Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7YT16

- LYS1_MUSDO

UniProt

Q7YT16 - LYS1_MUSDO

Protein

Lysozyme 1

Gene
N/A
Organism
Musca domestica (House fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May not function as a self-defense protein, but as a digestive enzyme, probably in the gut of the insect body. Inactive towards Micrococcus luteus. Active toward glycol chitin.

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    pH dependencei

    Active at acidic pHs. Inactive above pH 7.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei51 – 511PROSITE-ProRule annotation
    Active sitei69 – 691PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BRENDAi3.2.1.17. 3486.

    Protein family/group databases

    CAZyiGH22. Glycoside Hydrolase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme 1 (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase 1
    OrganismiMusca domestica (House fly)
    Taxonomic identifieri7370 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 141122Lysozyme 1PRO_0000018508Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 140PROSITE-ProRule annotation
    Disulfide bondi46 ↔ 130PROSITE-ProRule annotation
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
    Disulfide bondi93 ↔ 111PROSITE-ProRule annotation
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    Secondary structure

    1
    141
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi24 – 3310
    Helixi38 – 403
    Helixi41 – 5212
    Beta strandi55 – 573
    Turni71 – 744
    Turni77 – 804
    Helixi97 – 1015
    Beta strandi102 – 1043
    Helixi106 – 11914
    Helixi121 – 1233
    Helixi127 – 1304
    Helixi138 – 1403

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FBDX-ray1.90A/B20-141[»]
    2H5ZX-ray1.92A/B20-141[»]
    ProteinModelPortaliQ7YT16.
    SMRiQ7YT16. Positions 20-141.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7YT16.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PfamiPF00062. Lys. 1 hit.
    [Graphical view]
    PRINTSiPR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTiSM00263. LYZ1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7YT16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFFIVLVAA LALAAPAMGK TFTRCSLARE MYALGVPKSE LPQWTCIAEH    50
    ESSYRTNVVG PTNSNGSNDY GIFQINNYYW CQPSNGRFSY NECHLSCDAL 100
    LTDNISNSVT CARKIKSQQG WTAWSTWKYC SGSLPSINDC F 141
    Length:141
    Mass (Da):15,733
    Last modified:October 1, 2003 - v1
    Checksum:iC640C6407AD80F0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY344589 mRNA. Translation: AAQ20048.1.
    PIRiPC4062.
    RefSeqiXP_005181668.1. XM_005181611.1.
    XP_005185827.1. XM_005185770.1.
    XP_005185828.1. XM_005185771.1.
    XP_005185831.1. XM_005185774.1.

    Genome annotation databases

    GeneIDi101892974.
    101893151.
    101893594.
    101895951.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY344589 mRNA. Translation: AAQ20048.1 .
    PIRi PC4062.
    RefSeqi XP_005181668.1. XM_005181611.1.
    XP_005185827.1. XM_005185770.1.
    XP_005185828.1. XM_005185771.1.
    XP_005185831.1. XM_005185774.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FBD X-ray 1.90 A/B 20-141 [» ]
    2H5Z X-ray 1.92 A/B 20-141 [» ]
    ProteinModelPortali Q7YT16.
    SMRi Q7YT16. Positions 20-141.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH22. Glycoside Hydrolase Family 22.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101892974.
    101893151.
    101893594.
    101895951.

    Enzyme and pathway databases

    BRENDAi 3.2.1.17. 3486.

    Miscellaneous databases

    EvolutionaryTracei Q7YT16.

    Family and domain databases

    InterProi IPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    Pfami PF00062. Lys. 1 hit.
    [Graphical view ]
    PRINTSi PR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTi SM00263. LYZ1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and characterization of a digestive lysozyme from Musca domestica midgut."
      Chimoy P., Marana S.R., Ferreira C., Terra W.R.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Midgut epithelium.
    2. "Insect lysozyme from house fly (Musca domestica) larvae: possible digestive function based on sequence and enzymatic properties."
      Ito Y., Nakamura M., Hotani T., Imoto T.
      J. Biochem. 118:546-551(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-141.
      Tissue: Larva.

    Entry informationi

    Entry nameiLYS1_MUSDO
    AccessioniPrimary (citable) accession number: Q7YT16
    Secondary accession number(s): Q7M437
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3