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Q7Y1I7

- DNM1A_ORYSJ

UniProt

Q7Y1I7 - DNM1A_ORYSJ

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Protein

DNA (cytosine-5)-methyltransferase 1A

Gene

MET1A

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probably methylates CpG residues and maintains DNA methylation. May be involved in methylation-dependent gene silencing.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1197 – 11971PROSITE-ProRule annotation

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  3. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA methylation on cytosine within a CG sequence Source: UniProtKB
  2. gene silencing Source: UniProtKB
  3. maintenance of DNA methylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

DNA-binding, S-adenosyl-L-methionine

Protein family/group databases

REBASEi7658. M.OsaDnmt1A.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase 1A (EC:2.1.1.37)
Short name:
OsMET1a
Alternative name(s):
DNA methyltransferase 1-1
Short name:
OsMET1-1
Gene namesi
Name:MET1A
Synonyms:MET1-1
Ordered Locus Names:Os03g0798300, LOC_Os03g58400
ORF Names:OsJ_12965, OSJNBa0094F01.4
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 3

Organism-specific databases

GrameneiQ7Y1I7.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15271527DNA (cytosine-5)-methyltransferase 1APRO_0000381939Add
BLAST

Expressioni

Tissue specificityi

Expressed in roots, panicles, anthers, pistils, endosperm and imbibed embryos.2 Publications

Gene expression databases

ExpressionAtlasiQ7Y1I7. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ7Y1I7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini742 – 874133BAH 1PROSITE-ProRule annotationAdd
BLAST
Domaini910 – 1049140BAH 2PROSITE-ProRule annotationAdd
BLAST
Domaini1092 – 1526435SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 2 BAH domains.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0270.
InParanoidiQ7Y1I7.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF01426. BAH. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 2 hits.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Y1I7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKSPRSVVT TGTKRRRAKV HKEDEPVENE NLESEFDVSK KESNGATEPG
60 70 80 90 100
NEPVASKRPK RAAACSNFKE KSLDLSEKDS IITIKESRVE EKEIEAVNLT
110 120 130 140 150
RTGPEDGQPC RKIIDFILHD GDGNLQPFEM SEVDDIFITA LIMPLDDDLE
160 170 180 190 200
KDRGKGICCS GFGRIENWAI SGYDEGAAVI WVSTETSDYK CVKPASSYRS
210 220 230 240 250
YFEHFSEKAR VCVEVYKKLA RSVGGNPQVD LEELIAGVVR SINSNRSFNG
260 270 280 290 300
TVTKDFVISS GEFIYKQLIG LDHTAGNDDE MLATLPVLVA LKDECKSRAG
310 320 330 340 350
FTHLPAMPSN GTLRIKDGQD KGLTEDEDAK LARLLQEEEE WKMMKQRGKR
360 370 380 390 400
GTSQKNIYIK ICETEIANDY PLPAYYKPYN QEMDEYIFDS DIGMYSDDVP
410 420 430 440 450
VRILDNWALY NSDSRLISLE LIPMKAGAEN DIVVFGSGFM REDDGSCCST
460 470 480 490 500
AELAQLHSSS SKSGREDPGV PIYLSPIKEW VVEFGGSMIC ITIRTDVAWY
510 520 530 540 550
KLRQPTKQYA PWCEPVLKTA RLAVSIITLL KEQSRASKLS FAEVIKKVAE
560 570 580 590 600
FDSRHPAFIS SKAPTVERYV VVHGQIILQQ FADFPDESVK RCAFITGLLA
610 620 630 640 650
KMEESRHTKL AIKKKSQQMR GENLNPSAKM GPILRKKLMR ATTTMLISKI
660 670 680 690 700
WGEYYATYFP GDTKEEDQNE PKEIDDDQEE NEDNDAEEEV NVQDEKATRT
710 720 730 740 750
PPSTRSRKSS ADTRKEIKWE GQTAGKTVSG EVLYKCVIVQ DLSISVGATV
760 770 780 790 800
TTEDDSGETI MCFVEYMYEK LDGKNMIHGI ILQEGSQTVL GNAANDREVF
810 820 830 840 850
LTNDCLEFEA SDIKELVTVN IQSLPWGHKY RKENSEAKRI EKAKAEERKR
860 870 880 890 900
KGLPVEYICK SLYWPEKGGF FSLPYDKIGN GTGICSSCER KPVGNEFKLL
910 920 930 940 950
SESSFVFENI TYNIHDFLYI RPEFFSQGEG HETYKAGRNV GLKPYAVCHL
960 970 980 990 1000
LSVHGPAGSR KANPESTKVK VRRFYRPDDI SSTKAYSSDI REVYYSEDII
1010 1020 1030 1040 1050
SVPVVMIEGK CEVRLKDDLP NSDLPAVVEH VFCCEYLYDP ANGALKQLPP
1060 1070 1080 1090 1100
NVRLVTLTRK VPASKKNKGK QICDIELGGS DKPKDGQSEN CLATLDIFAG
1110 1120 1130 1140 1150
CGGLSEGLQR SGLSLTKWAI EYEEPAGDAF GENHPEAAVF VENCNVILKA
1160 1170 1180 1190 1200
IMDKCGDSDD CISTSEAAER AAKLSEDKIK NLPVPGEVEF INGGPPCQGF
1210 1220 1230 1240 1250
SGMNRFNQSP WSKVQCEMIL AFLSFAEYFR PRFFLLENVR NFVSFNKGQT
1260 1270 1280 1290 1300
FRLTLASLLE MGYQVRFGIL EAGAYGVAQS RKRAFIWAAA PGETLPEWPE
1310 1320 1330 1340 1350
PMHVFASPEL KITLPDGKFY AAVKSTAAGA PFRSITVRDT IGDLPAVENG
1360 1370 1380 1390 1400
AGKPTIQYGS GPVSWFQKKI RSDMASLNDH ISKEMNELNL IRCKHIPKRP
1410 1420 1430 1440 1450
GCDWHDLPDE KVKLSTGQMV DLIPWCLPNT AKRHNQWKGL YGRLDWEGNF
1460 1470 1480 1490 1500
PTSVTDPQPM GKVGMCFHPE QDRIITVREC ARSQGFPDSY RFAGNIQNKH
1510 1520
RQIGNAVPPP LAYALGRKLK QAIDAKR
Length:1,527
Mass (Da):170,856
Last modified:October 1, 2003 - v1
Checksum:i75159928CDDCF098
GO
Isoform 2 (identifier: Q7Y1I7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: Missing.
     6-11: RSVVTT → MDTCLY

