Reviewed, UniProtKB/Swiss-Prot Q7YS37 (G6PD_BOSIN)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:

G6PD

Organism

Bos indicus (Zebu)

Taxonomic identifier

9915 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.
Caution	Pro-263 is present instead of the conserved His which is expected to act as the active site proton acceptor.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 515	514	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068080
Sites
	Binding site	40	1	NADP By similarity
	Binding site	72	1	NADP By similarity
	Binding site	201	1	Substrate By similarity
	Binding site	205	1	Substrate By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	89	1	N6-acetyllysine By similarity
	Modified residue	171	1	N6-acetyllysine By similarity
	Modified residue	386	1	N6-acetyllysine By similarity
	Modified residue	401	1	Phosphotyrosine By similarity
	Modified residue	403	1	N6-acetyllysine By similarity
	Modified residue	432	1	N6-acetyllysine By similarity
	Modified residue	497	1	N6-acetyllysine By similarity
	Modified residue	503	1	Phosphotyrosine By similarity
	Modified residue	507	1	Phosphotyrosine By similarity
	Modified residue	514	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7YS37-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 2397324759DD9972	FASTA	515	59,584
	10 20 30 40 50 60 MAEQVALSQT QTCGILWEEL CQSYSFHQSD THIFIIMGAS GDLAKRNIYP TIWWLFQDGL 70 80 90 100 110 120 LPKDTFIVGY TDSHFTVANI RKQSEPFFKS TPEEEPKLEE FFAHSSYMAS QYDDVASYEH 130 140 150 160 170 180 LNSGMNALHQ GPQANCLFYL ALLPSGYRTV TKNICDTCTS QTGWNRIIVE KPFGRDLQSS 190 200 210 220 230 240 NQLSNHIASL FHEDQIYRID HYLGKEVVQN LMVLRFVNRI LGPIWNRDNI ACMSFTFKEP 250 260 270 280 290 300 FGTEGRWSYL SESGIIWEVM QNPLLQILCL VAMEKPISTN SDNIRDDKVR VLKCISKVQV 310 320 330 340 350 360 SNVVLSQYME NPTEEGEATR GYPEDPRVPH GSTTDTFAAA VLYVENERWD GVPFILRCGK 370 380 390 400 410 420 ALNERKAEVR LQFRDVAGDI FRQQCKRNEL VIRVQPNEAV YTKMMTKKPG MFFNPEESEL 430 440 450 460 470 480 DLTYGNRYKN VKFPDAYERL ILDVFCGSQM HFVRSDELRE AWRIFTPLLH HIEREKARPI 490 500 510 PYVYGSRGPV EADELMKRVG FQYEGTYKWV NPHKL

References

[1]	"Molecular characterization of g6pd in cattle." Ravi Kumar G.V.P.P.S., Sharma A., Suryanarayana V.V.S., Ravi Kumar P. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ566767 mRNA. Translation: CAD97761.1.
3D structure databases
SMR	Q7YS37. Positions 28-515.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q7YS37.
Enzyme and pathway databases
BRENDA	1.1.1.49. 272771.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DH. IPR019796. Glc-6-P_DH_AS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_BOSIN

Accession

Primary (citable) accession number: Q7YS37

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	January 23, 2007
Last modified:	February 9, 2010
This is version 49 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)