Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7YQJ9

- UB2Q2_RABIT

UniProt

Q7YQJ9 - UB2Q2_RABIT

Protein

Ubiquitin-conjugating enzyme E2 Q2

Gene

UBE2Q2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination By similarity.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei298 – 2981Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. protein K48-linked ubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Q2 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein Q2
    Ubiquitin-conjugating enzyme UBCi
    Ubiquitin-protein ligase Q2
    Gene namesi
    Name:UBE2Q2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Ubiquitin-conjugating enzyme E2 Q2PRO_0000223881Add
    BLAST

    Expressioni

    Tissue specificityi

    Detected at embryo implantation sites in the luminal epithelium of pregnant endometrium. Detected at low levels in ovary and liver.1 Publication

    Inductioni

    Up-regulated in pregnant endometrium during implantation.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000021489.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7YQJ9.
    SMRiQ7YQJ9. Positions 195-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi129 – 17244Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG320521.
    GeneTreeiENSGT00390000018573.
    HOGENOMiHOG000007757.
    HOVERGENiHBG061368.
    OMAiSYKAGIY.
    OrthoDBiEOG76DTSS.
    TreeFamiTF313338.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 2 hits.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7YQJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPLLTL    50
    HCNITESYPS SSPIWFVDSD DPNLTSVLER LEDSKNNNSL RQQLKWLICE 100
    LCRLYNLPKH LDVEMLDQPL PTGQNGTTEE VTSEEEEEEE MAEDIEDLDH 150
    YEMKEEEPIN GRKSEDEGIE KENLAILEKI RKSQRQDHLN GAVSGSVQAS 200
    DRLMKELRDI YRSQSYKTGI YSVELINDSL YDWHVKLQKV DPDSPLHSDL 250
    QILKEKEGIE YILLNFSFKD NFPFDPPFVR VVLPVLSGGY VLGGGALCME 300
    LLTKQGWSSA YSIESVIMQI NATLVKGKAR VQFGANKNQY NLARAQQSYN 350
    SIVQIHEKNG WYTPPKEDG 369
    Length:369
    Mass (Da):42,192
    Last modified:October 1, 2003 - v1
    Checksum:i3B88532499960CF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY330351 mRNA. Translation: AAP93920.1.
    RefSeqiNP_001076163.1. NM_001082694.1.
    UniGeneiOcu.3117.

    Genome annotation databases

    EnsembliENSOCUT00000029964; ENSOCUP00000021489; ENSOCUG00000022720.
    GeneIDi100009425.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY330351 mRNA. Translation: AAP93920.1 .
    RefSeqi NP_001076163.1. NM_001082694.1.
    UniGenei Ocu.3117.

    3D structure databases

    ProteinModelPortali Q7YQJ9.
    SMRi Q7YQJ9. Positions 195-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000021489.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOCUT00000029964 ; ENSOCUP00000021489 ; ENSOCUG00000022720 .
    GeneIDi 100009425.

    Organism-specific databases

    CTDi 92912.

    Phylogenomic databases

    eggNOGi NOG320521.
    GeneTreei ENSGT00390000018573.
    HOGENOMi HOG000007757.
    HOVERGENi HBG061368.
    OMAi SYKAGIY.
    OrthoDBi EOG76DTSS.
    TreeFami TF313338.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 2 hits.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression of genes in the endometrium at implantation: upregulation of a novel member of the E2 class of ubiquitin-conjugating enzymes."
      Melner M.H., Ducharme N.A., Brash A.R., Winfrey V.P., Olson G.E.
      Biol. Reprod. 70:406-414(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Endometrium.

    Entry informationi

    Entry nameiUB2Q2_RABIT
    AccessioniPrimary (citable) accession number: Q7YQJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3