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Q7Y1I7 (DNM1A_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA (cytosine-5)-methyltransferase 1A

Short name=OsMET1a
EC=2.1.1.37
Alternative name(s):
DNA methyltransferase 1-1
Short name=OsMET1-1
Gene names
Name:MET1A
Synonyms:MET1-1
Ordered Locus Names:Os03g0798300, LOC_Os03g58400
ORF Names:OsJ_12965, OSJNBa0094F01.4
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length1527 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably methylates CpG residues and maintains DNA methylation. May be involved in methylation-dependent gene silencing. Ref.1

Catalytic activity

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in roots, panicles, anthers, pistils, endosperm and imbibed embryos. Ref.1 Ref.2

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

Contains 2 BAH domains.

Contains 1 SAM-dependent MTase C5-type domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Y1I7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Y1I7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: Missing.
     6-11: RSVVTT → MDTCLY
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15271527DNA (cytosine-5)-methyltransferase 1A
PRO_0000381939

Regions

Domain742 – 874133BAH 1
Domain910 – 1049140BAH 2
Domain1092 – 1526435SAM-dependent MTase C5-type

Sites

Active site11971 By similarity

Natural variations

Alternative sequence1 – 55Missing in isoform 2.
VSP_037849
Alternative sequence6 – 116RSVVTT → MDTCLY in isoform 2.
VSP_037850

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 75159928CDDCF098

FASTA1,527170,856
        10         20         30         40         50         60 
MAKSPRSVVT TGTKRRRAKV HKEDEPVENE NLESEFDVSK KESNGATEPG NEPVASKRPK 

        70         80         90        100        110        120 
RAAACSNFKE KSLDLSEKDS IITIKESRVE EKEIEAVNLT RTGPEDGQPC RKIIDFILHD 

       130        140        150        160        170        180 
GDGNLQPFEM SEVDDIFITA LIMPLDDDLE KDRGKGICCS GFGRIENWAI SGYDEGAAVI 

       190        200        210        220        230        240 
WVSTETSDYK CVKPASSYRS YFEHFSEKAR VCVEVYKKLA RSVGGNPQVD LEELIAGVVR 

       250        260        270        280        290        300 
SINSNRSFNG TVTKDFVISS GEFIYKQLIG LDHTAGNDDE MLATLPVLVA LKDECKSRAG 

       310        320        330        340        350        360 
FTHLPAMPSN GTLRIKDGQD KGLTEDEDAK LARLLQEEEE WKMMKQRGKR GTSQKNIYIK 

       370        380        390        400        410        420 
ICETEIANDY PLPAYYKPYN QEMDEYIFDS DIGMYSDDVP VRILDNWALY NSDSRLISLE 

       430        440        450        460        470        480 
LIPMKAGAEN DIVVFGSGFM REDDGSCCST AELAQLHSSS SKSGREDPGV PIYLSPIKEW 

       490        500        510        520        530        540 
VVEFGGSMIC ITIRTDVAWY KLRQPTKQYA PWCEPVLKTA RLAVSIITLL KEQSRASKLS 

       550        560        570        580        590        600 
FAEVIKKVAE FDSRHPAFIS SKAPTVERYV VVHGQIILQQ FADFPDESVK RCAFITGLLA 

       610        620        630        640        650        660 
KMEESRHTKL AIKKKSQQMR GENLNPSAKM GPILRKKLMR ATTTMLISKI WGEYYATYFP 

       670        680        690        700        710        720 
GDTKEEDQNE PKEIDDDQEE NEDNDAEEEV NVQDEKATRT PPSTRSRKSS ADTRKEIKWE 

       730        740        750        760        770        780 
GQTAGKTVSG EVLYKCVIVQ DLSISVGATV TTEDDSGETI MCFVEYMYEK LDGKNMIHGI 

       790        800        810        820        830        840 
ILQEGSQTVL GNAANDREVF LTNDCLEFEA SDIKELVTVN IQSLPWGHKY RKENSEAKRI 

       850        860        870        880        890        900 
EKAKAEERKR KGLPVEYICK SLYWPEKGGF FSLPYDKIGN GTGICSSCER KPVGNEFKLL 

