKFKS EDYPEWKPVI FETDGLPRTR LIAHYLAMDI GVVTPSKDGM NLVAKEMLVC 

       790        800        810        820        830        840 
NPTASLVLST GAGTEVQLSN AQFYSEQEGK CYHRVEEISN TEAFADNFFA AATESKETRT 

       850        860        870        880        890        900 
KHGEKINQFL CVHDIDEWSD QFLDPKWTHE VISQCEVKQL GQFYGLMSRT AQVRRQIVEC 

       910        920        930        940        950        960 
VLKGLPIRPH FRYSLENAKN SLESSCKSGT KLSLEADEES GEEKGFEITY DIHDELSEME 

       970        980        990       1000       1010       1020 
KDLAFLAFIQ SDEYENAEEF IKTLGSFYEG GPVLFKNEVK QAAEMLQQGI HYNTFFTDRD 

      1030       1040       1050       1060       1070       1080 
GTLKSYACSY PTSVQPAYSA VIQAQFARRC ATFCAIVTTA PLLHTGILEV ATIPEGYYAY 

      1090       1100       1110       1120       1130       1140 
GASAGREWYL NPAQQFKDRS FSAIDLNLMN KVFDIIEELL ERPEFRIFKW IGSGIQKHCG 

      1150       1160       1170       1180       1190       1200 
HITIAKQDVN GTIPSRKVIR LYEQLVKIVN DFDPNGTTLT MRESDLDFKI YVKAKLKGRI 

      1210       1220       1230       1240       1250       1260 
FNKGHGIRLV RERLKPNMSK GNCLVCGDNE SDIPMLEECL KLAGSKVYTI WVTADTNLQE 

      1270       1280       1290       1300       1310       1320 
KVTQLCDRFS CSNIHFVSCP QVLLGAMAYA TAHTLVDERN RKLDYYYDSD TPMDQEESST 

      1330 
LGASLGTSFG N 

« Hide

Isoform b [UniParc].

Checksum: F10EA7BF1E386CA6
Show »

FASTA1,294146,967

References

« Hide 'large scale' references
[1]"Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes."
Pellerone F.I., Archer S.K., Behm C.A., Grant W.N., Lacey M.J., Somerville A.C.
Int. J. Parasitol. 33:1195-1206(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
Strain: Bristol N2.
[2]"Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
Strain: Bristol N2.
[3]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ512332 mRNA. Translation: CAD54506.1.
AJ811573 mRNA. Translation: CAH18875.1.
FO080803 Genomic DNA. Translation: CCD66907.1.
FO080803 Genomic DNA. Translation: CCD66908.1.
RefSeqNP_001041302.1. NM_001047837.2. [Q7YZT6-1]
NP_001041303.1. NM_001047838.2. [Q7YZT6-2]
UniGeneCel.17727.

3D structure databases

ProteinModelPortalQ7YZT6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.ZK54.2a.

Protein family/group databases

CAZyGT20. Glycosyltransferase Family 20.

Proteomic databases

PaxDbQ7YZT6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK54.2a.1; ZK54.2a.1; WBGene00006602. [Q7YZT6-1]
ZK54.2a.2; ZK54.2a.2; WBGene00006602. [Q7YZT6-1]
ZK54.2a.3; ZK54.2a.3; WBGene00006602. [Q7YZT6-1]
GeneID181778.
KEGGcel:CELE_ZK54.2.
UCSCZK54.2b.3. c. elegans. [Q7YZT6-1]

Organism-specific databases

CTD181778.
WormBaseZK54.2a; CE07617; WBGene00006602; tps-1.
ZK54.2b; CE30330; WBGene00006602; tps-1.

Phylogenomic databases

eggNOGCOG0380.
GeneTreeENSGT00550000075394.
HOGENOMHOG000016516.
InParanoidQ7YZT6.
OMAIAHYLAM.

Family and domain databases

Gene3D3.40.50.1000. 2 hits.
InterProIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
ProtoNetSearch...

Other

NextBio915306.

Entry information

Entry nameTPS1_CAEEL
AccessionPrimary (citable) accession number: Q7YZT6
Secondary accession number(s): Q23515, Q2L6W2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase