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Q7YZT6

- TPS1_CAEEL

UniProt

Q7YZT6 - TPS1_CAEEL

Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1

Gene

tps-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process.

    Catalytic activityi

    UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

    GO - Molecular functioni

    1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. trehalose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT20. Glycosyltransferase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 (EC:2.4.1.15)
    Alternative name(s):
    Trehalose-6-phosphate synthase 1
    UDP-glucose-glucosephosphate glucosyltransferase 1
    Gene namesi
    Name:tps-1
    Synonyms:tps1
    ORF Names:ZK54.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiZK54.2a; CE07617; WBGene00006602; tps-1.
    ZK54.2b; CE30330; WBGene00006602; tps-1.

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13311331Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1PRO_0000385176Add
    BLAST

    Proteomic databases

    PaxDbiQ7YZT6.

    Expressioni

    Developmental stagei

    Expressed in all development stages.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.ZK54.2a.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7YZT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
    In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.Curated

    Phylogenomic databases

    eggNOGiCOG0380.
    GeneTreeiENSGT00550000075394.
    HOGENOMiHOG000016516.
    InParanoidiQ7YZT6.
    OMAiIAHYLAM.

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR001830. Glyco_trans_20.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00982. Glyco_transf_20. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q7YZT6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTDTATGVHS NANGVEKVPT PVFSIEGEPT QETAPTRMDP FDRPKNDNDP     50
    FEDALKRCHK ILEKLDCPFV TGKEKDLDES DDMTENEDHD EMANEDDGIP 100
    SNEKKVETRK MDCTSGQLLA PKLPEKAESI SSASESSEDS ESVAILKYTV 150
    RTCYAIWKKR QKNSEIALKG LMIVLELCLS QPSARDDAFS ALLETLGYNT 200
    VTFWKAVVPQ IYNSDLSYAT QYREALLFSL VLYDVNHSKN RLRELYAAVP 250
    GVRQSMLGIR AKQFGERYRH LQMKIARSRA SSRMSSKMGS EENLPAMASM 300
    MNDVVFDEEP HTQSPLVDMS HDKQRVINVS NAPPVSISRK TSGSWEIKQG 350
    SGGLVACVDP VMSADKKNIW LSNLGVNMQE ELKEHSTSTN SLGLPLIKQA 400
    CAGEVFCVLE RNEKKEELTP KQQAVESDMS LLSVLNTYNK HSYQLNPVVV 450
    NQDDYNTYYG GISNGLLWPA LHNLPQYISP CFDDPELLRE QWCAYVRVNY 500
    LFAINAARNS RAQDFIWIHD YHLMLCGQIM RSLESSLDIG FFIHIPFQPP 550
    ANFMTKYKTV ADPIMRALLR FTKVGFQTSR DRDTFVKLVA KHIKRTKIEY 600
    DSRLDRYTIE HDGWTCSLGV FPVSIKIADF VNIAKNPQTI IEAEEIKKQI 650
    MGRSADGGQL FFSVERFDYT KGISEKLRAW QRYFEKYPDR IGKDVLFQVA 700
    VTNRRSVDSY RQYQDDVLAV ADLINQKFKS EDYPEWKPVI FETDGLPRTR 750
    LIAHYLAMDI GVVTPSKDGM NLVAKEMLVC NPTASLVLST GAGTEVQLSN 800
    AQFYSEQEGK CYHRVEEISN TEAFADNFFA AATESKETRT KHGEKINQFL 850
    CVHDIDEWSD QFLDPKWTHE VISQCEVKQL GQFYGLMSRT AQVRRQIVEC 900
    VLKGLPIRPH FRYSLENAKN SLESSCKSGT KLSLEADEES GEEKGFEITY 950
    DIHDELSEME KDLAFLAFIQ SDEYENAEEF IKTLGSFYEG GPVLFKNEVK 1000
    QAAEMLQQGI HYNTFFTDRD GTLKSYACSY PTSVQPAYSA VIQAQFARRC 1050
    ATFCAIVTTA PLLHTGILEV ATIPEGYYAY GASAGREWYL NPAQQFKDRS 1100
    FSAIDLNLMN KVFDIIEELL ERPEFRIFKW IGSGIQKHCG HITIAKQDVN 1150
    GTIPSRKVIR LYEQLVKIVN DFDPNGTTLT MRESDLDFKI YVKAKLKGRI 1200
    FNKGHGIRLV RERLKPNMSK GNCLVCGDNE SDIPMLEECL KLAGSKVYTI 1250
    WVTADTNLQE KVTQLCDRFS CSNIHFVSCP QVLLGAMAYA TAHTLVDERN 1300
    RKLDYYYDSD TPMDQEESST LGASLGTSFG N 1331

    Note: No experimental confirmation available.