       910        920        930        940        950        960 
SESSFVFENI TYNIHDFLYI RPEFFSQGEG HETYKAGRNV GLKPYAVCHL LSVHGPAGSR 

       970        980        990       1000       1010       1020 
KANPESTKVK VRRFYRPDDI SSTKAYSSDI REVYYSEDII SVPVVMIEGK CEVRLKDDLP 

      1030       1040       1050       1060       1070       1080 
NSDLPAVVEH VFCCEYLYDP ANGALKQLPP NVRLVTLTRK VPASKKNKGK QICDIELGGS 

      1090       1100       1110       1120       1130       1140 
DKPKDGQSEN CLATLDIFAG CGGLSEGLQR SGLSLTKWAI EYEEPAGDAF GENHPEAAVF 

      1150       1160       1170       1180       1190       1200 
VENCNVILKA IMDKCGDSDD CISTSEAAER AAKLSEDKIK NLPVPGEVEF INGGPPCQGF 

      1210       1220       1230       1240       1250       1260 
SGMNRFNQSP WSKVQCEMIL AFLSFAEYFR PRFFLLENVR NFVSFNKGQT FRLTLASLLE 

      1270       1280       1290       1300       1310       1320 
MGYQVRFGIL EAGAYGVAQS RKRAFIWAAA PGETLPEWPE PMHVFASPEL KITLPDGKFY 

      1330       1340       1350       1360       1370       1380 
AAVKSTAAGA PFRSITVRDT IGDLPAVENG AGKPTIQYGS GPVSWFQKKI RSDMASLNDH 

      1390       1400       1410       1420       1430       1440 
ISKEMNELNL IRCKHIPKRP GCDWHDLPDE KVKLSTGQMV DLIPWCLPNT AKRHNQWKGL 

      1450       1460       1470       1480       1490       1500 
YGRLDWEGNF PTSVTDPQPM GKVGMCFHPE QDRIITVREC ARSQGFPDSY RFAGNIQNKH 

      1510       1520 
RQIGNAVPPP LAYALGRKLK QAIDAKR 

« Hide

Isoform 2 [UniParc].

Checksum: ECDF2FCDAC99BA5D
Show »

FASTA1,522170,424

References

« Hide 'large scale' references
[1]"Characterization of two rice DNA methyltransferase genes and RNAi-mediated reactivation of a silenced transgene in rice callus."
Teerawanichpan P., Chandrasekharan M.B., Jiang Y., Narangajavana J., Hall T.C.
Planta 218:337-349(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
Strain: cv. Nipponbare.
[2]"Alternative splicing of the rice OsMET1 genes encoding maintenance DNA methyltransferase."
Yamauchi T., Moritoh S., Johzuka-Hisatomi Y., Ono A., Terada R., Nakamura I., Iida S.
J. Plant Physiol. 165:1774-1782(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: cv. Nipponbare.
[3]"Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
The rice chromosome 3 sequencing consortium
Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S. expand/collapse author list , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[4]"The genomes of Oryza sativa: a history of duplications."
Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. expand/collapse author list , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[5]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1115-1527.
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF462029 Genomic DNA. Translation: AAL77415.1.
AB362510 Genomic DNA. Translation: BAG15928.1.
AC093713 Genomic DNA. Translation: AAP44671.1.
CM000140 Genomic DNA. Translation: EEE60102.1.
AK108034 mRNA. No translation available.

3D structure databases

ProteinModelPortalQ7Y1I7.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

REBASE7658. M.OsaDnmt1A.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneQ7Y1I7.

Phylogenomic databases

eggNOGCOG0270.

Family and domain databases

InterProIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR017198. DNA_C5-MeTrfase_1_euk.
[Graphical view]
PANTHERPTHR10629. PTHR10629. 1 hit.
PfamPF01426. BAH. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 2 hits.
[Graphical view]
PIRSFPIRSF037404. DNMT1. 1 hit.
PRINTSPR00105. C5METTRFRASE.
SMARTSM00439. BAH. 2 hits.
[Graphical view]
TIGRFAMsTIGR00675. dcm. 1 hit.
PROSITEPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNM1A_ORYSJ
AccessionPrimary (citable) accession number: Q7Y1I7
Secondary accession number(s): Q8S4C3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations