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Q7Y1I7

- DNM1A_ORYSJ

UniProt

Q7Y1I7 - DNM1A_ORYSJ

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Protein
DNA (cytosine-5)-methyltransferase 1A
Gene
MET1A, MET1-1, Os03g0798300, LOC_Os03g58400, OsJ_12965, OSJNBa0094F01.4
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably methylates CpG residues and maintains DNA methylation. May be involved in methylation-dependent gene silencing.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1197 – 11971 By similarity

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: UniProtKB-KW
  3. chromatin binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. DNA methylation on cytosine within a CG sequence Source: UniProtKB
  2. gene silencing Source: UniProtKB
  3. maintenance of DNA methylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

DNA-binding, S-adenosyl-L-methionine

Protein family/group databases

REBASEi7658. M.OsaDnmt1A.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase 1A (EC:2.1.1.37)
Short name:
OsMET1a
Alternative name(s):
DNA methyltransferase 1-1
Short name:
OsMET1-1
Gene namesi
Name:MET1A
Synonyms:MET1-1
Ordered Locus Names:Os03g0798300, LOC_Os03g58400
ORF Names:OsJ_12965, OSJNBa0094F01.4
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 3

Organism-specific databases

GrameneiQ7Y1I7.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15271527DNA (cytosine-5)-methyltransferase 1A
PRO_0000381939Add
BLAST

Expressioni

Tissue specificityi

Expressed in roots, panicles, anthers, pistils, endosperm and imbibed embryos.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ7Y1I7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini742 – 874133BAH 1
Add
BLAST
Domaini910 – 1049140BAH 2
Add
BLAST
Domaini1092 – 1526435SAM-dependent MTase C5-type
Add
BLAST

Sequence similaritiesi

Contains 2 BAH domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0270.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF01426. BAH. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 2 hits.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Y1I7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAKSPRSVVT TGTKRRRAKV HKEDEPVENE NLESEFDVSK KESNGATEPG     50
NEPVASKRPK RAAACSNFKE KSLDLSEKDS IITIKESRVE EKEIEAVNLT 100
RTGPEDGQPC RKIIDFILHD GDGNLQPFEM SEVDDIFITA LIMPLDDDLE 150
KDRGKGICCS GFGRIENWAI SGYDEGAAVI WVSTETSDYK CVKPASSYRS 200
YFEHFSEKAR VCVEVYKKLA RSVGGNPQVD LEELIAGVVR SINSNRSFNG 250
TVTKDFVISS GEFIYKQLIG LDHTAGNDDE MLATLPVLVA LKDECKSRAG 300
FTHLPAMPSN GTLRIKDGQD KGLTEDEDAK LARLLQEEEE WKMMKQRGKR 350
GTSQKNIYIK ICETEIANDY PLPAYYKPYN QEMDEYIFDS DIGMYSDDVP 400
VRILDNWALY NSDSRLISLE LIPMKAGAEN DIVVFGSGFM REDDGSCCST 450
AELAQLHSSS SKSGREDPGV PIYLSPIKEW VVEFGGSMIC ITIRTDVAWY 500
KLRQPTKQYA PWCEPVLKTA RLAVSIITLL KEQSRASKLS FAEVIKKVAE 550
FDSRHPAFIS SKAPTVERYV VVHGQIILQQ FADFPDESVK RCAFITGLLA 600
KMEESRHTKL AIKKKSQQMR GENLNPSAKM GPILRKKLMR ATTTMLISKI 650
WGEYYATYFP GDTKEEDQNE PKEIDDDQEE NEDNDAEEEV NVQDEKATRT 700
PPSTRSRKSS ADTRKEIKWE GQTAGKTVSG EVLYKCVIVQ DLSISVGATV 750
TTEDDSGETI MCFVEYMYEK LDGKNMIHGI ILQEGSQTVL GNAANDREVF 800
LTNDCLEFEA SDIKELVTVN IQSLPWGHKY RKENSEAKRI EKAKAEERKR 850
KGLPVEYICK SLYWPEKGGF FSLPYDKIGN GTGICSSCER KPVGNEFKLL 900
SESSFVFENI TYNIHDFLYI RPEFFSQGEG HETYKAGRNV GLKPYAVCHL 950
LSVHGPAGSR KANPESTKVK VRRFYRPDDI SSTKAYSSDI REVYYSEDII 1000
SVPVVMIEGK CEVRLKDDLP NSDLPAVVEH VFCCEYLYDP ANGALKQLPP 1050
NVRLVTLTRK VPASKKNKGK QICDIELGGS DKPKDGQSEN CLATLDIFAG 1100
CGGLSEGLQR SGLSLTKWAI EYEEPAGDAF GENHPEAAVF VENCNVILKA 1150
IMDKCGDSDD CISTSEAAER AAKLSEDKIK NLPVPGEVEF INGGPPCQGF 1200
SGMNRFNQSP WSKVQCEMIL AFLSFAEYFR PRFFLLENVR NFVSFNKGQT 1250
FRLTLASLLE MGYQVRFGIL EAGAYGVAQS RKRAFIWAAA PGETLPEWPE 1300
PMHVFASPEL KITLPDGKFY AAVKSTAAGA PFRSITVRDT IGDLPAVENG 1350
AGKPTIQYGS GPVSWFQKKI RSDMASLNDH ISKEMNELNL IRCKHIPKRP 1400
GCDWHDLPDE KVKLSTGQMV DLIPWCLPNT AKRHNQWKGL YGRLDWEGNF 1450
PTSVTDPQPM GKVGMCFHPE QDRIITVREC ARSQGFPDSY RFAGNIQNKH 1500
RQIGNAVPPP LAYALGRKLK QAIDAKR 1527
Length:1,527
Mass (Da):170,856
Last modified:October 1, 2003 - v1
Checksum:i75159928CDDCF098
GO
Isoform 2 (identifier: Q7Y1I7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: Missing.
     6-11: RSVVTT → MDTCLY

