Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone deacetylase 1

Gene

HDAC1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (Probable). Regulates negatively the expression of the NAC48/NAC6 gene that controls root growth in seedlings. Epigenetically represses the expression of NAC48/NAC6 by deacetylating "Lys-9" (H3K9ac), "Lys-14" (H3K14ac) and "Lys-18" (H3K18ac) of histone H3, and "Lys-5" (H4K5ac), "Lys-12" (H4K12ac) and "Lys-16" (H4K16ac) of histone H4 (PubMed:19453457). Functions in the regulation of gene expression in the whole genome (PubMed:12581311). Acts as chromatin remodeling regulator to promote the formation of a repressive chromatin state. Functions with MODD via its interaction with TPR3, to down-regulates the histone acetylation level at BZIP46 target genes. BZIP46 is a positive regulator of abscisic acid (ABA) signaling and drought stress tolerance (PubMed:27468891).1 Publication3 Publications

Miscellaneous

Plants over-expressing HDAC1 exhibit increased growth rate and altered plant architecture (PubMed:12581311). Plants silencing HDAC1 exhibit narrow leaves, reduced diameter of stems and reduced plant height (PubMed:19664599).2 Publications

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei153By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-OSA-1538133. G0 and Early G1.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 11 Publication (EC:3.5.1.98By similarity)
Short name:
OsHDAC11 Publication
Gene namesi
Name:HDAC11 Publication
Synonyms:HDA7021 Publication
Ordered Locus Names:Os06g0583400Imported, LOC_Os06g38470Curated
ORF Names:P0498C03.28-1Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004405601 – 518Histone deacetylase 1Add BLAST518

Expressioni

Tissue specificityi

Expressed in roots and leaves.1 Publication

Inductioni

Down-regulated by drought and salt stresses.1 Publication

Gene expression databases

ExpressionAtlasiQ7Y0Y8. baseline and differential.

Interactioni

Subunit structurei

Interacts with TPR3.1 Publication

Protein-protein interaction databases

STRINGi39947.LOC_Os06g38470.1.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 333Histone deacetylaseCuratedAdd BLAST312

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000225180.
KOiK06067.
OMAiKRVCYFF.
OrthoDBiEOG093609CH.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Y0Y8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDASAGGGGN SLPTAGADGA KRRVCYFYDA EVGNYYYGQG HPMKPHRIRM
60 70 80 90 100
THALLAHYGL LDQMQVLKPH PARDRDLCRF HADDYVAFLR SVTPETQQDQ
110 120 130 140 150
IRALKRFNVG EDCPVFDGLY SFCQTYAGGS VGGAVKLNHG HDIAINWAGG
160 170 180 190 200
LHHAKKCEAS GFCYVNDIVL AILELLKYHQ RVLYVDIDIH HGDGVEEAFY
210 220 230 240 250
TTDRVMTVSF HKFGDYFPGT GDIRDIGHSK GKYYSLNVPL DDGIDDESYQ
260 270 280 290 300
SLFKPIMGKV MEVFRPGAVV LQCGADSLSG DRLGCFNLSI RGHAECVRFM
310 320 330 340 350
RSFNVPLLLL GGGGYTIRNV ARCWCYETGV ALGHELTDKM PPNEYFEYFG
360 370 380 390 400
PDYTLHVAPS NMENKNTRQQ LDDIRSRLLD NLSKLRHAPS VQFQERPPEA
410 420 430 440 450
ELPEQDEDQE DPDERHHADS DVEMDDVKPL DDSGRRSSIQ NVRVKRESAE
460 470 480 490 500
TDAADQDGNR VAAENTKGTE PAADGVGSSK QTVPTDASAM AIDEPGSLKV
510
EPDNSNKLQD QPSVHQKT
Length:518
Mass (Da):57,506
Last modified:October 1, 2003 - v1
Checksum:i2179EA9ED8D09EA4
GO
Isoform 2 (identifier: Q7Y0Y8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     457-460: DGNR → VFFY
     461-518: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:460
Mass (Da):51,690
Checksum:iCC6D843D0E9B5F13
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058970457 – 460DGNR → VFFY in isoform 2. 4
Alternative sequenceiVSP_058971461 – 518Missing in isoform 2. Add BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513382 mRNA. Translation: AAP47171.1.
AP003724 Genomic DNA. Translation: BAD68730.1.
AP003724 Genomic DNA. Translation: BAD68731.1.
AP008212 Genomic DNA. Translation: BAF19857.1.
AP014962 Genomic DNA. Translation: BAS98377.1.
AP014962 Genomic DNA. Translation: BAS98378.1.
AK068051 mRNA. Translation: BAG90733.1.
AK068682 mRNA. Translation: BAG91027.1.
RefSeqiXP_015643781.1. XM_015788295.1.
UniGeneiOs.10708.

Genome annotation databases

EnsemblPlantsiOS06T0583400-01; OS06T0583400-01; OS06G0583400. [Q7Y0Y8-1]
OS06T0583400-02; OS06T0583400-02; OS06G0583400. [Q7Y0Y8-2]
GeneIDi4341387.
GrameneiOS06T0583400-01; OS06T0583400-01; OS06G0583400. [Q7Y0Y8-1]
OS06T0583400-02; OS06T0583400-02; OS06G0583400. [Q7Y0Y8-2]
KEGGiosa:4341387.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHDAC1_ORYSJ
AccessioniPrimary (citable) accession number: Q7Y0Y8
Secondary accession number(s): Q5VP94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2017
Last sequence update: October 1, 2003
Last modified: July 5, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families