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Q7Y1I7

- DNM1A_ORYSJ

UniProt

Q7Y1I7 - DNM1A_ORYSJ

Protein

DNA (cytosine-5)-methyltransferase 1A

Gene

MET1A

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Probably methylates CpG residues and maintains DNA methylation. May be involved in methylation-dependent gene silencing.1 Publication

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1197 – 11971PROSITE-ProRule annotation

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    3. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA methylation on cytosine within a CG sequence Source: UniProtKB
    2. gene silencing Source: UniProtKB
    3. maintenance of DNA methylation Source: UniProtKB

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    DNA-binding, S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi7658. M.OsaDnmt1A.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA (cytosine-5)-methyltransferase 1A (EC:2.1.1.37)
    Short name:
    OsMET1a
    Alternative name(s):
    DNA methyltransferase 1-1
    Short name:
    OsMET1-1
    Gene namesi
    Name:MET1A
    Synonyms:MET1-1
    Ordered Locus Names:Os03g0798300, LOC_Os03g58400
    ORF Names:OsJ_12965, OSJNBa0094F01.4
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 3

    Organism-specific databases

    GrameneiQ7Y1I7.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15271527DNA (cytosine-5)-methyltransferase 1APRO_0000381939Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in roots, panicles, anthers, pistils, endosperm and imbibed embryos.2 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Y1I7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini742 – 874133BAH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini910 – 1049140BAH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1092 – 1526435SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 2 BAH domains.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0270.

    Family and domain databases

    Gene3Di3.40.50.150. 2 hits.
    InterProiIPR001025. BAH_dom.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR022702. Cytosine_MeTrfase1_RFD.
    IPR017198. DNA_C5-MeTrfase_1_euk.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF01426. BAH. 2 hits.
    PF00145. DNA_methylase. 1 hit.
    PF12047. DNMT1-RFD. 2 hits.
    [Graphical view]
    PIRSFiPIRSF037404. DNMT1. 1 hit.
    PRINTSiPR00105. C5METTRFRASE.
    SMARTiSM00439. BAH. 2 hits.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 3 hits.
    TIGRFAMsiTIGR00675. dcm. 1 hit.
    PROSITEiPS51038. BAH. 2 hits.
    PS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Y1I7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKSPRSVVT TGTKRRRAKV HKEDEPVENE NLESEFDVSK KESNGATEPG     50
    NEPVASKRPK RAAACSNFKE KSLDLSEKDS IITIKESRVE EKEIEAVNLT 100
    RTGPEDGQPC RKIIDFILHD GDGNLQPFEM SEVDDIFITA LIMPLDDDLE 150
    KDRGKGICCS GFGRIENWAI SGYDEGAAVI WVSTETSDYK CVKPASSYRS 200
    YFEHFSEKAR VCVEVYKKLA RSVGGNPQVD LEELIAGVVR SINSNRSFNG 250
    TVTKDFVISS GEFIYKQLIG LDHTAGNDDE MLATLPVLVA LKDECKSRAG 300
    FTHLPAMPSN GTLRIKDGQD KGLTEDEDAK LARLLQEEEE WKMMKQRGKR 350
    GTSQKNIYIK ICETEIANDY PLPAYYKPYN QEMDEYIFDS DIGMYSDDVP 400
    VRILDNWALY NSDSRLISLE LIPMKAGAEN DIVVFGSGFM REDDGSCCST 450
    AELAQLHSSS SKSGREDPGV PIYLSPIKEW VVEFGGSMIC ITIRTDVAWY 500
    KLRQPTKQYA PWCEPVLKTA RLAVSIITLL KEQSRASKLS FAEVIKKVAE 550
    FDSRHPAFIS SKAPTVERYV VVHGQIILQQ FADFPDESVK RCAFITGLLA 600
    KMEESRHTKL AIKKKSQQMR GENLNPSAKM GPILRKKLMR ATTTMLISKI 650
    WGEYYATYFP GDTKEEDQNE PKEIDDDQEE NEDNDAEEEV NVQDEKATRT 700
    PPSTRSRKSS ADTRKEIKWE GQTAGKTVSG EVLYKCVIVQ DLSISVGATV 750
    TTEDDSGETI MCFVEYMYEK LDGKNMIHGI ILQEGSQTVL GNAANDREVF 800
    LTNDCLEFEA SDIKELVTVN IQSLPWGHKY RKENSEAKRI EKAKAEERKR 850
    KGLPVEYICK SLYWPEKGGF FSLPYDKIGN GTGICSSCER KPVGNEFKLL 900
    SESSFVFENI TYNIHDFLYI RPEFFSQGEG HETYKAGRNV GLKPYAVCHL 950
    LSVHGPAGSR KANPESTKVK VRRFYRPDDI SSTKAYSSDI REVYYSEDII 1000
    SVPVVMIEGK CEVRLKDDLP NSDLPAVVEH VFCCEYLYDP ANGALKQLPP 1050
    NVRLVTLTRK VPASKKNKGK QICDIELGGS DKPKDGQSEN CLATLDIFAG 1100
    CGGLSEGLQR SGLSLTKWAI EYEEPAGDAF GENHPEAAVF VENCNVILKA 1150
    IMDKCGDSDD CISTSEAAER AAKLSEDKIK NLPVPGEVEF INGGPPCQGF 1200
    SGMNRFNQSP WSKVQCEMIL AFLSFAEYFR PRFFLLENVR NFVSFNKGQT 1250
    FRLTLASLLE MGYQVRFGIL EAGAYGVAQS RKRAFIWAAA PGETLPEWPE 1300
    PMHVFASPEL KITLPDGKFY AAVKSTAAGA PFRSITVRDT IGDLPAVENG 1350
    AGKPTIQYGS GPVSWFQKKI RSDMASLNDH ISKEMNELNL IRCKHIPKRP 1400
    GCDWHDLPDE KVKLSTGQMV DLIPWCLPNT AKRHNQWKGL YGRLDWEGNF 1450
    PTSVTDPQPM GKVGMCFHPE QDRIITVREC ARSQGFPDSY RFAGNIQNKH 1500
    RQIGNAVPPP LAYALGRKLK QAIDAKR 1527
    Length:1,527
    Mass (Da):170,856
    Last modified:October 1, 2003 - v1
    Checksum:i75159928CDDCF098
    GO
    Isoform 2 (identifier: Q7Y1I7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-5: Missing.
         6-11: RSVVTT → MDTCLY