Note: No experimental confirmation available.

Show »
Length:1,522
Mass (Da):170,424
Checksum:iECDF2FCDAC99BA5D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 55Missing in isoform 2. CuratedVSP_037849
Alternative sequencei6 – 116RSVVTT → MDTCLY in isoform 2. CuratedVSP_037850

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF462029 Genomic DNA. Translation: AAL77415.1.
AB362510 Genomic DNA. Translation: BAG15928.1.
AC093713 Genomic DNA. Translation: AAP44671.1.
CM000140 Genomic DNA. Translation: EEE60102.1.
AK108034 mRNA. No translation available.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF462029 Genomic DNA. Translation: AAL77415.1 .
AB362510 Genomic DNA. Translation: BAG15928.1 .
AC093713 Genomic DNA. Translation: AAP44671.1 .
CM000140 Genomic DNA. Translation: EEE60102.1 .
AK108034 mRNA. No translation available.

3D structure databases

ProteinModelPortali Q7Y1I7.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 7658. M.OsaDnmt1A.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q7Y1I7.

Phylogenomic databases

eggNOGi COG0270.
InParanoidi Q7Y1I7.

Gene expression databases

ExpressionAtlasi Q7Y1I7. baseline.

Family and domain databases

Gene3Di 3.40.50.150. 2 hits.
InterProi IPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF01426. BAH. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 2 hits.
[Graphical view ]
PIRSFi PIRSF037404. DNMT1. 1 hit.
PRINTSi PR00105. C5METTRFRASE.
SMARTi SM00439. BAH. 2 hits.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 3 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two rice DNA methyltransferase genes and RNAi-mediated reactivation of a silenced transgene in rice callus."
    Teerawanichpan P., Chandrasekharan M.B., Jiang Y., Narangajavana J., Hall T.C.
    Planta 218:337-349(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: cv. Nipponbare.
  2. "Alternative splicing of the rice OsMET1 genes encoding maintenance DNA methyltransferase."
    Yamauchi T., Moritoh S., Johzuka-Hisatomi Y., Ono A., Terada R., Nakamura I., Iida S.
    J. Plant Physiol. 165:1774-1782(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: cv. Nipponbare.
  3. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1115-1527.
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiDNM1A_ORYSJ
AccessioniPrimary (citable) accession number: Q7Y1I7
Secondary accession number(s): Q8S4C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3