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Q7YS70 (MECR_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trans-2-enoyl-CoA reductase, mitochondrial

EC=1.3.1.38
Alternative name(s):
Nuclear receptor-binding factor 1
Short name=BtNrbf-1
Short name=NRBF-1
Gene names
Name:MECR
Synonyms:NBRF1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis.

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH. Ref.1

Subunit structure

Homodimer. Ref.1

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 5353Mitochondrion Potential
Chain54 – 373320Trans-2-enoyl-CoA reductase, mitochondrial
PRO_0000000887

Regions

Nucleotide binding193 – 1964NADP By similarity
Nucleotide binding216 – 2183NADP By similarity
Nucleotide binding285 – 2884NADP By similarity
Nucleotide binding310 – 3123NADP By similarity

Sites

Binding site1671NADP By similarity
Binding site3681NADP By similarity

Amino acid modifications

Modified residue611N6-acetyllysine; alternate By similarity
Modified residue611N6-succinyllysine; alternate By similarity
Modified residue2521N6-acetyllysine; alternate By similarity
Modified residue2521N6-succinyllysine; alternate By similarity
Modified residue2671N6-acetyllysine; alternate By similarity
Modified residue2671N6-succinyllysine; alternate By similarity
Modified residue3161N6-succinyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7YS70 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 7921122C7735A95D

FASTA37340,275
        10         20         30         40         50         60 
MWVCGALCRT RAPAQLGQRL LPESRRRRPA SASFSASAEP SRVRALVYGH HGDPAKVVEL 

        70         80         90        100        110        120 
KNLELAAVGG SHVHVKMLAA PINPSDINMI QGNYGLLPQL PAVGGNEGVG QVVAVGSGVT 

       130        140        150        160        170        180 
GVKPGDWVIP ANPGLGTWRT EAVFGEEELI TVPSDIPLQS AATLGVNPCT AYRMLVDFER 

       190        200        210        220        230        240 
LRPRDSIIQN ASNSGVGQAV IQIAAARGLR TINVLRDTPD LQKLTDTLKN LGANHVVTEE 

       250        260        270        280        290        300 
ELRKPEMKSF FKDVPQPRLA LNCVGGKSST ELLRHLAPGG TMVTYGGMAK QPVIASVSQL 

       310        320        330        340        350        360 
IFKDLKLRGF WLSQWKKDHS PDQFKELILT LCDLIRRGQL TAPACSEVPL QDYLCALEAS 

       370 
TQPFVSSKQI LTM 

« Hide

References

[1]"Characterization of 2-enoyl thioester reductase from mammals: an ortholog of Ybr026p/Mrf1'p of the yeast mitochondrial fatty acid synthesis type II."
Miinalainen I.J., Chen Z.-J., Torkko J.M., Pirilae P.L., Sormunen R.T., Bergmann U., Qin Y.-M., Hiltunen J.K.
J. Biol. Chem. 278:20154-20161(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, ENZYME ACTIVITY, SUBUNIT.
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY256973 mRNA. Translation: AAP45003.1.
RefSeqNP_858055.1. NM_181669.2.
UniGeneBt.18851.

3D structure databases

ProteinModelPortalQ7YS70.
SMRQ7YS70. Positions 40-373.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ7YS70.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID353301.
KEGGbta:353301.

Organism-specific databases

CTD51102.

Phylogenomic databases

eggNOGCOG0604.
HOGENOMHOG000294683.
HOVERGENHBG052446.
InParanoidQ7YS70.
KOK07512.

Enzyme and pathway databases

SABIO-RKQ7YS70.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
ProtoNetSearch...

Other

NextBio20812729.

Entry information

Entry nameMECR_BOVIN
AccessionPrimary (citable) accession number: Q7YS70
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: March 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families