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Q7XRB5

- PDI12_ORYSJ

UniProt

Q7XRB5 - PDI12_ORYSJ

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Protein
Protein disulfide isomerase-like 1-2
Gene
PDIL1-2, Os04g0436300, LOC_Os04g35600, OSJNBa0006B20.4
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis By similarity.

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Nucleophile By similarity
Sitei62 – 621Contributes to redox potential value By similarity
Sitei63 – 631Contributes to redox potential value By similarity
Active sitei64 – 641Nucleophile By similarity
Sitei129 – 1291Lowers pKa of C-terminal Cys of first active site By similarity
Active sitei407 – 4071Nucleophile By similarity
Sitei408 – 4081Contributes to redox potential value By similarity
Sitei409 – 4091Contributes to redox potential value By similarity
Active sitei410 – 4101Nucleophile By similarity
Sitei470 – 4701Lowers pKa of C-terminal Cys of second active site By similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide isomerase-like 1-2 (EC:5.3.4.1)
Short name:
OsPDIL1-2
Gene namesi
Name:PDIL1-2
Ordered Locus Names:Os04g0436300, LOC_Os04g35600
ORF Names:OSJNBa0006B20.4
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 4

Organism-specific databases

GrameneiQ7XRB5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 517494Protein disulfide isomerase-like 1-2
PRO_0000400029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi61 ↔ 64Redox-active By similarity
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi407 ↔ 410Redox-active By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ7XRB5.

Structurei

3D structure databases

ProteinModelPortaliQ7XRB5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 143120Thioredoxin 1
Add
BLAST
Domaini357 – 484128Thioredoxin 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi514 – 5174Prevents secretion from ER By similarity

Sequence similaritiesi

Contains 2 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000162459.
KOiK09580.
OMAiDYDFFHT.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7XRB5-1 [UniParc]FASTAAdd to Basket

« Hide

MAVNLVLSFA LAILISSSPT AVGVDATEEL KEAVLTLDAG NFSEVVAKHP    50
FIVVKFYAPW CGHCKQLAPE YEKAASILRK NELPVVLAKV DAYNERNKEL 100
KDKYGVYSYP TIKIMKNGGS DVRGYGGPRE ADGIVEYLKR QVGPASLKLE 150
SAEEAAHSVV DKGVILVGVF PEFAGMEYEN FMVVAEKMRA DYDFFHTSDA 200
SILPRGDQSV KGPIVRLFKP FDELFVDSED FGKDALEKFI EVSGFPMVVT 250
YDADPTNHKF LERYYSTPSS KAMLFVSFGD DRIESFKSQI HEAARKFSGN 300
NISFLIGDVA DADRVFQYFG LRESDVPLLF VIASTGKYLN PTMDPDQIIP 350
WLKQYIVEYG NLTPYVKSEP IPKVNDQPVK VVVADNIDDI VFNSGKNVLL 400
EFYAPWCGHC RKFALILEEI AVSLQDDQDI VIAKMDGTVN DIPTDFTVEG 450
YPTIYFYSSS GNLLSYDGAR TAEEIISFIN ENRGPKAGAA AAVDEKTQID 500
AVEEEVTSSS EPVKDEL 517
Length:517
Mass (Da):57,335
Last modified:March 1, 2004 - v2
Checksum:iB7DB4CEEEE6AAD65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY739308 mRNA. Translation: AAX14679.1.
AL606592 Genomic DNA. Translation: CAE02742.2.
AP008210 Genomic DNA. Translation: BAF14766.2.
RefSeqiNP_001052852.2. NM_001059387.2.
UniGeneiOs.53966.

Genome annotation databases

GeneIDi4335906.
KEGGiosa:4335906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY739308 mRNA. Translation: AAX14679.1 .
AL606592 Genomic DNA. Translation: CAE02742.2 .
AP008210 Genomic DNA. Translation: BAF14766.2 .
RefSeqi NP_001052852.2. NM_001059387.2.
UniGenei Os.53966.

3D structure databases

ProteinModelPortali Q7XRB5.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7XRB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4335906.
KEGGi osa:4335906.

Organism-specific databases

Gramenei Q7XRB5.

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000162459.
KOi K09580.
OMAi DYDFFHT.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
    Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
    Plant Physiol. 137:762-778(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  5. "The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
    d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
    BMC Plant Biol. 10:101-101(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPDI12_ORYSJ
AccessioniPrimary (citable) accession number: Q7XRB5
Secondary accession number(s): Q0JD21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: March 1, 2004
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi