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Q7XPW5

- PMM_ORYSJ

UniProt

Q7XPW5 - PMM_ORYSJ

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Protein

Phosphomannomutase

Gene

PMM

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in ascorbic acid biosynthesis and in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei14 – 141NucleophileBy similarity
Active sitei16 – 161Proton donor/acceptorSequence Analysis
Binding sitei23 – 231SubstrateBy similarity
Binding sitei125 – 1251SubstrateBy similarity
Binding sitei136 – 1361SubstrateBy similarity
Binding sitei143 – 1431SubstrateBy similarity
Binding sitei181 – 1811SubstrateBy similarity
Binding sitei183 – 1831SubstrateBy similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. cytoskeleton organization Source: EnsemblPlants/Gramene
  2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  3. gluconeogenesis Source: EnsemblPlants/Gramene
  4. glycolytic process Source: EnsemblPlants/Gramene
  5. Golgi organization Source: EnsemblPlants/Gramene
  6. hyperosmotic response Source: EnsemblPlants/Gramene
  7. L-ascorbic acid biosynthetic process Source: EnsemblPlants/Gramene
  8. mannose biosynthetic process Source: EnsemblPlants/Gramene
  9. proteasomal protein catabolic process Source: EnsemblPlants/Gramene
  10. response to cadmium ion Source: EnsemblPlants/Gramene
  11. response to temperature stimulus Source: EnsemblPlants/Gramene
  12. second-messenger-mediated signaling Source: EnsemblPlants/Gramene
  13. water transport Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_222723. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
OsPMM
Gene namesi
Name:PMM
Ordered Locus Names:Os04g0682300, LOC_Os04g58580
ORF Names:OsJ_015937, OSJNBa0032F06.16
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 4

Organism-specific databases

GrameneiQ7XPW5.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248PhosphomannomutasePRO_0000326493Add
BLAST

Proteomic databases

PRIDEiQ7XPW5.

Expressioni

Gene expression databases

ExpressionAtlasiQ7XPW5. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os04g58580.1.

Structurei

3D structure databases

ProteinModelPortaliQ7XPW5.
SMRiQ7XPW5. Positions 10-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiCOG0561.
InParanoidiQ7XPW5.
KOiK17497.
OMAiTYCLQHV.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7XPW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARKNAGVL ALFDVDGTLT APRKVVTPEM LQFMKQLREH VTVGVVGGSD
60 70 80 90 100
LVKISEQLGK SVTTDYDYCF SENGLVAHKN GELIGTQSLK SFLGDDQLKE
110 120 130 140 150
FINFTLHYIA DLDIPIKRGT FIEFRSGMLN VSPIGRNCSQ EERDEFEKYD
160 170 180 190 200
KVHNIRPKMV SVLREKFAHL NLTFSIGGQI SFDVFPQGWD KTYCLRYLEE
210 220 230 240
FQEIHFFGDK TYKGGNDYEI FESDRTIGHT VTSPDDTAEQ CRSLFMSK
Length:248
Mass (Da):28,193
Last modified:March 1, 2004 - v2
Checksum:iC28CA4DD5B233DE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ442992 mRNA. Translation: ABD97871.1.
AL606641 Genomic DNA. Translation: CAE03433.2.
AP008210 Genomic DNA. Translation: BAF16209.1.
CM000141 Genomic DNA. Translation: EAZ32454.1.
RefSeqiNP_001054295.1. NM_001060830.1.
UniGeneiOs.8518.

Genome annotation databases

EnsemblPlantsiOS04T0682300-01; OS04T0682300-01; OS04G0682300.
OS04T0682300-02; OS04T0682300-02; OS04G0682300.
GeneIDi4337437.
KEGGiosa:4337437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ442992 mRNA. Translation: ABD97871.1 .
AL606641 Genomic DNA. Translation: CAE03433.2 .
AP008210 Genomic DNA. Translation: BAF16209.1 .
CM000141 Genomic DNA. Translation: EAZ32454.1 .
RefSeqi NP_001054295.1. NM_001060830.1.
UniGenei Os.8518.

3D structure databases

ProteinModelPortali Q7XPW5.
SMRi Q7XPW5. Positions 10-245.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os04g58580.1.

Proteomic databases

PRIDEi Q7XPW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS04T0682300-01 ; OS04T0682300-01 ; OS04G0682300 .
OS04T0682300-02 ; OS04T0682300-02 ; OS04G0682300 .
GeneIDi 4337437.
KEGGi osa:4337437.

Organism-specific databases

Gramenei Q7XPW5.

Phylogenomic databases

eggNOGi COG0561.
InParanoidi Q7XPW5.
KOi K17497.
OMAi TYCLQHV.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00424 .
Reactomei REACT_222723. Synthesis of GDP-mannose.

Gene expression databases

ExpressionAtlasi Q7XPW5. baseline.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view ]
PANTHERi PTHR10466. PTHR10466. 1 hit.
Pfami PF03332. PMM. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and functional analysis of phosphomannomutase (PMM) from higher plants and genetic evidence for the involvement of PMM in ascorbic acid biosynthesis in Arabidopsis and Nicotiana benthamiana."
    Qian W., Yu C., Qin H., Liu X., Zhang A., Johansen I.E., Wang D.
    Plant J. 49:399-413(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  5. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiPMM_ORYSJ
AccessioniPrimary (citable) accession number: Q7XPW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2004
Last modified: October 29, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3