Note: No experimental confirmation available.

Show »
Length:1,522
Mass (Da):170,424
Checksum:iECDF2FCDAC99BA5D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 55Missing in isoform 2.
VSP_037849
Alternative sequencei6 – 116RSVVTT → MDTCLY in isoform 2.
VSP_037850

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF462029 Genomic DNA. Translation: AAL77415.1.
AB362510 Genomic DNA. Translation: BAG15928.1.
AC093713 Genomic DNA. Translation: AAP44671.1.
CM000140 Genomic DNA. Translation: EEE60102.1.
AK108034 mRNA. No translation available.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF462029 Genomic DNA. Translation: AAL77415.1 .
AB362510 Genomic DNA. Translation: BAG15928.1 .
AC093713 Genomic DNA. Translation: AAP44671.1 .
CM000140 Genomic DNA. Translation: EEE60102.1 .
AK108034 mRNA. No translation available.

3D structure databases

ProteinModelPortali Q7Y1I7.
ModBasei Search...

Protein family/group databases

REBASEi 7658. M.OsaDnmt1A.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q7Y1I7.

Phylogenomic databases

eggNOGi COG0270.

Family and domain databases

Gene3Di 3.40.50.150. 2 hits.
InterProi IPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF01426. BAH. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 2 hits.
[Graphical view ]
PIRSFi PIRSF037404. DNMT1. 1 hit.
PRINTSi PR00105. C5METTRFRASE.
SMARTi SM00439. BAH. 2 hits.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 3 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two rice DNA methyltransferase genes and RNAi-mediated reactivation of a silenced transgene in rice callus."
    Teerawanichpan P., Chandrasekharan M.B., Jiang Y., Narangajavana J., Hall T.C.
    Planta 218:337-349(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: cv. Nipponbare.
  2. "Alternative splicing of the rice OsMET1 genes encoding maintenance DNA methyltransferase."
    Yamauchi T., Moritoh S., Johzuka-Hisatomi Y., Ono A., Terada R., Nakamura I., Iida S.
    J. Plant Physiol. 165:1774-1782(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: cv. Nipponbare.
  3. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1115-1527.
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiDNM1A_ORYSJ
AccessioniPrimary (citable) accession number: Q7Y1I7
Secondary accession number(s): Q8S4C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi