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Protein

Myogenic factor 6

Gene

MYF6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-375170. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factor 6
Short name:
Myf-6
Alternative name(s):
Muscle-specific regulatory factor 4
Gene namesi
Name:MYF6
Synonyms:MRF4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273501 – 242Myogenic factor 6Add BLAST242

Proteomic databases

PaxDbiQ7YS80.
PRIDEiQ7YS80.

Expressioni

Gene expression databases

BgeeiENSBTAG00000014003.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein Interacts with CSRP3.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018607.

Structurei

3D structure databases

ProteinModelPortaliQ7YS80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 144bHLHPROSITE-ProRule annotationAdd BLAST52

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3960. Eukaryota.
ENOG4111SED. LUCA.
GeneTreeiENSGT00530000063004.
HOGENOMiHOG000234799.
HOVERGENiHBG006429.
InParanoidiQ7YS80.
KOiK18485.
OMAiQQDKMQE.
OrthoDBiEOG091G0GKD.
TreeFamiTF316344.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR002546. Basic.
IPR011598. bHLH_dom.
[Graphical view]
PfamiPF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7YS80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPP
60 70 80 90 100
EAGSDSSGEE HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL
110 120 130 140 150
RERRRLKKIN EAFEALKRRT VANPNQRLPK VEILRSAINY IERLQDLLHR
160 170 180 190 200
LDQQDKMQEL GVDPFSYRPK QENLEGADFL RTCSSQWPSV SDHSRGLVIT
210 220 230 240
AKEGGTSIDS SASSSLRCLS SIVDSISSEE HKLPCVEEVV EK
Length:242
Mass (Da):26,976
Last modified:October 1, 2003 - v1
Checksum:i0359147B18071020
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110601 mRNA. Translation: BAC76804.1.
BC142159 mRNA. Translation: AAI42160.1.
RefSeqiNP_861527.1. NM_181811.1.
UniGeneiBt.22973.

Genome annotation databases

EnsembliENSBTAT00000018607; ENSBTAP00000018607; ENSBTAG00000014003.
GeneIDi281336.
KEGGibta:281336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110601 mRNA. Translation: BAC76804.1.
BC142159 mRNA. Translation: AAI42160.1.
RefSeqiNP_861527.1. NM_181811.1.
UniGeneiBt.22973.

3D structure databases

ProteinModelPortaliQ7YS80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018607.

Proteomic databases

PaxDbiQ7YS80.
PRIDEiQ7YS80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018607; ENSBTAP00000018607; ENSBTAG00000014003.
GeneIDi281336.
KEGGibta:281336.

Organism-specific databases

CTDi4618.

Phylogenomic databases

eggNOGiKOG3960. Eukaryota.
ENOG4111SED. LUCA.
GeneTreeiENSGT00530000063004.
HOGENOMiHOG000234799.
HOVERGENiHBG006429.
InParanoidiQ7YS80.
KOiK18485.
OMAiQQDKMQE.
OrthoDBiEOG091G0GKD.
TreeFamiTF316344.

Enzyme and pathway databases

ReactomeiR-BTA-375170. CDO in myogenesis.

Gene expression databases

BgeeiENSBTAG00000014003.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR002546. Basic.
IPR011598. bHLH_dom.
[Graphical view]
PfamiPF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYF6_BOVIN
AccessioniPrimary (citable) accession number: Q7YS80
Secondary accession number(s): A5PJL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.