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Protein

Arginine decarboxylase 2

Gene

ADC2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.
Proteins known to be involved in this subpathway in this organism are:
  1. Arginine decarboxylase (P0431A03.15), Arginine decarboxylase (OsJ_20004), Arginine decarboxylase 1 (ADC1), Arginine decarboxylase 2 (ADC2), Arginine decarboxylase (Os08g0433000), Arginine decarboxylase (Os08g0433000), Arginine decarboxylase (OsJ_27424)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPutrescine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase 2 (EC:4.1.1.19)
Short name:
ARGDC2
Short name:
OsADC2
Gene namesi
Name:ADC2
Ordered Locus Names:Os04g0107600, LOC_Os04g01690
ORF Names:OsJ_13525, OSJNBb0085F13.14
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003922061 – 623Arginine decarboxylase 2Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ7XRA1
PRIDEiQ7XRA1

Expressioni

Tissue specificityi

Expressed in stems (at protein level).1 Publication

Gene expression databases

ExpressionAtlasiQ7XRA1 differential
GenevisibleiQ7XRA1 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os04g01690.1

Structurei

3D structure databases

ProteinModelPortaliQ7XRA1
SMRiQ7XRA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni295 – 305Substrate-bindingBy similarityAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JX8P Eukaryota
COG1166 LUCA
InParanoidiQ7XRA1
KOiK01583
OrthoDBiEOG09360480

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7XRA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKNYGQVY NILGWGDPYF TVNSHGHLAV KPHGRDTMSG QDIDVHSVIH
60 70 80 90 100
RALATTITTN DGDKKPQFPM ILRFPDVLKN RLDSLHAAFH GAVDSTGYAS
110 120 130 140 150
RYQGVFPIKV NQNKAVVQDL VTFGHGYSYG LEAGSKPELL IAMSCLAKAK
160 170 180 190 200
PGAYLVCNGY KDADYVALAL SARAMGLNAI IVLEMEEELD IVVEQSARLG
210 220 230 240 250
VEPVIGVRAK LLTKIPGHFG STAGKHGKFG MLADKIYEVA GKLKKMGKLH
260 270 280 290 300
WLKLLHYHVG SMIPTTDIVY NAAAEAAGIY CALVKEHGAT GMTTLDCGGG
310 320 330 340 350
LGVDYDGTRS GSSDMSVAYG LEQYASSIVQ AVRLTCDDNG VPHPVLCTES
360 370 380 390 400
GRAMASHHSM IILEALSAIP EPQDEEDTHH RLLSKIQDLS SKQPRTAHTV
410 420 430 440 450
NGGGGVDAMH SHAVELKKHG IEMYKLAKKL SKRVTGDANG IYNYHMNLSV
460 470 480 490 500
FSLVPDFWGI GQLFPMMPVS RLNEKPTING TLVDITCDSD GKVEKFIRDA
510 520 530 540 550
VTLPLHPLDD AAAEHGGYYV AALLSGAYQE ALACKHNLFS GPTLVRVESA
560 570 580 590 600
GGGGAFKIVS VELGPTAEEV IGTMRYDVKN DISDVIEKVA TENGVWPMVE
610 620
PLMKKGLTTM PYLNDYKPPK TTF
Length:623
Mass (Da):67,335
Last modified:March 1, 2004 - v2
Checksum:iA4980874AE0FBA87
GO

Sequence cautioni

The sequence ACN65507 differs from that shown. Sequencing errors.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ746894 mRNA Translation: ACN65507.1 Sequence problems.
AL606620 Genomic DNA Translation: CAE02767.2
AP008210 Genomic DNA Translation: BAF13932.1
AP014960 Genomic DNA Translation: BAS87548.1
CM000141 Genomic DNA Translation: EAZ29450.1
AK058573 mRNA Translation: BAG86737.1
AK121110 mRNA Translation: BAH00321.1
RefSeqiXP_015633833.1, XM_015778347.1
XP_015633834.1, XM_015778348.1
UniGeneiOs.50413

Genome annotation databases

EnsemblPlantsiOs04t0107600-01; Os04t0107600-01; Os04g0107600
Os04t0107600-02; Os04t0107600-02; Os04g0107600
GeneIDi4334917
GrameneiOs04t0107600-01; Os04t0107600-01; Os04g0107600
Os04t0107600-02; Os04t0107600-02; Os04g0107600
KEGGiosa:4334917

Similar proteinsi

Entry informationi

Entry nameiADC2_ORYSJ
AccessioniPrimary (citable) accession number: Q7XRA1
Secondary accession number(s): A0A0P0W684, C0LN13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 1, 2004
Last modified: May 23, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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