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Q7YRB7

- AOFB_CANFA

UniProt

Q7YRB7 - AOFB_CANFA

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Protein
Amine oxidase [flavin-containing] B
Gene
MAOB
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine By similarity.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561Important for catalytic activity By similarity
Sitei365 – 3651Important for catalytic activity By similarity
Sitei382 – 3821Important for catalytic activity By similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amine oxidase [flavin-containing] B (EC:1.4.3.4)
    Alternative name(s):
    Monoamine oxidase type B
    Short name:
    MAO-B
    Gene namesi
    Name:MAOB
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 489488Cytoplasmic By similarity
    Add
    BLAST
    Transmembranei490 – 51627Helical; Anchor for type IV membrane protein; By similarity
    Add
    BLAST
    Topological domaini517 – 5204Mitochondrial intermembrane By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed By similarity
    Chaini2 – 520519Amine oxidase [flavin-containing] B
    PRO_0000099857Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine By similarity
    Modified residuei52 – 521N6-acetyllysine By similarity
    Modified residuei397 – 3971S-8alpha-FAD cysteine By similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000030886.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7YRB7.
    SMRiQ7YRB7. Positions 4-499.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi36 – 5217Arg/Lys-rich (basic)
    Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1231.
    HOGENOMiHOG000221615.
    HOVERGENiHBG004255.
    KOiK00274.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00757. AMINEOXDASEF.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7YRB7-1 [UniParc]FASTAAdd to Basket

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    MSGKCDVVVV GGGISGMAAA KLLHDFGLNV VVLEARDRVG GRTYTIRNQK    50
    VKYLDLGGSY VGPTQNCILR LAKELGLETY KVNEVERLIH HVKGKSYPFR 100
    GPFPPVWNPI AYLDHNNLWR TMDDMGREIP SDAPWKAPLA EEWDHMTMKE 150
    LLDKICWTES AKQLATLFVN LCVTAETHEV SALWFLWYVK QCGGTTRIIS 200
    TTNGGQERKF VGGSGQVSER IMDLLGDQVK LERPVTHIDQ TGENVLVETL 250
    NHEVYEAKYV ISAIPPTLGM KIHFNPPLPM MRNQLITRVP LGSVIKCIVY 300
    YKEPFWRKKD YCGTMIIEGE EAPIAYTLDD TKPDGNYAAI MGFILAHKAR 350
    KLARLTKDER MKKLCELYAK VLGSQEALQP VHYEEKNWCE EQYSGGCYTT 400
    YFPPGIMTQY GRVLRQPVGR IYFAGTETAT HWSGYMEGAV EAGERAAREI 450
    LHAMGKIPED EIWQSEPESV DVPAQPITTT FLERHLPSVP GLLRLIGLTA 500
    IFSATALGVL AHKRGLLVRV 520
    Length:520
    Mass (Da):58,384
    Last modified:January 23, 2007 - v3
    Checksum:iD5C6295875D7D8BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070958 mRNA. Translation: BAB86936.1.
    RefSeqiNP_001002970.1. NM_001002970.1.
    UniGeneiCfa.152.

    Genome annotation databases

    GeneIDi403451.
    KEGGicfa:403451.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070958 mRNA. Translation: BAB86936.1 .
    RefSeqi NP_001002970.1. NM_001002970.1.
    UniGenei Cfa.152.

    3D structure databases

    ProteinModelPortali Q7YRB7.
    SMRi Q7YRB7. Positions 4-499.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000030886.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403451.
    KEGGi cfa:403451.

    Organism-specific databases

    CTDi 4129.

    Phylogenomic databases

    eggNOGi COG1231.
    HOGENOMi HOG000221615.
    HOVERGENi HBG004255.
    KOi K00274.

    Miscellaneous databases

    NextBioi 20816969.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00757. AMINEOXDASEF.
    ProtoNeti Search...

    Publicationsi

    1. Hashizume C., Mori Y.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
      Tissue: Brain.

    Entry informationi

    Entry nameiAOFB_CANFA
    AccessioniPrimary (citable) accession number: Q7YRB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: January 23, 2007
    Last modified: March 19, 2014
    This is version 73 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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