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Protein

Phosphomannomutase

Gene

PMM

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in ascorbic acid biosynthesis and in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphomannomutase (Os04g58580), Phosphomannomutase (PMM), Phosphomannomutase (Os04g0682300)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei14NucleophileBy similarity1
Active sitei16Proton donor/acceptorSequence analysis1
Binding sitei23SubstrateBy similarity1
Binding sitei125SubstrateBy similarity1
Binding sitei136SubstrateBy similarity1
Binding sitei143SubstrateBy similarity1
Binding sitei181SubstrateBy similarity1
Binding sitei183SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiR-OSA-446205. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
OsPMM
Gene namesi
Name:PMM
Ordered Locus Names:Os04g0682300, LOC_Os04g58580
ORF Names:OsJ_015937, OSJNBa0032F06.16
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003264931 – 248PhosphomannomutaseAdd BLAST248

Proteomic databases

PaxDbiQ7XPW5.

Expressioni

Gene expression databases

ExpressionAtlasiQ7XPW5. baseline and differential.
GenevisibleiQ7XPW5. OS.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os04g58580.1.

Structurei

3D structure databases

ProteinModelPortaliQ7XPW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiKOG3189. Eukaryota.
COG0561. LUCA.
InParanoidiQ7XPW5.
KOiK17497.
OMAiITKEMDG.
OrthoDBiEOG09360J1K.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7XPW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARKNAGVL ALFDVDGTLT APRKVVTPEM LQFMKQLREH VTVGVVGGSD
60 70 80 90 100
LVKISEQLGK SVTTDYDYCF SENGLVAHKN GELIGTQSLK SFLGDDQLKE
110 120 130 140 150
FINFTLHYIA DLDIPIKRGT FIEFRSGMLN VSPIGRNCSQ EERDEFEKYD
160 170 180 190 200
KVHNIRPKMV SVLREKFAHL NLTFSIGGQI SFDVFPQGWD KTYCLRYLEE
210 220 230 240
FQEIHFFGDK TYKGGNDYEI FESDRTIGHT VTSPDDTAEQ CRSLFMSK
Length:248
Mass (Da):28,193
Last modified:March 1, 2004 - v2
Checksum:iC28CA4DD5B233DE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ442992 mRNA. Translation: ABD97871.1.
AL606641 Genomic DNA. Translation: CAE03433.2.
AP008210 Genomic DNA. Translation: BAF16209.1.
AP014960 Genomic DNA. Translation: BAS91688.1.
CM000141 Genomic DNA. Translation: EAZ32454.1.
AK061384 mRNA. Translation: BAG87893.1.
AK104004 mRNA. Translation: BAG96367.1.
RefSeqiXP_015633714.1. XM_015778228.1.
UniGeneiOs.8518.

Genome annotation databases

EnsemblPlantsiOS04T0682300-01; OS04T0682300-01; OS04G0682300.
OS04T0682300-02; OS04T0682300-02; OS04G0682300.
GeneIDi4337437.
GrameneiOS04T0682300-01; OS04T0682300-01; OS04G0682300.
OS04T0682300-02; OS04T0682300-02; OS04G0682300.
KEGGiosa:4337437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ442992 mRNA. Translation: ABD97871.1.
AL606641 Genomic DNA. Translation: CAE03433.2.
AP008210 Genomic DNA. Translation: BAF16209.1.
AP014960 Genomic DNA. Translation: BAS91688.1.
CM000141 Genomic DNA. Translation: EAZ32454.1.
AK061384 mRNA. Translation: BAG87893.1.
AK104004 mRNA. Translation: BAG96367.1.
RefSeqiXP_015633714.1. XM_015778228.1.
UniGeneiOs.8518.

3D structure databases

ProteinModelPortaliQ7XPW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os04g58580.1.

Proteomic databases

PaxDbiQ7XPW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS04T0682300-01; OS04T0682300-01; OS04G0682300.
OS04T0682300-02; OS04T0682300-02; OS04G0682300.
GeneIDi4337437.
GrameneiOS04T0682300-01; OS04T0682300-01; OS04G0682300.
OS04T0682300-02; OS04T0682300-02; OS04G0682300.
KEGGiosa:4337437.

Phylogenomic databases

eggNOGiKOG3189. Eukaryota.
COG0561. LUCA.
InParanoidiQ7XPW5.
KOiK17497.
OMAiITKEMDG.
OrthoDBiEOG09360J1K.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.
ReactomeiR-OSA-446205. Synthesis of GDP-mannose.

Gene expression databases

ExpressionAtlasiQ7XPW5. baseline and differential.
GenevisibleiQ7XPW5. OS.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPMM_ORYSJ
AccessioniPrimary (citable) accession number: Q7XPW5
Secondary accession number(s): B7E696
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2004
Last modified: November 30, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.