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Q7YFV7 (COX2_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Synonyms:CoxII
Ordered Locus Names:AMI001W
ORF Names:AgCOX2
Encoded onMitochondrion
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subunit structure

Composed of at least 11 subunits.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Post-translational modification

The signal sequence of COX2 is processed by IMP1 By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1212 By similarity
Chain13 – 248236Cytochrome c oxidase subunit 2
PRO_0000006037

Regions

Topological domain13 – 3927Mitochondrial intermembrane Potential
Transmembrane40 – 6122Helical; Potential
Topological domain62 – 7918Mitochondrial matrix Potential
Transmembrane80 – 10425Helical; Potential
Topological domain105 – 248144Mitochondrial intermembrane Potential

Sites

Metal binding1831Copper A By similarity
Metal binding2181Copper A By similarity
Metal binding2221Copper A By similarity
Metal binding2261Copper A By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7YFV7 [UniParc].

Last modified July 19, 2004. Version 2.
Checksum: 5DC760E717804240

FASTA24828,676
        10         20         30         40         50         60 
MLLMNLFTII NNDVPTPYNM YFQDSTTPHQ EGILELHDNI MFYMLTVLGL VSWMMIIIIK 

        70         80         90        100        110        120 
DYKNNPITYK YIKHGQMIEI IWTILPAIIL LMIAFPSFIL LYLCDEVISP AMTIKVIGLQ 

       130        140        150        160        170        180 
WYWKYEYSDF INDNGETIEY ESYMIPEELL EEGQLRMLDT DTSIVIPVDT HVRFIVTATD 

       190        200        210        220        230        240 
VIHDFAVPSL GIKIDTTPGR LSQVSTLIQR EGIFYGQCSE LCGAQHSAMP IKIETVKLPT 


FLTWLNEQ 

« Hide

References

« Hide 'large scale' references
[1]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]"Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[3]"Phylogenetic relationships among yeasts of the 'Saccharomyces complex' determined from multigene sequence analyses."
Kurtzman C.P., Robnett C.J.
FEMS Yeast Res. 3:417-432(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-233.
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016821 Genomic DNA. Translation: AAS50168.1.
AF442273 Genomic DNA. Translation: AAP57840.1.
RefSeqNP_987078.1. NC_005789.1.

3D structure databases

ProteinModelPortalQ7YFV7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33169.AGOS_AMI001W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAS50168; AAS50168; AGOS_AMI001W.
GeneID2760769.
KEGGago:AGOS_AMI001W.

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000264988.
KOK02261.
OrthoDBEOG7WDNDC.
PhylomeDBQ7YFV7.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_ASHGO
AccessionPrimary (citable) accession number: Q7YFV7
Secondary accession number(s): Q75G36
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families