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Q7YRU4

- MDHC_FELCA

UniProt

Q7YRU4 - MDHC_FELCA

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Protein
Malate dehydrogenase, cytoplasmic
Gene
MDH1
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921Substrate By similarity
Binding sitei98 – 981Substrate By similarity
Binding sitei105 – 1051NAD By similarity
Binding sitei112 – 1121NAD By similarity
Binding sitei131 – 1311Substrate By similarity
Binding sitei162 – 1621Substrate By similarity
Active sitei187 – 1871Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 177NAD By similarity
Nucleotide bindingi129 – 1313NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, cytoplasmic (EC:1.1.1.37)
Alternative name(s):
Cytosolic malate dehydrogenase
Gene namesi
Name:MDH1
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Chromosome A3

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 334333Malate dehydrogenase, cytoplasmicUniRule annotation
PRO_0000226736Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei110 – 1101N6-succinyllysine By similarity
Modified residuei118 – 1181N6-acetyllysine By similarity
Modified residuei121 – 1211N6-acetyllysine By similarity
Modified residuei214 – 2141N6-succinyllysine By similarity
Modified residuei298 – 2981N6-acetyllysine; alternate By similarity
Modified residuei298 – 2981N6-succinyllysine; alternate By similarity
Modified residuei318 – 3181N6-succinyllysine By similarity
Modified residuei333 – 3331Phosphoserine By similarity

Post-translational modificationi

ISGylated By similarity.UniRule annotation
Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation By similarity.UniRule annotation

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000015559.

Structurei

3D structure databases

ProteinModelPortaliQ7YRU4.
SMRiQ7YRU4. Positions 2-334.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
GeneTreeiENSGT00530000063410.
HOVERGENiHBG006340.
KOiK00025.
OMAiNCLIASK.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR011274. Malate_DH_NAD-dep_euk.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
TIGR01758. MDH_euk_cyt. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7YRU4-1 [UniParc]FASTAAdd to Basket

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MSEPIRVLVT GAAGQIAYSL LYSIGNGSVF GKDQPIILVL LDITPMMGVL    50
DGVLMELQDC ALPLLKDVIA TDKEDVAFKD LDVAILVGSM PRRDGMERKD 100
LLKANVKIFK CQGAALEKYA KKSVKVIVVG NPANTNCLTA CKSAPSIPKE 150
NFSCLTRLDH NRAKAQIALK LGVTSDDVKN VIIWGNHSST QYPDVSHAKV 200
KLHGKEVGVY DALKDDSWLK GEFITTVQQR GAAVIKARKL SSAMSAAKAI 250
CDHVRDIWFG TPEGEFVSMG IISDGNPYGV PDDLLYSFPV TIKNKTWKVV 300
EGLTINDFSR EKMDLTAKEL AEEKETAFEF LSSA 334
Length:334
Mass (Da):36,423
Last modified:January 23, 2007 - v3
Checksum:i31FEB6E50FF5D946
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB113364 mRNA. Translation: BAC78621.1.
RefSeqiNP_001009329.1. NM_001009329.1.

Genome annotation databases

EnsembliENSFCAT00000027082; ENSFCAP00000017047; ENSFCAG00000024183.
GeneIDi493924.
KEGGifca:493924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB113364 mRNA. Translation: BAC78621.1 .
RefSeqi NP_001009329.1. NM_001009329.1.

3D structure databases

ProteinModelPortali Q7YRU4.
SMRi Q7YRU4. Positions 2-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000015559.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSFCAT00000027082 ; ENSFCAP00000017047 ; ENSFCAG00000024183 .
GeneIDi 493924.
KEGGi fca:493924.

Organism-specific databases

CTDi 4190.

Phylogenomic databases

eggNOGi COG0039.
GeneTreei ENSGT00530000063410.
HOVERGENi HBG006340.
KOi K00025.
OMAi NCLIASK.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR011274. Malate_DH_NAD-dep_euk.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
TIGR01758. MDH_euk_cyt. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of feline cytosolic malate dehydrogenase."
    Nakamura M., Sasaki N., Arai T.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiMDHC_FELCA
AccessioniPrimary (citable) accession number: Q7YRU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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