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Q7YQJ9 (UB2Q2_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 Q2
EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein Q2
Ubiquitin-conjugating enzyme UBCi
Ubiquitin-protein ligase Q2
Gene names
Name:UBE2Q2
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Detected at embryo implantation sites in the luminal epithelium of pregnant endometrium. Detected at low levels in ovary and liver. Ref.1

Induction

Up-regulated in pregnant endometrium during implantation.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein K48-linked ubiquitination

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin-protein ligase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Ubiquitin-conjugating enzyme E2 Q2
PRO_0000223881

Regions

Compositional bias129 – 17244Glu-rich

Sites

Active site2981Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7YQJ9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 3B88532499960CF3

FASTA36942,192
        10         20         30         40         50         60 
MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPLLTL HCNITESYPS 

        70         80         90        100        110        120 
SSPIWFVDSD DPNLTSVLER LEDSKNNNSL RQQLKWLICE LCRLYNLPKH LDVEMLDQPL 

       130        140        150        160        170        180 
PTGQNGTTEE VTSEEEEEEE MAEDIEDLDH YEMKEEEPIN GRKSEDEGIE KENLAILEKI 

       190        200        210        220        230        240 
RKSQRQDHLN GAVSGSVQAS DRLMKELRDI YRSQSYKTGI YSVELINDSL YDWHVKLQKV 

       250        260        270        280        290        300 
DPDSPLHSDL QILKEKEGIE YILLNFSFKD NFPFDPPFVR VVLPVLSGGY VLGGGALCME 

       310        320        330        340        350        360 
LLTKQGWSSA YSIESVIMQI NATLVKGKAR VQFGANKNQY NLARAQQSYN SIVQIHEKNG 


WYTPPKEDG

« Hide

References

[1]"Differential expression of genes in the endometrium at implantation: upregulation of a novel member of the E2 class of ubiquitin-conjugating enzymes."
Melner M.H., Ducharme N.A., Brash A.R., Winfrey V.P., Olson G.E.
Biol. Reprod. 70:406-414(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Endometrium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY330351 mRNA. Translation: AAP93920.1.
RefSeqNP_001076163.1. NM_001082694.1.
UniGeneOcu.3117.

3D structure databases

ProteinModelPortalQ7YQJ9.
SMRQ7YQJ9. Positions 195-356.
ModBaseSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000021489.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSOCUT00000029964; ENSOCUP00000021489; ENSOCUG00000022720.
GeneID100009425.

Organism-specific databases

CTD92912.

Phylogenomic databases

eggNOGNOG320521.
GeneTreeENSGT00390000018573.
HOGENOMHOG000007757.
HOVERGENHBG061368.
OMASYKAGIY.
OrthoDBEOG48D0VK.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. False negative.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUB2Q2_RABIT
AccessionPrimary (citable) accession number: Q7YQJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2003
Last modified: April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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