Q7XJS0 (ASHR1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase ASHR1
EC=2.1.1.43

Alternative name(s):
ASH1-related protein 1
Protein SET DOMAIN GROUP 37

Gene names

Name:	ASHR1
Synonyms:	SDG37, SET37
Ordered Locus Names:	At2g17900
ORF Names:	T13L16.8

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Histone methyltransferase By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity. Chromosome By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. SET2 subfamily. Contains 1 MYND-type zinc finger. Contains 1 SET domain.

Ontologies

Keywords
Cellular component	Chromosome Nucleus
Domain	Zinc-finger
Ligand	Metal-binding S-adenosyl-L-methionine Zinc
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 480	480	Histone-lysine N-methyltransferase ASHR1		PRO_0000233374
Regions
	Domain	134 – 252	119	SET
	Zinc finger	56 – 93	38	MYND-type

Sequences

	Sequence		Length	Mass (Da)
	Q7XJS0 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: 6A90425589785D1E	FASTA	480	54,828
	10 20 30 40 50 60 MADLQRFLQD RCLGVSNLPQ KGRSLFTARD FRPGEVILSQ KPYICVPNNT SSESRCDGCF 70 80 90 100 110 120 KTNNLKKCSA CQVVWYCGSS CQKSEWKLHR DECKALTRLE KEKRKFVTPT IRLMVRLYIK 130 140 150 160 170 180 RNLQNEKVLP ITTTDNYSLV EALVSHMSEI DEKQMLLYAQ MANLVNLILQ FPSVDLREIA 190 200 210 220 230 240 ENFSKFSCNA HSICDSELRP QGIGLFPLVS IINHSCSPNA VLVFEEQMAV VRAMDNISKD 250 260 270 280 290 300 SEITISYIET AGSTLTRQKS LKEQYLFHCQ CARCSNFGKP HDIEESAILE GYRCANEKCT 310 320 330 340 350 360 GFLLRDPEEK GFVCQKCLLL RSKEEVKKLA SDLKTVSEKA PTSPSAEDKQ AAIELYKTIE 370 380 390 400 410 420 KLQVKLYHSF SIPLMRTREK LLKMLMDVEI WREALNYCRL IVPVYQRVYP ATHPLIGLQF 430 440 450 460 470 480 YTQGKLEWLL GETKEAVSSL IKAFDILRIS HGISTPFMKE LSAKLEEARA EASYKQLALH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Arabidopsis ORF clones." Bautista-Mercan V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes." Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B. Nucleic Acids Res. 29:4319-4333(2001) [PubMed: 11691919] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002685 Genomic DNA. Translation: AEC06700.1. BT030467 mRNA. Translation: ABP88121.1.
IPI	IPI00540242.
PIR	T00834.
RefSeq	NP_849969.1. NM_179638.1.
UniGene	At.52792.
3D structure databases
ProteinModelPortal	Q7XJS0.
SMR	Q7XJS0. Positions 11-472.
ModBase	Search...
Proteomic databases
PRIDE	Q7XJS0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G17900.1; AT2G17900.1; AT2G17900.
GeneID	816300.
GenomeReviews	Gene locus AT2G17900 in contig CT485783_GR.
KEGG	ath:AT2G17900.
NMPDR	fig|3702.1.peg.8785.
Organism-specific databases
TAIR	At2g17900.
Phylogenomic databases
eggNOG	KOG2084.
GeneTree	EPGT00070000029173.
HOGENOM	HBG319036.
InParanoid	Q7XJS0.
OMA	LKVEKFA.
PhylomeDB	Q7XJS0.
ProtClustDB	CLSN2690757.
Gene expression databases
ArrayExpress	Q7XJS0.
Genevestigator	Q7XJS0.
GermOnline	AT2G17900. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001214. SET_dom. IPR002893. Znf_MYND. [Graphical view]
KO	K11426.
Pfam	PF00856. SET. 1 hit. PF01753. zf-MYND. 1 hit. [Graphical view]
SMART	SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50280. SET. 1 hit. PS01360. ZF_MYND_1. 1 hit. PS50865. ZF_MYND_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASHR1_ARATH

Accession

Primary (citable) accession number: Q7XJS0
Secondary accession number(s): A4VCM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	May 2, 2006
Last modified:	November 16, 2011
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program