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Q7YR49

- PO5F1_PANTR

UniProt

Q7YR49 - PO5F1_PANTR

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Protein

POU domain, class 5, transcription factor 1

Gene
POU5F1, OCT3, OTF3
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi230 – 28960HomeoboxAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. miRNA binding Source: Ensembl
  3. sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  5. transcription corepressor activity Source: Ensembl
  6. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. BMP signaling pathway involved in heart induction Source: Ensembl
  2. cardiac cell fate determination Source: Ensembl
  3. ectodermal cell fate commitment Source: Ensembl
  4. endodermal cell fate specification Source: Ensembl
  5. germ-line stem cell maintenance Source: Ensembl
  6. mesodermal cell fate commitment Source: Ensembl
  7. mRNA transcription from RNA polymerase II promoter Source: Ensembl
  8. negative regulation of calcium ion-dependent exocytosis Source: Ensembl
  9. negative regulation of gene silencing by miRNA Source: Ensembl
  10. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. positive regulation of catenin import into nucleus Source: Ensembl
  12. positive regulation of SMAD protein import into nucleus Source: Ensembl
  13. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. regulation of asymmetric cell division Source: Ensembl
  15. regulation of heart induction by regulation of canonical Wnt signaling pathway Source: Ensembl
  16. regulation of methylation-dependent chromatin silencing Source: Ensembl
  17. response to retinoic acid Source: Ensembl
  18. response to wounding Source: Ensembl
  19. somatic stem cell maintenance Source: Ensembl
  20. trophectodermal cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 5, transcription factor 1
Alternative name(s):
Octamer-binding protein 3
Short name:
Oct-3
Octamer-binding transcription factor 3
Short name:
OTF-3
Gene namesi
Name:POU5F1
Synonyms:OCT3, OTF3
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 6

Subcellular locationi

Cytoplasm. Nucleus
Note: Expressed in a diffuse and slightly punctuate pattern By similarity.

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nucleoplasm Source: Ensembl
  3. transcriptional repressor complex Source: Ensembl
  4. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360POU domain, class 5, transcription factor 1PRO_0000100750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei111 – 1111Phosphoserine; by MAPK By similarity
Cross-linki123 – 123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Modified residuei235 – 2351Phosphothreonine By similarity
Modified residuei236 – 2361Phosphoserine By similarity
Modified residuei289 – 2891Phosphoserine By similarity
Modified residuei290 – 2901Phosphoserine By similarity
Modified residuei355 – 3551Phosphoserine By similarity

Post-translational modificationi

Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression By similarity.
Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation By similarity.
ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription By similarity.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Interactioni

Subunit structurei

Interacts with ZSCAN10, UBE2I and PKM. Interacts with WWP2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ7YR49.
SMRiQ7YR49. Positions 144-289.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 21275POU-specificAdd
BLAST

Domaini

The POU-specific domain mediates interaction with PKM By similarity.

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG329627.
GeneTreeiENSGT00750000117482.
HOGENOMiHOG000089941.
HOVERGENiHBG057998.
InParanoidiQ7YR49.
KOiK09367.
OrthoDBiEOG7DJSMG.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5.
IPR000327. POU_specific.
[Graphical view]
PANTHERiPTHR11636:SF15. PTHR11636:SF15. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7YR49-1 [UniParc]FASTAAdd to Basket

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MAGHLTSDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG    50
VGPGSEVWGI PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG 100
VGVESNSDGA SPEPCTVTPG AVKLEKEKLE QNPEESQDIK ALQKELEQFA 150
KLLKQKRITL GYTQADVGLT LGVLFGKVFS QTTICRFEAL QLSFKNMCKL 200
RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR VRGNLENLFL 250
QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA 300
AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV 350
TTLGSPMHSN 360
Length:360
Mass (Da):38,601
Last modified:October 1, 2003 - v1
Checksum:i375D4ADB3C01348C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61T → A in BAE92816. 1 Publication
Sequence conflicti6 – 61T → A in BAE92818. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000041 Genomic DNA. Translation: BAC78165.1.
AB210197 Genomic DNA. Translation: BAE92816.1.
AB210198 Genomic DNA. Translation: BAE92818.1.
RefSeqiNP_001238970.1. NM_001252041.1.

Genome annotation databases

EnsembliENSPTRT00000033151; ENSPTRP00000030631; ENSPTRG00000017953.
GeneIDi744263.
KEGGiptr:744263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000041 Genomic DNA. Translation: BAC78165.1 .
AB210197 Genomic DNA. Translation: BAE92816.1 .
AB210198 Genomic DNA. Translation: BAE92818.1 .
RefSeqi NP_001238970.1. NM_001252041.1.

3D structure databases

ProteinModelPortali Q7YR49.
SMRi Q7YR49. Positions 144-289.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000033151 ; ENSPTRP00000030631 ; ENSPTRG00000017953 .
GeneIDi 744263.
KEGGi ptr:744263.

Organism-specific databases

CTDi 5460.

Phylogenomic databases

eggNOGi NOG329627.
GeneTreei ENSGT00750000117482.
HOGENOMi HOG000089941.
HOVERGENi HBG057998.
InParanoidi Q7YR49.
KOi K09367.
OrthoDBi EOG7DJSMG.
TreeFami TF316413.

Miscellaneous databases

NextBioi 20911216.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5.
IPR000327. POU_specific.
[Graphical view ]
PANTHERi PTHR11636:SF15. PTHR11636:SF15. 1 hit.
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence."
    Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A., Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y., Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., Meyer A., Ikeo K.
    , Gojobori T., Bahram S., Inoko H.
    Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
    Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
    , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
    Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPO5F1_PANTR
AccessioniPrimary (citable) accession number: Q7YR49
Secondary accession number(s): Q1XHV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi