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Q7YZT6

- TPS1_CAEEL

UniProt

Q7YZT6 - TPS1_CAEEL

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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1

Gene
tps-1, tps1, ZK54.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process.

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase 1
UDP-glucose-glucosephosphate glucosyltransferase 1
Gene namesi
Name:tps-1
Synonyms:tps1
ORF Names:ZK54.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiZK54.2a; CE07617; WBGene00006602; tps-1.
ZK54.2b; CE30330; WBGene00006602; tps-1.

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13311331Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1PRO_0000385176Add
BLAST

Proteomic databases

PaxDbiQ7YZT6.

Expressioni

Developmental stagei

Expressed in all development stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK54.2a.

Structurei

3D structure databases

ProteinModelPortaliQ7YZT6.

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.
In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.

Phylogenomic databases

eggNOGiCOG0380.
GeneTreeiENSGT00550000075394.
HOGENOMiHOG000016516.
InParanoidiQ7YZT6.
OMAiIAHYLAM.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q7YZT6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTDTATGVHS NANGVEKVPT PVFSIEGEPT QETAPTRMDP FDRPKNDNDP     50
FEDALKRCHK ILEKLDCPFV TGKEKDLDES DDMTENEDHD EMANEDDGIP 100
SNEKKVETRK MDCTSGQLLA PKLPEKAESI SSASESSEDS ESVAILKYTV 150
RTCYAIWKKR QKNSEIALKG LMIVLELCLS QPSARDDAFS ALLETLGYNT 200
VTFWKAVVPQ IYNSDLSYAT QYREALLFSL VLYDVNHSKN RLRELYAAVP 250
GVRQSMLGIR AKQFGERYRH LQMKIARSRA SSRMSSKMGS EENLPAMASM 300
MNDVVFDEEP HTQSPLVDMS HDKQRVINVS NAPPVSISRK TSGSWEIKQG 350
SGGLVACVDP VMSADKKNIW LSNLGVNMQE ELKEHSTSTN SLGLPLIKQA 400
CAGEVFCVLE RNEKKEELTP KQQAVESDMS LLSVLNTYNK HSYQLNPVVV 450
NQDDYNTYYG GISNGLLWPA LHNLPQYISP CFDDPELLRE QWCAYVRVNY 500
LFAINAARNS RAQDFIWIHD YHLMLCGQIM RSLESSLDIG FFIHIPFQPP 550
ANFMTKYKTV ADPIMRALLR FTKVGFQTSR DRDTFVKLVA KHIKRTKIEY 600
DSRLDRYTIE HDGWTCSLGV FPVSIKIADF VNIAKNPQTI IEAEEIKKQI 650
MGRSADGGQL FFSVERFDYT KGISEKLRAW QRYFEKYPDR IGKDVLFQVA 700
VTNRRSVDSY RQYQDDVLAV ADLINQKFKS EDYPEWKPVI FETDGLPRTR 750
LIAHYLAMDI GVVTPSKDGM NLVAKEMLVC NPTASLVLST GAGTEVQLSN 800
AQFYSEQEGK CYHRVEEISN TEAFADNFFA AATESKETRT KHGEKINQFL 850
CVHDIDEWSD QFLDPKWTHE VISQCEVKQL GQFYGLMSRT AQVRRQIVEC 900
VLKGLPIRPH FRYSLENAKN SLESSCKSGT KLSLEADEES GEEKGFEITY 950
DIHDELSEME KDLAFLAFIQ SDEYENAEEF IKTLGSFYEG GPVLFKNEVK 1000
QAAEMLQQGI HYNTFFTDRD GTLKSYACSY PTSVQPAYSA VIQAQFARRC 1050
ATFCAIVTTA PLLHTGILEV ATIPEGYYAY GASAGREWYL NPAQQFKDRS 1100
FSAIDLNLMN KVFDIIEELL ERPEFRIFKW IGSGIQKHCG HITIAKQDVN 1150
GTIPSRKVIR LYEQLVKIVN DFDPNGTTLT MRESDLDFKI YVKAKLKGRI 1200
FNKGHGIRLV RERLKPNMSK GNCLVCGDNE SDIPMLEECL KLAGSKVYTI 1250
WVTADTNLQE KVTQLCDRFS CSNIHFVSCP QVLLGAMAYA TAHTLVDERN 1300
RKLDYYYDSD TPMDQEESST LGASLGTSFG N 1331

Note: No experimental confirmation available.

