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Protein

Lysozyme 1

Gene
N/A
Organism
Musca domestica (House fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May not function as a self-defense protein, but as a digestive enzyme, probably in the gut of the insect body. Inactive towards Micrococcus luteus. Active toward glycol chitin.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

pH dependencei

Active at acidic pHs. Inactive above pH 7.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51PROSITE-ProRule annotation1
Active sitei69PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.17. 3486.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme 1 (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase 1
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001850820 – 141Lysozyme 1Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 140PROSITE-ProRule annotation
Disulfide bondi46 ↔ 130PROSITE-ProRule annotation
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
Disulfide bondi93 ↔ 111PROSITE-ProRule annotation
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 33Combined sources10
Helixi38 – 40Combined sources3
Helixi41 – 52Combined sources12
Beta strandi55 – 57Combined sources3
Turni71 – 74Combined sources4
Turni77 – 80Combined sources4
Helixi97 – 101Combined sources5
Beta strandi102 – 104Combined sources3
Helixi106 – 119Combined sources14
Helixi121 – 123Combined sources3
Helixi127 – 130Combined sources4
Helixi138 – 140Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FBDX-ray1.90A/B20-141[»]
2H5ZX-ray1.92A/B20-141[»]
ProteinModelPortaliQ7YT16.
SMRiQ7YT16.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7YT16.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

KOiK13915.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7YT16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFIVLVAA LALAAPAMGK TFTRCSLARE MYALGVPKSE LPQWTCIAEH
60 70 80 90 100
ESSYRTNVVG PTNSNGSNDY GIFQINNYYW CQPSNGRFSY NECHLSCDAL
110 120 130 140
LTDNISNSVT CARKIKSQQG WTAWSTWKYC SGSLPSINDC F
Length:141
Mass (Da):15,733
Last modified:October 1, 2003 - v1
Checksum:iC640C6407AD80F0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344589 mRNA. Translation: AAQ20048.1.
PIRiPC4062.
RefSeqiNP_001295901.1. NM_001308972.1.
XP_005185827.1. XM_005185770.2.
XP_005185828.1. XM_005185771.1.
XP_011293474.1. XM_011295172.1.
XP_011293475.1. XM_011295173.1.

Genome annotation databases

GeneIDi101892974.
101893151.
101895951.
KEGGimde:101892974.
mde:101893151.
mde:101895951.
VectorBaseiMDOA012752-RB; MDOA012752-PB; MDOA012752.
MDOA012752-RD; MDOA012752-PD; MDOA012752.
MDOA012752-RE; MDOA012752-PE; MDOA012752.
MDOA012964-RB; MDOA012964-PB; MDOA012964.
MDOA013199-RA; MDOA013199-PA; MDOA013199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344589 mRNA. Translation: AAQ20048.1.
PIRiPC4062.
RefSeqiNP_001295901.1. NM_001308972.1.
XP_005185827.1. XM_005185770.2.
XP_005185828.1. XM_005185771.1.
XP_011293474.1. XM_011295172.1.
XP_011293475.1. XM_011295173.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FBDX-ray1.90A/B20-141[»]
2H5ZX-ray1.92A/B20-141[»]
ProteinModelPortaliQ7YT16.
SMRiQ7YT16.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101892974.
101893151.
101895951.
KEGGimde:101892974.
mde:101893151.
mde:101895951.
VectorBaseiMDOA012752-RB; MDOA012752-PB; MDOA012752.
MDOA012752-RD; MDOA012752-PD; MDOA012752.
MDOA012752-RE; MDOA012752-PE; MDOA012752.
MDOA012964-RB; MDOA012964-PB; MDOA012964.
MDOA013199-RA; MDOA013199-PA; MDOA013199.

Phylogenomic databases

KOiK13915.

Enzyme and pathway databases

BRENDAi3.2.1.17. 3486.

Miscellaneous databases

EvolutionaryTraceiQ7YT16.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYS1_MUSDO
AccessioniPrimary (citable) accession number: Q7YT16
Secondary accession number(s): Q7M437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.