Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7YS70

- MECR_BOVIN

UniProt

Q7YS70 - MECR_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Trans-2-enoyl-CoA reductase, mitochondrial

Gene

MECR

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis.

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei167 – 1671NADPBy similarity
Binding sitei368 – 3681NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi193 – 1964NADPBy similarity
Nucleotide bindingi216 – 2183NADPBy similarity
Nucleotide bindingi285 – 2884NADPBy similarity
Nucleotide bindingi310 – 3123NADPBy similarity

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
  2. fatty acid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKQ7YS70.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
Alternative name(s):
Nuclear receptor-binding factor 1
Short name:
BtNrbf-1
Short name:
NRBF-1
Gene namesi
Name:MECR
Synonyms:NBRF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5353MitochondrionSequence AnalysisAdd
BLAST
Chaini54 – 373320Trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611N6-acetyllysine; alternateBy similarity
Modified residuei61 – 611N6-succinyllysine; alternateBy similarity
Modified residuei252 – 2521N6-acetyllysine; alternateBy similarity
Modified residuei252 – 2521N6-succinyllysine; alternateBy similarity
Modified residuei267 – 2671N6-acetyllysine; alternateBy similarity
Modified residuei267 – 2671N6-succinyllysine; alternateBy similarity
Modified residuei316 – 3161N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ7YS70.

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ7YS70.
SMRiQ7YS70. Positions 40-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
HOGENOMiHOG000294683.
HOVERGENiHBG052446.
InParanoidiQ7YS70.
KOiK07512.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7YS70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWVCGALCRT RAPAQLGQRL LPESRRRRPA SASFSASAEP SRVRALVYGH
60 70 80 90 100
HGDPAKVVEL KNLELAAVGG SHVHVKMLAA PINPSDINMI QGNYGLLPQL
110 120 130 140 150
PAVGGNEGVG QVVAVGSGVT GVKPGDWVIP ANPGLGTWRT EAVFGEEELI
160 170 180 190 200
TVPSDIPLQS AATLGVNPCT AYRMLVDFER LRPRDSIIQN ASNSGVGQAV
210 220 230 240 250
IQIAAARGLR TINVLRDTPD LQKLTDTLKN LGANHVVTEE ELRKPEMKSF
260 270 280 290 300
FKDVPQPRLA LNCVGGKSST ELLRHLAPGG TMVTYGGMAK QPVIASVSQL
310 320 330 340 350
IFKDLKLRGF WLSQWKKDHS PDQFKELILT LCDLIRRGQL TAPACSEVPL
360 370
QDYLCALEAS TQPFVSSKQI LTM
Length:373
Mass (Da):40,275
Last modified:October 1, 2003 - v1
Checksum:i7921122C7735A95D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY256973 mRNA. Translation: AAP45003.1.
RefSeqiNP_858055.1. NM_181669.2.
UniGeneiBt.18851.

Genome annotation databases

GeneIDi353301.
KEGGibta:353301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY256973 mRNA. Translation: AAP45003.1 .
RefSeqi NP_858055.1. NM_181669.2.
UniGenei Bt.18851.

3D structure databases

ProteinModelPortali Q7YS70.
SMRi Q7YS70. Positions 40-373.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7YS70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 353301.
KEGGi bta:353301.

Organism-specific databases

CTDi 51102.

Phylogenomic databases

eggNOGi COG0604.
HOGENOMi HOG000294683.
HOVERGENi HBG052446.
InParanoidi Q7YS70.
KOi K07512.

Enzyme and pathway databases

SABIO-RK Q7YS70.

Miscellaneous databases

NextBioi 20812729.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization of 2-enoyl thioester reductase from mammals: an ortholog of Ybr026p/Mrf1'p of the yeast mitochondrial fatty acid synthesis type II."
    Miinalainen I.J., Chen Z.-J., Torkko J.M., Pirilae P.L., Sormunen R.T., Bergmann U., Qin Y.-M., Hiltunen J.K.
    J. Biol. Chem. 278:20154-20161(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, ENZYME ACTIVITY, SUBUNIT.
    Tissue: Heart.

Entry informationi

Entry nameiMECR_BOVIN
AccessioniPrimary (citable) accession number: Q7YS70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3