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Protein

Protein disulfide isomerase-like 1-2

Gene

PDIL1-2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis (By similarity).By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611NucleophileBy similarity
Sitei62 – 621Contributes to redox potential valueBy similarity
Sitei63 – 631Contributes to redox potential valueBy similarity
Active sitei64 – 641NucleophileBy similarity
Sitei129 – 1291Lowers pKa of C-terminal Cys of first active siteBy similarity
Active sitei407 – 4071NucleophileBy similarity
Sitei408 – 4081Contributes to redox potential valueBy similarity
Sitei409 – 4091Contributes to redox potential valueBy similarity
Active sitei410 – 4101NucleophileBy similarity
Sitei470 – 4701Lowers pKa of C-terminal Cys of second active siteBy similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide isomerase-like 1-2 (EC:5.3.4.1)
Short name:
OsPDIL1-2
Gene namesi
Name:PDIL1-2
Ordered Locus Names:Os04g0436300, LOC_Os04g35600
ORF Names:OSJNBa0006B20.4
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763 Componenti: Chromosome 4

Organism-specific databases

GrameneiQ7XRB5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 517494Protein disulfide isomerase-like 1-2PRO_0000400029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi61 ↔ 64Redox-activePROSITE-ProRule annotation
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi407 ↔ 410Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ7XRB5.

Expressioni

Gene expression databases

ExpressionAtlasiQ7XRB5. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ7XRB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 143120Thioredoxin 1PROSITE-ProRule annotationAdd
BLAST
Domaini357 – 484128Thioredoxin 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi514 – 5174Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 2 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000162459.
InParanoidiQ7XRB5.
KOiK09580.
OMAiGKYLNPT.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7XRB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVNLVLSFA LAILISSSPT AVGVDATEEL KEAVLTLDAG NFSEVVAKHP
60 70 80 90 100
FIVVKFYAPW CGHCKQLAPE YEKAASILRK NELPVVLAKV DAYNERNKEL
110 120 130 140 150
KDKYGVYSYP TIKIMKNGGS DVRGYGGPRE ADGIVEYLKR QVGPASLKLE
160 170 180 190 200
SAEEAAHSVV DKGVILVGVF PEFAGMEYEN FMVVAEKMRA DYDFFHTSDA
210 220 230 240 250
SILPRGDQSV KGPIVRLFKP FDELFVDSED FGKDALEKFI EVSGFPMVVT
260 270 280 290 300
YDADPTNHKF LERYYSTPSS KAMLFVSFGD DRIESFKSQI HEAARKFSGN
310 320 330 340 350
NISFLIGDVA DADRVFQYFG LRESDVPLLF VIASTGKYLN PTMDPDQIIP
360 370 380 390 400
WLKQYIVEYG NLTPYVKSEP IPKVNDQPVK VVVADNIDDI VFNSGKNVLL
410 420 430 440 450
EFYAPWCGHC RKFALILEEI AVSLQDDQDI VIAKMDGTVN DIPTDFTVEG
460 470 480 490 500
YPTIYFYSSS GNLLSYDGAR TAEEIISFIN ENRGPKAGAA AAVDEKTQID
510
AVEEEVTSSS EPVKDEL
Length:517
Mass (Da):57,335
Last modified:March 1, 2004 - v2
Checksum:iB7DB4CEEEE6AAD65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY739308 mRNA. Translation: AAX14679.1.
AL606592 Genomic DNA. Translation: CAE02742.2.
AP008210 Genomic DNA. Translation: BAF14766.2.
RefSeqiNP_001052852.2. NM_001059387.2.
UniGeneiOs.53966.

Genome annotation databases

GeneIDi4335906.
KEGGiosa:4335906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY739308 mRNA. Translation: AAX14679.1.
AL606592 Genomic DNA. Translation: CAE02742.2.
AP008210 Genomic DNA. Translation: BAF14766.2.
RefSeqiNP_001052852.2. NM_001059387.2.
UniGeneiOs.53966.

3D structure databases

ProteinModelPortaliQ7XRB5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7XRB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4335906.
KEGGiosa:4335906.

Organism-specific databases

GrameneiQ7XRB5.

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000162459.
InParanoidiQ7XRB5.
KOiK09580.
OMAiGKYLNPT.

Gene expression databases

ExpressionAtlasiQ7XRB5. baseline.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
    Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
    Plant Physiol. 137:762-778(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  5. "The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
    d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
    BMC Plant Biol. 10:101-101(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPDI12_ORYSJ
AccessioniPrimary (citable) accession number: Q7XRB5
Secondary accession number(s): Q0JD21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: March 1, 2004
Last modified: January 7, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.