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Protein

Radiation-inducible immediate-early gene IEX-1

Gene

IER3

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Radiation-inducible immediate-early gene IEX-1
Alternative name(s):
Immediate early protein GLY96
Immediate early response 3 protein
Gene namesi
Name:IER3
Synonyms:IEX1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 6

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8282CytoplasmicSequence analysisAdd
BLAST
Transmembranei83 – 9917Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini100 – 15657ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Radiation-inducible immediate-early gene IEX-1PRO_0000084161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181Phosphothreonine; by MAPK1By similarity
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei123 – 1231Phosphothreonine; by MAPK1By similarity
Modified residuei126 – 1261Phosphoserine; by MAPK1By similarity
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated.By similarity
Phosphorylated at Thr-18, Thr-123 and Ser-126 by MAPK1/ERK2 and probably MAPK3/ERK1. Upon phosphorylation by MAPK1/ERK2 and MAPK3/ERK1, acquires the ability to inhibit cell death induced by various stimuli (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7YR42.

Interactioni

Subunit structurei

Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000030609.

Family & Domainsi

Sequence similaritiesi

Belongs to the IER3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ8Q. Eukaryota.
ENOG410Z2E4. LUCA.
GeneTreeiENSGT00390000003213.
HOGENOMiHOG000113001.
HOVERGENiHBG000172.
InParanoidiQ7YR42.
OMAiMCHSRSS.
OrthoDBiEOG7Q5HG8.
TreeFamiTF338252.

Family and domain databases

InterProiIPR024829. IEX-1.
[Graphical view]
PANTHERiPTHR16915. PTHR16915. 1 hit.
PRINTSiPR02100. GENEIEX1.

Sequencei

Sequence statusi: Complete.

Q7YR42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHSRSCHPT MTILQAPTPA PSTNPGPRRG SGPEIFTFDP LPEPAAAPAG
60 70 80 90 100
RPSASRGHRK RSRRVLYPRV VRRQLPVEEP NPAKRLLFLL LTIVFCQILM
110 120 130 140 150
AEEGVPAPLP PEDAPNAASL APTPVSPVLE PFNLTSEPSD YALDLSTFLQ

QHPAAF
Length:156
Mass (Da):16,930
Last modified:October 1, 2003 - v1
Checksum:i83C067CDCAC09650
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000041 Genomic DNA. Translation: BAC78173.1.
AB210163 Genomic DNA. Translation: BAE92767.1.
AB210164 Genomic DNA. Translation: BAE92769.1.
RefSeqiNP_001038966.1. NM_001045501.1.
UniGeneiPtr.6342.

Genome annotation databases

EnsembliENSPTRT00000033129; ENSPTRP00000030609; ENSPTRG00000017941.
GeneIDi462547.
KEGGiptr:462547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000041 Genomic DNA. Translation: BAC78173.1.
AB210163 Genomic DNA. Translation: BAE92767.1.
AB210164 Genomic DNA. Translation: BAE92769.1.
RefSeqiNP_001038966.1. NM_001045501.1.
UniGeneiPtr.6342.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000030609.

Proteomic databases

PaxDbiQ7YR42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000033129; ENSPTRP00000030609; ENSPTRG00000017941.
GeneIDi462547.
KEGGiptr:462547.

Organism-specific databases

CTDi8870.

Phylogenomic databases

eggNOGiENOG410IZ8Q. Eukaryota.
ENOG410Z2E4. LUCA.
GeneTreeiENSGT00390000003213.
HOGENOMiHOG000113001.
HOVERGENiHBG000172.
InParanoidiQ7YR42.
OMAiMCHSRSS.
OrthoDBiEOG7Q5HG8.
TreeFamiTF338252.

Miscellaneous databases

NextBioi20841797.

Family and domain databases

InterProiIPR024829. IEX-1.
[Graphical view]
PANTHERiPTHR16915. PTHR16915. 1 hit.
PRINTSiPR02100. GENEIEX1.
ProtoNetiSearch...

Publicationsi

  1. "Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence."
    Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A., Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y., Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., Meyer A., Ikeo K.
    , Gojobori T., Bahram S., Inoko H.
    Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
    Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
    , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
    Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiIEX1_PANTR
AccessioniPrimary (citable) accession number: Q7YR42
Secondary accession number(s): Q1XI01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.