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Q7X7L3

- ELP3_ORYSJ

UniProt

Q7X7L3 - ELP3_ORYSJ

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Protein

Elongator complex protein 3

Gene

ELP3

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Histone acetyltransferase. Part of the large multiprotein complex Elongator that is involved in the regulation of transcription initiation and elongation. May also have a methyltransferase activity (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactori

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi125 – 1251Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi135 – 1351Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi138 – 1381Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. iron-sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. auxin-activated signaling pathway Source: EnsemblPlants/Gramene
  2. cell proliferation Source: EnsemblPlants/Gramene
  3. DNA mediated transformation Source: EnsemblPlants/Gramene
  4. organ growth Source: EnsemblPlants/Gramene
  5. protein maturation Source: EnsemblPlants/Gramene
  6. regulation of auxin mediated signaling pathway Source: EnsemblPlants/Gramene
  7. regulation of leaf formation Source: EnsemblPlants/Gramene
  8. regulation of transcription, DNA-templated Source: UniProtKB-KW
  9. specification of organ axis polarity Source: EnsemblPlants/Gramene
  10. transcription, DNA-templated Source: UniProtKB-KW
  11. tRNA wobble uridine modification Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3 (EC:2.3.1.48)
Alternative name(s):
Elongator component 3
Gene namesi
Name:ELP3
Ordered Locus Names:Os04g0484900, LOC_Os04g40840
ORF Names:OJ000223_09.4, OSJNBa0081L15.14
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 4

Organism-specific databases

GrameneiQ7X7L3.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. cytosol Source: EnsemblPlants/Gramene
  2. Elongator holoenzyme complex Source: EnsemblPlants/Gramene
  3. nuclear euchromatin Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Elongator complex protein 3PRO_0000232129Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ7X7L3. baseline.

Interactioni

Subunit structurei

Part of the Elongator core subcomplex.

Structurei

3D structure databases

ProteinModelPortaliQ7X7L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini422 – 573152N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 146Poly-Gly

Sequence similaritiesi

Belongs to the ELP3 family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1243.
HOGENOMiHOG000227514.
InParanoidiQ7X7L3.
KOiK07739.
OMAiGYKVVSH.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7X7L3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATAVAAAGG GGGGEQPRRR KPAPGRGGVV LPAGLSEEEA RVRAIAEIVS
60 70 80 90 100
AMGELSRRGE DVDLNALKSA ACRRYGLARA PKLVEMIAAV PEADRAALLP
110 120 130 140 150
RLRAKPVRTA SGIAVVAVMS KPHRCPHIAT TGNICVYCPG GPDSDFEYST
160 170 180 190 200
QSYTGYEPTS MRAIRARYNP YVQARSRIDQ LKRLGHSVDK VEFILMGGTF
210 220 230 240 250
MSLPADYRDY FIRNLHDALS GHTSANVEEA VCYSEHGAVK CIGMTIETRP
260 270 280 290 300
DYCLGPHLRQ MLSYGCTRLE IGVQSTYEDV ARDTNRGHTV AAVADCFCLA
310 320 330 340 350
KDAGFKVVAH MMPDLPNVGV ERDLESFREF FENPAFRADG LKIYPTLVIR
360 370 380 390 400
GTGLYELWKT GRYRNYPPEL LVDIVARILS MVPPWTRVYR VQRDIPMPLV
410 420 430 440 450
TSGVEKGNLR ELALARMEDL GLKCRDVRTR EAGIQDIHHK IRPDEVELVR
460 470 480 490 500
RDYAANEGWE TFLSYEDTQQ DILIGLLRLR KCGRNVTCPE LVGRCSIVRE
510 520 530 540 550
LHVYGTAVPV HGRDADKLQH QGYGTLLMEE AERIARKEHR SKKIAVISGV
560 570
GTRHYYRKLG YELEGPYMVK CLV
Length:573
Mass (Da):63,775
Last modified:July 5, 2004 - v2
Checksum:i9CCDB95C057F2B54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL606998 Genomic DNA. Translation: CAE02005.2.
AL606623 Genomic DNA. Translation: CAE03152.2.
AK122179 mRNA. No translation available.
RefSeqiNP_001053128.1. NM_001059663.1.
UniGeneiOs.17516.

Genome annotation databases

EnsemblPlantsiOS04T0484900-01; OS04T0484900-01; OS04G0484900.
GeneIDi4336205.
KEGGiosa:4336205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL606998 Genomic DNA. Translation: CAE02005.2 .
AL606623 Genomic DNA. Translation: CAE03152.2 .
AK122179 mRNA. No translation available.
RefSeqi NP_001053128.1. NM_001059663.1.
UniGenei Os.17516.

3D structure databases

ProteinModelPortali Q7X7L3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS04T0484900-01 ; OS04T0484900-01 ; OS04G0484900 .
GeneIDi 4336205.
KEGGi osa:4336205.

Organism-specific databases

Gramenei Q7X7L3.

Phylogenomic databases

eggNOGi COG1243.
HOGENOMi HOG000227514.
InParanoidi Q7X7L3.
KOi K07739.
OMAi GYKVVSH.

Gene expression databases

ExpressionAtlasi Q7X7L3. baseline.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR01211. ELP3. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiELP3_ORYSJ
AccessioniPrimary (citable) accession number: Q7X7L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3