Q7XUA6 (PIP23_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable aquaporin PIP2-3

Alternative name(s):
OsPIP2;3
Plasma membrane intrinsic protein 2-3

Gene names

Name:	PIP2-3
Ordered Locus Names:	Os04g0521100, LOC_Os04g44060
ORF Names:	OSJNBa0019D11.16

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Expressed in roots. Ref.4
Induction	Circadian-regulation. Expression is higher during the light phase than during the dark phase. Down-regulated by chilling. Ref.4
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	hydrogen peroxide transmembrane transport Inferred from electronic annotation. Source: EnsemblPlants/Gramene response to abscisic acid stimulus Inferred from electronic annotation. Source: EnsemblPlants/Gramene response to desiccation Inferred from electronic annotation. Source: EnsemblPlants/Gramene response to nematode Inferred from electronic annotation. Source: EnsemblPlants/Gramene response to osmotic stress Inferred from electronic annotation. Source: EnsemblPlants/Gramene water transport Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Cellular_component	chloroplast Inferred from electronic annotation. Source: EnsemblPlants/Gramene integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell vacuole Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Probable aquaporin PIP2-3		PRO_0000064036
Regions
	Transmembrane	43 – 63	21	Helical; Name=1; Potential
	Transmembrane	82 – 102	21	Helical; Name=2; Potential
	Transmembrane	131 – 151	21	Helical; Name=3; Potential
	Transmembrane	173 – 193	21	Helical; Name=4; Potential
	Transmembrane	207 – 227	21	Helical; Name=5; Potential
	Transmembrane	255 – 275	21	Helical; Name=6; Potential
	Motif	112 – 114	3	NPA 1
	Motif	233 – 235	3	NPA 2

Sequences

	Sequence		Length	Mass (Da)
	Q7XUA6 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: D27EABEFB266D851	FASTA	290	30,416
	10 20 30 40 50 60 MAKDIEAAAA AEGGEYMAKD YSDPPPAPLI DAEELTKWSL YRAVIAEFVA TLLFLYITVA 70 80 90 100 110 120 TVIGYKHQSD PGANAADAAC SGVGILGIAW AFGGMIFILV YCTAGVSGGH INPAVTFGLF 130 140 150 160 170 180 LARKVSLVRA VLYIVAQSLG AICGVGLVKG FQSAFYVRYG GGANELSDGY SKGTGLAAEI 190 200 210 220 230 240 IGTFVLVYTV FSATDPKRNA RDSHVPVLAP LPIGFAVFMV HLATIPITGT GINPARSLGA 250 260 270 280 290 AVIYNQHKAW HDHWIFWVGP LIGAAIAAAY HQYVLRASAA KLGSSSSFRG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of rice chromosome 4." Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y., Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q., Zhang L. , Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T., Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R., Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G., Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C., Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J., Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J., Li J., Hong G., Xue Y., Han B. Nature 420:316-320(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[4]	"Identification of 33 rice aquaporin genes and analysis of their expression and function." Sakurai J., Ishikawa F., Yamaguchi T., Uemura M., Maeshima M. Plant Cell Physiol. 46:1568-1577(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL662958 Genomic DNA. Translation: CAD41442.1. AP008210 Genomic DNA. Translation: BAF15249.1.
RefSeq	NP_001053335.1. NM_001059870.2.
UniGene	Os.5916.
3D structure databases
ProteinModelPortal	Q7XUA6.
SMR	Q7XUA6. Positions 27-284.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os04g44060.1; LOC_Os04g44060.1; LOC_Os04g44060.
GeneID	4336424.
KEGG	osa:4336424.
Organism-specific databases
Gramene	Q7XUA6.
Phylogenomic databases
eggNOG	COG0580.
HOGENOM	HOG000288286.
KO	K09872.
OMA	WEFRSMS.
ProtClustDB	CLSN2692959.
Gene expression databases
ArrayExpress	Q7XUA6.
Family and domain databases
Gene3D	1.20.1080.10. 1 hit.
InterPro	IPR023271. Aquaporin-like. IPR000425. MIP. IPR022357. MIP_CS. [Graphical view]
PANTHER	PTHR19139. PTHR19139. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PRINTS	PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
TIGRFAMs	TIGR00861. MIP. 1 hit.
PROSITE	PS00221. MIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PIP23_ORYSJ

Accession

Primary (citable) accession number: Q7XUA6
Secondary accession number(s): Q0JBN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program