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Q7YS37

- G6PD_BOSIN

UniProt

Q7YS37 - G6PD_BOSIN

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
G6PD
Organism
Bos indicus (Zebu)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471NADP 1 By similarity
Binding sitei171 – 1711NADP 1; via carbonyl oxygen By similarity
Binding sitei171 – 1711Substrate By similarity
Binding sitei239 – 2391Substrate By similarity
Binding sitei258 – 2581Substrate By similarity
Binding sitei357 – 3571NADP 2 By similarity
Binding sitei360 – 3601Substrate By similarity
Binding sitei365 – 3651Substrate By similarity
Binding sitei366 – 3661NADP 2 By similarity
Binding sitei370 – 3701NADP 2 By similarity
Binding sitei393 – 3931NADP 2 By similarity
Binding sitei395 – 3951Substrate By similarity
Binding sitei487 – 4871NADP 2 By similarity
Binding sitei503 – 5031NADP 2 By similarity
Binding sitei509 – 5091NADP 2 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458NADP 1 By similarity
Nucleotide bindingi401 – 4033NADP 2 By similarity
Nucleotide bindingi421 – 4233NADP 2 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glucose 6-phosphate metabolic process Source: UniProtKB
  2. NADP metabolic process Source: UniProtKB
  3. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:G6PD
OrganismiBos indicus (Zebu)
Taxonomic identifieri9915 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 515514Glucose-6-phosphate 1-dehydrogenaseUniRule annotationPRO_0000068080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei89 – 891N6-acetyllysine By similarity
Modified residuei171 – 1711N6-acetyllysine By similarity
Modified residuei403 – 4031N6-acetyllysine By similarity
Modified residuei432 – 4321N6-acetyllysine By similarity
Modified residuei497 – 4971N6-acetyllysine By similarity

Post-translational modificationi

Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity By similarity.

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ7YS37.

Interactioni

Subunit structurei

Homotetramer; dimer of dimers. Interacts with SIRT2; the interaction is enhanced by H2O2 treatment By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ7YS37.
SMRiQ7YS37. Positions 28-515.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni201 – 2055Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000856.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7YS37-1 [UniParc]FASTAAdd to Basket

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MAEQVALSQT QTCGILWEEL CQSYSFHQSD THIFIIMGAS GDLAKRNIYP    50
TIWWLFQDGL LPKDTFIVGY TDSHFTVANI RKQSEPFFKS TPEEEPKLEE 100
FFAHSSYMAS QYDDVASYEH LNSGMNALHQ GPQANCLFYL ALLPSGYRTV 150
TKNICDTCTS QTGWNRIIVE KPFGRDLQSS NQLSNHIASL FHEDQIYRID 200
HYLGKEVVQN LMVLRFVNRI LGPIWNRDNI ACMSFTFKEP FGTEGRWSYL 250
SESGIIWEVM QNPLLQILCL VAMEKPISTN SDNIRDDKVR VLKCISKVQV 300
SNVVLSQYME NPTEEGEATR GYPEDPRVPH GSTTDTFAAA VLYVENERWD 350
GVPFILRCGK ALNERKAEVR LQFRDVAGDI FRQQCKRNEL VIRVQPNEAV 400
YTKMMTKKPG MFFNPEESEL DLTYGNRYKN VKFPDAYERL ILDVFCGSQM 450
HFVRSDELRE AWRIFTPLLH HIEREKARPI PYVYGSRGPV EADELMKRVG 500
FQYEGTYKWV NPHKL 515
Length:515
Mass (Da):59,584
Last modified:January 23, 2007 - v3
Checksum:i2397324759DD9972
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ566767 mRNA. Translation: CAD97761.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ566767 mRNA. Translation: CAD97761.1 .

3D structure databases

ProteinModelPortali Q7YS37.
SMRi Q7YS37. Positions 28-515.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7YS37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000856.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of g6pd in cattle."
    Ravi Kumar G.V.P.P.S., Sharma A., Suryanarayana V.V.S., Ravi Kumar P.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiG6PD_BOSIN
AccessioniPrimary (citable) accession number: Q7YS37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Pro-263 is present instead of the conserved His which is expected to act as the active site proton acceptor.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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