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Q7YZT6

- TPS1_CAEEL

UniProt

Q7YZT6 - TPS1_CAEEL

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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1

Gene

tps-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process.

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase 1
UDP-glucose-glucosephosphate glucosyltransferase 1
Gene namesi
Name:tps-1
Synonyms:tps1
ORF Names:ZK54.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiZK54.2a; CE07617; WBGene00006602; tps-1.
ZK54.2b; CE30330; WBGene00006602; tps-1.

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13311331Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1PRO_0000385176Add
BLAST

Proteomic databases

PaxDbiQ7YZT6.

Expressioni

Developmental stagei

Expressed in all development stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK54.2a.

Structurei

3D structure databases

ProteinModelPortaliQ7YZT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.Curated

Phylogenomic databases

eggNOGiCOG0380.
GeneTreeiENSGT00550000075394.
HOGENOMiHOG000016516.
InParanoidiQ7YZT6.
OMAiIAHYLAM.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q7YZT6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDTATGVHS NANGVEKVPT PVFSIEGEPT QETAPTRMDP FDRPKNDNDP
60 70 80 90 100
FEDALKRCHK ILEKLDCPFV TGKEKDLDES DDMTENEDHD EMANEDDGIP
110 120 130 140 150
SNEKKVETRK MDCTSGQLLA PKLPEKAESI SSASESSEDS ESVAILKYTV
160 170 180 190 200
RTCYAIWKKR QKNSEIALKG LMIVLELCLS QPSARDDAFS ALLETLGYNT
210 220 230 240 250
VTFWKAVVPQ IYNSDLSYAT QYREALLFSL VLYDVNHSKN RLRELYAAVP
260 270 280 290 300
GVRQSMLGIR AKQFGERYRH LQMKIARSRA SSRMSSKMGS EENLPAMASM
310 320 330 340 350
MNDVVFDEEP HTQSPLVDMS HDKQRVINVS NAPPVSISRK TSGSWEIKQG
360 370 380 390 400
SGGLVACVDP VMSADKKNIW LSNLGVNMQE ELKEHSTSTN SLGLPLIKQA
410 420 430 440 450
CAGEVFCVLE RNEKKEELTP KQQAVESDMS LLSVLNTYNK HSYQLNPVVV
460 470 480 490 500
NQDDYNTYYG GISNGLLWPA LHNLPQYISP CFDDPELLRE QWCAYVRVNY
510 520 530 540 550
LFAINAARNS RAQDFIWIHD YHLMLCGQIM RSLESSLDIG FFIHIPFQPP
560 570 580 590 600
ANFMTKYKTV ADPIMRALLR FTKVGFQTSR DRDTFVKLVA KHIKRTKIEY
610 620 630 640 650
DSRLDRYTIE HDGWTCSLGV FPVSIKIADF VNIAKNPQTI IEAEEIKKQI
660 670 680 690 700
MGRSADGGQL FFSVERFDYT KGISEKLRAW QRYFEKYPDR IGKDVLFQVA
710 720 730 740 750
VTNRRSVDSY RQYQDDVLAV ADLINQKFKS EDYPEWKPVI FETDGLPRTR
760 770 780 790 800
LIAHYLAMDI GVVTPSKDGM NLVAKEMLVC NPTASLVLST GAGTEVQLSN
810 820 830 840 850
AQFYSEQEGK CYHRVEEISN TEAFADNFFA AATESKETRT KHGEKINQFL
860 870 880 890 900
CVHDIDEWSD QFLDPKWTHE VISQCEVKQL GQFYGLMSRT AQVRRQIVEC
910 920 930 940 950
VLKGLPIRPH FRYSLENAKN SLESSCKSGT KLSLEADEES GEEKGFEITY
960 970 980 990 1000
DIHDELSEME KDLAFLAFIQ SDEYENAEEF IKTLGSFYEG GPVLFKNEVK
1010 1020 1030 1040 1050
QAAEMLQQGI HYNTFFTDRD GTLKSYACSY PTSVQPAYSA VIQAQFARRC
1060 1070 1080 1090 1100
ATFCAIVTTA PLLHTGILEV ATIPEGYYAY GASAGREWYL NPAQQFKDRS
1110 1120 1130 1140 1150
FSAIDLNLMN KVFDIIEELL ERPEFRIFKW IGSGIQKHCG HITIAKQDVN
1160 1170 1180 1190 1200
GTIPSRKVIR LYEQLVKIVN DFDPNGTTLT MRESDLDFKI YVKAKLKGRI
1210 1220 1230 1240 1250
FNKGHGIRLV RERLKPNMSK GNCLVCGDNE SDIPMLEECL KLAGSKVYTI
1260 1270 1280 1290 1300
WVTADTNLQE KVTQLCDRFS CSNIHFVSCP QVLLGAMAYA TAHTLVDERN
1310 1320 1330
RKLDYYYDSD TPMDQEESST LGASLGTSFG N

Note: No experimental confirmation available.

Length:1,331
Mass (Da):150,819
Last modified:October 1, 2003 - v1
Checksum:i80A59C0D37783E75
GO
Isoform b (identifier: Q7YZT6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Note: No experimental confirmation available.

Show »
Length:1,294
Mass (Da):146,967
Checksum:iF10EA7BF1E386CA6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3737Missing in isoform b. CuratedVSP_038112Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512332 mRNA. Translation: CAD54506.1.
AJ811573 mRNA. Translation: CAH18875.1.
FO080803 Genomic DNA. Translation: CCD66907.1.
FO080803 Genomic DNA. Translation: CCD66908.1.
RefSeqiNP_001041302.1. NM_001047837.2. [Q7YZT6-1]
NP_001041303.1. NM_001047838.2. [Q7YZT6-2]
UniGeneiCel.17727.

Genome annotation databases

EnsemblMetazoaiZK54.2a.1; ZK54.2a.1; WBGene00006602. [Q7YZT6-1]
ZK54.2a.2; ZK54.2a.2; WBGene00006602. [Q7YZT6-1]
ZK54.2a.3; ZK54.2a.3; WBGene00006602. [Q7YZT6-1]
GeneIDi181778.
KEGGicel:CELE_ZK54.2.
UCSCiZK54.2b.3. c. elegans. [Q7YZT6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512332 mRNA. Translation: CAD54506.1 .
AJ811573 mRNA. Translation: CAH18875.1 .
FO080803 Genomic DNA. Translation: CCD66907.1 .
FO080803 Genomic DNA. Translation: CCD66908.1 .
RefSeqi NP_001041302.1. NM_001047837.2. [Q7YZT6-1 ]
NP_001041303.1. NM_001047838.2. [Q7YZT6-2 ]
UniGenei Cel.17727.

3D structure databases

ProteinModelPortali Q7YZT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.ZK54.2a.

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Proteomic databases

PaxDbi Q7YZT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZK54.2a.1 ; ZK54.2a.1 ; WBGene00006602 . [Q7YZT6-1 ]
ZK54.2a.2 ; ZK54.2a.2 ; WBGene00006602 . [Q7YZT6-1 ]
ZK54.2a.3 ; ZK54.2a.3 ; WBGene00006602 . [Q7YZT6-1 ]
GeneIDi 181778.
KEGGi cel:CELE_ZK54.2.
UCSCi ZK54.2b.3. c. elegans. [Q7YZT6-1 ]

Organism-specific databases

CTDi 181778.
WormBasei ZK54.2a ; CE07617 ; WBGene00006602 ; tps-1.
ZK54.2b ; CE30330 ; WBGene00006602 ; tps-1.

Phylogenomic databases

eggNOGi COG0380.
GeneTreei ENSGT00550000075394.
HOGENOMi HOG000016516.
InParanoidi Q7YZT6.
OMAi IAHYLAM.

Miscellaneous databases

NextBioi 915306.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes."
    Pellerone F.I., Archer S.K., Behm C.A., Grant W.N., Lacey M.J., Somerville A.C.
    Int. J. Parasitol. 33:1195-1206(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    Strain: Bristol N2.
  2. "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
    Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
    Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Strain: Bristol N2.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiTPS1_CAEEL
AccessioniPrimary (citable) accession number: Q7YZT6
Secondary accession number(s): Q23515, Q2L6W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3