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Protein

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Gene

MCL1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Gene namesi
Name:MCL1
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430791 – 350Induced myeloid leukemia cell differentiation protein Mcl-1 homologAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei121PhosphoserineBy similarity1
Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei159Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity1
Modified residuei162PhosphoserineBy similarity1
Modified residuei163Phosphothreonine; by MAPKBy similarity1
Cross-linki194Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment.By similarity
Rapidly degraded in the absence of phosphorylation in the PEST region.By similarity
Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites (By similarity).By similarity
Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei127 – 128Cleavage; by caspase-3By similarity2
Sitei157 – 158Cleavage; by caspase-3By similarity2

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Interactioni

Subunit structurei

Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BOK, BIK, BAX, BAK1, and TPT1. Interacts with unphosphorylated BAD (By similarity). Interacts with BMF, BBC3 and PMAIP1 (By similarity). Interacts with BOP (By similarity). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000023698.

Structurei

3D structure databases

ProteinModelPortaliQ7YRZ9.
SMRiQ7YRZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 175PEST-likeBy similarityAdd BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi209 – 223BH3Add BLAST15
Motifi252 – 272BH1Add BLAST21
Motifi304 – 319BH2Add BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 173Poly-Glu6

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOGENOMiHOG000232116.
HOVERGENiHBG003527.
InParanoidiQ7YRZ9.
KOiK02539.
TreeFamiTF315834.

Family and domain databases

Gene3Di1.10.437.10. 1 hit.
InterProiView protein in InterPro
IPR013281. Apop_reg_Mc1.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR036834. Blc2-like_sf.
IPR026298. Blc2_fam.
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF46. PTHR11256:SF46. 1 hit.
PfamiView protein in Pfam
PF00452. Bcl-2. 1 hit.
PRINTSiPR01866. APOPREGMCL1.
PR01862. BCL2FAMILY.
SUPFAMiSSF56854. SSF56854. 1 hit.
PROSITEiView protein in PROSITE
PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7YRZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGLKRNAVI GLNLYCGGAG LAAGSGGASS SGGRLVAVGK EATARREVGG
60 70 80 90 100
GEAGAVIGGS AGASPPATLA PDARRVARPS PIGAEGPDVT ATPPKLLFFA
110 120 130 140 150
ATRCASPPEE MEGPAADAIM SPEEELDGYE PEPLGKRPAV LPLLELVGEA
160 170 180 190 200
SSGPGTDGSL PSTPPPAEEE EDELFRQSLE IISRYLREQA TGAKDAKPLG
210 220 230 240 250
GSGAASRKAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE NDVKSLSRVM
260 270 280 290 300
VHVFSDGVTN WGRIVTLISF GAFVAKHLKS INQESCIEPL AESITDVLVR
310 320 330 340 350
TKRDWLVKQR GWDGFVEFFH VEDLEGGIRN VLLAFAGVAG VGAGLAYLIR
Length:350
Mass (Da):36,635
Last modified:October 1, 2003 - v1
Checksum:iA0ED16D584577463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB112589 mRNA. Translation: BAC77771.1.
RefSeqiNP_001009374.1. NM_001009374.1.

Genome annotation databases

GeneIDi493970.
KEGGifca:493970.

Similar proteinsi

Entry informationi

Entry nameiMCL1_FELCA
AccessioniPrimary (citable) accession number: Q7YRZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2003
Last modified: October 25, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families