Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi183Copper ABy similarity1
Metal bindingi218Copper ABy similarity1
Metal bindingi222Copper ABy similarity1
Metal bindingi226Copper ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:CoxII
Ordered Locus Names:AMI001W
ORF Names:AgCOX2
Encoded oniMitochondrion
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini13 – 39Mitochondrial intermembraneSequence analysisAdd BLAST27
Transmembranei40 – 61HelicalSequence analysisAdd BLAST22
Topological domaini62 – 79Mitochondrial matrixSequence analysisAdd BLAST18
Transmembranei80 – 104HelicalSequence analysisAdd BLAST25
Topological domaini105 – 248Mitochondrial intermembraneSequence analysisAdd BLAST144

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 12By similarityAdd BLAST12
ChainiPRO_000000603713 – 248Cytochrome c oxidase subunit 2Add BLAST236

Post-translational modificationi

The signal sequence of COX2 is processed by IMP1.By similarity

Interactioni

Subunit structurei

Composed of at least 11 subunits.

Protein-protein interaction databases

STRINGi33169.AAS50168

Structurei

3D structure databases

ProteinModelPortaliQ7YFV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988
InParanoidiQ7YFV7
KOiK02261
OMAiWSYEYTD
OrthoDBiEOG092C40RV

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7YFV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLMNLFTII NNDVPTPYNM YFQDSTTPHQ EGILELHDNI MFYMLTVLGL
60 70 80 90 100
VSWMMIIIIK DYKNNPITYK YIKHGQMIEI IWTILPAIIL LMIAFPSFIL
110 120 130 140 150
LYLCDEVISP AMTIKVIGLQ WYWKYEYSDF INDNGETIEY ESYMIPEELL
160 170 180 190 200
EEGQLRMLDT DTSIVIPVDT HVRFIVTATD VIHDFAVPSL GIKIDTTPGR
210 220 230 240
LSQVSTLIQR EGIFYGQCSE LCGAQHSAMP IKIETVKLPT FLTWLNEQ
Length:248
Mass (Da):28,676
Last modified:July 19, 2004 - v2
Checksum:i5DC760E717804240
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016821 Genomic DNA Translation: AAS50168.1
AF442273 Genomic DNA Translation: AAP57840.1
RefSeqiNP_987078.1, NC_005789.1

Genome annotation databases

EnsemblFungiiAAS50168; AAS50168; AGOS_AMI001W
GeneIDi2760769
KEGGiago:AGOS_AMI001W

Similar proteinsi

Entry informationi

Entry nameiCOX2_ASHGO
AccessioniPrimary (citable) accession number: Q7YFV7
Secondary accession number(s): Q75G36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health