Q7YFV7 (COX2_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	COX2
Synonyms:	CoxII
Ordered Locus Names:	AMI001W
ORF Names:	AgCOX2

Encoded on

Mitochondrion

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium › Ashbya gossypii

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subunit structure	Composed of at least 11 subunits.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Post-translational modification	The signal sequence of COX2 is processed by IMP1 By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from electronic annotation. Source: EnsemblFungi mitochondrial electron transport, cytochrome c to oxygen Inferred from electronic annotation. Source: EnsemblFungi
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain complex IV Inferred from electronic annotation. Source: EnsemblFungi
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 12	12	By similarity
	Chain	13 – 248	236	Cytochrome c oxidase subunit 2		PRO_0000006037
Regions
	Topological domain	13 – 39	27	Mitochondrial intermembrane Potential
	Transmembrane	40 – 61	22	Helical; Potential
	Topological domain	62 – 79	18	Mitochondrial matrix Potential
	Transmembrane	80 – 104	25	Helical; Potential
	Topological domain	105 – 248	144	Mitochondrial intermembrane Potential
Sites
	Metal binding	183	1	Copper A By similarity
	Metal binding	218	1	Copper A By similarity
	Metal binding	222	1	Copper A By similarity
	Metal binding	226	1	Copper A By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7YFV7 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 5DC760E717804240	FASTA	248	28,676
	10 20 30 40 50 60 MLLMNLFTII NNDVPTPYNM YFQDSTTPHQ EGILELHDNI MFYMLTVLGL VSWMMIIIIK 70 80 90 100 110 120 DYKNNPITYK YIKHGQMIEI IWTILPAIIL LMIAFPSFIL LYLCDEVISP AMTIKVIGLQ 130 140 150 160 170 180 WYWKYEYSDF INDNGETIEY ESYMIPEELL EEGQLRMLDT DTSIVIPVDT HVRFIVTATD 190 200 210 220 230 240 VIHDFAVPSL GIKIDTTPGR LSQVSTLIQR EGIFYGQCSE LCGAQHSAMP IKIETVKLPT FLTWLNEQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]	"Phylogenetic relationships among yeasts of the 'Saccharomyces complex' determined from multigene sequence analyses." Kurtzman C.P., Robnett C.J. FEMS Yeast Res. 3:417-432(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-233. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016821 Genomic DNA. Translation: AAS50168.1. AF442273 Genomic DNA. Translation: AAP57840.1.
RefSeq	NP_987078.1. NC_005789.1.
3D structure databases
ProteinModelPortal	Q7YFV7.
ModBase	Search...
Protein-protein interaction databases
STRING	33169.AGOS_AMI001W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	AAS50168; AAS50168; AGOS_AMI001W.
GeneID	2760769.
KEGG	ago:AGOS_AMI001W.
Phylogenomic databases
eggNOG	COG1622.
HOGENOM	HOG000264988.
KO	K02261.
OrthoDB	EOG4ZW8M5.
PhylomeDB	Q7YFV7.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_ASHGO

Accession

Primary (citable) accession number: Q7YFV7
Secondary accession number(s): Q75G36

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program