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Q7XPL2 (HEM6_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, chloroplastic
Short name=Coprogen oxidase
Short name=Coproporphyrinogenase
EC=1.3.3.3
Gene names
Name:CPX
Ordered Locus Names:Os04g0610800, LOC_Os04g52130
ORF Names:OSJNBa0085I10.14
OrganismOryza sativa subsp. japonica (Rice)
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity.

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O.

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Plastid › chloroplast Probable.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Sequence caution

The sequence BAF15747.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncoproporphyrinogen oxidase activity

Inferred from electronic annotation. Source: EC

protein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 5252Chloroplast Potential
Chain53 – 399347Coproporphyrinogen-III oxidase, chloroplastic
PRO_0000376070

Regions

Region129 – 13810Important for dimerization By similarity
Region201 – 2033Substrate binding By similarity
Region337 – 37236Important for dimerization By similarity
Region355 – 3606Substrate binding By similarity

Sites

Active site1991Proton donor By similarity
Binding site1851Substrate By similarity
Site2721Important for dimerization By similarity

Experimental info

Sequence conflict3741D → Y in AAO72663. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q7XPL2 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: C41A89FBCF860079

FASTA39943,871
        10         20         30         40         50         60 
MAPSLLTTPS QALALAPGAA ASRVGGGGGG SARVSFPSGR VQRRGALGMR VRASVAIEKE 

        70         80         90        100        110        120 
TPESEPPPTF LREDGSGAGS GSVRERFEAM IRRVQGEVCA ALEEADGSGA RFVEDVWSRP 

       130        140        150        160        170        180 
GGGGGISRVL QDGRVFEKAG VNVSVVYGVM PPDAYRAAKG EAGKNGAAAD GPKAGPVPFF 

       190        200        210        220        230        240 
AAGISSVLHP KNPFAPTLHF NYRYFETDAP KDAPGAPRQW WFGGGTDLTP SYIIEEDVKH 

       250        260        270        280        290        300 
FHSVQKQACD KFDPSFYPRF KKWCDDYFYI KHRNERRGLG GIFFDDLNDY DQEMLLNFAT 

       310        320        330        340        350        360 
ECADSVVPAY IPIIERRKDT PFTEEHKAWQ QLRRGRYVEF NLVYDRGTTF GLKTGGRIES 

       370        380        390 
ILVSLPLTAR WQYDHTPEEG TEERKLLDAC INPKEWLDL

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of rice chromosome 4."
Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y., Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q., Zhang L. expand/collapse author list , Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T., Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R., Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G., Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C., Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J., Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J., Li J., Hong G., Xue Y., Han B.
Nature 420:316-320(2002) [PubMed: 12447439] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed: 16100779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.
[4]"Identification of rice (Oryza sativa) proteins linked to the cyclin-mediated regulation of the cell cycle."
Cooper B., Hutchison D., Park S., Guimil S., Luginbuehl P., Ellero C., Goff S.A., Glazebrook J.
Plant Mol. Biol. 53:273-279(2003) [PubMed: 14750518] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 79-399.
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL606684 Genomic DNA. Translation: CAE03569.2.
AP008210 Genomic DNA. Translation: BAF15747.1. Different initiation.
AY224543 mRNA. Translation: AAO72663.1.
RefSeqNP_001053833.1. NM_001060368.1.
UniGeneOs.99812.

3D structure databases

HSSPHSSP built from PDB template 1TK1 based on UniProtKB P11353.
ProteinModelPortalQ7XPL2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7XPL2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsLOC_Os04g52130.1; LOC_Os04g52130.1; LOC_Os04g52130.
GeneID4336951.
KEGGosa:4336951.

Organism-specific databases

GrameneQ7XPL2.

Phylogenomic databases

GeneTreeEPGT00050000012010.
HOGENOMHBG631180.
OMAVFKPWCD.
ProtClustDBPLN02873.

Family and domain databases

InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM6_ORYSJ
AccessionPrimary (citable) accession number: Q7XPL2
Secondary accession number(s): Q0JA90, Q84VE2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: March 1, 2004
Last modified: November 16, 2011
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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