Q7YR75 (RM12_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L12, mitochondrial
Short name=L12mt
Short name=MRP-L12

Gene names

Name:

MRPL12

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with NOA1 By similarity.
Subcellular location	Mitochondrion Ref.4.
Sequence similarities	Belongs to the ribosomal protein L7/L12P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial large ribosomal subunit Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 45	45	Mitochondrion HAMAP-Rule MF_00368
	Chain	46 – 198	153	39S ribosomal protein L12, mitochondrial HAMAP-Rule MF_00368		PRO_0000239700

Sequences

	Sequence		Length	Mass (Da)
	Q7YR75 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 3A98308C159F3493	FASTA	198	21,400
	10 20 30 40 50 60 MLPSATSLLR GPCLGLRAAA LRLVRQQVPH VCAVRLMRCS SHRRGEALTG APLDNAPKEY 70 80 90 100 110 120 PPKIQQLVQD IASLTLLEIS DLNELLKKTL KIQDVGLMPM GGMVPGAAPA PTAPEAAEED 130 140 150 160 170 180 VPKQKERTHF TVRLTEAKPV DKVKLIKEIK NYVQGINLVQ AKKLVESLPQ EIKANVAKAE 190 AEKIKAALEA VGGTVVLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional compatibility of elongation factors between mammalian mitochondrial and bacterial ribosomes: characterization of GTPase activity and translation elongation by hybrid ribosomes bearing heterologous L7/12 proteins." Terasaki M., Suzuki T., Hanada T., Watanabe K. J. Mol. Biol. 336:331-342(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.
[4]	"Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle." Graack H.R., Bryant M.L., O'Brien T.W. Biochemistry 38:16569-16577(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 45-69, SUBCELLULAR LOCATION.
[5]	"A structural model for the large subunit of the mammalian mitochondrial ribosome." Mears J.A., Sharma M.R., Gutell R.R., McCook A.S., Richardson P.E., Caulfield T.R., Agrawal R.K., Harvey S.C. J. Mol. Biol. 358:193-212(2006) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY ELECTRON MICROSCOPY (12.1 ANGSTROMS) OF 62-198.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB116379 mRNA. Translation: BAC81567.1.
BT020735 mRNA. Translation: AAX08752.1.
BT020755 mRNA. Translation: AAX08772.1.
BT020982 mRNA. Translation: AAX08999.1.
BT030597 mRNA. Translation: ABQ13037.1.
BC134767 mRNA. Translation: AAI34768.1.

IPI

IPI00691477.

RefSeq

NP_963900.1. NM_201606.2.

UniGene

Bt.8177.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FTC	electron microscopy	12.10	E/F	62-198	[»]

ProteinModelPortal

Q7YR75.

ModBase

Search...

Proteomic databases

PRIDE

Q7YR75.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

399560.

KEGG

bta:399560.

Organism-specific databases

CTD

6182.

Phylogenomic databases

eggNOG

NOG312691.

HOGENOM

HOG000248814.

HOVERGEN

HBG001832.

KO

K02935.

OrthoDB

EOG4R5044.

Family and domain databases

Gene3D

3.30.1390.10. 1 hit.

HAMAP

MF_00368. Ribosomal_L7_L12.

InterPro

IPR015607. Ribosomal_L12_mit.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR013823. Ribosomal_L7/L12_C.
IPR008932. Ribosomal_L7/L12_oligo.
[Graphical view]

PANTHER

PTHR11809:SF2. PTHR11809:SF2. 1 hit.

Pfam

PF00542. Ribosomal_L12. 1 hit.
[Graphical view]

ProDom

PD001326. Ribosomal_L7/L12_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF48300. Ribosomal_L12/7. 1 hit.
SSF54736. Ribosomal_L7/12_C/ClpS-like. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q7YR75.

NextBio

20816606.

Entry information

Entry name

RM12_BOVIN

Accession

Primary (citable) accession number: Q7YR75
Secondary accession number(s): A5D9H8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program