Q7YQB2 (Q7YQB2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
MHC class I antigen EMBL AAL49978.1

Gene names

Name:	HLA-Cw EMBL AAL49978.1
Synonyms:	HLA-C EMBL ACJ03767.1

Organism

Homo sapiens (Human) EMBL AAL49978.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system By similarity. SAAS SAAS010579
Sequence similarities	Belongs to the MHC class I family. RuleBase RU004439 Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS010579

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC I SAAS SAAS010579 Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS010579
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7YQB2 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 4073C3BC53E55D0C	FASTA	366	40,820
	10 20 30 40 50 60 MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV SLRNLRGYYN QSEDGSHTFQ 130 140 150 160 170 180 RMYGCDLGPD GRLLRGYDQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQD 190 200 210 220 230 240 RAYLEGTCVE WLRRYLENGK KTLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 310 320 330 340 350 360 SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES LITCKA

References

[1]	"A novel variant of HLA-Cw*0704." Bunce M., Cox S., Marsh H. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Sequencing of a new HLA-Cw*07 allele." Balas A., Garcia-Sanchez F., Vicario J.L. Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"HLA-Cw full length cloning and sequencing: Sequence analysis from 5' upstream region through 3' downstream region." Xu Y., Deng Z., Yang B. Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY064404 Genomic DNA. Translation: AAL49978.1. FJ264200 Genomic DNA. Translation: ACJ03767.1. FJ785728 Genomic DNA. Translation: ACN97194.1.
IPI	IPI00642409.
UniGene	Hs.654404. Hs.656020.
3D structure databases
HSSP	HSSP built from PDB template 1M05 based on UniProtKB Q9MY78.
ProteinModelPortal	Q7YQB2.
SMR	Q7YQB2. Positions 26-302.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7YQB2.
Proteomic databases
PRIDE	Q7YQB2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.30.500.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-C. human.

Entry information

Entry name

Q7YQB2_HUMAN

Accession

Primary (citable) accession number: Q7YQB2

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	March 6, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.