Q7YRG5 (ARY2_MACMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arylamine N-acetyltransferase 2
EC=2.3.1.5

Alternative name(s):
Arylamide acetylase 2
N-acetyltransferase type 2
Short name=NAT-2
Polymorphic arylamine N-acetyltransferase
Short name=PNAT

Gene names

Name:	NAT2
Synonyms:	AAC2, NAT

Organism

Macaca mulatta (Rhesus macaque)

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens By similarity.
Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Acyltransferase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Arylamine N-acetyltransferase 2		PRO_0000254005
Regions
	Region	106 – 107	2	Substrate binding By similarity
Sites
	Active site	68	1	Acyl-thioester intermediate By similarity
	Active site	107	1	By similarity
	Active site	122	1	By similarity
	Binding site	103	1	Coenzyme A By similarity
	Binding site	104	1	Coenzyme A; via amide nitrogen By similarity
	Binding site	208	1	Coenzyme A By similarity
	Binding site	214	1	Coenzyme A By similarity
	Binding site	287	1	Coenzyme A By similarity
Amino acid modifications
	Modified residue	246	1	Phosphotyrosine By similarity
Natural variations
	Natural variant	231	1	V → I in allele 2. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q7YRG5 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 36C686573BDC79A0	FASTA	290	33,429
	10 20 30 40 50 60 MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGEAMEL GLETIFDHIV 70 80 90 100 110 120 RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYVYIPAANK YSTGMIHLLL QVTIDGRNYI 130 140 150 160 170 180 ADAGFGSSSQ MWQPLELISG KDQPQMPSIF RLTEQKGIWY LDQIRREQYI PNTEFLNSDL 190 200 210 220 230 240 LPKTTHQKVY SFTLEPRKIE DFESMNTYLQ TSPTSAFTTT SFCSLQTPEG VHCLVGFTLT 250 260 270 280 290 YRIFNYKDNT DLIEFKTLIE EEVEEVLKNI FKISLGRKLV PKPGNGSFTI

References

[1]

"Cloning of a gene encoding for arylamine N-acetyltransferase in the rhezus monkey; description and functional analysis of two polymorphic alleles." Fakis G., Boukouvala S., Sim E., Kennedy S. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-231.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ504439 Genomic DNA. Translation: CAD43197.1. AJ504440 Genomic DNA. Translation: CAD43198.1.
RefSeq	NP_001038201.1. NM_001044736.1.
UniGene	Mmu.10844.
3D structure databases
HSSP	HSSP built from PDB template 2BSZ based on UniProtKB Q98D42.
ProteinModelPortal	Q7YRG5.
SMR	Q7YRG5. Positions 2-290.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7YRG5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMMUT00000030505; ENSMMUP00000028547; ENSMMUG00000021680.
GeneID	704357.
KEGG	mcc:704357.
Organism-specific databases
CTD	10.
Phylogenomic databases
eggNOG	prNOG19441.
GeneTree	ENSGT00390000012054.
HOVERGEN	HBG000165.
InParanoid	Q7YRG5.
OMA	PTSHERY.
OrthoDB	EOG4JDH7B.
Family and domain databases
InterPro	IPR001447. N-AcTrfase. [Graphical view]
KO	K00622.
PANTHER	PTHR11786. Acetyltransf2. 1 hit.
Pfam	PF00797. Acetyltransf_2. 1 hit. [Graphical view]
PRINTS	PR01543. ANATRNSFRASE.
ProtoNet	Search...

Entry information

Entry name

ARY2_MACMU

Accession

Primary (citable) accession number: Q7YRG5
Secondary accession number(s): Q7YRG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	October 1, 2003
Last modified:	November 16, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program