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Protein

Ubiquitin-conjugating enzyme E2 Q2

Gene

UBE2Q2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (By similarity).By similarity

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei298 – 2981Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ligase activity Source: UniProtKB-KW
  3. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Q2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein Q2
Ubiquitin-conjugating enzyme UBCi
Ubiquitin-protein ligase Q2
Gene namesi
Name:UBE2Q2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Ubiquitin-conjugating enzyme E2 Q2PRO_0000223881Add
BLAST

Expressioni

Tissue specificityi

Detected at embryo implantation sites in the luminal epithelium of pregnant endometrium. Detected at low levels in ovary and liver.1 Publication

Inductioni

Up-regulated in pregnant endometrium during implantation.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021489.

Structurei

3D structure databases

ProteinModelPortaliQ7YQJ9.
SMRiQ7YQJ9. Positions 195-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 17244Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG320521.
GeneTreeiENSGT00390000018573.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiQ7YQJ9.
KOiK10582.
OMAiSPLRCEQ.
OrthoDBiEOG76DTSS.
TreeFamiTF313338.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 2 hits.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7YQJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPLLTL
60 70 80 90 100
HCNITESYPS SSPIWFVDSD DPNLTSVLER LEDSKNNNSL RQQLKWLICE
110 120 130 140 150
LCRLYNLPKH LDVEMLDQPL PTGQNGTTEE VTSEEEEEEE MAEDIEDLDH
160 170 180 190 200
YEMKEEEPIN GRKSEDEGIE KENLAILEKI RKSQRQDHLN GAVSGSVQAS
210 220 230 240 250
DRLMKELRDI YRSQSYKTGI YSVELINDSL YDWHVKLQKV DPDSPLHSDL
260 270 280 290 300
QILKEKEGIE YILLNFSFKD NFPFDPPFVR VVLPVLSGGY VLGGGALCME
310 320 330 340 350
LLTKQGWSSA YSIESVIMQI NATLVKGKAR VQFGANKNQY NLARAQQSYN
360
SIVQIHEKNG WYTPPKEDG
Length:369
Mass (Da):42,192
Last modified:October 1, 2003 - v1
Checksum:i3B88532499960CF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY330351 mRNA. Translation: AAP93920.1.
RefSeqiNP_001076163.1. NM_001082694.1.
UniGeneiOcu.3117.

Genome annotation databases

EnsembliENSOCUT00000029964; ENSOCUP00000021489; ENSOCUG00000022720.
GeneIDi100009425.
KEGGiocu:100009425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY330351 mRNA. Translation: AAP93920.1.
RefSeqiNP_001076163.1. NM_001082694.1.
UniGeneiOcu.3117.

3D structure databases

ProteinModelPortaliQ7YQJ9.
SMRiQ7YQJ9. Positions 195-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021489.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000029964; ENSOCUP00000021489; ENSOCUG00000022720.
GeneIDi100009425.
KEGGiocu:100009425.

Organism-specific databases

CTDi92912.

Phylogenomic databases

eggNOGiNOG320521.
GeneTreeiENSGT00390000018573.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiQ7YQJ9.
KOiK10582.
OMAiSPLRCEQ.
OrthoDBiEOG76DTSS.
TreeFamiTF313338.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 2 hits.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differential expression of genes in the endometrium at implantation: upregulation of a novel member of the E2 class of ubiquitin-conjugating enzymes."
    Melner M.H., Ducharme N.A., Brash A.R., Winfrey V.P., Olson G.E.
    Biol. Reprod. 70:406-414(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Endometrium.

Entry informationi

Entry nameiUB2Q2_RABIT
AccessioniPrimary (citable) accession number: Q7YQJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2003
Last modified: March 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.