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Protein

T-cell surface glycoprotein CD3 epsilon chain

Gene

CD3E

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD3 epsilon chain
Alternative name(s):
CD_antigen: CD3e
Gene namesi
Name:CD3E
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 11695ExtracellularSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Topological domaini138 – 19659CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 196175T-cell surface glycoprotein CD3 epsilon chainPRO_0000014610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 91PROSITE-ProRule annotation
Modified residuei177 – 1771PhosphotyrosinePROSITE-ProRule annotationBy similarity
Modified residuei188 – 1881PhosphotyrosinePROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ7YRN2.

Interactioni

Subunit structurei

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. Interacts with CD6.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016015.

Structurei

3D structure databases

ProteinModelPortaliQ7YRN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10275Ig-likeAdd
BLAST
Domaini167 – 19428ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYD1. Eukaryota.
ENOG41123JN. LUCA.
HOGENOMiHOG000290664.
HOVERGENiHBG102121.
InParanoidiQ7YRN2.
KOiK06451.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7YRN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSGNLWKVL GLCLLSVGAW GQEDIERPDE DTQKTFKVSI SGDKVELTCP
60 70 80 90 100
EDPESEKMTW KRNDMQIYES YDNYMLLESF SEVENSGYYT CTVGEKTSHR
110 120 130 140 150
LYLKARVCEN CVEVDLMAVV TIIVVDICIT LGLLMVVYYY SKSRKAKAMP
160 170 180 190
VTRGAGAGGR PRGQNRERPP PVPNPDYEPI RKGQRDLYSG LNQRGR
Length:196
Mass (Da):22,198
Last modified:October 1, 2003 - v1
Checksum:iB1840232E575964E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323829 mRNA. Translation: AAP85530.1.
RefSeqiNP_999392.1. NM_214227.1.
UniGeneiSsc.16186.

Genome annotation databases

GeneIDi397455.
KEGGissc:397455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323829 mRNA. Translation: AAP85530.1.
RefSeqiNP_999392.1. NM_214227.1.
UniGeneiSsc.16186.

3D structure databases

ProteinModelPortaliQ7YRN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016015.

Proteomic databases

PaxDbiQ7YRN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397455.
KEGGissc:397455.

Organism-specific databases

CTDi916.

Phylogenomic databases

eggNOGiENOG410IYD1. Eukaryota.
ENOG41123JN. LUCA.
HOGENOMiHOG000290664.
HOVERGENiHBG102121.
InParanoidiQ7YRN2.
KOiK06451.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of porcine CD3 epsilon."
    Wang J., Yang H., Guo X.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCD3E_PIG
AccessioniPrimary (citable) accession number: Q7YRN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.