Length:1,331
Mass (Da):150,819
Last modified:October 1, 2003 - v1
Checksum:i80A59C0D37783E75
GO
Isoform b (identifier: Q7YZT6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Note: No experimental confirmation available.

Show »
Length:1,294
Mass (Da):146,967
Checksum:iF10EA7BF1E386CA6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3737Missing in isoform b. VSP_038112Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ512332 mRNA. Translation: CAD54506.1.
AJ811573 mRNA. Translation: CAH18875.1.
FO080803 Genomic DNA. Translation: CCD66907.1.
FO080803 Genomic DNA. Translation: CCD66908.1.
RefSeqiNP_001041302.1. NM_001047837.2. [Q7YZT6-1]
NP_001041303.1. NM_001047838.2. [Q7YZT6-2]
UniGeneiCel.17727.

Genome annotation databases

EnsemblMetazoaiZK54.2a.1; ZK54.2a.1; WBGene00006602. [Q7YZT6-1]
ZK54.2a.2; ZK54.2a.2; WBGene00006602. [Q7YZT6-1]
ZK54.2a.3; ZK54.2a.3; WBGene00006602. [Q7YZT6-1]
GeneIDi181778.
KEGGicel:CELE_ZK54.2.
UCSCiZK54.2b.3. c. elegans. [Q7YZT6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ512332 mRNA. Translation: CAD54506.1 .
AJ811573 mRNA. Translation: CAH18875.1 .
FO080803 Genomic DNA. Translation: CCD66907.1 .
FO080803 Genomic DNA. Translation: CCD66908.1 .
RefSeqi NP_001041302.1. NM_001047837.2. [Q7YZT6-1 ]
NP_001041303.1. NM_001047838.2. [Q7YZT6-2 ]
UniGenei Cel.17727.

3D structure databases

ProteinModelPortali Q7YZT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.ZK54.2a.

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Proteomic databases

PaxDbi Q7YZT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZK54.2a.1 ; ZK54.2a.1 ; WBGene00006602 . [Q7YZT6-1 ]
ZK54.2a.2 ; ZK54.2a.2 ; WBGene00006602 . [Q7YZT6-1 ]
ZK54.2a.3 ; ZK54.2a.3 ; WBGene00006602 . [Q7YZT6-1 ]
GeneIDi 181778.
KEGGi cel:CELE_ZK54.2.
UCSCi ZK54.2b.3. c. elegans. [Q7YZT6-1 ]

Organism-specific databases

CTDi 181778.
WormBasei ZK54.2a ; CE07617 ; WBGene00006602 ; tps-1.
ZK54.2b ; CE30330 ; WBGene00006602 ; tps-1.

Phylogenomic databases

eggNOGi COG0380.
GeneTreei ENSGT00550000075394.
HOGENOMi HOG000016516.
InParanoidi Q7YZT6.
OMAi IAHYLAM.

Miscellaneous databases

NextBioi 915306.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes."
    Pellerone F.I., Archer S.K., Behm C.A., Grant W.N., Lacey M.J., Somerville A.C.
    Int. J. Parasitol. 33:1195-1206(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    Strain: Bristol N2.
  2. "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
    Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
    Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Strain: Bristol N2.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiTPS1_CAEEL
AccessioniPrimary (citable) accession number: Q7YZT6
Secondary accession number(s): Q23515, Q2L6W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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