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Q7XRB5

- PDI12_ORYSJ

UniProt

Q7XRB5 - PDI12_ORYSJ

Protein

Protein disulfide isomerase-like 1-2

Gene

PDIL1-2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis By similarity.By similarity

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei61 – 611NucleophileBy similarity
    Sitei62 – 621Contributes to redox potential valueBy similarity
    Sitei63 – 631Contributes to redox potential valueBy similarity
    Active sitei64 – 641NucleophileBy similarity
    Sitei129 – 1291Lowers pKa of C-terminal Cys of first active siteBy similarity
    Active sitei407 – 4071NucleophileBy similarity
    Sitei408 – 4081Contributes to redox potential valueBy similarity
    Sitei409 – 4091Contributes to redox potential valueBy similarity
    Active sitei410 – 4101NucleophileBy similarity
    Sitei470 – 4701Lowers pKa of C-terminal Cys of second active siteBy similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide isomerase-like 1-2 (EC:5.3.4.1)
    Short name:
    OsPDIL1-2
    Gene namesi
    Name:PDIL1-2
    Ordered Locus Names:Os04g0436300, LOC_Os04g35600
    ORF Names:OSJNBa0006B20.4
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 4

    Organism-specific databases

    GrameneiQ7XRB5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 517494Protein disulfide isomerase-like 1-2PRO_0000400029Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi61 ↔ 64Redox-activePROSITE-ProRule annotation
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi407 ↔ 410Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ7XRB5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7XRB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 143120Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini357 – 484128Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi514 – 5174Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 2 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000162459.
    KOiK09580.
    OMAiDYDFFHT.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7XRB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVNLVLSFA LAILISSSPT AVGVDATEEL KEAVLTLDAG NFSEVVAKHP    50
    FIVVKFYAPW CGHCKQLAPE YEKAASILRK NELPVVLAKV DAYNERNKEL 100
    KDKYGVYSYP TIKIMKNGGS DVRGYGGPRE ADGIVEYLKR QVGPASLKLE 150
    SAEEAAHSVV DKGVILVGVF PEFAGMEYEN FMVVAEKMRA DYDFFHTSDA 200
    SILPRGDQSV KGPIVRLFKP FDELFVDSED FGKDALEKFI EVSGFPMVVT 250
    YDADPTNHKF LERYYSTPSS KAMLFVSFGD DRIESFKSQI HEAARKFSGN 300
    NISFLIGDVA DADRVFQYFG LRESDVPLLF VIASTGKYLN PTMDPDQIIP 350
    WLKQYIVEYG NLTPYVKSEP IPKVNDQPVK VVVADNIDDI VFNSGKNVLL 400
    EFYAPWCGHC RKFALILEEI AVSLQDDQDI VIAKMDGTVN DIPTDFTVEG 450
    YPTIYFYSSS GNLLSYDGAR TAEEIISFIN ENRGPKAGAA AAVDEKTQID 500
    AVEEEVTSSS EPVKDEL 517
    Length:517
    Mass (Da):57,335
    Last modified:March 1, 2004 - v2
    Checksum:iB7DB4CEEEE6AAD65
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY739308 mRNA. Translation: AAX14679.1.
    AL606592 Genomic DNA. Translation: CAE02742.2.
    AP008210 Genomic DNA. Translation: BAF14766.2.
    RefSeqiNP_001052852.2. NM_001059387.2.
    UniGeneiOs.53966.

    Genome annotation databases

    GeneIDi4335906.
    KEGGiosa:4335906.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY739308 mRNA. Translation: AAX14679.1 .
    AL606592 Genomic DNA. Translation: CAE02742.2 .
    AP008210 Genomic DNA. Translation: BAF14766.2 .
    RefSeqi NP_001052852.2. NM_001059387.2.
    UniGenei Os.53966.

    3D structure databases

    ProteinModelPortali Q7XRB5.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q7XRB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4335906.
    KEGGi osa:4335906.

    Organism-specific databases

    Gramenei Q7XRB5.

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000162459.
    KOi K09580.
    OMAi DYDFFHT.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
      Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
      Plant Physiol. 137:762-778(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    4. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    5. "The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
      d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
      BMC Plant Biol. 10:101-101(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPDI12_ORYSJ
    AccessioniPrimary (citable) accession number: Q7XRB5
    Secondary accession number(s): Q0JD21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2010
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3