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Q7X7L3

- ELP3_ORYSJ

UniProt

Q7X7L3 - ELP3_ORYSJ

Protein

Elongator complex protein 3

Gene

ELP3

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Histone acetyltransferase. Part of the large multiprotein complex Elongator that is involved in the regulation of transcription initiation and elongation. May also have a methyltransferase activity By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Cofactori

    Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi125 – 1251Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi135 – 1351Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi138 – 1381Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC
    2. iron-sulfur cluster binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell proliferation Source: EnsemblPlants/Gramene
    2. DNA mediated transformation Source: EnsemblPlants/Gramene
    3. organ growth Source: EnsemblPlants/Gramene
    4. regulation of auxin mediated signaling pathway Source: EnsemblPlants/Gramene
    5. regulation of leaf formation Source: EnsemblPlants/Gramene
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. specification of organ axis polarity Source: EnsemblPlants/Gramene
    8. transcription, DNA-templated Source: UniProtKB-KW
    9. tRNA wobble uridine modification Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongator complex protein 3 (EC:2.3.1.48)
    Alternative name(s):
    Elongator component 3
    Gene namesi
    Name:ELP3
    Ordered Locus Names:Os04g0484900, LOC_Os04g40840
    ORF Names:OJ000223_09.4, OSJNBa0081L15.14
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 4

    Organism-specific databases

    GrameneiQ7X7L3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytosol Source: EnsemblPlants/Gramene
    2. Elongator holoenzyme complex Source: EnsemblPlants/Gramene
    3. nuclear euchromatin Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573Elongator complex protein 3PRO_0000232129Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the Elongator core subcomplex.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7X7L3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini422 – 573152N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi9 – 146Poly-Gly

    Sequence similaritiesi

    Belongs to the ELP3 family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1243.
    HOGENOMiHOG000227514.
    KOiK07739.
    OMAiGYKVVSH.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR01211. ELP3. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7X7L3-1 [UniParc]FASTAAdd to Basket

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    MATAVAAAGG GGGGEQPRRR KPAPGRGGVV LPAGLSEEEA RVRAIAEIVS    50
    AMGELSRRGE DVDLNALKSA ACRRYGLARA PKLVEMIAAV PEADRAALLP 100
    RLRAKPVRTA SGIAVVAVMS KPHRCPHIAT TGNICVYCPG GPDSDFEYST 150
    QSYTGYEPTS MRAIRARYNP YVQARSRIDQ LKRLGHSVDK VEFILMGGTF 200
    MSLPADYRDY FIRNLHDALS GHTSANVEEA VCYSEHGAVK CIGMTIETRP 250
    DYCLGPHLRQ MLSYGCTRLE IGVQSTYEDV ARDTNRGHTV AAVADCFCLA 300
    KDAGFKVVAH MMPDLPNVGV ERDLESFREF FENPAFRADG LKIYPTLVIR 350
    GTGLYELWKT GRYRNYPPEL LVDIVARILS MVPPWTRVYR VQRDIPMPLV 400
    TSGVEKGNLR ELALARMEDL GLKCRDVRTR EAGIQDIHHK IRPDEVELVR 450
    RDYAANEGWE TFLSYEDTQQ DILIGLLRLR KCGRNVTCPE LVGRCSIVRE 500
    LHVYGTAVPV HGRDADKLQH QGYGTLLMEE AERIARKEHR SKKIAVISGV 550
    GTRHYYRKLG YELEGPYMVK CLV 573
    Length:573
    Mass (Da):63,775
    Last modified:July 5, 2004 - v2
    Checksum:i9CCDB95C057F2B54
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL606998 Genomic DNA. Translation: CAE02005.2.
    AL606623 Genomic DNA. Translation: CAE03152.2.
    AK122179 mRNA. No translation available.
    RefSeqiNP_001053128.1. NM_001059663.1.
    UniGeneiOs.17516.

    Genome annotation databases

    EnsemblPlantsiOS04T0484900-01; OS04T0484900-01; OS04G0484900.
    GeneIDi4336205.
    KEGGiosa:4336205.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL606998 Genomic DNA. Translation: CAE02005.2 .
    AL606623 Genomic DNA. Translation: CAE03152.2 .
    AK122179 mRNA. No translation available.
    RefSeqi NP_001053128.1. NM_001059663.1.
    UniGenei Os.17516.

    3D structure databases

    ProteinModelPortali Q7X7L3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS04T0484900-01 ; OS04T0484900-01 ; OS04G0484900 .
    GeneIDi 4336205.
    KEGGi osa:4336205.

    Organism-specific databases

    Gramenei Q7X7L3.

    Phylogenomic databases

    eggNOGi COG1243.
    HOGENOMi HOG000227514.
    KOi K07739.
    OMAi GYKVVSH.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR01211. ELP3. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiELP3_ORYSJ
    AccessioniPrimary (citable) accession number: Q7X7L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3