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Q7YQJ9

- UB2Q2_RABIT

UniProt

Q7YQJ9 - UB2Q2_RABIT

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Protein

Ubiquitin-conjugating enzyme E2 Q2

Gene

UBE2Q2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (By similarity).By similarity

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei298 – 2981Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Q2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein Q2
Ubiquitin-conjugating enzyme UBCi
Ubiquitin-protein ligase Q2
Gene namesi
Name:UBE2Q2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Ubiquitin-conjugating enzyme E2 Q2PRO_0000223881Add
BLAST

Expressioni

Tissue specificityi

Detected at embryo implantation sites in the luminal epithelium of pregnant endometrium. Detected at low levels in ovary and liver.1 Publication

Inductioni

Up-regulated in pregnant endometrium during implantation.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021489.

Structurei

3D structure databases

ProteinModelPortaliQ7YQJ9.
SMRiQ7YQJ9. Positions 195-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 17244Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG320521.
GeneTreeiENSGT00390000018573.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiQ7YQJ9.
OMAiSYKAGIY.
OrthoDBiEOG76DTSS.
TreeFamiTF313338.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 2 hits.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7YQJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPLLTL
60 70 80 90 100
HCNITESYPS SSPIWFVDSD DPNLTSVLER LEDSKNNNSL RQQLKWLICE
110 120 130 140 150
LCRLYNLPKH LDVEMLDQPL PTGQNGTTEE VTSEEEEEEE MAEDIEDLDH
160 170 180 190 200
YEMKEEEPIN GRKSEDEGIE KENLAILEKI RKSQRQDHLN GAVSGSVQAS
210 220 230 240 250
DRLMKELRDI YRSQSYKTGI YSVELINDSL YDWHVKLQKV DPDSPLHSDL
260 270 280 290 300
QILKEKEGIE YILLNFSFKD NFPFDPPFVR VVLPVLSGGY VLGGGALCME
310 320 330 340 350
LLTKQGWSSA YSIESVIMQI NATLVKGKAR VQFGANKNQY NLARAQQSYN
360
SIVQIHEKNG WYTPPKEDG
Length:369
Mass (Da):42,192
Last modified:October 1, 2003 - v1
Checksum:i3B88532499960CF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY330351 mRNA. Translation: AAP93920.1.
RefSeqiNP_001076163.1. NM_001082694.1.
UniGeneiOcu.3117.

Genome annotation databases

EnsembliENSOCUT00000029964; ENSOCUP00000021489; ENSOCUG00000022720.
GeneIDi100009425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY330351 mRNA. Translation: AAP93920.1 .
RefSeqi NP_001076163.1. NM_001082694.1.
UniGenei Ocu.3117.

3D structure databases

ProteinModelPortali Q7YQJ9.
SMRi Q7YQJ9. Positions 195-356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000021489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000029964 ; ENSOCUP00000021489 ; ENSOCUG00000022720 .
GeneIDi 100009425.

Organism-specific databases

CTDi 92912.

Phylogenomic databases

eggNOGi NOG320521.
GeneTreei ENSGT00390000018573.
HOGENOMi HOG000007757.
HOVERGENi HBG061368.
InParanoidi Q7YQJ9.
OMAi SYKAGIY.
OrthoDBi EOG76DTSS.
TreeFami TF313338.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 2 hits.
PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential expression of genes in the endometrium at implantation: upregulation of a novel member of the E2 class of ubiquitin-conjugating enzymes."
    Melner M.H., Ducharme N.A., Brash A.R., Winfrey V.P., Olson G.E.
    Biol. Reprod. 70:406-414(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Endometrium.

Entry informationi

Entry nameiUB2Q2_RABIT
AccessioniPrimary (citable) accession number: Q7YQJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3