    Length:1,331
    Mass (Da):150,819
    Last modified:October 1, 2003 - v1
    Checksum:i80A59C0D37783E75
    GO
    Isoform b (identifier: Q7YZT6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-37: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,294
    Mass (Da):146,967
    Checksum:iF10EA7BF1E386CA6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3737Missing in isoform b. CuratedVSP_038112Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ512332 mRNA. Translation: CAD54506.1.
    AJ811573 mRNA. Translation: CAH18875.1.
    FO080803 Genomic DNA. Translation: CCD66907.1.
    FO080803 Genomic DNA. Translation: CCD66908.1.
    RefSeqiNP_001041302.1. NM_001047837.2. [Q7YZT6-1]
    NP_001041303.1. NM_001047838.2. [Q7YZT6-2]
    UniGeneiCel.17727.

    Genome annotation databases

    EnsemblMetazoaiZK54.2a.1; ZK54.2a.1; WBGene00006602. [Q7YZT6-1]
    ZK54.2a.2; ZK54.2a.2; WBGene00006602. [Q7YZT6-1]
    ZK54.2a.3; ZK54.2a.3; WBGene00006602. [Q7YZT6-1]
    GeneIDi181778.
    KEGGicel:CELE_ZK54.2.
    UCSCiZK54.2b.3. c. elegans. [Q7YZT6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ512332 mRNA. Translation: CAD54506.1 .
    AJ811573 mRNA. Translation: CAH18875.1 .
    FO080803 Genomic DNA. Translation: CCD66907.1 .
    FO080803 Genomic DNA. Translation: CCD66908.1 .
    RefSeqi NP_001041302.1. NM_001047837.2. [Q7YZT6-1 ]
    NP_001041303.1. NM_001047838.2. [Q7YZT6-2 ]
    UniGenei Cel.17727.

    3D structure databases

    ProteinModelPortali Q7YZT6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.ZK54.2a.

    Protein family/group databases

    CAZyi GT20. Glycosyltransferase Family 20.

    Proteomic databases

    PaxDbi Q7YZT6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZK54.2a.1 ; ZK54.2a.1 ; WBGene00006602 . [Q7YZT6-1 ]
    ZK54.2a.2 ; ZK54.2a.2 ; WBGene00006602 . [Q7YZT6-1 ]
    ZK54.2a.3 ; ZK54.2a.3 ; WBGene00006602 . [Q7YZT6-1 ]
    GeneIDi 181778.
    KEGGi cel:CELE_ZK54.2.
    UCSCi ZK54.2b.3. c. elegans. [Q7YZT6-1 ]

    Organism-specific databases

    CTDi 181778.
    WormBasei ZK54.2a ; CE07617 ; WBGene00006602 ; tps-1.
    ZK54.2b ; CE30330 ; WBGene00006602 ; tps-1.

    Phylogenomic databases

    eggNOGi COG0380.
    GeneTreei ENSGT00550000075394.
    HOGENOMi HOG000016516.
    InParanoidi Q7YZT6.
    OMAi IAHYLAM.

    Miscellaneous databases

    NextBioi 915306.

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR001830. Glyco_trans_20.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00982. Glyco_transf_20. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes."
      Pellerone F.I., Archer S.K., Behm C.A., Grant W.N., Lacey M.J., Somerville A.C.
      Int. J. Parasitol. 33:1195-1206(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
      Strain: Bristol N2.
    2. "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
      Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
      Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
      Strain: Bristol N2.
    3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiTPS1_CAEEL
    AccessioniPrimary (citable) accession number: Q7YZT6
    Secondary accession number(s): Q23515, Q2L6W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3