Q7YZT6 (TPS1_CAEEL) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 57.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 EC=2.4.1.15 Alternative name(s): Trehalose-6-phosphate synthase 1 UDP-glucose-glucosephosphate glucosyltransferase 1 | ||||||
| Gene names |
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| Organism | Caenorhabditis elegans [Reference proteome] | ||||||
| Taxonomic identifier | 6239 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 1331 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process. |
| Catalytic activity | UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate. |
| Developmental stage | Expressed in all development stages. Ref.1 |
| Disruption phenotype | No visible phenotype. Ref.1 |
| Sequence similarities | In the N-terminal section; belongs to the glycosyltransferase 20 family. In the C-terminal section; belongs to the gob-1 trehalose phosphatase family. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | trehalose biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular_function | alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform a (identifier: Q7YZT6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform b (identifier: Q7YZT6-2) The sequence of this isoform differs from the canonical sequence as follows: 1-37: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes." Pellerone F.I., Archer S.K., Behm C.A., Grant W.N., Lacey M.J., Somerville A.C. Int. J. Parasitol. 33:1195-1206(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE. Strain: Bristol N2. |
| [2] | "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins." Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A. Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). Strain: Bristol N2. |
| [3] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ512332 mRNA. Translation: CAD54506.1. AJ811573 mRNA. Translation: CAH18875.1. FO080803 Genomic DNA. Translation: CCD66907.1. FO080803 Genomic DNA. Translation: CCD66908.1. |
| RefSeq | NP_001041302.1. NM_001047837.2. NP_001041303.1. NM_001047838.2. |
| UniGene | Cel.17727. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1UQT based on UniProtKB P31677. |
| ProteinModelPortal | Q7YZT6. |
| SMR | Q7YZT6. Positions 450-863. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 6239.ZK54.2a. |
Protein family/group databases | |
| CAZy | GT20. Glycosyltransferase Family 20. |
Proteomic databases | |
| PaxDb | Q7YZT6. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | ZK54.2a.1; ZK54.2a.1; ZK54.2. ZK54.2a.2; ZK54.2a.2; ZK54.2. ZK54.2a.3; ZK54.2a.3; ZK54.2. |
| GeneID | 181778. |
| KEGG | cel:CELE_ZK54.2. |
| UCSC | ZK54.2b.3. c. elegans. |
Organism-specific databases | |
| CTD | 181778. |
| WormBase | ZK54.2a; CE07617; WBGene00006602; tps-1. ZK54.2b; CE30330; WBGene00006602; tps-1. |
Phylogenomic databases | |
| eggNOG | COG0380. |
| GeneTree | ENSGT00550000075394. |
| HOGENOM | HOG000016516. |
| InParanoid | Q7YZT6. |
| OMA | IAHYLAM. |
Family and domain databases | |
| Gene3D | 3.40.50.1000. 2 hits. |
| InterPro | IPR001830. Glyco_trans_20. IPR023214. HAD-like_dom. [Graphical view] |
| Pfam | PF00982. Glyco_transf_20. 1 hit. [Graphical view] |
| SUPFAM | SSF56784. HAD-like_dom. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 915306. |
Entry information
| Entry name | TPS1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q7YZT6 Secondary accession number(s): Q23515, Q2L6W2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormBase |
| SIMILARITY comments Index of protein domains and families |