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Q7YS37 (G6PD_BOSIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 28, 2011. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase
Short name=G6PD
EC=1.1.1.49
Gene names
Name:G6PD
OrganismBos indicus (Zebu)
Taxonomic identifier9915 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Caution

Pro-263 is present instead of the conserved His which is expected to act as the active site proton acceptor.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   PTMAcetylation
Phosphoprotein
Gene Ontology (GO)
   Biological processglucose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 515514Glucose-6-phosphate 1-dehydrogenase
PRO_0000068080

Sites

Binding site401NADP By similarity
Binding site721NADP By similarity
Binding site2011Substrate By similarity
Binding site2051Substrate By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue891N6-acetyllysine By similarity
Modified residue1711N6-acetyllysine By similarity
Modified residue3861N6-acetyllysine By similarity
Modified residue4011Phosphotyrosine By similarity
Modified residue4031N6-acetyllysine By similarity
Modified residue4321N6-acetyllysine By similarity
Modified residue4971N6-acetyllysine By similarity
Modified residue5031Phosphotyrosine By similarity
Modified residue5071Phosphotyrosine By similarity
Modified residue5141N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7YS37 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 2397324759DD9972

FASTA51559,584
        10         20         30         40         50         60 
MAEQVALSQT QTCGILWEEL CQSYSFHQSD THIFIIMGAS GDLAKRNIYP TIWWLFQDGL 

        70         80         90        100        110        120 
LPKDTFIVGY TDSHFTVANI RKQSEPFFKS TPEEEPKLEE FFAHSSYMAS QYDDVASYEH 

       130        140        150        160        170        180 
LNSGMNALHQ GPQANCLFYL ALLPSGYRTV TKNICDTCTS QTGWNRIIVE KPFGRDLQSS 

       190        200        210        220        230        240 
NQLSNHIASL FHEDQIYRID HYLGKEVVQN LMVLRFVNRI LGPIWNRDNI ACMSFTFKEP 

       250        260        270        280        290        300 
FGTEGRWSYL SESGIIWEVM QNPLLQILCL VAMEKPISTN SDNIRDDKVR VLKCISKVQV 

       310        320        330        340        350        360 
SNVVLSQYME NPTEEGEATR GYPEDPRVPH GSTTDTFAAA VLYVENERWD GVPFILRCGK 

       370        380        390        400        410        420 
ALNERKAEVR LQFRDVAGDI FRQQCKRNEL VIRVQPNEAV YTKMMTKKPG MFFNPEESEL 

       430        440        450        460        470        480 
DLTYGNRYKN VKFPDAYERL ILDVFCGSQM HFVRSDELRE AWRIFTPLLH HIEREKARPI 

       490        500        510 
PYVYGSRGPV EADELMKRVG FQYEGTYKWV NPHKL

« Hide

References

[1]"Molecular characterization of g6pd in cattle."
Ravi Kumar G.V.P.P.S., Sharma A., Suryanarayana V.V.S., Ravi Kumar P.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ566767 mRNA. Translation: CAD97761.1.

3D structure databases

ProteinModelPortalQ7YS37.
SMRQ7YS37. Positions 28-515.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000856.

Family and domain databases

InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR23429. G6PDH. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. Zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_BOSIN
AccessionPrimary (citable) accession number: Q7YS37
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: June 28, 2011
This is version 57 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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