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Protein

Radiation-inducible immediate-early gene IEX-1

Gene

IER3

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Radiation-inducible immediate-early gene IEX-1
Alternative name(s):
Immediate early protein GLY96
Immediate early response 3 protein
Gene namesi
Name:IER3
Synonyms:IEX1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 82CytoplasmicSequence analysisAdd BLAST82
Transmembranei83 – 99Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini100 – 156ExtracellularSequence analysisAdd BLAST57

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841611 – 156Radiation-inducible immediate-early gene IEX-1Add BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Phosphothreonine; by MAPK1By similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei123Phosphothreonine; by MAPK1By similarity1
Modified residuei126Phosphoserine; by MAPK1By similarity1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity
Phosphorylated at Thr-18, Thr-123 and Ser-126 by MAPK1/ERK2 and probably MAPK3/ERK1. Upon phosphorylation by MAPK1/ERK2 and MAPK3/ERK1, acquires the ability to inhibit cell death induced by various stimuli (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7YR42

Expressioni

Gene expression databases

BgeeiENSPTRG00000017941

Interactioni

Subunit structurei

Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000030609

Family & Domainsi

Sequence similaritiesi

Belongs to the IER3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ8Q Eukaryota
ENOG410Z2E4 LUCA
HOGENOMiHOG000113001
HOVERGENiHBG000172
InParanoidiQ7YR42
OMAiFCQILMA
OrthoDBiEOG091G0UO1
TreeFamiTF338252

Family and domain databases

InterProiView protein in InterPro
IPR024829 IEX-1
PANTHERiPTHR16915 PTHR16915, 1 hit
PRINTSiPR02100 GENEIEX1

Sequencei

Sequence statusi: Complete.

Q7YR42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHSRSCHPT MTILQAPTPA PSTNPGPRRG SGPEIFTFDP LPEPAAAPAG
60 70 80 90 100
RPSASRGHRK RSRRVLYPRV VRRQLPVEEP NPAKRLLFLL LTIVFCQILM
110 120 130 140 150
AEEGVPAPLP PEDAPNAASL APTPVSPVLE PFNLTSEPSD YALDLSTFLQ

QHPAAF
Length:156
Mass (Da):16,930
Last modified:October 1, 2003 - v1
Checksum:i83C067CDCAC09650
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000041 Genomic DNA Translation: BAC78173.1
AB210163 Genomic DNA Translation: BAE92767.1
AB210164 Genomic DNA Translation: BAE92769.1
RefSeqiNP_001038966.1, NM_001045501.1
UniGeneiPtr.6342

Genome annotation databases

GeneIDi462547
KEGGiptr:462547

Similar proteinsi

Entry informationi

Entry nameiIEX1_PANTR
AccessioniPrimary (citable) accession number: Q7YR42
Secondary accession number(s): Q1XI01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome