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Protein

AP-3 complex subunit beta-1

Gene

AP3B1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit beta-1
Alternative name(s):
Adaptor protein complex AP-3 subunit beta-1
Adaptor-related protein complex 3 subunit beta-1
Beta-3A-adaptin
Clathrin assembly protein complex 3 beta-1 large chain
Gene namesi
Name:AP3B1
Synonyms:ADTB3A
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937451 – 1091AP-3 complex subunit beta-1Add BLAST1091

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei276PhosphoserineBy similarity1
Modified residuei609PhosphoserineBy similarity1
Modified residuei748PhosphoserineBy similarity1
Modified residuei750PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7YRF1.
PRIDEiQ7YRF1.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). AP-3 associates with the BLOC-1 complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000013540.

Structurei

3D structure databases

ProteinModelPortaliQ7YRF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi678 – 800Glu/Ser-richAdd BLAST123

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1060. Eukaryota.
COG5096. LUCA.
HOGENOMiHOG000033978.
HOVERGENiHBG050519.
InParanoidiQ7YRF1.
KOiK12397.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026740. AP3_beta.
IPR029394. AP3B1_Ser.
IPR029390. AP3B_C.
IPR026739. AP_beta.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR015151. B-adaptin_app_sub_C.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PANTHERiPTHR11134. PTHR11134. 2 hits.
PfamiPF01602. Adaptin_N. 1 hit.
PF14796. AP3B1_C. 1 hit.
PF14797. SEEEED. 1 hit.
[Graphical view]
PIRSFiPIRSF037096. AP3_complex_beta. 1 hit.
SMARTiSM01355. AP3B1_C. 1 hit.
SM01020. B2-adapt-app_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7YRF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNSFAYSE QAGGGEATEL GQEATSTVSP SGAFGLFSSD LKKNEDLKQM
60 70 80 90 100
LESNKDSAKL DAMKRIVGMI AKGKNASELF PAVVKNVASK NIEIKKLVYV
110 120 130 140 150
YLVRYAEEQQ DLALLSISTF QRALKDPNQL IRASALRVLS SIRVPIIVPI
160 170 180 190 200
MMLAIKEASA DLSPYVRKNA AHAIQKLYSL DPEQKEMLIE VIEKLLKDKS
210 220 230 240 250
TLVAGSVVMA FEEVCPDRID LIHKNYRKLC NLLVDVEEWG QVVIIHMLTR
260 270 280 290 300
YARTQFVSPW KEDDGLEDNE KNFYESDDEQ KEKTDQKKKP YAMDPDHRLL
310 320 330 340 350
IRNTKPLLQS RNAAVVMAVA QLYWHISPKS EVGIISKSLV RLLRSNREVQ
360 370 380 390 400
YIVLQNIATM SIQRKGMLEP YLKSFYVRST DPTMIKILKL EILTNLANEA
410 420 430 440 450
NISTLLREFQ TYVKSQDKQF AAATIQTIGR CATSISEVTD TCLSGLVCLL
460 470 480 490 500
SNRDEIVVAE SVVVIKKLLQ MQPAQHGEII KHMAKLLDSI TVPVARASIL
510 520 530 540 550
WLIGENCERV PKIAPDVLRK MAKSFTNEDD LVKLQILNLG AKLYLTNSKQ
560 570 580 590 600
TKLLTQYILN LGKYDQNYDI RDRTRFIRQL IVPNEKSGAL SKYAKKIFLA
610 620 630 640 650
QKPAPLLESP FKDRDHFQLG TLSHTLNTKA IGYLELSNWP EVAPDPSVRN
660 670 680 690 700
VEVIELQAKE WTPAGKAKKE NPARKFYSDS EEEEDSSDSS SDSESESGSA
710 720 730 740 750
SGEQDEEGDS SEDSSEDSSS EHRSDSESVS EVGDKRTAKR NSKSKGKSDS
760 770 780 790 800
EDEEKENEKS KTSDSSSTDS SSVEESSSDS ESESESESES ESKKVTMEKE
810 820 830 840 850
KKTKEDRNLT KDVSLLDLDD FNPVSTPVVL PTPALSPSLI ADLEGLNLST
860 870 880 890 900
SSSVISVNTP VFVPVKTHVL LHRMSGRGLA AHYFFPRQPC IFGDKMVSIQ
910 920 930 940 950
ITLNNTTDRK IENIHIEGKK LPMGMQMHVF NPIESLEPEG SITVSMGIDF
960 970 980 990 1000
CDSTQTASFQ LCTKDDCFNV NIQPPVGELL LPVAMSEKDF KKEQGMLTGM
1010 1020 1030 1040 1050
NETSTVIIAA PQNFTPSVIL QKVVNIANVG VVPSGQDNIY RFAAKTVHSG
1060 1070 1080 1090
SLMLVTVELK EGSTAQLIIN TERTVIGSVL LRELKPVLSQ G
Length:1,091
Mass (Da):121,191
Last modified:October 1, 2003 - v1
Checksum:i53212E479694B4C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY221640 mRNA. Translation: AAP45786.1.
RefSeqiNP_001002974.1. NM_001002974.2.
UniGeneiCfa.169.

Genome annotation databases

GeneIDi403459.
KEGGicfa:403459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY221640 mRNA. Translation: AAP45786.1.
RefSeqiNP_001002974.1. NM_001002974.2.
UniGeneiCfa.169.

3D structure databases

ProteinModelPortaliQ7YRF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000013540.

Proteomic databases

PaxDbiQ7YRF1.
PRIDEiQ7YRF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403459.
KEGGicfa:403459.

Organism-specific databases

CTDi8546.

Phylogenomic databases

eggNOGiKOG1060. Eukaryota.
COG5096. LUCA.
HOGENOMiHOG000033978.
HOVERGENiHBG050519.
InParanoidiQ7YRF1.
KOiK12397.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026740. AP3_beta.
IPR029394. AP3B1_Ser.
IPR029390. AP3B_C.
IPR026739. AP_beta.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR015151. B-adaptin_app_sub_C.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PANTHERiPTHR11134. PTHR11134. 2 hits.
PfamiPF01602. Adaptin_N. 1 hit.
PF14796. AP3B1_C. 1 hit.
PF14797. SEEEED. 1 hit.
[Graphical view]
PIRSFiPIRSF037096. AP3_complex_beta. 1 hit.
SMARTiSM01355. AP3B1_C. 1 hit.
SM01020. B2-adapt-app_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiAP3B1_CANLF
AccessioniPrimary (citable) accession number: Q7YRF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.