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Protein

Phosphoinositide phosphatase SAC6

Gene

SAC6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphoinositide phosphatase that hydrolyzes PtdIns3P and PtdIns4P. Involved in priming for different defense responses.2 Publications

GO - Molecular functioni

GO - Biological processi

  • response to salt stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciARA:AT5G66020-MONOMER.
ReactomeiR-ATH-1483248. Synthesis of PIPs at the ER membrane.
R-ATH-1660514. Synthesis of PIPs at the Golgi membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phosphatase SAC6 (EC:3.1.3.-)
Short name:
AtSAC6
Alternative name(s):
Protein IMPAIRED IN BABA-INDUCED STERILITY 2
Protein SUPPRESSOR OF ACTIN 1B
Short name:
AtSAC1b
Protein SUPPRESSOR OF ACTIN 6
SAC domain protein 6
SAC1-like protein AtSAC1b
Gene namesi
Name:SAC6
Synonyms:IBS2, SAC1B
Ordered Locus Names:At5g66020
ORF Names:K2A18.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G66020.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei526 – 54621HelicalSequence analysisAdd
BLAST
Transmembranei555 – 57521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Impaired in BABA-induced sterility (ibs) and BABA-induced protection against P.syringae, H.parasitica, and salt. Affected in the priming for callose deposition.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Phosphoinositide phosphatase SAC6PRO_0000421972Add
BLAST

Proteomic databases

PaxDbiQ7X911.
PRIDEiQ7X911.

Expressioni

Tissue specificityi

Predominantly expressed in flowers.2 Publications

Inductioni

By salt stress.1 Publication

Gene expression databases

GenevisibleiQ7X911. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G66020.1.

Structurei

3D structure databases

ProteinModelPortaliQ7X911.
SMRiQ7X911. Positions 58-457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 456329SACPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi391 – 40212Phosphatase catalytic coreAdd
BLAST

Domaini

The phosphatase catalytic core motif (or RXNCXDCLDRTN motif) from the SAC domain is found in metal-independent protein phosphatases and inositol polyphosphate phosphatases.By similarity

Sequence similaritiesi

Contains 1 SAC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1889. Eukaryota.
COG5329. LUCA.
HOGENOMiHOG000189112.
InParanoidiQ7X911.
OMAiSIFARHM.
PhylomeDBiQ7X911.

Family and domain databases

InterProiIPR030069. SAC6/7/8.
IPR002013. SAC_dom.
[Graphical view]
PANTHERiPTHR11200:SF120. PTHR11200:SF120. 1 hit.
PfamiPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7X911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSRLKIHSG LRLWEFPDQY VIEPTDGSSA SCLDISRLDG SMKLIDQVAE
60 70 80 90 100
CNSLRVPKIR SIFGVVGMLK LLAGSYLVVV TESESVGSFL GHPIYKINSL
110 120 130 140 150
KFLPCDHSLE NPHEEQKKME TDDYSRLLSV AERTTGLYFS YEINLTLTAQ
160 170 180 190 200
RLHDLGDESK LLPLWRQAEP RFLWNNYMLE VLIDNKLDQF LLPVIQGSFH
210 220 230 240 250
SFQTAIGRDI VDITLIARRC SRRNGTRMWR RGADPDGYVA NFVETEQIVR
260 270 280 290 300
MNGYTSSFVQ IRGSMPFMWE QIVDLTYKPK FEIVQPEEAA RIAERHFLDL
310 320 330 340 350
RKKYGSVLAV DLVNKHGGEG RLSERFAGAM QHITGDDVRY LHFDFHHICG
360 370 380 390 400
HIHFERLAIL YEQMEDFLEK NGYFLLNEKG EKMKEQLGIV RTNCIDCLDR
410 420 430 440 450
TNVTQSMIGR KLLELQLKRI GVFGAEETIR SHQNFDECYK ILWANHGDDI
460 470 480 490 500
SIQYSGTPAL KGDFVRYGQR TIQGVLQDGW NALARYYLNN FADGTKQDAI
510 520 530 540 550
DLVQGHYIVA VSRDMAPVPR KRGLEAVANF PVALTVILIS FWFATMSVKQ
560 570 580 590
VGSGYKHLLF SLVWAGISVA VAALVRANGR IFCNRPSLHK PRS
Length:593
Mass (Da):67,626
Last modified:October 1, 2003 - v1
Checksum:i03272BA0818B97C2
GO

Sequence cautioni

The sequence BAB10407.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF266458 mRNA. Translation: AAP41367.1.
AY227249 mRNA. Translation: AAP49839.1.
AB011474 Genomic DNA. Translation: BAB10407.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED98142.1.
RefSeqiNP_201403.2. NM_125999.2.
UniGeneiAt.28885.

Genome annotation databases

EnsemblPlantsiAT5G66020.1; AT5G66020.1; AT5G66020.
GeneIDi836732.
GrameneiAT5G66020.1; AT5G66020.1; AT5G66020.
KEGGiath:AT5G66020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF266458 mRNA. Translation: AAP41367.1.
AY227249 mRNA. Translation: AAP49839.1.
AB011474 Genomic DNA. Translation: BAB10407.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED98142.1.
RefSeqiNP_201403.2. NM_125999.2.
UniGeneiAt.28885.

3D structure databases

ProteinModelPortaliQ7X911.
SMRiQ7X911. Positions 58-457.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G66020.1.

Proteomic databases

PaxDbiQ7X911.
PRIDEiQ7X911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G66020.1; AT5G66020.1; AT5G66020.
GeneIDi836732.
GrameneiAT5G66020.1; AT5G66020.1; AT5G66020.
KEGGiath:AT5G66020.

Organism-specific databases

TAIRiAT5G66020.

Phylogenomic databases

eggNOGiKOG1889. Eukaryota.
COG5329. LUCA.
HOGENOMiHOG000189112.
InParanoidiQ7X911.
OMAiSIFARHM.
PhylomeDBiQ7X911.

Enzyme and pathway databases

BioCyciARA:AT5G66020-MONOMER.
ReactomeiR-ATH-1483248. Synthesis of PIPs at the ER membrane.
R-ATH-1660514. Synthesis of PIPs at the Golgi membrane.

Miscellaneous databases

PROiQ7X911.

Gene expression databases

GenevisibleiQ7X911. AT.

Family and domain databases

InterProiIPR030069. SAC6/7/8.
IPR002013. SAC_dom.
[Graphical view]
PANTHERiPTHR11200:SF120. PTHR11200:SF120. 1 hit.
PfamiPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Three SAC1-like genes show overlapping patterns of expression in Arabidopsis but are remarkably silent during embryo development."
    Despres B., Bouissonnie F., Wu H.J., Gomord V., Guilleminot J., Grellet F., Berger F., Delseny M., Devic M.
    Plant J. 34:293-306(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION.
    Strain: cv. Wassilewskija.
    Tissue: Flower bud.
  2. "The SAC domain-containing protein gene family in Arabidopsis."
    Zhong R., Ye Z.-H.
    Plant Physiol. 132:544-555(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, DOMAIN, TISSUE SPECIFICITY, INDUCTION BY SALT.
  3. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
    Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Dissecting the beta-aminobutyric acid-induced priming phenomenon in Arabidopsis."
    Ton J., Jakab G., Toquin V., Flors V., Iavicoli A., Maeder M.N., Metraux J.P., Mauch-Mani B.
    Plant Cell 17:987-999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.

Entry informationi

Entry nameiSAC6_ARATH
AccessioniPrimary (citable) accession number: Q7X911
Secondary accession number(s): Q9FKY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: October 1, 2003
Last modified: February 17, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.