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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi183Copper ABy similarity1
Metal bindingi218Copper ABy similarity1
Metal bindingi222Copper ABy similarity1
Metal bindingi226Copper ABy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:CoxII
Ordered Locus Names:AMI001W
ORF Names:AgCOX2
Encoded oniMitochondrion
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini13 – 39Mitochondrial intermembraneSequence analysisAdd BLAST27
Transmembranei40 – 61HelicalSequence analysisAdd BLAST22
Topological domaini62 – 79Mitochondrial matrixSequence analysisAdd BLAST18
Transmembranei80 – 104HelicalSequence analysisAdd BLAST25
Topological domaini105 – 248Mitochondrial intermembraneSequence analysisAdd BLAST144

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 12By similarityAdd BLAST12
ChainiPRO_000000603713 – 248Cytochrome c oxidase subunit 2Add BLAST236

Post-translational modificationi

The signal sequence of COX2 is processed by IMP1.By similarity

Interactioni

Subunit structurei

Composed of at least 11 subunits.

Structurei

3D structure databases

ProteinModelPortaliQ7YFV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988.
InParanoidiQ7YFV7.
KOiK02261.
OMAiPLKIFEM.
OrthoDBiEOG092C40RV.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7YFV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLMNLFTII NNDVPTPYNM YFQDSTTPHQ EGILELHDNI MFYMLTVLGL
60 70 80 90 100
VSWMMIIIIK DYKNNPITYK YIKHGQMIEI IWTILPAIIL LMIAFPSFIL
110 120 130 140 150
LYLCDEVISP AMTIKVIGLQ WYWKYEYSDF INDNGETIEY ESYMIPEELL
160 170 180 190 200
EEGQLRMLDT DTSIVIPVDT HVRFIVTATD VIHDFAVPSL GIKIDTTPGR
210 220 230 240
LSQVSTLIQR EGIFYGQCSE LCGAQHSAMP IKIETVKLPT FLTWLNEQ
Length:248
Mass (Da):28,676
Last modified:July 19, 2004 - v2
Checksum:i5DC760E717804240
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016821 Genomic DNA. Translation: AAS50168.1.
AF442273 Genomic DNA. Translation: AAP57840.1.
RefSeqiNP_987078.1. NC_005789.1.

Genome annotation databases

EnsemblFungiiAAS50168; AAS50168; AGOS_AMI001W.
GeneIDi2760769.
KEGGiago:AGOS_AMI001W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016821 Genomic DNA. Translation: AAS50168.1.
AF442273 Genomic DNA. Translation: AAP57840.1.
RefSeqiNP_987078.1. NC_005789.1.

3D structure databases

ProteinModelPortaliQ7YFV7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS50168; AAS50168; AGOS_AMI001W.
GeneIDi2760769.
KEGGiago:AGOS_AMI001W.

Phylogenomic databases

HOGENOMiHOG000264988.
InParanoidiQ7YFV7.
KOiK02261.
OMAiPLKIFEM.
OrthoDBiEOG092C40RV.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_ASHGO
AccessioniPrimary (citable) accession number: Q7YFV7
Secondary accession number(s): Q75G36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.