    Note: No experimental confirmation available.

    Show »
    Length:1,522
    Mass (Da):170,424
    Checksum:iECDF2FCDAC99BA5D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 55Missing in isoform 2. CuratedVSP_037849
    Alternative sequencei6 – 116RSVVTT → MDTCLY in isoform 2. CuratedVSP_037850

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF462029 Genomic DNA. Translation: AAL77415.1.
    AB362510 Genomic DNA. Translation: BAG15928.1.
    AC093713 Genomic DNA. Translation: AAP44671.1.
    CM000140 Genomic DNA. Translation: EEE60102.1.
    AK108034 mRNA. No translation available.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF462029 Genomic DNA. Translation: AAL77415.1 .
    AB362510 Genomic DNA. Translation: BAG15928.1 .
    AC093713 Genomic DNA. Translation: AAP44671.1 .
    CM000140 Genomic DNA. Translation: EEE60102.1 .
    AK108034 mRNA. No translation available.

    3D structure databases

    ProteinModelPortali Q7Y1I7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 7658. M.OsaDnmt1A.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei Q7Y1I7.

    Phylogenomic databases

    eggNOGi COG0270.

    Family and domain databases

    Gene3Di 3.40.50.150. 2 hits.
    InterProi IPR001025. BAH_dom.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR022702. Cytosine_MeTrfase1_RFD.
    IPR017198. DNA_C5-MeTrfase_1_euk.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF01426. BAH. 2 hits.
    PF00145. DNA_methylase. 1 hit.
    PF12047. DNMT1-RFD. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF037404. DNMT1. 1 hit.
    PRINTSi PR00105. C5METTRFRASE.
    SMARTi SM00439. BAH. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 3 hits.
    TIGRFAMsi TIGR00675. dcm. 1 hit.
    PROSITEi PS51038. BAH. 2 hits.
    PS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two rice DNA methyltransferase genes and RNAi-mediated reactivation of a silenced transgene in rice callus."
      Teerawanichpan P., Chandrasekharan M.B., Jiang Y., Narangajavana J., Hall T.C.
      Planta 218:337-349(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: cv. Nipponbare.
    2. "Alternative splicing of the rice OsMET1 genes encoding maintenance DNA methyltransferase."
      Yamauchi T., Moritoh S., Johzuka-Hisatomi Y., Ono A., Terada R., Nakamura I., Iida S.
      J. Plant Physiol. 165:1774-1782(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: cv. Nipponbare.
    3. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
      The rice chromosome 3 sequencing consortium
      Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
      , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
      Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1115-1527.
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiDNM1A_ORYSJ
    AccessioniPrimary (citable) accession number: Q7Y1I7
    Secondary accession number(s): Q8S4C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3