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Q7YRZ9 (MCL1_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Gene names
Name:MCL1
OrganismFelis catus (Cat) (Felis silvestris catus) [Complete proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis By similarity.

Subunit structure

Interacts with BAD, BOK, BIK, BFM, BAX, BAK1, BBC3, TPT1, PMAIP1, BCL2L11 and BOP By similarity.

Subcellular location

Membrane; Single-pass membrane protein By similarity. Cytoplasm By similarity. Mitochondrion By similarity. Nucleus › nucleoplasm By similarity. Note: Cytoplasmic, associated with mitochondria.

Post-translational modification

Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment By similarity.

Rapidly degraded in the absence of phosphorylation in the PEST region By similarity.

Phosphorylated on several Ser and Thr residues By similarity.

Sequence similarities

Belongs to the Bcl-2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
PRO_0000143079

Regions

Transmembrane328 – 34821Helical; Potential
Region104 – 17572PEST-like By similarity
Motif209 – 22315BH3
Motif252 – 27221BH1
Motif304 – 31916BH2
Compositional bias168 – 1736Poly-Glu

Sites

Site127 – 1282Cleavage; by caspase-3 By similarity
Site157 – 1582Cleavage; by caspase-3 By similarity

Amino acid modifications

Modified residue1211Phosphoserine By similarity
Modified residue1621Phosphoserine By similarity
Modified residue1631Phosphothreonine; by MAPK By similarity
Cross-link5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-link40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-link136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-link194Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-link197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7YRZ9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: A0ED16D584577463

FASTA35036,635
        10         20         30         40         50         60 
MFGLKRNAVI GLNLYCGGAG LAAGSGGASS SGGRLVAVGK EATARREVGG GEAGAVIGGS 

        70         80         90        100        110        120 
AGASPPATLA PDARRVARPS PIGAEGPDVT ATPPKLLFFA ATRCASPPEE MEGPAADAIM 

       130        140        150        160        170        180 
SPEEELDGYE PEPLGKRPAV LPLLELVGEA SSGPGTDGSL PSTPPPAEEE EDELFRQSLE 

       190        200        210        220        230        240 
IISRYLREQA TGAKDAKPLG GSGAASRKAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE 

       250        260        270        280        290        300 
NDVKSLSRVM VHVFSDGVTN WGRIVTLISF GAFVAKHLKS INQESCIEPL AESITDVLVR 

       310        320        330        340        350 
TKRDWLVKQR GWDGFVEFFH VEDLEGGIRN VLLAFAGVAG VGAGLAYLIR

« Hide

References

[1]"Moleculer cloning of feline bcl-2 family."
Nagafuchi S., Sano J., Kano R., Hasegawa A.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB112589 mRNA. Translation: BAC77771.1.
RefSeqNP_001009374.1. NM_001009374.1.

3D structure databases

ProteinModelPortalQ7YRZ9.
SMRQ7YRZ9. Positions 172-321.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493970.
KEGGfca:493970.

Organism-specific databases

CTD4170.

Phylogenomic databases

eggNOGNOG282183.
HOGENOMHOG000232116.
HOVERGENHBG003527.
KOK02539.
OrthoDBEOG4M65K0.

Family and domain databases

InterProIPR013281. Apop_reg_Mc1.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF6. PTHR11256:SF6. 1 hit.
PfamPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSPR01866. APOPREGMCL1.
PR01862. BCL2FAMILY.
PROSITEPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMCL1_FELCA
AccessionPrimary (citable) accession number: Q7YRZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2003
Last modified: May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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