Q7YR43 (DDR1_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Epithelial discoidin domain-containing receptor 1
Short name=Epithelial discoidin domain receptor 1
EC=2.7.10.1

Alternative name(s):
CD167 antigen-like family member A
Discoidin receptor tyrosine kinase
Tyrosine kinase DDR
CD_antigen=CD167a

Gene names

Name:	DDR1
Synonyms:	EDDR1

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	909 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in cell-cell interactions and recognition By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit structure	Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Domain	The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 1 F5/8 type C domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 909	891	Epithelial discoidin domain-containing receptor 1		PRO_0000016744
Regions
	Topological domain	19 – 412	394	Extracellular Potential
	Transmembrane	413 – 439	27	Helical; Potential
	Topological domain	440 – 909	470	Cytoplasmic Potential
	Domain	31 – 181	151	F5/8 type C
	Domain	606 – 901	296	Protein kinase
	Nucleotide binding	612 – 620	9	ATP By similarity
	Motif	477 – 480	4	PPxY motif
	Compositional bias	373 – 411	39	Gly/Pro-rich
	Compositional bias	472 – 597	126	Gly/Pro-rich
Sites
	Active site	762	1	Proton acceptor By similarity
	Binding site	651	1	ATP By similarity
Amino acid modifications
	Modified residue	509	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	627	1	Phosphoserine By similarity
	Modified residue	788	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	792	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	793	1	Phosphotyrosine; by autocatalysis By similarity
	Glycosylation	207	1	N-linked (GlcNAc...) Potential
	Glycosylation	256	1	N-linked (GlcNAc...) Potential
	Glycosylation	366	1	N-linked (GlcNAc...) Potential
	Glycosylation	390	1	N-linked (GlcNAc...) Potential
	Disulfide bond	31 ↔ 181		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7YR43 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 5E30275EE6D0D931	FASTA	909	100,642
	10 20 30 40 50 60 MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR 70 80 90 100 110 120 HSSDGDGAWC PAGSVFPKEE EYLQVDLQRL HLVALVGTQG RHAGGLGKEF SRSYRLRYSR 130 140 150 160 170 180 DGRRWMGWKD RWGQEVISGN EDPEGVVLKD LGPPMVARLV RFYPRADRVM SVCLRVELYG 190 200 210 220 230 240 CLWRDGLLSY TAPVGQTMYL SEAVYLNDST YDGHTVGGLQ YGGLGQLADG VVGLDDFRKS 250 260 270 280 290 300 QELRVWPGYD YVGWSNHSFS SGYVEMEFEF DRLRAFQAMQ VHCNNMHTLG ARLPGGVECR 310 320 330 340 350 360 FRRGPAMAWE GEPMRHNLGG NLGDPRARAV SVPLGGRVAR FLQCRFLFAG PWLLFSEISF 370 380 390 400 410 420 ISDVVNNSSP ALGGTFPPAP WWPPGPPPTN FSSLELEPRG QQPVAKAEGS PTAILIGCLV 430 440 450 460 470 480 AIILLLLLII ALMLWRLHWR RLLSKAERRV LEEELTVHLS VPGDTILINN RPGPREPPPY 490 500 510 520 530 540 QEPRPRGNPP HSAPCVPNGS ALLLSNPAYR LLLATYARPP RGPGPPTPAW AKPTNTQAYS 550 560 570 580 590 600 GDYMEPEKPG APLLPPPPQN SVPHYAEADI VTLQGVTGGN TYAVPALPPG AVGDGPPRVD 610 620 630 640 650 660 FPRSRLRFKE KLGEGQFGEV HLCEVDSPQD LVSLDFPLNV RKGHPLLVAV KILRPDATKN 670 680 690 700 710 720 ARNDFLKEVK IMSRLKDPNI IRLLGVCVQD DPLCMITDYM ENGDLNQFLS AHQLEDKAAE 730 740 750 760 770 780 GAPGDGQAAQ GPTISYPMLL HVAAQIASGM RYLATLNFVH RDLATRNCLV GENFTIKIAD 790 800 810 820 830 840 FGMSRNLYAG DYYRVQGRAV LPIRWMAWEC ILMGKFTTAS DVWAFGVTLW EVLMLCRAQP 850 860 870 880 890 900 FGQLTDEQVI ENAGEFFRDQ GRQVYLSRPP ACPQGLYELM LRCWSRESEQ RPPFSQLHRF LAEDALNTV

References

[1]

"Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence." Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A., Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y., Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., Meyer A., Ikeo K. , Gojobori T., Bahram S., Inoko H. Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003) [PubMed: 12799463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000041 Genomic DNA. Translation: BAC78172.1.
RefSeq	NP_001038967.1. NM_001045502.1.
UniGene	Ptr.6269.
3D structure databases
ProteinModelPortal	Q7YR43.
SMR	Q7YR43. Positions 27-182.
ModBase	Search...
Proteomic databases
PRIDE	Q7YR43.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000033132; ENSPTRP00000030612; ENSPTRG00000017942.
GeneID	462548.
KEGG	ptr:462548.
Organism-specific databases
CTD	780.
Phylogenomic databases
GeneTree	ENSGT00600000084105.
HOVERGEN	HBG005461.
Family and domain databases
InterPro	IPR000421. Coagulation_fac_5/8-C_type_dom. IPR008979. Galactose-bd-like. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR001245. Ser-Thr/Tyr_kinase. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR002011. Tyr_kinase_rcpt_2_CS. [Graphical view]
KO	K05124.
Pfam	PF00754. F5_F8_type_C. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00231. FA58C. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF49785. Gal_bind_like. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS01285. FA58C_1. 1 hit. PS01286. FA58C_2. 1 hit. PS50022. FA58C_3. 1 hit. PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DDR1_PANTR

Accession

Primary (citable) accession number: Q7YR43

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 1, 2003
Last modified:	November 16, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program