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Q7YT16

- LYS1_MUSDO

UniProt

Q7YT16 - LYS1_MUSDO

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Protein

Lysozyme 1

Gene
N/A
Organism
Musca domestica (House fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May not function as a self-defense protein, but as a digestive enzyme, probably in the gut of the insect body. Inactive towards Micrococcus luteus. Active toward glycol chitin.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

pH dependencei

Active at acidic pHs. Inactive above pH 7.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511PROSITE-ProRule annotation
Active sitei69 – 691PROSITE-ProRule annotation

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.17. 3486.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme 1 (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase 1
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 141122Lysozyme 1PRO_0000018508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 140PROSITE-ProRule annotation
Disulfide bondi46 ↔ 130PROSITE-ProRule annotation
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
Disulfide bondi93 ↔ 111PROSITE-ProRule annotation
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

Secondary structure

1
141
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 3310Combined sources
Helixi38 – 403Combined sources
Helixi41 – 5212Combined sources
Beta strandi55 – 573Combined sources
Turni71 – 744Combined sources
Turni77 – 804Combined sources
Helixi97 – 1015Combined sources
Beta strandi102 – 1043Combined sources
Helixi106 – 11914Combined sources
Helixi121 – 1233Combined sources
Helixi127 – 1304Combined sources
Helixi138 – 1403Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FBDX-ray1.90A/B20-141[»]
2H5ZX-ray1.92A/B20-141[»]
ProteinModelPortaliQ7YT16.
SMRiQ7YT16. Positions 20-141.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7YT16.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7YT16-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFFIVLVAA LALAAPAMGK TFTRCSLARE MYALGVPKSE LPQWTCIAEH
60 70 80 90 100
ESSYRTNVVG PTNSNGSNDY GIFQINNYYW CQPSNGRFSY NECHLSCDAL
110 120 130 140
LTDNISNSVT CARKIKSQQG WTAWSTWKYC SGSLPSINDC F
Length:141
Mass (Da):15,733
Last modified:October 1, 2003 - v1
Checksum:iC640C6407AD80F0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344589 mRNA. Translation: AAQ20048.1.
PIRiPC4062.
RefSeqiXP_005181668.1. XM_005181611.1.
XP_005185827.1. XM_005185770.1.
XP_005185828.1. XM_005185771.1.
XP_005185831.1. XM_005185774.1.

Genome annotation databases

GeneIDi101892974.
101893151.
101893594.
101895951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344589 mRNA. Translation: AAQ20048.1 .
PIRi PC4062.
RefSeqi XP_005181668.1. XM_005181611.1.
XP_005185827.1. XM_005185770.1.
XP_005185828.1. XM_005185771.1.
XP_005185831.1. XM_005185774.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FBD X-ray 1.90 A/B 20-141 [» ]
2H5Z X-ray 1.92 A/B 20-141 [» ]
ProteinModelPortali Q7YT16.
SMRi Q7YT16. Positions 20-141.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101892974.
101893151.
101893594.
101895951.

Enzyme and pathway databases

BRENDAi 3.2.1.17. 3486.

Miscellaneous databases

EvolutionaryTracei Q7YT16.

Family and domain databases

InterProi IPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view ]
Pfami PF00062. Lys. 1 hit.
[Graphical view ]
PRINTSi PR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTi SM00263. LYZ1. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing and characterization of a digestive lysozyme from Musca domestica midgut."
    Chimoy P., Marana S.R., Ferreira C., Terra W.R.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Midgut epithelium.
  2. "Insect lysozyme from house fly (Musca domestica) larvae: possible digestive function based on sequence and enzymatic properties."
    Ito Y., Nakamura M., Hotani T., Imoto T.
    J. Biochem. 118:546-551(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-141.
    Tissue: Larva.

Entry informationi

Entry nameiLYS1_MUSDO
AccessioniPrimary (citable) accession number: Q7YT16
Secondary accession number(s): Q7M437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3