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Q7YS70

- MECR_BOVIN

UniProt

Q7YS70 - MECR_BOVIN

Protein

Trans-2-enoyl-CoA reductase, mitochondrial

Gene

MECR

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis.

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei167 – 1671NADPBy similarity
    Binding sitei368 – 3681NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi193 – 1964NADPBy similarity
    Nucleotide bindingi216 – 2183NADPBy similarity
    Nucleotide bindingi285 – 2884NADPBy similarity
    Nucleotide bindingi310 – 3123NADPBy similarity

    GO - Molecular functioni

    1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW
    2. fatty acid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    SABIO-RKQ7YS70.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
    Alternative name(s):
    Nuclear receptor-binding factor 1
    Short name:
    BtNrbf-1
    Short name:
    NRBF-1
    Gene namesi
    Name:MECR
    Synonyms:NBRF1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5353MitochondrionSequence AnalysisAdd
    BLAST
    Chaini54 – 373320Trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000887Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611N6-acetyllysine; alternateBy similarity
    Modified residuei61 – 611N6-succinyllysine; alternateBy similarity
    Modified residuei252 – 2521N6-acetyllysine; alternateBy similarity
    Modified residuei252 – 2521N6-succinyllysine; alternateBy similarity
    Modified residuei267 – 2671N6-acetyllysine; alternateBy similarity
    Modified residuei267 – 2671N6-succinyllysine; alternateBy similarity
    Modified residuei316 – 3161N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ7YS70.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ7YS70.
    SMRiQ7YS70. Positions 40-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0604.
    HOGENOMiHOG000294683.
    HOVERGENiHBG052446.
    InParanoidiQ7YS70.
    KOiK07512.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7YS70-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWVCGALCRT RAPAQLGQRL LPESRRRRPA SASFSASAEP SRVRALVYGH    50
    HGDPAKVVEL KNLELAAVGG SHVHVKMLAA PINPSDINMI QGNYGLLPQL 100
    PAVGGNEGVG QVVAVGSGVT GVKPGDWVIP ANPGLGTWRT EAVFGEEELI 150
    TVPSDIPLQS AATLGVNPCT AYRMLVDFER LRPRDSIIQN ASNSGVGQAV 200
    IQIAAARGLR TINVLRDTPD LQKLTDTLKN LGANHVVTEE ELRKPEMKSF 250
    FKDVPQPRLA LNCVGGKSST ELLRHLAPGG TMVTYGGMAK QPVIASVSQL 300
    IFKDLKLRGF WLSQWKKDHS PDQFKELILT LCDLIRRGQL TAPACSEVPL 350
    QDYLCALEAS TQPFVSSKQI LTM 373
    Length:373
    Mass (Da):40,275
    Last modified:October 1, 2003 - v1
    Checksum:i7921122C7735A95D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY256973 mRNA. Translation: AAP45003.1.
    RefSeqiNP_858055.1. NM_181669.2.
    UniGeneiBt.18851.

    Genome annotation databases

    GeneIDi353301.
    KEGGibta:353301.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY256973 mRNA. Translation: AAP45003.1 .
    RefSeqi NP_858055.1. NM_181669.2.
    UniGenei Bt.18851.

    3D structure databases

    ProteinModelPortali Q7YS70.
    SMRi Q7YS70. Positions 40-373.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7YS70.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 353301.
    KEGGi bta:353301.

    Organism-specific databases

    CTDi 51102.

    Phylogenomic databases

    eggNOGi COG0604.
    HOGENOMi HOG000294683.
    HOVERGENi HBG052446.
    InParanoidi Q7YS70.
    KOi K07512.

    Enzyme and pathway databases

    SABIO-RK Q7YS70.

    Miscellaneous databases

    NextBioi 20812729.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of 2-enoyl thioester reductase from mammals: an ortholog of Ybr026p/Mrf1'p of the yeast mitochondrial fatty acid synthesis type II."
      Miinalainen I.J., Chen Z.-J., Torkko J.M., Pirilae P.L., Sormunen R.T., Bergmann U., Qin Y.-M., Hiltunen J.K.
      J. Biol. Chem. 278:20154-20161(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, ENZYME ACTIVITY, SUBUNIT.
      Tissue: Heart.

    Entry informationi

    Entry nameiMECR_BOVIN
    AccessioniPrimary (citable) accession number: Q7YS70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3