Reviewed, UniProtKB/Swiss-Prot Q7YQJ9 (UB2Q2_RABIT)

Names and origin

Protein names

Recommended name:
    Ubiquitin-conjugating enzyme E2 Q2
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase Q2
    Ubiquitin carrier protein Q2
    Ubiquitin-conjugating enzyme UBCi

Gene names

Name:

UBE2Q2

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Detected at embryo implantation sites in the luminal epithelium of pregnant endometrium. Detected at low levels in ovary and liver. Ref.1
Induction	Up-regulated in pregnant endometrium during implantation.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW post-translational protein modification Inferred from electronic annotation. Source: InterPro regulation of protein metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	Ubiquitin-conjugating enzyme E2 Q2		PRO_0000223881
Regions
	Compositional bias	129 – 172	44	Glu-rich
Sites
	Active site	298	1	Glycyl thioester intermediate By similarity
Amino acid modifications
	Modified residue	363	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7YQJ9-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 3B88532499960CF3	FASTA	369	42,192
	10 20 30 40 50 60 MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPLLTL HCNITESYPS 70 80 90 100 110 120 SSPIWFVDSD DPNLTSVLER LEDSKNNNSL RQQLKWLICE LCRLYNLPKH LDVEMLDQPL 130 140 150 160 170 180 PTGQNGTTEE VTSEEEEEEE MAEDIEDLDH YEMKEEEPIN GRKSEDEGIE KENLAILEKI 190 200 210 220 230 240 RKSQRQDHLN GAVSGSVQAS DRLMKELRDI YRSQSYKTGI YSVELINDSL YDWHVKLQKV 250 260 270 280 290 300 DPDSPLHSDL QILKEKEGIE YILLNFSFKD NFPFDPPFVR VVLPVLSGGY VLGGGALCME 310 320 330 340 350 360 LLTKQGWSSA YSIESVIMQI NATLVKGKAR VQFGANKNQY NLARAQQSYN SIVQIHEKNG WYTPPKEDG

References

[1]

"Differential expression of genes in the endometrium at implantation: upregulation of a novel member of the E2 class of ubiquitin-conjugating enzymes." Melner M.H., Ducharme N.A., Brash A.R., Winfrey V.P., Olson G.E. Biol. Reprod. 70:406-414(2004) [PubMed: 14561654] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Endometrium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY330351 mRNA. Translation: AAP93920.1.
RefSeq	NP_001076163.1.
UniGene	Ocu.3117
3D structure databases
SMR	Q7YQJ9. Positions 195-356.
ModBase	Search...
Genome annotation databases
GeneID	100009425.
Phylogenomic databases
HOVERGEN	Q7YQJ9.
Enzyme and pathway databases
BRENDA	6.3.2.19. 255.
Family and domain databases
InterPro	IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view]
Gene3D	G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
ProDom	PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00212. UBCc. 1 hit. [Graphical view]
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. False negative. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UB2Q2_RABIT

Accession

Primary (citable) accession number: Q7YQJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)